Early morphological and chemical changes induced by cisplatin in the guinea pig organ of Corti
1986 ◽
Vol 100
(12)
◽
pp. 1375-1383
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Keyword(s):
X Ray
◽
AbstractGuinea pigs were treated with a single dose of Cisplatin (5 mg IP). After 2–4 days the cochleas were prepared for morphological analysis by scanning electron microscopy and chemical analysis by X-ray dispersive microanalysis. Following Cisplatin, the bundles of stereocilia on the hair cells were found to be rough, disarrayed, fused, and finally absorbed. Significant increases were found in the levels of calcium, sulphur, and phosporus in the abnormal hair cells. It is suggested that the high calcium levels might be due to the inhibition of enzymes which normally keep cytoplasmic calcium low, and that some of the changes in the stereocilia might be secondary to this.
1982 ◽
Vol 96
(7)
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pp. 591-597
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Keyword(s):
1974 ◽
Vol 13
(4)
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pp. 290-301
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Keyword(s):
1972 ◽
Vol 203
(1)
◽
pp. 1-15
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1984 ◽
Vol 42
◽
pp. 288-289
1995 ◽
Vol 53
◽
pp. 692-693
1992 ◽
Vol 50
(2)
◽
pp. 1322-1323