PLATO'S THEORY OF INCARCERATION

Ramus ◽  
2021 ◽  
Vol 50 (1-2) ◽  
pp. 68-86
Author(s):  
Jacob Abolafia
Keyword(s):  
Political Institution ◽  
Democratic Politics ◽  
Criminal Punishment ◽  
Athenian Democracy ◽  
Popular Government ◽  
Precise Role

In addition to its many famous innovations in popular government, the Athenian democracy seems to have also experimented with another, more ambivalent political institution familiar to modern societies—penal incarceration. In recent years, there has been renewed debate over the precise role of imprisonment in Athens, as an increasing number of voices, including Marcus Folch in this volume, make the case that imprisonment was an important point of contact between criminal punishment and democratic politics and society in Athens.

Mortal Democracy and Plato’s Apology

2020 ◽  
pp. 009059172098295
Author(s):  
Elizabeth Barringer
Keyword(s):  
Democratic Politics ◽  
Political Life ◽  
Partial Transformation ◽  
Critical Space ◽  
Athenian Democracy ◽  
Precarious Work ◽  
Democratic Practice

The Apology is often read as showing a conflict between democracy and philosophy. I argue here that Socrates’s defense critically engages deeply political Athenian conventions of death, showing a mutual entanglement between Socratic philosophy and democratic practice. I suggest that Socrates’s aporetic insistence within the Apology that we “do not know if death is a good or a bad thing” structures a critical space of inquiry that I term “mortal ignorance;” a space from which Socrates reapproaches settled questions of death’s appropriate place in political life, ultimately prompting a partial transformation of Athenian democracy. I argue here that Socratic mortal ignorance supports a self-reflective politics of death, one which produces many potential responses and accepts the impossibility of closing off death’s meaning in any final sense—an aporia suitable for the unending, precarious work of democratic politics.

scholarly journals Cholinergic Signaling, Neural Excitability, and Epilepsy

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2258
Author(s):  
Yu Wang ◽  
Bei Tan ◽  
Yi Wang ◽  
Zhong Chen
Keyword(s):  
Cholinergic Neurons ◽  
Epileptic Seizures ◽  
Brain Disorder ◽  
Neural Excitability ◽  
Cholinergic Signaling ◽  
The Central Nervous System ◽  
Muscarinic And Nicotinic Receptors ◽  
Cumulative Evidence ◽  
Precise Role

Epilepsy is a common brain disorder characterized by recurrent epileptic seizures with neuronal hyperexcitability. Apart from the classical imbalance between excitatory glutamatergic transmission and inhibitory γ-aminobutyric acidergic transmission, cumulative evidence suggest that cholinergic signaling is crucially involved in the modulation of neural excitability and epilepsy. In this review, we briefly describe the distribution of cholinergic neurons, muscarinic, and nicotinic receptors in the central nervous system and their relationship with neural excitability. Then, we summarize the findings from experimental and clinical research on the role of cholinergic signaling in epilepsy. Furthermore, we provide some perspectives on future investigation to reveal the precise role of the cholinergic system in epilepsy.

scholarly journals The Constitutive Centromere Component CENP-50 Is Required for Recovery from Spindle Damage

2005 ◽  
Vol 25 (23) ◽  
pp. 10315-10328 ◽  
Author(s):  
Yukinori Minoshima ◽  
Tetsuya Hori ◽  
Masahiro Okada ◽  
Hiroshi Kimura ◽  
Tokuko Haraguchi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Growth Rate ◽  
Mitotic Checkpoint ◽  
Loss Of Function ◽  
Wild Type ◽  
Centromere Function ◽  
Dt40 Cells ◽  
Precise Role ◽  
Chicken Dt40 Cell

ABSTRACT We identified CENP-50 as a novel kinetochore component. We found that CENP-50 is a constitutive component of the centromere that colocalizes with CENP-A and CENP-H throughout the cell cycle in vertebrate cells. To determine the precise role of CENP-50, we examined its role in centromere function by generating a loss-of-function mutant in the chicken DT40 cell line. The CENP-50 knockout was not lethal; however, the growth rate of cells with this mutation was slower than that of wild-type cells. We observed that the time for CENP-50-deficient cells to complete mitosis was longer than that for wild-type cells. Centromeric localization of CENP-50 was abolished in both CENP-H- and CENP-I-deficient cells. Coimmunoprecipitation experiments revealed that CENP-50 interacted with the CENP-H/CENP-I complex in chicken DT40 cells. We also observed severe mitotic defects in CENP-50-deficient cells with apparent premature sister chromatid separation when the mitotic checkpoint was activated, indicating that CENP-50 is required for recovery from spindle damage.

