scholarly journals Association between dietary fibre intake and asthma (symptoms and control): results from the French national e-cohort NutriNet-Santé

2019 ◽  
Vol 122 (9) ◽  
pp. 1040-1051 ◽  
Author(s):  
Roland M. Andrianasolo ◽  
Serge Hercberg ◽  
Emmanuelle Kesse-Guyot ◽  
Nathalie Druesne-Pecollo ◽  
Mathilde Touvier ◽  
...  
Keyword(s):  
Asthma Control ◽  
Symptom Score ◽  
Dietary Fibre ◽  
Asthma Symptom ◽  
Fibre Intake ◽  
Asthma Symptoms ◽  
Insoluble Fibre ◽  
Dietary Fibre Intake ◽  
Total Dietary Fibre ◽  
Asthma Symptom Score

AbstractDespite growing evidence suggesting a potential health benefit of high fibre intake for the prevention of chronic inflammatory diseases, studies regarding the role of total dietary fibre intake, types and sources of fibre on asthma are lacking. The present study aimed to investigate the cross-sectional association of dietary fibre intakes and source of fibre with the asthma symptom score and asthma control. A total of 35 380 participants from the NutriNet-Santé cohort were included. Asthma was defined by the asthma symptom score and asthma control by the asthma control test. Fibre intake (g/d) was categorised according to sex-specific quintiles. Multi-adjusted negative binomial regressions were used to evaluate the association between dietary fibre with the asthma symptom score and logistic regressions with asthma control. Participants were aged on average 54 years. After adjustment for confounders, higher intake of total, soluble, insoluble fibres from cereals, fruit and seeds were significantly negatively associated with the asthma symptom score both among women and men; OR for the highest quintile of total dietary fibre compared with the lowest quintile were 0·73 (95 % CI 0·67, 0·79) in women and 0·63 (95 % CI 0·55, 0·73) in men. We also found inverse significant associations between total, soluble and insoluble fibre with uncontrolled asthma; OR for participants in the highest quintile of total dietary fibre was 0·72 (95 % CI 0·55, 0·95) in women and 0·45 (95 % CI 0·26, 0·79) in men. Our results suggested that higher intake of dietary fibre, mostly insoluble fibre and fibre from cereals, was associated with fewer asthma symptoms and greater asthma control.

scholarly journals Associations between dietary scores with asthma symptoms and asthma control in adults

2018 ◽  
Vol 52 (1) ◽  
pp. 1702572 ◽  
Author(s):  
Roland M. Andrianasolo ◽  
Emmanuelle Kesse-Guyot ◽  
Moufidath Adjibade ◽  
Serge Hercberg ◽  
Pilar Galan ◽  
...  
Keyword(s):  
Asthma Control ◽  
Symptom Score ◽  
Asthma Symptom ◽  
Healthy Eating Index ◽  
Negative Association ◽  
Asthma Control Test ◽  
Asthma Symptoms ◽  
Adherence Score ◽  
Asthma Symptom Score

Associations between asthma and the nutritional quality of diet remain poorly understood. We investigated the associations between overall quality of diet evaluated by three dietary scores (the Alternate Healthy Eating Index 2010 (AHEI-2010), the literature-based adherence score to Mediterranean diet (MEDI-LITE) and the modified Programme National Nutrition Santé Guideline Score (mPNNS-GS)) and the asthma symptom score and asthma control.In 2017, 34 766 participants from the NutriNet-Santé cohort answered a detailed respiratory questionnaire. Asthma was defined by the asthma symptom score (as the sum of five questions) and asthma control by the asthma control test (ACT).Roughly 25% of participants reported at least one asthma symptom and for the three dietary scores we observed a statistically significant negative association between a healthier diet and the asthma symptom score (for AHEI-2010, the adjusted OR was 0.79 (95% CI 0.75–0.84) for women and 0.67 (95% CI 0.60–0.75) for men). Among participants with asthma (n=2609) we also observed a negative association between a healthier diet and poorly controlled asthma. This was significant in men (OR 0.39 (95% CI 0.18–0.84) for the AHEI-2010) and borderline significant in women (OR 0.73 (95% CI 0.53–1.01) for the AHEI-2010; p=0.06 for trend).Healthier diet behaviours were associated with fewer asthma symptoms and greater asthma control.

