Squamous cell carcinomas of the head and neck: descriptive analysis of 1293 cases

1997 ◽  
Vol 111 (6) ◽  
pp. 531-535 ◽  
Author(s):  
Sevgi Y. Kurtulmaz ◽  
Haldun Ş. Erkal ◽  
Meltem Serin ◽  
Atilla H. Elhan ◽  
Ahmet Çakmak
Keyword(s):  
Oral Cavity ◽  
Head And Neck ◽  
Squamous Cell ◽  
Primary Tumour ◽  
Descriptive Analysis ◽  
Female Ratio ◽  
T Stage ◽  
Medical Reports ◽  
Advanced Stages ◽  
Male To Female

AbstractMedical reports of 1293 patients with squamous cell carcinoma (SCC) of the head and neck were retrospectively evaluated. The patients were classified according to their age, sex, primary tumour localization and tumoral stage. There were 1181 males (91.3 per cent) and 112 females (8.7 per cent), with a male to female ratio of 10.5:1. The peak incidences for all primary tumour localizations were observed in the fifth decade. Most common primary tumour localizations were the larynx (71.1 per cent), the nasopharynx (10.1 per cent) and the oral cavity (8.8 per cent). Of all patients in whom staging was complete, 43.1 per cent presented at early and 56.9 per cent at advanced stages. The proportion of patients presenting with metastatic neck nodes was 34.4 per cent and the incidence of metastatic neck nodes increased with increasing T stage. The supraglottic region was the most common primary site among all laryngeal SCC, with a supraglottic to glottic SCC ratio of 1.5:1. Glottic SCC presented at earlier stages compared to supraglottic SCC. The incidence of nodal metastases increased with increasing T stage for SCC of the larynx, the oral cavity and the oropharynx.

scholarly journals Profile of oral cavity neoplastic lesions: two year pilot study at tertiary care centre

2020 ◽  
Vol 6 (6) ◽  
pp. 1107
Author(s):  
Manish Munjal ◽  
Ramandeep Kaur ◽  
Porshia Rishi ◽  
Nitika Tuli ◽  
Harjinder Singh ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Survival Rate ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Neoplastic Lesions

<p class="abstract"><strong>Background:</strong> In India 53,251 new head and neck cancer cases are diagnosed every year. Benign tumours are more frequently in the oral cavity than oropharynx.</p><p class="abstract"><strong>Methods:</strong> The prospective study was carried out in the Department of Otolaryngology and Head and Neck Surgery, Dayanand Medical College and Hospital, Ludhiana, over a period of two and half years, comprised of 66 cases of head and neck neoplasia. The demographic, gender profile, clinical presentation, histopathological diagnosis, therapeutic modality undertaken and post op complications of neoplastic lesions of the oral cavity were studied. follow up was done for 6 months. The therapeutic modalities included surgery, radiotherapy and chemotherapy as per the stage of the lesion.</p><p class="abstract"><strong>Results:</strong> Incidence of oral cancer is 13.6% among head and neck neoplasms over a period of 2 years (2011-2012). The overall male to female ratio was 1:1.25, among benign was 1:1 and among malignant was 1:1.3. Benign oral cavity tumors were managed surgically with wide excision. Out of 7, 4 (44%) malignant oral cavity tumor patient experienced difficulty in swallowing. Three (43%) out of 4 squamous cell carcinoma patients complained of difficulty in speaking, which is commonly seen in post-glossectomy patients. The survival rate for 6 months follows up, was 100%.</p><p class="abstract"><strong>Conclusions:</strong> Squamous cell carcinoma is the commonest oral cavity neoplasia. At post treatment follow up period of 6 months survival rate of benign neoplasia is better than malignant neoplasia.</p>

scholarly journals Are the demographics for squamous cell cancer in the head and neck changing in the United Kingdom?

