Effects of milking, over-milking and vacuum levels on front and rear quarter teats in dairy cows

2021 ◽  
pp. 1-5
Author(s):  
Theresa Vierbauch ◽  
Walter Peinhopf-Petz ◽  
Thomas Wittek
Keyword(s):  
Dairy Cows ◽  
Morphological Changes ◽  
Multivariable Analysis ◽  
Mechanical Forces ◽  
Limited Impact ◽  
Vacuum Measurement ◽  
Before And After ◽  
Stepwise Procedure ◽  
Morphological Differences ◽  
Teat Canal

Abstract Mechanical forces to the teat and vacuum during milking negatively affect teat condition and may result in increased mastitis risk. We compared vacuum levels during milking and over-milking as well as teat condition before and after milking between front and rear teats. We expected that the lower milk yield of the front quarters would result in a longer over-milking and higher vacuum levels in front teats, resulting in morphological differences. The study comprised 540 dairy cows in 41 Austrian dairy farms with conventional milking systems. Before and after milking teats were visually assessed (colour, swelling, rings, hyperkeratosis) and teat dimensions (length, diameter, wall thickness, teat canal length) were measured manually and ultrasonographically. Vacuum measurements were taken using a vacuum measurement device attached to the cluster (short milk tube, pulsation tube and mouth-piece chamber). These various measurements of front and rear teats were compared and a multivariable analysis with backward stepwise procedure was used for inclusion or exclusion from the model. Front teats showed a poorer teat condition and were over-milked for longer in comparison to the rear teats. However, during milking and over-milking the vacuum levels in the mouthpiece chamber were significantly higher at the rear teats. The changes in front teat morphology were only partially caused by milking, over-milking and vacuum levels, with approximately 70% of the variation due to other, undetermined variables. Milking, over-milking and vacuum levels had no or very limited impact on the morphological changes of the rear teats.

scholarly journals Biological impact of an enhanced recovery after surgery programme in liver surgery

BJS Open ◽  
2020 ◽  
Vol 5 (2) ◽  
Author(s):  
S Gonvers ◽  
J Jurt ◽  
G -R Joliat ◽  
N Halkic ◽  
E Melloul ◽  
...  
Keyword(s):  
Liver Surgery ◽  
Enhanced Recovery ◽  
Enhanced Recovery After Surgery ◽  
Surgical Stress ◽  
Multivariable Analysis ◽  
Albumin Concentration ◽  
Biological Impact ◽  
Reactive Protein ◽  
Before And After ◽  
Major Resection

Abstract Background The clinical and economic impacts of enhanced recovery after surgery (ERAS) programmes have been demonstrated extensively. Whether ERAS protocols also have a biological effect remains unclear. This study aimed to investigate the biological impact of an ERAS programme in patients undergoing liver surgery. Methods A retrospective analysis of patients undergoing liver surgery (2010–2018) was undertaken. Patients operated before and after ERAS implementation in 2013 were compared. Surrogate markers of surgical stress were monitored: white blood cell count (WBC), C-reactive protein (CRP) level, albumin concentration, and haematocrit. Their perioperative fluctuations were defined as Δvalues, calculated on postoperative day (POD) 0 for Δalbumin and Δhaematocrit and POD 2 for ΔWBC and ΔCRP. Results A total of 541 patients were included, with 223 and 318 patients in non-ERAS and ERAS groups respectively. Groups were comparable, except for higher rates of laparoscopy (24.8 versus 11.2 per cent; P < 0.001) and major resection (47.5 versus 38.1 per cent; P = 0.035) in the ERAS group. Patients in the ERAS group showed attenuated ΔWBC (2.00 versus 2.75 g/l; P = 0.013), ΔCRP (60 versus 101 mg/l; P <0.001) and Δalbumin (12 versus 16 g/l; P < 0.001) compared with those in the no-ERAS group. Subgroup analysis of open resection showed similar results. Multivariable analysis identified ERAS as the only independent factor associated with high ΔWBC (odds ratio (OR) 0.65, 95 per cent c.i. 0.43 to 0.98; P = 0.038), ΔCRP (OR 0.41, 0.23 to 0.73; P = 0.003) and Δalbumin (OR 0.40, 95 per cent c.i. 0.22 to 0.72; P = 0.002). Conclusion Compared with conventional management, implementation of ERAS was associated with an attenuated stress response in patients undergoing liver surgery.

