Endoscopic, assisted, modified turbinoplasty with mucosal flap

2012 ◽  
Vol 126 (5) ◽  
pp. 525-528 ◽  
Author(s):  
M M Puterman ◽  
N Segal ◽  
B-Z Joshua
Keyword(s):  
Side Effects ◽  
Large Volume ◽  
Inferior Turbinate ◽  
Nasal Airway ◽  
Mucosal Flap ◽  
Surgical Methods ◽  
Endoscopic Assistance

AbstractA variety of surgical methods have been developed to reduce the volume of the inferior turbinates, in order to create a more patent nasal airway. We describe a technique used in our department since February 2002 for all patients undergoing inferior turbinectomy. We resect with endoscopic assistance the lateral mucosa and bony inferior turbinate. This technique can reduce a large volume of the turbinate while preserving the mucosal continuity and the submucosa by covering the raw surface with a mucosal flap. We believe our method minimises post-operative side effects and complications such as dryness, infection, bleeding and pain.

The Effect of Nasoalveolar Molding on Nasal Airway Anatomy

2018 ◽  
Vol 55 (4) ◽  
pp. 596-601 ◽  
Author(s):  
Jonathan P. Massie ◽  
Karl Bruckman ◽  
William J. Rifkin ◽  
Christopher M. Runyan ◽  
Pradip R. Shetye ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Inferior Turbinate ◽  
Septal Deviation ◽  
Nasal Airway ◽  
Retrospective Case ◽  
Tertiary Referral Center ◽  
Nasal Cartilage ◽  
Inferior Turbinate Hypertrophy ◽  
Nasoalveolar Molding ◽  
Control Study

Objective: To determine the effects of nasoalveolar molding (NAM) on nasal airway architecture. Design: Retrospective case-control study of patients with unilateral cleft lip treated with NAM vs without NAM. Setting: Tertiary referral center specializing in cleft and craniofacial care. Patients, Participants, and Interventions: Thirty-six patients with complete unilateral cleft lip and alveolus: 19 with NAM therapy and 17 without NAM therapy. Main Outcome Measures: Cone beam computed tomography (CBCT) scans were compared in multiple coronal sections and were evaluated for linear and angular septal deviation, inferior turbinate hypertrophy, and linear and 2-dimensional airway area. Results: There were no significant differences in linear or angular septal deviation, inferior turbinate area, linear stenosis, or airway area between NAM- and non-NAM-treated patients. Conclusions: NAM effectively molds the external nasal cartilage and structures but may have limited effects on internal nasal structures.

scholarly journals Topical Diltiazem Versus Topical Glyceryl Trinitrate In The Management Of Chronic Anal Fissure

JMS SKIMS ◽  
2014 ◽  
Vol 17 (2) ◽  
pp. 55-58
Author(s):  
Shams Ul Bari ◽  
Ajaz Ahmad Malik ◽  
Khurshid Alam Wani ◽  
Ajaz A Rather
Keyword(s):  
Side Effects ◽  
Anal Fissure ◽  
Chronic Anal Fissure ◽  
P Value ◽  
Double Blind ◽  
Surgical Methods ◽  
Significant Difference ◽  
Topical Glyceryl Trinitrate ◽  
One Year

