The relationship between microfilaraemic and amicrofilaraemic loiasis involving co-infection with Mansonella perstans and clinical symptoms in an exposed population from Gabon

2015 ◽  
Vol 90 (4) ◽  
pp. 469-475 ◽  
Author(s):  
M.K. Bouyou Akotet ◽  
M. Owono-Medang ◽  
D.P. Mawili-Mboumba ◽  
M.N. Moussavou-Boussougou ◽  
S. Nzenze Afène ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Control Strategies ◽  
Strong Predictor ◽  
Loa Loa ◽  
Exposed Population ◽  
Specific Objective ◽  
Mansonella Perstans ◽  
Worm Migration ◽  
And Control ◽  
The Relationship

AbstractThe relationship between the frequency of loiasis objective symptoms and microfilaraemic or amicrofilaraemic infection was assessed in 1148 exposed patients also infected, or not, with Mansonella perstans. Filarial infections were detected by direct microscopy, leucoconcentration and serology, with prevalence values of 39.5% Loa loa, 5.6% M. perstans and 3.4% co-infection with both filarial species. Amicrofilaraemic or occult loiasis (OL) predominated among L. loa-infected individuals, with a prevalence of 58.2%. Hypermicrofilaraemia (>8000 microfilariae (mf)/ml) was found in 18.4% of L. loa microfilaraemic patients, with 25.7% of them harbouring more than 30,000 mf/ml. Up to 34% of patients with OL showed evidence of Calabar swelling, compared with 26.3% of microfilaraemic patients (P= 0.03). Overall 5.3% of patients presented with adult worm migration across the eye, representing 16.3% of microfilaraemic individuals and 11.4% of amicrofilaraemic patients (P= 0.13). This symptom was similarly found in patients with more than 30,000 mf/ml (22%), those with microfilaraemia between 8 and 30,000 mf/ml (15.4%) and also in individuals with low or without microfilaraemia (16.1%) (P= 0.7). Five (14.3%) hypermicrofilaraemic patients did not present any L. loa-specific objective symptoms, as well as all the patients with single M. perstans infection. The presence of adult eye worm migration as a strong predictor of high microfilaraemia density would obscure the real burden of L. loa hypermicrofilaraemia in exposed individuals. For epidemiological purposes and control strategies, the mapping of L. loa in endemic areas should also take into account the group of patients with occult loiasis.

scholarly journals Review of Infective Dose, Routes of Transmission, and Outcome of COVID-19 Caused by the SARS-CoV-2 Virus: Comparison with Other Respiratory Viruses

2020 ◽  
Author(s):  
Sedighe Karimzadeh ◽  
Raj Bhopal ◽  
Huy Nguyen Tien
Keyword(s):  
Viral Load ◽  
Animal Studies ◽  
Control Strategies ◽  
H1n1 Influenza ◽  
Respiratory Viruses ◽  
Rapid Review ◽  
Viral Dynamics ◽  
Infective Dose ◽  
And Control ◽  
The Relationship

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is pandemic. Prevention and control strategies require an improved understanding of SARS-CoV-2 dynamics. We did a rapid review of the literature on SARS-CoV-2 viral dynamics with a focus on infective dose. We sought comparisons of SARS-CoV-2 with other respiratory viruses including SARS-CoV-1 and MERS-CoV. We examined laboratory animal, and human studies. The literature on infective dose, transmission, and routes of exposure was limited specially in humans, and varying endpoints were used for measurement of infection. We propose the minimum infective dose of COVID-19 in humans, is higher than 100 particles, possibly slightly lower than the 700 particles estimated for H1N1 influenza. Despite variability in animal studies, there was some evidence that increased dose at exposure correlated with higher viral load clinically, and severer symptoms. Higher viral load measures did not reflect COVID-19 severity. Aerosol transmission seemed to raise the risk of more severe respiratory complications in animals. An accurate quantitative estimate of the infective dose of SARS-CoV-2 in humans is not currently feasible and needs further research. Further work is also required on the relationship between routes of transmission, infective dose, co-infection, and outcomes.