2006 ◽  
Vol 121 (2) ◽  
pp. 154-157 ◽  
Author(s):  
M A Hassan ◽  
V J Lund ◽  
D J Howard ◽  
A A Sacker
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Female Ratio ◽  
The United Kingdom ◽  
Male To Female

Head and neck squamous cell carcinoma is well known to be more common in men than women. Smoking and alcohol are the key risk factors causing such malignancies and there are several publications which have suggested that the prevalence of these diseases is increasing more in women than in men in western countries due to increased smoking and alcohol use.We collected our data at the Institute of Laryngology and Otology from the last 45 years and analysed the disease ratios in male to female patients in different sites within the head and neck. Our results revealed a decreasing male to female ratio, though this was not statistically significant. However, it draws attention to the increasing number of women with head and neck cancer, which may reflect their increasing use of cigarettes and alcohol.

scholarly journals Neoadjuvant immunotherapy in resectable head and neck cancer: oral cavity carcinoma as a potential research model

2021 ◽  
Vol 13 ◽  
pp. 175883592098406
Author(s):  
Vanesa Gutiérrez Calderón ◽  
Alexandra Cantero González ◽  
Laura Gálvez Carvajal ◽  
Yolanda Aguilar Lizarralde ◽  
Antonio Rueda Domínguez
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Surgical Resection ◽  
Squamous Cell ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Research Model

Squamous cell carcinoma of oral cavity (OCSCC) accounts for approximately 25% of cases of head and neck squamous cell carcinoma (HNSCC). Tobacco and alcohol consumption are the main risk factors for both cancers. Surgical resection, combined with adjuvant radiotherapy or radiochemotherapy in patients with high risk of relapse, is the key element in management in the initial stages. However, despite the availability of aggressive multidisciplinary treatments, advanced resectable OCSCC carries poor prognosis; only half of the patients are disease-free 5 years after the surgery. Immunotherapy based on the use of immune checkpoint inhibitors has been proven to be effective in a wide variety of tumours, including recurrent and metastatic HNSCC. These positive results resulted in investigations into its effectiveness in earlier stages of the disease with OCSCC emerging as an interesting research model because of the accessible location of the tumours. This article reviews the potential advantages of emerging immunotherapeutic agents [mainly monoclonal antibodies against programmed cell death-1 ( PD-1) immune checkpoint inhibitors] as neoadjuvant treatment for OCSCC at locoregional stages as well as the ongoing clinical trials, challenges in evaluating tumour response, and possible predictive biomarkers of response with highlights regarding the role of oral microbiota as modulators of immune response. The efficacy and safety of anti- PD-1 drugs in these patients have been proven in preliminary trials. If there is a decrease in the relapse rate and an improvement in the overall survival after surgical resection in ongoing trials, preoperative immunotherapy may be established as a treatment option for patients with early stages of the disease.

scholarly journals A RETROGRADE STUDY OF MYIASIS IN A TERTIARY CARE CENTRE

2020 ◽  
pp. 3-5
Author(s):  
Ayesha Goel ◽  
Ritu Nigam
Keyword(s):  
Oral Cavity ◽  
Head And Neck ◽  
Tertiary Care ◽  
Personal Hygiene ◽  
Intracranial Extension ◽  
Atrophic Rhinitis ◽  
Time Interval ◽  
Age Group ◽  
Predisposing Factor ◽  
Female Ratio

Myiasis in head and neck region is a rare occurrence and is usually found in tropical countries like India. Poor hygiene, unsanitary living conditions, mental retardation, neglected wounds, diabetes mellitus and old age along with a warm and humid climate lay down a conducive environment for the larva of dipterous fly to infest humans. Maggots due to their tissue destructive properties can affect many regions in otolaryngorhinology like nasal cavity, ears, oral cavity, tracheostomy site ostoma, PNS, the skin and ulcerative lesions of head and neck. The burden of the disease lies in the fact that the complications range from minor tissue destruction, perforation of either the tympanic membrane, palate or septum, vertigo, angioedema to severe neurological manifestations, intracranial extension or rarely even death. Objective: To assess the commonly affected age group and gender infested by myiasis, it’s seasonal trend, socioeconomic status of the affected patients and the relationship of myiasis infestation with various predisposing factors. Methodology: Retrograde study was conducted on 95 patients of department of otorhinolaryngology. The study was done from January 2015 to October 2018 by collecting data of 3 years 10 months time interval and results tabulated. Ethical clearance was sort and patients consent obtained. Result: The most commonly affected age group was found to be elderly, in the 7th decade of life (56.84%). Females were more commonly affected than males consisting of 55 out of 95 cases (57.89%), with a male female ratio of 1:1.4. Majority of cases presented in the months of October-January, with a peak in November (32/95). Nasal myiasis was found to be more common (69 cases) in comparison to aural and oral cavity myiasis. The most common predisposing factor was found to be Atrophic Rhinitis in 66.7% cases. Conclusion : With awareness and improved personal hygiene a devastating disease like myiasis is easily preventable and curable.

