Rate ofLeishmania-induced skin-lesion development in rodents depends on the site of inoculation

Parasitology ◽  
1987 ◽  
Vol 94 (3) ◽  
pp. 451-465 ◽  
Author(s):  
C. E. Kirkpatrick ◽  
T. J. Nolan ◽  
J. P. Farrell
Keyword(s):  
Skin Lesion ◽  
Skin Temperature ◽  
Metastatic Disease ◽  
Regional Differences ◽  
The Body ◽  
Lesion Development ◽  
Golden Hamsters ◽  
Immunological Reactions ◽  
Different Strains

Regional differences in the response of mice to infection with three strains of dermotropicLeishmaniaspp. were shown for skin covering the trunk. Lesions tended to appear earlier and to grow more rapidly on sites over the caudal half of the body than the cranial half, and caudal lesions were more likely than cranial ones to result in metastatic disease in susceptible strains of mice. Site-related variations in lesion development were observed in different strains of mice as well as in golden hamsters. The effect of these regional differences on the development of some parasite-specific, immunological reactions was examined, as were parasite thermosensitivity and location-related variations in host skin temperature as possible explanations.

Biocompatible Polymers and their Potential Biomedical Applications: A Review

2019 ◽  
Vol 25 (34) ◽  
pp. 3608-3619 ◽  
Author(s):  
Uzma Arif ◽  
Sajjad Haider ◽  
Adnan Haider ◽  
Naeem Khan ◽  
Abdulaziz A. Alghyamah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Biomedical Applications ◽  
Living System ◽  
Health Condition ◽  
The Body ◽  
Biocompatible Polymers ◽  
Nano Technology ◽  
Artificial Grafts ◽  
Immunological Reactions

Background: Biocompatible polymers are gaining great interest in the field of biomedical applications. The term biocompatibility refers to the suitability of a polymer to body and body fluids exposure. Biocompatible polymers are both synthetic (man-made) and natural and aid in the close vicinity of a living system or work in intimacy with living cells. These are used to gauge, treat, boost, or substitute any tissue, organ or function of the body. A biocompatible polymer improves body functions without altering its normal functioning and triggering allergies or other side effects. It encompasses advances in tissue culture, tissue scaffolds, implantation, artificial grafts, wound fabrication, controlled drug delivery, bone filler material, etc. Objectives: This review provides an insight into the remarkable contribution made by some well-known biopolymers such as polylactic-co-glycolic acid, poly(ε-caprolactone) (PCL), polyLactic Acid, poly(3- hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), Chitosan and Cellulose in the therapeutic measure for many biomedical applications. Methods: : Various techniques and methods have made biopolymers more significant in the biomedical fields such as augmentation (replaced petroleum based polymers), film processing, injection modeling, blow molding techniques, controlled / implantable drug delivery devices, biological grafting, nano technology, tissue engineering etc. Results: The fore mentioned techniques and other advanced techniques have resulted in improved biocompatibility, nontoxicity, renewability, mild processing conditions, health condition, reduced immunological reactions and minimized side effects that would occur if synthetic polymers are used in a host cell. Conclusion: Biopolymers have brought effective and attainable targets in pharmaceutics and therapeutics. There are huge numbers of biopolymers reported in the literature that has been used effectively and extensively.

Associated change in plantar temperature and sweating after transthoracic endoscopic T2–3 sympathectomy for palmar hyperhidrosis

2001 ◽  
Vol 95 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Han-Jung Chen ◽  
Cheng-Loong Liang ◽  
Kang Lu
Keyword(s):  
Skin Temperature ◽  
Temperature Change ◽  
The Body ◽  
Palmar Hyperhidrosis ◽  
Compensatory Sweating ◽  
Content Type ◽  
Postoperative Changes ◽  
The Face ◽  
The Difference ◽  
Fine Print