Analysis on Electronic Differential Control Strategies of Electric Vehicle

2012 ◽  
Vol 562-564 ◽  
pp. 1602-1605
Author(s):  
Cheng Qun Li ◽  
Cui Yu Zhou
Keyword(s):  
Detailed Analysis ◽  
Electric Current ◽  
Electric Vehicle ◽  
Control Strategies ◽  
Control Process ◽  
Control Torque ◽  
Control Scheme ◽  
Differential Control ◽  
And Control ◽  
The Relationship

Based on the relationship between the motor torque of each side and electric current when the electric vehicle turns, this article puts forward a control scheme of electronic differential which is used to regulate current and control torque, according to the micro electric vehicle with a double-wheel motor driven. In addition, the article makes detailed analysis for the electronic differential control process.

scholarly journals Neural structure of a sensory decoder for motor control

2020 ◽  
Author(s):  
Seth W. Egger ◽  
Stephen G. Lisberger
Keyword(s):  
Motor Control ◽  
Motor Behavior ◽  
Control Strategies ◽  
Surprising Result ◽  
Neural Responses ◽  
Multiple Sources ◽  
Neural Structure ◽  
Sources Of Variation ◽  
And Control ◽  
The Relationship

ABSTRACTWe seek to understand the neural mechanisms that perform sensory decoding for motor behavior, advancing the field by designing decoders based on neural circuits. A simple experiment produced a surprising result that shapes our approach. Changing the size of a target for smooth pursuit eye movements changes the relationship between the variance and mean of the evoked behavior in a way that contradicts the regime of “signal-dependent noise” and defies traditional decoding approaches. A theoretical analysis leads us to conclude that sensory decoding circuits for pursuit include multiple parallel pathways and multiple sources of variation. Behavioral and neural responses with biomimetic statistics emerge from a biologically-motivated circuit model with noise in the pathway that is dedicated to flexibly adjusting the strength of visual-motor transmission. Flexible adjustment of transmission strength applies much more broadly to issues in sensory-motor control such as Bayesian integration and control strategies to optimize motor behavior.

scholarly journals Projected Number of People With Onchocerciasis–Loiasis Coinfection in Africa, 1995 to 2025

2019 ◽  
Vol 70 (11) ◽  
pp. 2281-2289 ◽  
Author(s):  
Natalie V S Vinkeles Melchers ◽  
Luc E Coffeng ◽  
Michel Boussinesq ◽  
Belén Pedrique ◽  
Sébastien D S Pion ◽  
...  
Keyword(s):  
At Risk ◽  
Adverse Events ◽  
Control Strategies ◽  
Central Africa ◽  
Ivermectin Treatment ◽  
Loa Loa ◽  
Serious Adverse Events ◽  
West And Central Africa ◽  
And Control ◽  
The Impact

Abstract Background Onchocerciasis elimination through mass drug administration (MDA) is hampered by coendemicity of Loa loa, as people with high L. loa microfilariae (mf) density can develop serious adverse events (SAEs) after ivermectin treatment. We assessed the geographical overlap of onchocerciasis and loiasis prevalence and estimated the number of coinfected individuals at risk of post-ivermectin SAEs in West and Central Africa from 1995 to 2025. Methods Focusing on regions with suspected loiasis transmission in 14 countries, we overlaid precontrol maps of loiasis and onchocerciasis prevalence to calculate precontrol prevalence of coinfection by 5 km2 × 5 km2 pixel, distinguishing different categories of L. loa mf intensity. Using statistical and mathematical models, we predicted prevalence of both infections and coinfection for 2015 and 2025, accounting for the impact of MDA with ivermectin. Results The number of people infected with onchocerciasis was predicted to decline from almost 19 million in 1995 to 4 million in 2025. Of these, 137 000 people were estimated to also have L. loa hypermicrofilaremia (≥20 000 L. loa mf/mL) in 1995, declining to 31 000 in 2025. In 2025, 92.8% of coinfected cases with loiasis hypermicrofilaremia are predicted to live in hypoendemic areas currently not targeted for MDA. Conclusions Loiasis coinfection is a major concern for onchocerciasis elimination in Africa. We predict that under current strategies, at least 31 000 coinfected people still require treatment for onchocerciasis in 2025 while being at risk of SAEs, justifying continued efforts in research and development for safer drugs and control strategies.

scholarly journals COVID-19 Pandemic – Implications, Planning, and Recommendations related to Dental Care Services and Dental Education