scholarly journals Spontaneous resolution of atopic dermatitis incidental to participation in benralizumab clinical trial for severe, uncontrolled asthma: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
David N. Pham
Keyword(s):  
Atopic Dermatitis ◽  
Symptom Score ◽  
Asthma Symptom ◽  
Spontaneous Resolution ◽  
Cell Surface Receptor ◽  
Food Allergies ◽  
Uncontrolled Asthma ◽  
Exacerbation Rate ◽  
Asthma Symptoms ◽  
Asthma Symptom Score

Abstract Background T cell-mediated eosinophilia is associated with numerous conditions—including atopic dermatitis, food allergies, and asthma—collectively known as the “atopic march.” Benralizumab is a recombinant, humanized, afucosylated monoclonal antibody directed against the ⍺ chain of the eosinophil cell surface receptor IL-5R. Benralizumab treatment causes near-complete depletion of circulating eosinophils and was approved in 2017 for add-on, maintenance treatment of severe asthma with an eosinophilic phenotype, based on the results of the CALIMA and SIROCCO pivotal trials. Benralizumab is not currently approved for the treatment of eosinophilic conditions besides asthma; however, during the CALIMA trial, spontaneous resolution of atopic dermatitis was observed in a patient, concurrent with reduction in her asthma symptoms. Case presentation In January 2015, a 14-year-old Asian girl with severe, uncontrolled asthma was enrolled in CALIMA. The patient’s baseline eosinophil blood count was 1200 cells/μL, her pre-bronchodilator forced expiratory volume in 1 second (FEV1) was 1.9 L and FEV1/forced vital capacity (FVC) ratio was 71.4%, and her post-bronchodilator FEV1 was 3.2 L (FEV1/FVC of 115.9%). Her overall baseline asthma symptom score was 3.9 and her asthma exacerbation rate in the prior year was 4. She also displayed a pronounced, pruritic, chronic, inflammatory rash consistent with atopic dermatitis across her face. The investigator was blinded to the patient’s treatment group during treatment; however, her asthma symptoms diminished over the course of the study (FEV1 at 56 weeks, 3.01 L/110.5% (pre) and 3.25 L/119.3% (post); overall asthma symptom score 2.1; one influenza-associated exacerbation). Furthermore, her atopic dermatitis symptoms resolved spontaneously within the first 5 months of the study. After unblinding, the patient was confirmed to have been randomized to an active treatment arm, and her blood eosinophil count had dropped below the limit of detection after the first study dose. Conclusions Given the potential shared mechanisms between eosinophilic asthma and atopic dermatitis, it is plausible that benralizumab-induced eosinopenia factored into the resolution of the patient’s atopic dermatitis. Further clinical studies are warranted to determine whether benralizumab or other drugs targeted against IL-5/IL-5R may be useful in managing multiple conditions associated with eosinophilia.

scholarly journals Hyperlipidaemia and its risk factors in the Guangxi Bai Ku Yao and Han populations

2009 ◽  
Vol 12 (6) ◽  
pp. 816-824 ◽  
Author(s):  
Yin Ruixing ◽  
Yang Dezhai ◽  
Li Shuquan ◽  
Chen Yuming ◽  
Yang Hanjun ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Waist Circumference ◽  
Total Energy ◽  
Dietary Fibre ◽  
Activity Level ◽  
Fibre Intake ◽  
Dietary Fibre Intake ◽  
Total Dietary Fibre ◽  
Total Fat