Impact of a hospital specialty pharmacy in partnership with a free-standing care coordination organization on time to delivery and receipt of oral anticancer drugs.

2021 ◽  
Vol 39 (28_suppl) ◽  
pp. 43-43
Author(s):  
Melissa Parsons Beauchemin ◽  
Morgan RL Lichtenstein ◽  
Rohit R. Raghunathan ◽  
Sahil D Doshi ◽  
Cynthia Law ◽  
...  
Keyword(s):  
Care Coordination ◽  
Multivariable Analysis ◽  
Cancer Center ◽  
Free Standing ◽  
Delivery Date ◽  
Anti Cancer ◽  
Before And After ◽  
Specialty Pharmacy ◽  
Insurance Data ◽  
To Receive

43 Background: Most oral anti-cancer drugs (OACD) prescriptions require extensive coordination between providers and payers, which can delay drug receipt. Specialty pharmacies are intended to facilitate communication between multiple entities to deliver OACDs with increased efficiency. In 2018, our cancer center partnered with Shields Health Solutions (SHS), a freestanding organization providing care coordination to implement a hospital-based specialty pharmacy. We evaluated the rate of failed drug receipt (FR) and time to drug receipt (TTR) before and after specialty pharmacy implementation. Methods: We prospectively collected data on all new OACD prescriptions for adult oncology patients at a large, urban cancer center from 1/1/2018 to 12/31/2019. In fall 2018, a specialty pharmacy was opened to facilitate drug procurement for patients. We collected patient demographic, clinical, and insurance data, OACD name, date prescribed, delivery date, and interactions with payers and financial assistance groups. For prescriptions received, TTR was the number of days from OACD prescription to patient receipt of the drug. FR was defined as failure to receive a prescribed OACD. We excluded OACD prescriptions for a washout period of two months during pharmacy initiation. We used multivariable logistic regression to examine factors associated with TTR > 7 days and FR before and after specialty pharmacy implementation. Results: In total, 883 patients were prescribed 1145 new OACDs. The majority of prescribed drugs were targeted treatment (56%, N = 646) and 72% (N = 819) required prior authorization (PA). Of all prescriptions, 86% (N = 999) were successfully received with an overall median TTR of 7 days. Adjusted analyses showed that patients were more likely to receive their drugs in less than 7 days after specialty pharmacy implementation (OR: 1.4 95% CI 1.04 – 1.81), p = 0.03). In an unadjusted analysis, patients were more likely to receive their initial medications after specialty pharmacy implementation, compared to before specialty pharmacy implementation (89% vs. 84%, p = 0.04). Multivariable analysis showed a trend toward more patients receiving drugs after specialty pharmacy implementation (OR: 1.42, 95% CI 0.98 – 2.03, p = 0.06). Conclusions: The implementation of a hospital-based specialty pharmacy in partnership with SHS decreased TTR. This difference is in part attributable to improved care coordination and communication. A centralized approach may improve overall efficiency due to fewer clinical practice disruptions.