THE PRECISE ROLE OF CD28 AND CD154 POSITIVE AND CTLA4 NEGATIVE SIGNALS IN THE ALLOGRAFT RESPONSE.

2000 ◽  
Vol 69 (Supplement) ◽  
pp. S414-S415
Author(s):  
Xin Xiao Zheng ◽  
Thomas A. Markees ◽  
Martina Weber ◽  
Xian Chang Li ◽  
Yongsheng Li ◽  
...  
Keyword(s):  
Precise Role ◽  
Allograft Response

scholarly journals Sec1p directly stimulates SNARE-mediated membrane fusion in vitro

2004 ◽  
Vol 167 (1) ◽  
pp. 75-85 ◽  
Author(s):  
Brenton L. Scott ◽  
Jeffrey S. Van Komen ◽  
Hassan Irshad ◽  
Song Liu ◽  
Kirilee A. Wilson ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Membrane Fusion ◽  
Membrane Trafficking ◽  
Snare Complex ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Bud Neck ◽  
Precise Role

Sec1 proteins are critical players in membrane trafficking, yet their precise role remains unknown. We have examined the role of Sec1p in the regulation of post-Golgi secretion in Saccharomyces cerevisiae. Indirect immunofluorescence shows that endogenous Sec1p is found primarily at the bud neck in newly budded cells and in patches broadly distributed within the plasma membrane in unbudded cells. Recombinant Sec1p binds strongly to the t-SNARE complex (Sso1p/Sec9c) as well as to the fully assembled ternary SNARE complex (Sso1p/Sec9c;Snc2p), but also binds weakly to free Sso1p. We used recombinant Sec1p to test Sec1p function using a well-characterized SNARE-mediated membrane fusion assay. The addition of Sec1p to a traditional in vitro fusion assay moderately stimulates fusion; however, when Sec1p is allowed to bind to SNAREs before reconstitution, significantly more Sec1p binding is detected and fusion is stimulated in a concentration-dependent manner. These data strongly argue that Sec1p directly stimulates SNARE-mediated membrane fusion.

scholarly journals Are the determinants of markup size industry-specific? The case of Slovenian manufacturing firms

2011 ◽  
Vol 58 (2) ◽  
pp. 229-244 ◽  
Author(s):  
Nina Ponikvar ◽  
Maks Tajnikar
Keyword(s):  
Manufacturing Sector ◽  
Manufacturing Firms ◽  
Manufacturing Industries ◽  
Dynamic Panel ◽  
Pricing Policy ◽  
Large Variability ◽  
Oligopoly Theory ◽  
Determination Process ◽  
Precise Role

The aim of this paper is to identify factors that affect the pricing policy in Slovenian manufacturing firms in terms of the markup size and, most of all, to explicitly account for the possibility of differences in pricing procedures among manufacturing industries. Accordingly, the analysis of the dynamic panel is carried out on an industry-by-industry basis, allowing the coefficients on the markup determinants to vary across industries. We find that the oligopoly theory of markup determination for the most part holds for the manufacturing sector as a whole, although large variability in markup determinants exists across industries within the Slovenian manufacturing. Our main conclusion is that each industry should be investigated separately in detail in order to assess the precise role of markup factors in the markup-determination process.

The Distinctiveness Principle: Identity, Meaning, and the Bounds of Cultural Relativity

2000 ◽  
Vol 4 (4) ◽  
pp. 337-354 ◽  
Author(s):  
Vivian L. Vignoles ◽  
Xenia Chryssochoou ◽  
Glynis M. Breakwell
Keyword(s):  
Cross Cultural ◽  
Cultural Relativity ◽  
Identity Processes ◽  
Cultural Systems ◽  
Construction Of Meaning ◽  
The Cross ◽  
And Behavior ◽  
Precise Role

Extending theories of distinctiveness motivation in identity (Breakwell, 1987; Brewer, 1991; Snyder & Fromkin, 1980), we discuss the precise role of distinctiveness in identity processes and the cross-cultural generality of the distinctiveness principle. We argue that (a) within Western cultures, distinctiveness is necessaryfor the construction of meaning within identity, and (b) the distinctiveness principle is not incompatible with non-Western cultural systems. We propose a distinction among three sources of distinctiveness: position, difference, and separateness, with different implications for identity and behavior. These sources coexist within cultures, on both individual and group levels of selfrepresentation, but they may be emphasized differently according to culture and context.