AbstractObjectiveTo compare the differences in hyperlipidaemia prevalence and its risk factors between the Guangxi Bai Ku Yao and Han populations.DesignCross-sectional study of hyperlipidaemia.SettingBoth populations were from Lihu and Baxu villages in Nandan County, Guangxi Zhuang Autonomous Region, People’s Republic of China.SubjectsA total of 1170 healthy subjects of Bai Ku Yao and 1173 participants of Han Chinese aged 15–89 years were surveyed by a stratified randomized cluster sampling. Information on demographic, dietary and lifestyle characteristics was collected by standard questionnaires. Blood pressure, height, weight, waist circumference, serum lipids and apolipoproteins were measured, and BMI (kg/m2) was calculated as weight divided by the square of height.ResultsThe prevalence rates of hypercholesterolaemia, hypertriacylglycerolaemia and hyperlipidaemia in Bai Ku Yao and Han were 12·4 % v. 26·2 % (P < 0·001), 15·0 % v. 14·8 % (P > 0·05) and 24·4 % v. 33·9 % (P < 0·001), respectively. Hyperlipidaemia was positively correlated with BMI, waist circumference, total energy and total fat intakes, and negatively associated with physical activity and total dietary fibre intake in Bai Ku Yao (P < 0·05 to 0·001). Hyperlipidaemia was positively associated with age, alcohol consumption, BMI, waist circumference, total energy and total fat intakes, and inversely correlated with physical activity and total dietary fibre intake in Han (P < 0·05 to 0·001).ConclusionsThe prevalence of hypercholesterolaemia and hyperlipidaemia was significantly lower in the Bai Ku Yao than in the Han population, which might result from different dietary habits, lifestyle choices and physical activity level, as well as genetic factors between the two ethnic groups.

scholarly journals Dietary fibre intake and clinical indices in the French Supplementation en Vitamines et Minéraux AntioXydants (SU.VI.MAX) adult cohort

2003 ◽  
Vol 62 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Denis Lairon ◽  
Sandrine Bertrais ◽  
Stephanie Vincent ◽  
Nathalie Arnault ◽  
Pilar Galan ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Dietary Fibre ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Systolic Pressure ◽  
Food Sources ◽  
Fibre Intake ◽  
Clinical Indices ◽  
Dietary Fibre Intake ◽  
Total Dietary Fibre

The aim of our study was to investigate the relationship between dietary fibre intake and some clinical indices, blood biochemical variables and the incidence of cardiovascular disease and cancers in France, taking advantage of an ongoing cohort, the Supplementation en Vitamines et Minéraux AntioXydants (SU.VI.MAX) intervention study. This preliminary report provides data on dietary fibre intake in this French adult population group of 4080 subjects (2168 men and 1912 women) aged 45–65 years at inclusion. The data obtained for fibre intake indicate that most men and women have low to moderate intakes of total dietary fibre (mean 21·0 and 17·1 g/d respectively), with only 21% of the men and 7% of the women having total dietary fibre intakes at the recommended level (i.e. >25 g/d) and soluble fibre accounting for 19% of the total dietary fibre intake for both genders. The main food sources of dietary fibre are cereals (30–35% total), vegetables (20–24% total) and fruit (19–22% total). No marked regional differences were observed within France. The highest dietary fibre intakes have been found to be associated with a lower BMI, blood systolic pressure, plasma triacylglycerols and plasma glucose in men and lower BMI in women. Overall, these data support the concept of a beneficial effect of a high dietary fibre intake on cardiovascular disease risk.