Do demographics and tumour-related factors affect nodal yield at neck dissection? A retrospective cohort study

2016 ◽  
Vol 131 (S1) ◽  
pp. S36-S40 ◽  
Author(s):  
R S Lim ◽  
L Evans ◽  
A P George ◽  
N de Alwis ◽  
P Stimpson ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Confidence Interval ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Neck Squamous Cell Carcinoma ◽  
Nodal Yield

AbstractBackground:Nodal metastasis is an important prognostic factor in head and neck squamous cell carcinoma. This study aimed to determine the average nodal basin yield per level of neck dissection, and to investigate if age, gender, body mass index, tumour size, depth of tumour invasion and p16 status influence nodal yield.Method:A retrospective review of 185 patients with head and neck squamous cell carcinoma generated 240 neck dissection specimens.Results:The respective mean nodal yields for levels I, II, III, IV and V were 5.27, 9.43, 8.49, 7.43 and 9.02 in non-cutaneous squamous cell carcinoma patients, and 4.2, 7.57, 9.65, 4.33 and 12.29 in cutaneous squamous cell carcinoma patients. Multiple regression analysis revealed that p16-positive patients with mucosal squamous cell carcinoma yielded, on average, 2.4 more nodes than their p16-negative peers (p = 0.04, 95 per cent confidence interval = 0.116 to 4.693). This figure was 3.84 (p = 0.008, 95 per cent confidence interval = 1.070 to 6.605) for p16-positive patients with oral cavity squamous cell carcinoma.Conclusion:In mucosal squamous cell carcinoma, p16-positive status significantly influenced nodal yield, with the impact being more pronounced in oral cavity squamous cell carcinoma patients.

scholarly journals Loss of heterozygosity in FANCG, FANCF and BRIP1 from head and neck squamous cell carcinoma of the oral cavity

2017 ◽  
Vol 50 (6) ◽  
pp. 2207-2220 ◽  
Author(s):  
Christin Türke ◽  
Susanne Horn ◽  
Carola Petto ◽  
Dirk Labudde ◽  
Günter Lauer ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

Postoperative radiotherapy in head and neck squamous cell cancers: AIIMS experience

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 16514-16514
Author(s):  
M. Malik ◽  
T. Puri ◽  
B. K. Mohanti ◽  
G. K. Rath ◽  
P. K. Julka
Keyword(s):  
Lymph Node ◽  
Oral Cavity ◽  
Head And Neck ◽  
Squamous Cell ◽  
Postoperative Radiotherapy ◽  
Malignant Neoplasm ◽  
Margin Status ◽  
Lymph Node Status ◽  
Adjuvant Radiation ◽  
Node Status