Object. Transthoracic endoscopic T2–3 sympathectomy is currently the treatment of choice for palmar hyperhidrosis. Compensatory sweating of the face, trunk, thigh, and sole of the foot was found in more than 50% of patients who underwent this procedure. The authors conducted this study to investigate the associated intraoperative changes in plantar skin temperature and postoperative plantar sweating. Methods. One hundred patients with palmar hyperhidrosis underwent bilateral transthoracic endoscopic T2–3 sympathectomy. There were 60 female and 40 male patients who ranged in age from 13 to 40 years (mean age 21.6 years). Characteristics studied included changes in palmar and plantar skin temperature measured intraoperatively, as well as pre- and postoperative changes in plantar sweating and sympathetic skin responses (SSRs). In 59 patients (59%) elevation of plantar temperature was demonstrated at the end of the surgical procedure. In this group, plantar sweating was found to be exacerbated in three patients (5%); plantar sweating was improved in 52 patients (88.1%); and no change was demonstrated in four patients (6.8%). In the other group of patients in whom no temperature change occurred, increased plantar sweating was demonstrated in three patients (7.3%); plantar sweating was improved in 20 patients (48.8%); and no change was shown in 18 patients (43.9%). The difference between temperature and sweating change was significant (p = 0.001). Compared with the presympathectomy rate, the rate of absent SSR also significantly increased after sympathectomy: from 20 to 76% after electrical stimulation and 36 to 64% after deep inspiration stimulation, respectively (p < 0.05). Conclusions. In contrast to compensatory sweating in other parts of the body after T2–3 sympathetomy, improvement in plantar sweating was shown in 72% and worsened symptoms in 6% of patients. The intraoperative plantar skin temperature change and perioperative SSR demonstrated a correlation between these changes.

Strain difference in thermoregulation of rats surviving extreme heat

1982 ◽  
Vol 52 (2) ◽  
pp. 410-415 ◽  
Author(s):  
F. Furuyama
Keyword(s):  
Body Temperature ◽  
Heat Tolerance ◽  
Strain Difference ◽  
Body Weight Loss ◽  
The Body ◽  
Sprague Dawley ◽  
Survival Times ◽  
Sprague Dawley Rats ◽  
Thermoregulatory System ◽  
Different Strains

The survival times of unanesthetized rats in 42.5 degree C. 48% rh were studied in 12 different strains. In males, Sprague-Dawley rats (P less than 0.01) and Fisher 344/MK (P less than 0.05) showed significantly higher heat tolerance than the other 9 strains. Among Sprague-Dawley rats, females tolerated heat longer than males (P less than 0.05). There was no difference in lethal body temperature according to strains and exposure temperatures (38.5–48.5 degree C). Maximum survivable body temperature was 43.1 degree C in males and 43.3 degree C in females. The body weight loss in heat was greater in Sprague-Dawley, Fisher 344/MK, and JCL:Wistar strains. The degree of saliva spreading during the equilibrium period just below the maximum survivable body temperature correlated significantly with heat tolerance and was found to be the index of strain difference in heat tolerance. These findings demonstrated that the thermoregulatory system of rats is controlled genetically, though survival times of individuals in different strains sometimes overlap.

scholarly journals From Stones to Gendered Bodies: Regional Differences in the Production of the Body and Gender on the Copper Age Statue-Menhirs of Northern Italy and the Swiss Valais

2014 ◽  
Vol 17 (2) ◽  
pp. 264-285 ◽  
Author(s):  
Susanna Harris ◽  
Kerstin P. Hofmann
Keyword(s):  
Regional Differences ◽  
Northern Italy ◽  
The Body ◽  
Copper Age ◽  
Natural Form ◽  
Size And Shape ◽  
Gender And Age ◽  
Gendered Bodies ◽  
And Gender ◽  
Gender Categories

Much research has been carried out on identifying gendered iconography on statue-menhirs. This paper seeks to develop this perspective by considering the broader body concepts. Body concepts are of interest to archaeologists because they are closely connected to issues of sex, gender, and age. By investigating stone sculptures, however, we are looking at an ideological view of the body that was produced by reducing the stone from its natural form into a statue-menhir. The presence of bodily features on the statue-menhirs suggests that it was important to construct a body, and that certain aspects of the body were chosen to be represented, either through the size and shape of the stone or iconography, while others were neglected. We propose this is a significant means by which stones were made into bodies and gendered beings. To investigate body concepts, we pose two questions: how was a statue-menhir body made, and how was it gendered? By following the reduction sequence of the stone as the technique of production, we investigate which bodily features were important in constructing a body and in gendering it. We do this through analysing and comparing three regional examples of anthropomorphic statue-menhirs: (1) The Lunigiana groups A and B in northwestern Tuscany and eastern-most Liguria, (2) the Atesino group in Trentino-Alto Adige, and (3) the Sion Type A in the Swiss Valais and the Aosta Style I in northern Italy. Although there is a shared statue-menhir tradition in the three regions and beyond, the observations in this paper suggest that the bodily gender categories were negotiated regionally.