Lateral Thoracolumbar Listhesis as an Independent Predictor of Disability in Adult Scoliosis Patients: Multivariable Assessment Before and After Surgical Realignment

Neurosurgery ◽  
2021 ◽  
Author(s):  
Alan H Daniels ◽  
Wesley M Durand ◽  
Renaud Lafage ◽  
Andrew S Zhang ◽  
David K Hamilton ◽  
...  
Keyword(s):  
Cobb Angle ◽  
Multivariable Analysis ◽  
Deformity Correction ◽  
Adult Scoliosis ◽  
Leg Pain ◽  
Minimally Clinically Important Difference ◽  
Before And After ◽  
Plane Deformity ◽  
Numeric Scale

Abstract BACKGROUND Lateral (ie, coronal) vertebral listhesis may contribute to disability in adult scoliosis patients. OBJECTIVE To assess for a correlation between lateral listhesis and disability among patients with adult scoliosis. METHODS This was a retrospective multi-center analysis of prospectively collected data. Patients eligible for a minimum of 2-yr follow-up and with coronal plane deformity (defined as maximum Cobb angle ≥20º) were included (n = 724). Outcome measures were Oswestry Disability Index (ODI) and leg pain numeric scale rating. Lateral thoracolumbar listhesis was measured as the maximum vertebral listhesis as a percent of the superior endplate across T1-L5 levels. Linear and logistic regression was utilized, as appropriate. Multivariable analyses adjusted for demographics, comorbidities, surgical invasiveness, maximum Cobb angle, and T1-PA. Minimally clinically important difference (MCID) in ODI was defined as 12.8. RESULTS In total, 724 adult patients were assessed. The mean baseline maximum lateral thoracolumbar listhesis was 18.3% (standard deviation 9.7%). The optimal statistical grouping for lateral listhesis was empirically determined to be none/mild (<6.7%), moderate (6.7-15.4%), and severe (≥15.4%). In multivariable analysis, listhesis of moderate and severe vs none/mild was associated with worse baseline ODI (none/mild = 33.7; moderate = 41.6; severe = 43.9; P < .001 for both comparisons) and leg pain NSR (none/mild = 2.9, moderate = 4.0, severe = 5.1, P < .05). Resolution of severe lateral listhesis to none/mild was independently associated with increased likelihood of reaching MCID in ODI at 2 yr postoperatively (odds ratio 2.1 95% confidence interval 1.2–3.7, P = .0097). CONCLUSION Lateral thoracolumbar listhesis is associated with worse baseline disability among adult scoliosis patients. Resolution of severe lateral listhesis following deformity correction was independently associated with increased likelihood of reaching MCID in ODI at 2-yr follow-up.

scholarly journals How effective is river restoration in re-establishing groundwater–surface water interactions? – A case study

2015 ◽  
Vol 19 (6) ◽  
pp. 2663-2672 ◽  
Author(s):  
A.-M. Kurth ◽  
C. Weber ◽  
M. Schirmer
Keyword(s):  
Surface Water ◽  
River Restoration ◽  
Morphological Changes ◽  
Cost Effective ◽  
Urban Stream ◽  
Distributed Temperature Sensing ◽  
River Bed ◽  
Before And After ◽  
Restoration Measures

Abstract. In this study, we investigated whether river restoration was successful in re-establishing groundwater–surface water interactions in a degraded urban stream. Restoration measures included morphological changes to the river bed, such as the installation of gravel islands and spur dykes, as well as the planting of site-specific riparian vegetation. Standard distributed temperature sensing (DTS) and novel active and passive DTS approaches were employed to study groundwater–surface water interactions in two reference streams and an experimental reach of an urban stream before and after its restoration. Radon-222 analyses were utilized to validate the losing stream conditions of the urban stream in the experimental reach. Our results indicated that river restoration at the study site was indeed successful in increasing groundwater–surface water interactions. Increased surface water downwelling occurred locally at the tip of a gravel island created during river restoration. Hence, the installation of in-stream structures increased the vertical connectivity and thus groundwater–surface water interactions. With the methods presented in this publication, it would be possible to routinely investigate the success of river restorations in re-establishing vertical connectivity, thereby gaining insight into the effectiveness of specific restoration measures. This, in turn, would enable the optimization of future river restoration projects, rendering them more cost-effective and successful.

scholarly journals Assessment of Somaclonal Variation in Chrysan-themum (Dendranthema grandiflora Kitam.) using RAPD and Morphological Analysis