Background: Chemical sphincterotomy is a novel way for treating patients of chronic anal fissure which avoids the risk of fecal incontinence associated with traditional surgical methods. Aims and objectives: The aim of this study was to compare the results of topical Diltiazem with topical Glyceril trinitrate in the management of chronic anal fissure. Methods: 71 patients in the age group of 15 - 61 years with chronic anal fissure were included in this prospective, randomized, double-blind trial over a period of two years with further follow up for one year. The patients were randomly allocated to either Diltiazem gel 2% (37 patients) or Glyceril trinitrate ointment 0.2% (34 patients) and were asked to use the treatment twice daily for 8 weeks. Each patient was reviewed every two weeks. Symptoms, healing, side effects and recurrence were compared using SPSS version 10 employing X2 test. A p-value below 0.05 was considered statistically significant. Results: Patients who received topical diltiazem (DTZ) showed statistically significant difference than those who were prescribed topical glyceril trinitrate in terms of symptoms, wound healing, side effects ( headaches) and recurrence (p=0.03 and 0.003 respectively). Healing occurred in 34 of 37 (92%) patients treated with Diltiazem after 6 weeks and 27 of 34 (80%) patients treated with Glyceril trinitrate after 8 weeks, which shows a significant difference in favour of Diltiazem (P < 0.001). The rest of the patients did not heal and underwent sphincterotomy (SILS). Headache occurred in all of the patients treated with Glyceril trinitrate but none of the patients treated with Diltiazem. Conclusion: Diltiazem gel was found to be better than Glyceril trinitrate ointment due to significantly higher healing rate and fewer side-effects. JMS 2014;17(2):55-58

scholarly journals CLOSURE OF SEPTAL PERFORATION USING AN INFERIOR TURBINATE MUCOSAL FLAP

2000 ◽  
Vol 39 (2) ◽  
pp. 102-105
Author(s):  
Haruhiko Ishida ◽  
Mutsuo Amatsu ◽  
Satoko Shimoya
Keyword(s):  
Inferior Turbinate ◽  
Septal Perforation ◽  
Mucosal Flap

Medical Management of Trigeminal Neuralgia

2019 ◽  
pp. 591-609
Author(s):  
Niushen Zhang
Keyword(s):  
Side Effects ◽  
Trigeminal Neuralgia ◽  
Side Effect Profile ◽  
Clinical Use ◽  
Line Treatment ◽  
Nasal Sprays ◽  
Surgical Methods ◽  
Methods Of Treatment ◽  
First Line Treatment ◽  
Selection Of

The first-line treatment of trigeminal neuralgia can be very effective, but side effects are often difficult for patients to tolerate. This chapter is a guide to the broad selection of medical therapies currently available for the treatment of trigeminal neuralgia which includes oral therapies and other non-surgical methods of treatment such as IV medications, nasal sprays, topical ointments, and injections. The discussion of each treatment includes discussion of its evidence in current literature, its proposed mechanism of action, its dosing and appropriate setting for clinical use, and its side effect profile.

Subjective Comparison of Nd:YAG, Diode, and CO2 Lasers for Endoscopically Guided Inferior Turbinate Reduction Surgery

1998 ◽  
Vol 12 (3) ◽  
pp. 209-212 ◽  
Author(s):  
Ari DeRowe ◽  
Roy Landsberg ◽  
Yaron Leonov ◽  
Abraham Katzir ◽  
Dov Ophir
Keyword(s):  
Postoperative Bleeding ◽  
Inferior Turbinate ◽  
Nasal Airway ◽  
Objective Data ◽  
Treatment Groups ◽  
Endoscopic Control ◽  
Tissue Interactions ◽  
Significant Difference ◽  
Laser Systems ◽  
Turbinate Reduction

Lasers using different wavelengths and delivery systems have been used to reduce the inferior turbinate mass when hypertrophic inferior turbinates obstruct the nasal airway. Different laser systems produce different laser-tissue interactions. This study presents a comparison between three laser systems: CO2, Nd:YAG, and Diode lasers for inferior turbinate reduction surgery, all performed under endoscopic control. A total of 46 patients were randomized into three treatment groups and followed for more than 1 year. Subjective and objective data were collected. Subjective impressions of improved nasal airway was achieved in 41% (Diode), 47% (Nd: YAG) and 57% (CO2) and was not statistically significant. There was more postoperative bleeding in the CO2 laser group, with 3 patients requiring tamponade. The CO2 laser procedure also took longer to perform. These results failed to show a significant difference between the different lasers for inferior turbinate reduction. Overall, the results were not impressive.