2020 ◽  
Vol 24 (Supp-1) ◽  
pp. 92-98
Author(s):  
Fazal Ghani
Keyword(s):  
Infection Control ◽  
Prevention And Control ◽  
Infection Prevention ◽  
Clinical Symptoms ◽  
Dental Education ◽  
Control Strategies ◽  
Healthcare Personnel ◽  
Infection Prevention And Control ◽  
Dental Services ◽  
And Control

During the past few months, our understanding of the transmission, epidemiology, clinical symptoms, and management of Covid-19 has considerably improved. This had made the dental healthcare personnel confident enough and ready to provide safely by implementing efficient prevention and cross-infection control strategies in the dental clinical setting. , At the same time, it is necessary that we must be constantly aware of the continuation of such infectious threats challenging our infection control regimen and preparedness to provide dental treatments and teaching and education. Good infection prevention and control strategies need to be evidence-based and in line with the recommendations of the local and international public health agencies. The disruption in dental services and dental education all over the world resulted in this pandemic has emphasized and resulted in new, innovative and improved infection prevention and control strategies and adoption of alternative teaching, learning and assessment strategies for students. It further reinforces the need for continued research exploring ways for responding better to future contagious disease threats.  

Part 2. They scare because we care: The relationship between obsessive intrusive thoughts and appraisals and control strategies across 15 cities

2014 ◽  
Vol 3 (3) ◽  
pp. 280-291 ◽  
Author(s):  
Richard Moulding ◽  
Meredith E. Coles ◽  
Jonathan S. Abramowitz ◽  
Gillian M. Alcolado ◽  
Pino Alonso ◽  
...  
Keyword(s):  
Control Strategies ◽  
Intrusive Thoughts ◽  
And Control ◽  
The Relationship

From Container to Claustrum: Projective Identification in Couples

2014 ◽  
Vol 4 (2) ◽  
Author(s):  
Tamara Feldman
Keyword(s):  
Psychological Health ◽  
Projective Identification ◽  
The Self ◽  
The Other ◽  
Intimate Partners ◽  
And Control ◽  
The Relationship ◽  
As If

This paper is a contribution to the growing literature on the role of projective identification in understanding couples' dynamics. Projective identification as a defence is well suited to couples, as intimate partners provide an ideal location to deposit unwanted parts of the self. This paper illustrates how projective identification functions differently depending on the psychological health of the couple. It elucidates how healthier couples use projective identification more as a form of communication, whereas disturbed couples are inclined to employ it to invade and control the other, as captured by Meltzer's concept of "intrusive identification". These different uses of projective identification affect couples' capacities to provide what Bion called "containment". In disturbed couples, partners serve as what Meltzer termed "claustrums" whereby projections are not contained, but imprisoned or entombed in the other. Applying the concept of claustrum helps illuminate common feelings these couples express, such as feeling suffocated, stifled, trapped, held hostage, or feeling as if the relationship is killing them. Finally, this paper presents treatment challenges in working with more disturbed couples.

The Role of Archives on the Incorporation of the Former Kangwane Homeland to Mpumalanga Province

2018 ◽  
Vol 47 (2) ◽  
Author(s):  
Nkholedzeni Sidney Netshakhuma
Keyword(s):  
South Africa ◽  
Qualitative Methodology ◽  
Management Policy ◽  
Records Management ◽  
Record Keeping ◽  
Mpumalanga Province ◽  
Specific Objective ◽  
National Archives ◽  
And Control

This study was conceptualised in order to assess the strategies used to incorporate the homeland of KaNgwane into Mpumalanga province after the cessation of apartheid in 1994. The specific objective of the study was to investigate the compliance of records and archives with the National Archives and Records Service of South Africa Act (Act No 43 of 1996), during the incorporation of the homeland of KaNgwane into Mpumalanga. The study adopted a qualitative methodology through document analysis, interviews and observations. The key findings revealed that the archives of the former homeland of Kangwane were not aligned with the requirements of the National Archives and Records Service of South Africa Act (Act No.43 of 1996.) Institutions seem to lack experience when it comes to the challenges of storing records and implementing arrangement and control systems. The frequent lack of a records management policy and few to no staff with record-keeping and archival backgrounds was also a concern. A shortage of space to store records safely was also one of the major issues that the study uncovered. There appears to be no concerted effort to retain important historical records. Many records are stored in several different locations in government buildings.  I conclude that archives play an essential role to the nation as the institutional memory.

Sign in / Sign up

Export Citation Format

Share Document