Popular Access to the Decision‐making Process in Switzerland: The Role of Direct Democracy

1979 ◽  
Vol 14 (2) ◽  
pp. 180-197 ◽  
Author(s):  
Marjorie Mowlam
Keyword(s):  
Citizen Participation ◽  
Direct Democracy ◽  
Democratic Politics ◽  
Political Life ◽  
The Political ◽  
Decision Making Process ◽  
Political Choices ◽  
Selection Of ◽  
Popular Control

CENTRAL TO THE STUDY OF DEMOCRATIC POLITICS IS THE IDEA of popular control over the activities of elites. More specifically, how can the preferences of citizens be aggregated into a political choice for a government policy or government personnel? Popular control, the effects of citizen participation in political life, is the basis of a major value orientation in the discipline: the notion of participant democracy. The degree of citizen participation becomes the key to the nature of democracry in a society : the more participation, the more democratic the political life of a country becomes. Political participation may take a variety of forms, e.g., running for office, holding office,voting, soliciting votes, and campaigning for, or contributing funds to, I the party of one's choice. However, voting is the most emphasized aspect of citizen participation, since it is the only form of active participation many engage in. The limitations placed on voting as a mechanism for popular control over political choices are well documented. Voters do not choose when to vote, nor the agenda. They have minimal input into the selection of candidates and the choice of issues which divide the parties at elections. Public participation in the selection and resolution of important policy issues between elections is severely restricted.

Religion and Progressive Activism—Introducing and Mapping the Field

2017 ◽  
Author(s):  
Todd Nicholas Fuist ◽  
Ruth Braunstein ◽  
Rhys H. Williams
Keyword(s):  
United States ◽  
Social Movements ◽  
The United States ◽  
Democratic Politics ◽  
Political Life ◽  
Social Actors ◽  
Theories Of Religion ◽  
Religious Activism ◽  
Progressive Religion

This chapter introduces readers to the often-overlooked field of progressive religious activism in the United States, and maps its contours. First, it traces the history and continued relevance of progressive religious activism in American political life. Second, it argues that progressive religion should not be conceptualized as a category of social actors, but rather as a field of action defined by participants’ commitment to progressive action, progressive values, progressive identities, and/or progressive theology, as well as through participants’ efforts to distinguish themselves from the activities of religious conservatives and/or secular progressives. Finally, it assesses the varied ways that attention to progressive religion challenges common political binaries (like Right/Left and progress/tradition), and prompts a reconsideration of long accepted theories of religion and social movements as well as the role of faith in democratic politics and civic life.

Static Pressure-Volume Curves for the Lung of the Frog (Rana Pipiens)

1978 ◽  
Vol 76 (1) ◽  
pp. 149-165 ◽  
Author(s):  
G. M. HUGHES ◽  
G. A. VERGARA
Keyword(s):  
Volume Change ◽  
Rana Pipiens ◽  
Static Pressure ◽  
Large Diameter ◽  
The Difference ◽  
Isolated Lungs ◽  
Precise Role ◽  
Different Parts

1. Static pressure/volume curves have been determined for isolated frog lungs inflated with either air or saline. In both cases a hysteresis was present: the pressure required to produce unit change of volume being greater during inflation than deflation. 2. The pressure necessary for a given volume change was less for the saline-filled than the air-filled lungs. The difference between these curves is due to the surface tension at the air/lung interface. 3. Pressure/volume curves for air-filled lungs in situ were similar to curves for isolated lungs. However, a greater pressure was required for the same volume change during both inflation and deflation. 4. Compliance was calculated from different parts of air pressure/volume curves and gave values greater than those obtained using similar calculations for higher vertebrates. 5. These observations support other evidence for the presence of a surfactant in the lung lining of frogs in spite of the relatively large diameter of their ‘alveoli.’ The precise role of such a lining is uncertain and it is concluded that similar forces may be involved during the inflation and deflation of lungs of frogs and higher vertebrates in spite of differences in gross morphology.

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