scholarly journals Efficacy of the immune checkpoint inhibitor nivolumab in the treatment of advanced hepatocellular carcinoma with the exhausted possibilities of therapy with tyrosine kinase inhibitors

2021 ◽  
pp. 84-93
Author(s):  
A. Yu. Goryainova ◽  
A. I. Stukan ◽  
R. A. Murashko ◽  
S. V. Sharov ◽  
O. I. Kirsanova ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Side Effects ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
Multiple Drug Resistance ◽  
Response To Therapy ◽  
Advanced Hepatocellular Carcinoma ◽  
Surgical Methods ◽  
A Priority

Hepatocellular carcinoma is one of the most formidable and deadly cancers. The limited possibilities of surgical methods of treatment as well as the formation of multiple drug resistance caused by the biological characteristics of both the liver tissue itself and tumor cells with their microenvironment determine the unsatisfactory indicators of relapse free survival and overall survival of patients. In addition, therapy with tyrosine kinase inhibitors, which has become the “gold” standard, has limited possibilities: a large number of side effects significantly reduce the quality of life and adherence to treatment in patients with hepatocellular cancer. The search for molecular biological targets, as well as new therapeutic agents that block these targets, does not always lead to positive results. Immunotherapy in this sense is a priority, having good tolerance, a low number of side effects, no need for additional testing of the patient’s biological material before starting treatment, high efficiency and a long response time. However, there are many unresolved questions about the duration of therapy, predicting its efficacy, the optimal combination of drugs or the use of monotherapy, the formation of priority subgroups of patients. Understanding the mechanisms of immune evasion, an ability that hepatocellular carcinoma possesses, – is the key to successful use of immunotherapeutic agents alone, in combination with tyrosine kinase inhibitors, antiangiogenic drugs or among themselves. This article provides an overview of data from clinical studies of modern drugs for the treatment of hepatocellular carcinoma and describes the mechanism of liver immunological tolerance as a possible predictive marker of sensitivity to immunotherapy. It seems promising to study the role of cells in the microenvironment of hepatocellular carcinoma for predicting the effectiveness of immunotherapy. The clinical example is used to demonstrate the successful experience of using the immunotherapeutic drug nivolumab in the treatment of hepatocellular carcinoma resistance to tyrosine kinase inhibitors. This is a classic example of duration of response to therapy, lack of reactivation of chronic viral hepatitis and controlled toxicity. All these indicators enable the clinician to consider immunotherapy as a priority option for the treatment of inoperable hepatocellular carcinoma. 

scholarly journals Gastric Side Effects and the Stomach Dosimetric Analysis in Left-Sided Breast Cancer Radiotherapy in Free-Breathing and Deep Inspiration Breath-Hold Technique

2021 ◽  
Author(s):  
Dong Yang ◽  
Ying Piao ◽  
Fengshun Yuan ◽  
Hongtao Chen ◽  
Ding Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Adjuvant Radiotherapy ◽  
Hormone Receptors ◽  
Breath Hold ◽  
Breast Cancer Patients ◽  
Breast Radiotherapy ◽  
Breast Cancer Radiotherapy ◽  
Surgical Methods ◽  
Significant Difference

Abstract Background Adjuvant radiotherapy following surgery reduces the local recurrence and improves the prognosis. However, a considerable part of patients developed digestive reaction in daily treatment. In order to explore the correlation between breast radiotherapy and gastric toxicity, we investigated the clinic symptoms and stomach dose during DIBH or FB mode while left-sided breast cancer patients (LSBCP) receiving radiotherapy. Methods In the study, 124 LSBCP received adjuvant radiotherapy after surgery at our department were analyzed clinical characteristics and enquired about gastrointestinal side effects after treatment. Moreover, dosimetric parameters were assessed. Results There was no statistically significant difference between the two groups in age, T staging, N staging, hormone receptors, human epidermal receptor-2 (HER2), surgical methods, fractionated regimen, and chemotherapy conditions. Stomach volumes, the use of the DIBH gating technique (FB/DIBH), and higher fractionated dose (Dmax/F) were associated with a statistically significantly greater risk for acute radiotherapy toxicity. Conclusion In order to cut down gastric side effects after breast radiotherapy, large meals should be avoided before treatment. DIBH treatment should be implemented in centers where conditions are satisfied to reduce radiotherapy side effects. Furthermore, dose limitation in stomach should be considered when the radiotherapy plan was formulated, especially for the patients treated with hypofractionated radiotherapy.