Association between an individual dietary index based on the British Food Standard Agency Nutrient Profiling System and asthma symptoms

2019 ◽  
Vol 122 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Roland M. Andrianasolo ◽  
Chantal Julia ◽  
Raphaëlle Varraso ◽  
Manon Egnell ◽  
Mathilde Touvier ◽  
...  
Keyword(s):  
Public Health ◽  
Symptom Score ◽  
Nutritional Quality ◽  
Asthma Symptom ◽  
Food Choices ◽  
Asthma Symptoms ◽  
Dietary Index ◽  
Nutrient Profiling ◽  
Asthma Symptom Score

AbstractThe role of diet in asthma is still debated. In France, a front-of-pack (FOP) nutrition label based on a modified Food Standards Agency Nutrient Profiling System/High Council for Public Health (FSAm-NPS/HCSP) has recently been implemented to help consumers to make healthier food choices during purchase. At the individual level, the FSAm-NPS dietary index (DI) has been shown to reflect the nutritional quality of the diet. The aim of the present study was to investigate the association between the FSAm-NPS DI and the asthma symptom score. In total, 34 323 participants (25 823 women and 8500 men) from the NutriNet-Santé cohort were included. The overall nutritional quality of the diet was assessed using the FSAm-NPS DI. Increasing FSAm-NPS DI reflects decreasing overall diet quality. Asthma was defined by the asthma symptom score (sum of five questions). Negative binomial regression was used to evaluate the association between the FSA-NPS DI and the asthma symptom score. Overall, mean participant’s age was 54 ± 14 years, and about 27 % reported at least one asthma symptom. We observed a significant positive association between less healthy diet, as expressed by higher FSAm-NPS DI, and the asthma symptom score. The adjusted OR were 1·27 (95 % CI 1·17, 1·38) among women and 1·31 (95 % CI 1·13, 1·53) among men. Unhealthy food choices, as reflected by a higher FSAm-NPS DI, were associated with greater asthma symptoms. These results reinforce the relevance of public health approach to orient consumers towards healthier food choices by using a clear and easy-to-understand FOP nutrition label based on the FSAm-NPS, such as the Nutri-Score.

scholarly journals Fibre and bowel transit times

1981 ◽  
Vol 45 (1) ◽  
pp. 77-82 ◽  
Author(s):  
J. S. S. Gear ◽  
A. J. M. Brodribb ◽  
Alison Ware ◽  
J. I. Mannt
Keyword(s):  
Diverticular Disease ◽  
Transit Time ◽  
Dietary Fibre ◽  
Rapid Transit ◽  
Fibre Intake ◽  
Transit Times ◽  
Dietary Fibre Intake ◽  
Total Dietary Fibre

1. Bowel transit time has been investigated in vegetarians and non-vegetarians and related to dietary fibre intake and the presence of diverticular disease.2. Vegetarians who have less diverticular disease than non-vegetarians have more rapid transit times.3. Subjects with total dietary fibre intake of more than 30 g/d all had transit times of less than 75 h whereas 38% of those eating less had transit times exceeding 75 h and varying up to 124 h.4. Individuals with diverticular disease were found to have faster transit times than those without the disease.5. The colon may respond to a fibre-depleted diet either by becoming hyperactive and prone to diverticular disease or by becoming hypoactive leading to constipation.

scholarly journals Comparison of a Barcode-Based Smartphone Application to a Questionnaire to Assess the Use of Cleaning Products at Home and Their Association with Asthma Symptoms

2021 ◽  
Vol 18 (7) ◽  
pp. 3366
Author(s):  
Pierre Lemire ◽  
Sofia Temam ◽  
Sarah Lyon-Caen ◽  
Catherine Quinot ◽  
Etienne Sévin ◽  
...  
Keyword(s):  
Symptom Score ◽  
Measurement Errors ◽  
Asthma Symptom ◽  
Respiratory Health ◽  
Smartphone Application ◽  
Epidemiological Research ◽  
Logistic Regression Models ◽  
Asthma Symptoms ◽  
Cleaning Products ◽  
Asthma Symptom Score