1970 ◽  
Vol 18 (2) ◽  
pp. 139-149 ◽  
Author(s):  
P. Kengkarj ◽  
P. Smitamana ◽  
Y. Fujime
Keyword(s):  
Somaclonal Variation ◽  
Morphological Changes ◽  
Field Trials ◽  
Plant Production ◽  
Dendranthema Grandiflora ◽  
Shape Deviation ◽  
Floral Color ◽  
Rapd Pattern ◽  
Morphological Differences ◽  
Highly Correlated

Novel chrysanthemum (Dendranthema grandiflora Kitam.) somaclones from seven commercial cultivars were obtained through the petal segments culture. Morphological variation of the derived clones observed from the field trials was found to be cultivar specific. The major variants within the same cultivar were found only color and inflorescence shape deviation, whereby leaf and stem characters remained unchanged. Distinct variations were found in the 'Pinkgin' cultivar that color changed from magenta to red. The morphological differences of the tested somaclones showed high correlation with the RAPD patterns analysis.  The morphological differences of the tested somaclones were shown to be highly correlated using RAPD pattern analysis. RAPD markers, using ten primers could better separate each cultivar at 80% similarity value. All the somaclones could be singly separated at 90% similarity. However, the higher level of variability of RAPD patterns in chrysanthemum rendered these RAPD fragments as good candidates for somaclonal and cultivar identification. The results from this study revealed the potential increase in range of floral color and morphological changes of petal segment culture, thus this technique would be effectively used for novel plant production. Key words:  Petal culture, Dendranthema grandiflora, Somaclonal variation, RAPD, Identification D.O.I. 10.3329/ptcb.v18i2.3396 Plant Tissue Cult. & Biotech. 18(2): 139-149, 2008 (December)

scholarly journals Spectral OCT-Angiography in En Face Mode for Detection of Morphological Changes in the Retinal Pigment Epithelium before and after Selective Micro-Pulse Laser Exposure in Patients with Central Serous Chorioretinopathy

2019 ◽  
Vol 16 (2) ◽  
pp. 192-201
Author(s):  
P. L. Volodin ◽  
E. V. Ivanova ◽  
E. Iu. Polyakova ◽  
A. V. Fomin
Keyword(s):  
Retinal Pigment Epithelium ◽  
Central Serous Chorioretinopathy ◽  
Morphological Changes ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Laser System ◽  
Subretinal Fluid ◽  
Micropulse Laser ◽  
En Face ◽  
Before And After

Purpose — to study the morphological changes of the retinal pigment epithelium (RPE) by optical coherence tomography-angiography (OCT-A) in En Face mode before and after selective micropulse laser irradiation in patients with central serous chorioretinopathy (CSC), determine the correspondence between the topographic location of RPE defects and detachment on the OCT-angiogram in En Face mode and points of leakage on the FAG.Patients and methods. There were 20 patients (21 eyes) with CSC before and after laser treatment under the observation. All patients underwent high-resolution FAG and OCT-A using Angio Retina 2×2 or 3×3 mm protocol and Angio Retina HD 6×6 mm. The treatment was carried out in a selective micropulse mode with individual selection of parameters using the Navilas 577s navigation laser system (OD-OS, Germany) or the IQ 577 laser system (IRIDEX, USA).Results were evaluated at 2 weeks and 1 month after treatment. Results. In all cases, the leaking points of the subretinal fluid on FAG corresponded to the topographic location of defects and detachments of RPE detachment on OKT-A En Face. According to OCT-A En Face, the following morphological changes were revealed: in 5 cases — single defects of RPE, in 7 cases — multiple defects of RPE, in 9 cases of slit-like detachment of RPE, in 3 patients a combination of slit-like detachment and defect RPE. The sizes of RPE defects varied in the range from 21 to 159 microns, while their rounded shape prevailed. 1 month after the selective micropulse laser effect on OCT-A in the En Face mode, the defects were closed and the RPE detachments fit in all patients, which resulted in resorption of the subretinal fluid and the neurosensory retina attachment.Findings. OCT-A in En Face mode is a highly informative diagnostic method that allows noninvasive detection of morphological changes in RPE with a clear topographic localization relative to the retinal vascular network, as well as evaluating the effectiveness of selective micropulse laser treatment in patients with CSC. 