scholarly journals The effectiveness of surgical and non-surgical techniques in orthodontic practice in closing post-extraction spaces: a systematic review

2021 ◽  
Vol 19 (1) ◽  
pp. 31-38
Author(s):  
Z. S. Khabadze ◽  
M. E. Balashova
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Side Effects ◽  
Orthodontic Treatment ◽  
Surgical Techniques ◽  
Long Term Results ◽  
Publication Date ◽  
Controlled Clinical Trials ◽  
Surgical Methods

Reducing the orthodontic treatment duration is an important issue, especially for adult patients who want to complete treatment faster due to social or aesthetic reasons. In addition, an increase in the duration of orthodontic treatment has a number of side effects, therefore, orthodontists and patients are interested in the use of techniques that can accelerate the movement of teeth. Shorter treatment times can be achieved through a combination of orthodontic and surgical or non-surgical techniques.Aim. To systematically evaluate scientific data on the effectiveness and side effects of surgical and non-surgical methods in accelerating orthodontic treatment in situations with the removal of premolars and subsequent closure of the post-extraction spaces.Materials and methods. Electronic search of articles was carried out using search engines and databases: Cyberleninka, eLIBRARY, Google Scholar, Pub Med, SCOPUS. The publication date criterion was selected from January 2010 to January 2021. Articles included in the systematic review had to meet the following inclusion criteria: controlled clinical trials and randomized controlled clinical trials conducted in humans and published in the last 11 years in English language. The systematic review included and analyzed 15 full-text articles.Result. According to the systematic review, the speed of movement of teeth increases 2 times with corticotomy, and 1.5 times with piezocorticotomy, which is consistent with the data of other studies. At the same time, the effectiveness of the movement remains for no more than 2 months after the intervention.Conclusions. The corticotomy procedure reduces the treatment time in comparison with traditional methods by 30-50% (6-8 months). The investigated techniques did not have a significant effect on the depth of probing, the level of attachment, on the density of bone tissue, rotation and inclination of the moved teeth. Since no complications were identified for 2-4 months of observation, further studies are required to assess long-term results in the long term.

A Surgical and Educational Video of the Inferior Turbinate Mucosal Flap for the Nasal Floor and Intraoral Reconstruction in Unilateral Complete Cleft Lip Repair

2020 ◽  
Vol 57 (8) ◽  
pp. 1045-1050
Author(s):  
Rafael Denadai ◽  
Pang-Yun Chou ◽  
Soyeon Jung ◽  
Nobuhiro Sato ◽  
Dax Carlo G. Pascasio ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Inferior Turbinate ◽  
Original Description ◽  
Educational Video ◽  
Mucosal Flap ◽  
Intraoral Reconstruction ◽  
Nasal Floor ◽  
Cleft Lip Repair ◽  
Key Steps ◽  
Rotation Advancement

Since the original description of Millard rotation advancement principle for cleft lip repair, many important contributions have subsequently been described by other surgeons worldwide. However, the reconstruction of the nasal floor and intraoral lining has received less attention over time. This article demonstrates a modified unilateral complete cleft lip repair using the rotation advancement principle plus multipurpose inferior turbinate mucosal flap. The accompanying videos display the 10 key steps for rationale, design, and proper execution of the inferior turbinate mucosal flap for the nasal floor and intraoral reconstruction.

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