scholarly journals Evaluation and interpretation of latent class modelling strategies to characterise dietary trajectories across early life: a longitudinal study from the Southampton women's survey

2021 ◽  
Vol 80 (OCE5) ◽  
Author(s):  
K.V. Dalrymple ◽  
H.M. Inskip ◽  
C. Vogel ◽  
K.M. Godfrey ◽  
J. Baird ◽  
...  
2021 ◽  
pp. 0192513X2199387
Author(s):  
Jacqueline Bible ◽  
David T. Lardier ◽  
Frank Perrone ◽  
Brad van Eeden-Moorefield

Using a latent class analysis (LCA) with data from a subsample of children in stepfamilies ( N = 6,637) from the 2009 High School Longitudinal Study (HSLS), this study examined how stepfamily involvement in their (step)child’s education in and outside of school influenced their (step)child’s college preparation. Stepfamily involvement in their (step)child’s education in school (e.g., help with homework) and outside of school (e.g., educational experiences such as going to a museum) may help overcome challenges associated with academic and college preparation for children in stepfamilies. Results broadly indicate students with higher stepfamily involvement in education in and out of school had (step)parents who believed that college was attainable, students engaged in more activities that would prepare them for their future, and students took more AP/IB level courses and tests. Together, findings suggest that stepfamily involvement in education both in and out of school is important for their (step)child’s college preparation behaviors.


Author(s):  
Rebecca Bendayan ◽  
Yajing Zhu ◽  
A D Federman ◽  
R J B Dobson

Abstract Background We aimed to examine the multimorbidity patterns within a representative sample of UK older adults and their association with concurrent and subsequent memory. Methods Our sample consisted of 11,449 respondents (mean age at baseline was 65.02) from the English Longitudinal Study of Ageing (ELSA). We used fourteen health conditions and immediate and delayed recall scores (IMRC and DLRC) over 7 waves (14 years of follow up). Latent class analyses were performed to identify the multimorbidity patterns and linear mixed models were estimated to explore their association with their memory trajectories. Models were adjusted by socio-demographics, BMI and health behaviors. Results Results showed 8 classes: Class 1:Heart Disease/Stroke (26%), Class 2:Asthma/Lung Disease (16%), Class 3:Arthritis/Hypertension (13%), Class 4:Depression/Arthritis (12%), Class 5:Hypertension/Cataracts/Diabetes (10%), Class 6:Psychiatric Problems/Depression (10%), Class 7:Cancer (7%) and Class 8:Arthritis/Cataracts (6%). At baseline, Class 4 was found to have lower IMRC and DLRC scores and Class 5 in DLRC, compared to the no multimorbidity group (n=6380, 55.72% of total cohort). For both tasks, in unadjusted models, we found an accelerated decline in Classes 1, 3 and 8; and, for DLRC, also in Classes 2 and 5. However, it was fully attenuated after adjustments. Conclusions These findings suggest that individuals with certain combinations of health conditions are more likely to have lower levels of memory compared those with no multimorbidity and their memory scores tend to differ between combinations. Socio-demographics and health behaviours have a key role to understand who is more likely to be at risk of an accelerated decline.


2011 ◽  
Vol 140 (5) ◽  
pp. 835-841 ◽  
Author(s):  
L. H. MORTENSEN ◽  
A. B. MAIER ◽  
P. E. SLAGBOM ◽  
G. PAWELEC ◽  
E. DERHOVANESSIAN ◽  
...  

SUMMARYHuman cytomegalovirus (CMV) is a common herpesvirus establishing lifelong persisting infection, which has been implicated in immunosenescence and mortality in the elderly. Little is known about how and when susceptibility to CMV infection is determined. We measured CMV seroprevalence in two genetically informative cohorts. From the Leiden Longevity Study (LLS) we selected long-lived sib-pairs (n=844) and their middle-aged offspring and the offspring's partners (n=1452). From the Longitudinal Study of Aging Danish Twins (LSADT) 604 (302 pairs) same-sex monozygotic (MZ) and dizygotic (DZ) twins aged 73–94 years were included (n=302 pairs). Offspring of the long-lived LLS participants had significantly lower seroprevalence of CMV compared to their partners (offspring: 42%vs. partners: 51%,P=0·003). Of 372 offspring living with a CMV-positive partner, only 58% were infected. The corresponding number for partners was 71% (P<0·001). In the LSADT, MZ and DZ twins had high and similar CMV-positive concordance rates (MZ: 90%vs. DZ: 88%,P=0·51) suggesting that shared family environment accounts for the similarity within twin pairs. Our findings suggest that susceptibility to CMV infection – even under continuous within-partnership exposure – appears to be more strongly influenced by early-life environment than by genetic factors and adult environment.


Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Lisa Kakinami ◽  
Marie Lambert ◽  
Lise Gauvin ◽  
Louise Séguin ◽  
Béatrice Nikiéma ◽  
...  

Background: Childhood poverty is associated with poorer food consumption patterns but longitudinal data on this association is limited. To assess if the relationship between food consumption and poverty differs depending on the child’s age and pattern of poverty, we analyzed the relationship between consumption of selected foods and poverty trajectories at various ages in a birth cohort. Methods: The 1998-2010 "Quebec Longitudinal Study of Child Development" (n=2,120) cohort was used for these analyses. Household income was measured annually with poverty defined as income below the low-income thresholds established by Statistics Canada adjusted for household size and geographic region. Frequency of children’s consumption of dairy (milk, cheese, yogurt), fruits, and vegetables were reported by parents using a food frequency questionnaire. Analyses were conducted on the 739 children with food consumption data. Trajectories of poverty at 6, 8, 10, and 12 years were characterized with latent class group analysis using maximum likelihood in a semiparametric mixture model. Multivariable logistic regression predicted the likelihood of having less than 2 servings a day of dairy, fruits and vegetables based on poverty trajectories after adjusting for age and sex. Results: The poverty trajectories were stable and fell into 1 lower exposure category (consistently low exposure (73%, n=537)) and 3 higher exposure categories (increasing: 8%, n=61; decreasing: 10%, n=73; or consistently high exposure: 9%, n=68)). Compared to children experiencing low exposure to poverty, children with increasing or high exposure to poverty were less likely to have at least two servings of fruit a day at all ages, but the results were not significant. Compared to children experiencing low exposure to poverty, children with high exposure were 55% (CI: 0.2-0.8, p=0.001), 31% (CI: 0.4-1.2, p=0.23), 67% (CI: 0.2-0.6, p<.0001), and 49% (CI: 0.3-0.8, p=0.001) less likely to have at least two servings of dairy a day at 6, 8, 10, and 12 years, respectively. Compared to children with low exposure to poverty, children with high exposure were 43% (CI: 0.3-0.9, p=0.02), 46% (CI: 0.3-0.9, p=0.02), 55% (CI: 0.3-0.8, p=0.003), and 47% (CI: 0.3-0.9, p=0.02) less likely to have at least two servings of vegetables a day at 6, 8, 10, and 12 years, respectively. Children at all ages with decreasing or increasing exposure to poverty were less likely to have at least two servings of vegetables a day, but the results were not statistically significant. Conclusion: Experiencing high exposure to poverty has consistent effects on food consumption throughout childhood. In addition, compared to children with low exposure to poverty, children with increasing or decreasing exposure were less likely to have at least 2 servings of fruits and vegetables a day, suggesting any exposure to poverty may have detrimental effects on consumption of selected foods.


Author(s):  
Amy Ehntholt ◽  
Roman Pabayo ◽  
Lisa Berkman ◽  
Ichiro Kawachi

The misuse of prescription painkillers is a major contributor to the ongoing drug overdose epidemic. This study investigated variability in non-medical use of prescription painkillers (NMUPP) by race and early-life socioeconomic status (SES) in a sample now at increased risk for opioid overdose. Data from two waves of the National Longitudinal Study of Adolescent to Adult Health (n = 11,602) were used to calculate prevalence of reported NMUPP by Wave 4 (2008; mean age 28), and to assess variation by race and by equivalized household family income at Wave 1 (1994/5). Predicted values for prevalence of NMUPP were modelled, adjusting for age, sex, parental education, and region. Race and SES in adolescence were associated with later reported NMUPP. A gradient was seen in prevalence by SES (adjusted: family income quartile 1 = 13.3%; quartile 2 = 13.8%; quartile 3 = 14.8%; quartile 4 = 16.0%; trend p-value = 0.007). Prevalence was higher among males. Racial/ethnic differences in prevalence were seen (non-Hispanic white (NHW) = 18.5%; non-Hispanic black (NHB) = 5.8%; Hispanic = 10.5%; Other = 10.0%). SES differences were less pronounced upon stratification, with trend tests significant only among females (p = 0.004), and marginally significant among Hispanic males (p = 0.06). Early-life SES was associated with reported lifetime NMUPP: the higher the family income in adolescence, the greater the likelihood of NMUPP by young adulthood. Variations in NMUPP by income paled in comparison with racial/ethnic differences. Results point to a possible long-enduring association between SES and NMUPP, and a need to examine underlying mechanisms.


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