scholarly journals Effect of milking vacuum level and overmilking on cows’ teat characteristics

2011 ◽  
Vol 59 (5) ◽  
pp. 193-202 ◽  
Author(s):  
M. Pařilová ◽  
L. Stádník ◽  
A. Ježková ◽  
L. Štolc
Keyword(s):  
Wall Thickness ◽  
Treatment Effects ◽  
Vacuum Level ◽  
Milk Flow ◽  
Before And After ◽  
Teat Canal ◽  
Test Treatment

The influence of milking vacuum and milk flow level (resp. detachment level) on cows’ teat characteristics were studied in four experiments. The MIXED procedure was used to test treatment effects on the level of teat length, teat thickness at the base and half-way between the teat end and the base of udder, teat canal length, teat end width, teat wall thickness, teat cistern width after milking and on differences between these teat characteristics measured before and after milking. A total of 51 cows were included in all experiments. All the cows had clinically healthy udders. Some cows were involved in two or more experiments. Finally, 330 teat measurements of 165 cows were taken and statistically processed. Vacuum and milking with or without overmilking significantly (P < 0.05-0.001) influence monitored parameters. Milking vacuum has an influence on two of three measured external teat parameters: teat diameter measured at the base of the teat and half-way between the udder base and the teat tip. Change in teat length measured before and immediately after milking was higher when higher vacuum of 45 kPa was used. Detachment level also has an influence on teat proportions. Overmilked teats were longer and narrower compared to non-overmilked teats. Interaction between milking vacuum and detachment level influences external teat parameters as well.

scholarly journals Morphological changes in the trabecular meshwork and Schlemm’s canal after treatment with topical intraocular pressure-lowering agents

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ji-Hye Park ◽  
Hyun Woo Chung ◽  
Eun Gyu Yoon ◽  
Min Jung Ji ◽  
Chungkwon Yoo ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Trabecular Meshwork ◽  
Morphological Changes ◽  
Open Angle Glaucoma ◽  
Anterior Segment ◽  
Schlemm’S Canal ◽  
Schlemm's Canal ◽  
Before And After ◽  
Treatment Naïve ◽  
Aqueous Outflow

AbstractGlaucoma treatment is usually initiated with topical medication that lowers the intraocular pressure (IOP) by reducing the aqueous production, enhancing the aqueous outflow, or both. However, the effect of topical IOP-lowering medications on the microstructures of the aqueous outflow pathway are relatively unknown. In this retrospective, observational study, 56 treatment-naïve patients with primary open-angle glaucoma were enrolled. Images of the nasal and temporal corneoscleral limbus were obtained using anterior segment optical coherence tomography (AS-OCT). The conjunctival vessels and iris anatomy were used as landmarks to select the same limbal area scan, and the trabecular meshwork (TM) width, TM thickness, and Schlemm’s canal (SC) area were measured before and after using the IOP-lowering agents for 3 months. Among the 56 patients enrolled, 33 patients used prostaglandin (PG) analogues, and 23 patients used dorzolamide/timolol fixed combination (DTFC). After 3 months of DTFC usage, the TM width, TM thickness, and SC area did not show significant changes in either the nasal or temporal sectors. Conversely, after prostaglandin analog usage, the TM thickness significantly increased, and the SC area significantly decreased (all P < 0.01). These findings warrant a deeper investigation into their relationship to aqueous outflow through the conventional and unconventional outflow pathways after treatment with PG analogues.

scholarly journals Changes in teat parameters caused by milking and their recovery to their initial size