16514 Background: Squamous cell cancers of the head and neck are one of the most common malignancies in India. Most patients present in advanced stages of disease. Postoperative radiotherapy is generally an integral part of management in these patients. Methods: Patients of head and neck squamous cell cancers treated with surgery and postoperative radiotherapy at AIIMS between January 1999 to December 2004 were retrospectively analyzed. Results: A total of 386 patients were treated of which 281 were available for evaluation. There were 233 males and 48 females. Median age was 46 years (range 18–73). Site-wise distribution was: oral cavity- 202, larynx-55, hypopharynx-14, paranasal sinus-4, oropharynx-4, neck nodes with unknown primary-2. Post-surgical margins were adequate in 241, close in 5 (2%) and positive in 35 (12%). Pathological stage grouping was: Stage I- 11(4%), Stage II- 52 (18%), Stage III- 63(22%), Stage IV- 155 (55%). Neck node dissection was done in 245 patients and nodes were pathologically negative in 119 (42%). Extracapsular extension (ECE) was seen in 19(7%) patients. Bone/cartilage invasion was seen in 62(22%). Patients with high risk features (close/positive margins, ECE, 4/> positive nodes) were prescribed a dose of 64 Gy while the rest were planned to receive 60 Gy. 85% of patients completed the intended course of radiation. At a median follow up of 37 months, local recurrences were seen in 28 (10%), regional recurrence in 25 (9%) and distant metastasis in 10 (4%) patients. A second malignant neoplasm occurred in 6 patients (3-oropharynx, 2-oral cavity, 1-lung). Disease free survival (DFS) was 68%. ECE, post-surgical margin status and pathological lymph node status were significantly associated with DFS. Duration of postoperative radiotherapy and the surgery to radiotherapy interval did not significantly affect DFS. Conclusions: ECE, postsurgical margin status and pathological lymph node status significantly impact DFS in patients of surgically treated squamous cell cancers of head and neck. These patients require doses of adjuvant radiation >/=64 Gy. No significant financial relationships to disclose.

Upfront chemotherapy and accelerated radiotherapy with EGFR inhibition for locally advanced inoperable head and neck cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 6040-6040
Author(s):  
C. Mercke ◽  
G. Wickart-Johansson ◽  
H. Sjödin ◽  
G. Adell ◽  
J. Nyman ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Stage Iv ◽  
Resected Specimen ◽  
Stage Iv Disease

6040 Background: Concomitant chemoradiotherapy (CT/RT) is the standard treatment for locally advanced head and neck squamous cell carcinoma. However, late toxicity is substantial.This phase II trial explores the feasibility and efficacy of combining neoadjuvant TPF and accelerated RT where the concomitant cytostatic component is replaced with cetuximab (E), a chimeric IgG1 mAb against EGFR. Methods: Patients (pts) had previously untreated stage III/IV M0,WHO 0–1, unresectable squamous cell carcinoma of the oral cavity, oropharynx, larynx, or hypopharynx and were scheduled for 2 cycles of TPF (docetaxel 75 mg/m2 and cisplatin 75 mg/m2 day 1 and 5-FU 1,000 mg/m2 96 hours CI) every 3 weeks followed by RT (68 Gy/4.5 weeks) with E given one week before (400 mg/m2) and weekly during RT (250 mg/m2). A brachytherapy boost of 8 Gy was given to pts with oral cavity or oropharyngeal tumours. Neck dissection was planned for pts with N2–3 and complete response (CR) at the primary tumour. Tumour response was evaluated according to RECIST with CT, MRI or PET/CT after CT and at 6 weeks follow up. Toxicity (CTC 3.0) and quality of life (EORTC QLQ 30) was registered during and after treatment. Results: From 070401 to 081115 68 pts were enrolled, 56 had stage IV disease (T4, n = 14, N3, n = 9). Median age 57, 60 males, 3 oral cavity, 44 oropharynx, 10 larynx, and 11 hypopharynx. 30 pts were followed beyond 6 weeks and evaluated for response and early toxicity: stage IV disease 24 (T4, n = 6, N3, n = 3), median age 60, 25 males, 18 oropharynx, 5 larynx, and 7 hypopharynx. Remissions after TPF/after RT: CR 1/10, PR 15/18, SD 14/1, and PD 1. TPF as prescribed: 28/30 (pat refusal 1, renal insuff 1, dose reduction 0/28); E as prescribed: 22/30 (dermatitis 4, hypersensitivity 3, liver tox 1). Vital tumour in resected specimen 0/13. Alive at follow-up 29/30 (1 local failure). Conclusions: TPF followed by RT concomitant with E is feasible with manageable toxicities. Dermatitis in the irradiated neck, at least with the present accelerated fractionation, is troublesome to some patients but does not interrupt treatment and heals rapidly. To dispose of feeding tubes after disappearance of acute mucosal reactions has not been a problem. Early survival results are promising. Toxicity and survival results will be updated. [Table: see text]

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