Household disinfectant and cleaning products (HDCPs) assessment is challenging in epidemiological research. We hypothesized that a newly-developed smartphone application was more objective than questionnaires in assessing HDCPs. Therefore, we aimed to compare both methods, in terms of exposure assessments and respiratory health effects estimates. The women of the SEPAGES birth cohort completed repeated validated questionnaires on HDCPs and respiratory health and used an application to report HDCPs and scan products barcodes, subsequently linked with an ingredients database. Agreements between the two methods were assessed by Kappa coefficients. Logistic regression models estimated associations of HDCP with asthma symptom score. The 101 participants (18 with asthma symptom score ≥1) scanned 617 different products (580 with available ingredients list). Slight to fair agreements for sprays, bleach and scented HDCP were observed (Kappa: 0.35, 0.25, 0.11, respectively). Strength of the associations between HDCP and asthma symptom score varied between both methods but all odds ratios (OR) were greater than one. The number of scanned products used weekly was significantly associated with the asthma symptom score (adjusted-OR [CI 95%]: 1.15 [1.00–1.32]). This study shows the importance of using novel tools in epidemiological research to objectively assess HDCP and therefore reduce exposure measurement errors.

Item Responsiveness of a Rhinitis and Asthma Symptom Score During a Pollen Season

1999 ◽  
Vol 36 (5) ◽  
pp. 459-465 ◽  
Author(s):  
Jean-Blaise Wasserfallen ◽  
Karen Gold ◽  
Kevin A. Schulman ◽  
James N. Baraniuk
Keyword(s):  
Symptom Score ◽  
Pollen Season ◽  
Asthma Symptom ◽  
Asthma Symptom Score

scholarly journals Intake of dietary fibre and lifetime non-steroidal anti-inflammatory drug (NSAID) use and the incidence of colorectal polyps in a population screened for colorectal cancer

2017 ◽  
Vol 71 (10) ◽  
pp. 961-969 ◽  
Author(s):  
Eileen Shaw ◽  
Matthew T Warkentin ◽  
S Elizabeth McGregor ◽  
Susanna Town ◽  
Robert J Hilsden ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dietary Fibre ◽  
Cross Sectional Study ◽  
Colorectal Polyps ◽  
Cross Sectional ◽  
Fibre Intake ◽  
Screening Population ◽  
Lifestyle Questionnaire ◽  
Dietary Fibre Intake ◽  
Anti Inflammatory

BackgroundThere is suggestive evidence that increased intake of dietary fibre and the use of non-steroidal anti-inflammatory drugs (NSAIDs) are generally associated with decreased colorectal cancer risk. However, the effects on precursors of colorectal cancer, such as adenomatous polyps, are mixed. We present the associations between dietary fibre intake and NSAID use on the presence and type of colorectal polyps in a screening population.MethodsA cross-sectional study of 2548 individuals undergoing colonoscopy at the Forzani & MacPhail Colon Cancer Screening Centre (Calgary, Canada) was conducted. Dietary fibre intake and NSAID use were assessed using the Diet History Questionnaire I or II and the Health and Lifestyle Questionnaire. Colorectal outcomes were documented as a polyp or high-risk adenomatous polyp (HRAP; villous histology, high-grade dysplasia, ≥10 mm or ≥3 adenomas). Crude and ORs and 95% CIs were estimated using unconditional logistic regression.ResultsThere were 1450 negative colonoscopies and 1098 patients with polyps, of which 189 patients had HRAPs. Total dietary fibre intake was associated with a decreased presence of HRAPs (OR=0.50, 95% CI: 0.29 to 0.86) when comparing the highest to lowest quartiles and was observed with both soluble (OR=0.51, 95% CI: 0.30 to 0.88) and insoluble (OR=0.51, 95% CI: 0.30 to 0.86) fibres. Ever use of NSAIDs was also inversely associated with HRAPs (OR=0.65, 95% CI: 0.47 to 0.89), observed with monthly (OR=0.60, 95% CI: 0.37 to 0.95) and daily (OR=0.53, 95% CI: 0.32 to 0.86) use.ConclusionsDietary fibre intake and NSAID use were associated with a decreased risk of having a HRAP at screening.

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