2010 ◽  
Vol 53 (6) ◽  
pp. 650-662
Author(s):  
L. Stádník ◽  
F. Louda ◽  
J. Bezdíček ◽  
A. Ježková ◽  
M. Rákos
Keyword(s):  
Dairy Cows ◽  
Somatic Cell ◽  
Cell Count ◽  
Wall Thickness ◽  
Somatic Cell Count ◽  
Initial Size ◽  
Linear Description ◽  
Daily Milk Yield ◽  
Teat Canal ◽  
Daily Milk

Abstract. Dairy cows of 2 breeds, 74 Holstein (H) and 72 Czech Fleckvieh (C) cows in the 1st (H, n=38; C, n=38) and 2nd lactation (H, n=36; C, n=34) during the 1st period (n=74; H, n=40; C, n=34; to 150 days) and the 2nd period of lactation (n=72; H, n=34; C, n=38; above 150 days) were observed. Differences in external and internal proportions of teat closely before (the 1st measurement), immediately after (the 2nd measurement) and 3 h after milking (the 3rd measurement), udder conformation evaluated by linear description, somatic cell count, daily milk yield and the time of milking were evaluated in relation to the effect of breed and period of lactation. The length of the teat canal, area of the teat end, and wall thickness were measured from the axial picture recorded by ultrasound Aloka SSD500 (Aloka Co., Ltd., Tokyo, Japan). Significant interbreed differences were detected in external as well as internal teat proportions (P<0.05–0.001). Relative changes of teat diameter, comparing C and H cows, differed significantly between the 1st and the 3rd measurement (P<0.05). The length of teat increased during milking and didn´t achieve the beginning size during 3 h after milking. Significant diiference in the length of teat between the 2nd measurement and the 3rd measurement was determined in H cows only (P<0.001). The most significant changes of the length of the teat canal and the area of teat were found in both breeds between values measured closely before and immediately after milking (P<0.5–0.001). Wall thickness was strengthen in C cows (+15.6 %) during the 2nd measurement according to the 1st (P<0.05), while difference represented +18 % (P<0.001) in H cows. Non-significantly higher values of external proportions of teat were measured in the 2nd period of lactation except diameter of teat closely before milking. Internal proportions of teat were always significantly higher in the 2nd period of lactation in relation to the 1st period. Prolongation of teat canal by 0.15 cm (P<0.01) closely before, by 0.16 cm (P<0.001) immediately after, and by 0.13 cm (P<0.01) 3 h after milking was measured in the 2nd period of lactation. The area of teat end measured before milking was significantly larger in the 2nd period of lactation (P<0.01).

scholarly journals Characterization by TGA, SEM, and EDX of Polymeric Matrices Used as Cocaine Camouflages

2018 ◽  
Vol 12 (12) ◽  
pp. 119
Author(s):  
Carlos A. Díaz V ◽  
William F. Garzón M ◽  
Juan C. Higuita V ◽  
Elisabeth. Restrepo-Parra
Keyword(s):  
Surface Morphology ◽  
Thermo Gravimetric Analysis ◽  
Soxhlet Extraction ◽  
Structural Type ◽  
Extraction Process ◽  
Gravimetric Analysis ◽  
Before And After ◽  
The Matrix ◽  
Morphological Differences ◽  
Almost All

In this work, a study of samples that contained cocaine camouflaged inside unidentified polymers was performed. Samples were seized at the Dorado International airport in Colombia. Cocaine was adsorbed or occluded within the matrix. The objective of this research was to extract cocaine from the matrices using soxhlet extraction method. Thereafter matrices were analyzed to determine the surface morphology before and after the extraction. Several morphological differences were exhibited between samples including both adsorbed and occluded cocaine. Moreover, changes in the surface morphology were also observed before and after cocaine extraction. The chemical elemental composition of matrices was also studied using energy dispersive spectroscopy, observing that the alkaloid was totally removed in almost all samples after the extraction process. On the other hand, Thermo gravimetric analysis also allows comparing the results obtained for the samples with patterns of pure cocaine and other polymers as CMC, PVA and HEC, finding several similarities of structural type.

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