Studies on the ectoparasites of seals and penguins. 1. The ecology of the louse Lepidophthirus macrorhini Enderlein on the southern elephant seal, Mirounga leonina (L)

1965 ◽  
Vol 13 (3) ◽  
pp. 437 ◽  
Author(s):  
MD Murray ◽  
DG Nicholls
Keyword(s):  
Stratum Corneum ◽  
Skin Temperature ◽  
Elephant Seal ◽  
The Body ◽  
Southern Elephant Seal ◽  
Mirounga Leonina ◽  
Prolonged Stay ◽  
Blood Sucking ◽  
Southern Elephant Seals ◽  
Causes Of Mortality

Although the southern elephant seals, Mirounga leonina, that breed on Macquarie I., come ashore for only 3-5 weeks twice a year, the hind flippers of most of them are infested with the blood-sucking louse Lepidophthirus macrorhini. L. macrorhini does not oviposit, and eggs do not hatch, in water. Reproduction occurs when the elephant seal is ashore on the beach or in the adjacent tussock. The life cycle can be completed in c. 3 weeks and, because 6-9 eggs are laid daily, multiplication can be rapid. Temperatures greater than 25�C are required for rapid multiplication, and these temperatures occur more frequently on the hind flippers than elsewhere on the body. The number of L. macrorhini on a hind flipper however rarely exceeds 100. The principal causes of mortality of the lice are failure to survive the seal's prolonged stay at sea, the moult of the seal, and transmission to unfavourable sites on the seal. When an elephant seal goes to sea its skin temperature falls to nearly that of the sea. The reduction in the metabolic rate of the louse at low temperatures results in the amount of oxygen obtained from the sea by cutaneous respiration being sufficient for survival. The lice do not enter into a state of complete suspended animation, and a blood meal is required at least once a week to enable sufficient to survive to repopulate the seal. The skin temperature of a seal at sea rises more frequently on the flippers than elsewhere on the body because of the increased rate of blood flow to the flippers after diving and whenever it is necessary to dissipate heat. Consequently, there are more opportunities for the lice on the hind flippers to feed. L. macrorhini burrows into the stratum corneum, thus reducing losses to the population when the elephant seal annually sheds the outer layers of the stratum corneum attached to the hair, because only the roof of the burrow is lost. Lice do not reproduce on the older seals that moult in muddy wallows, and consequently fewer lice are found on these animals. Pups are infested within a few days of birth, and the gregarious habits of the elephant seal spread infestations through the seal population. Lice transfer to all parts of the bodies of seals but it is the multiplication of those on the flippers that maintains the louse population. The abundance of L. macrorhini is determined largely by the frequency and duration of opportunities to reproduce when the elephant seal is ashore, and to feed when the elephant seal is at sea.

Relationship between body heat content and finger temperature during cold exposure

2001 ◽  
Vol 90 (6) ◽  
pp. 2445-2452 ◽  
Author(s):  
Dragan Brajkovic ◽  
Michel B. Ducharme ◽  
John Frim
Keyword(s):  
Skin Temperature ◽  
Heat Storage ◽  
Heat Content ◽  
The Body ◽  
Finger Temperature ◽  
Finger Dexterity ◽  
The Relationship ◽  
Finger Skin ◽  
Body Heat ◽  
Partitional Calorimetry

The purpose of the present experiment was to examine the relationship between rate of body heat storage (S˙), change in body heat content (ΔHb), extremity temperatures, and finger dexterity. S˙, ΔHb , finger skin temperature (Tfing), toe skin temperature, finger dexterity, and rectal temperature were measured during active torso heating while the subjects sat in a chair and were exposed to −25°C air. S˙ and ΔHb were measured using partitional calorimetry, rather than thermometry, which was used in the majority of previous studies. Eight men were exposed to four conditions in which the clothing covering the body or the level of torso heating was modified. After 3 h, Tfing was 34.9 ± 0.4, 31.2 ± 1.2, 18.3 ± 3.1, and 12.1 ± 0.5°C for the four conditions, whereas finger dexterity decreased by 0, 0, 26, and 39%, respectively. In contrast to some past studies, extremity comfort can be maintained, despite S˙ that is slightly negative. This study also found a direct linear relationship between ΔHb and Tfing and toe skin temperature at a negative ΔHb. In addition, ΔHb was a better indicator of the relative changes in extremity temperatures and finger dexterity over time than S˙.

Elevated transglutaminase-2 expression in the epidermis of psoriatic skin and its role in the skin lesion development

2017 ◽  
Vol 44 (6) ◽  
pp. 699-702 ◽  
Author(s):  
Ching-Chyuan Su ◽  
Tzu-Rong Su ◽  
Ji-Ching Lai ◽  
Gregory-J Tsay ◽  
Hung-Ke Lin
Keyword(s):  
Skin Lesion ◽  
Transglutaminase 2 ◽  
Psoriatic Skin ◽  
Lesion Development

Body Composition (% Fat) and Heat Stress of Well Conditioned Young Adult Males

1982 ◽  
Vol 26 (6) ◽  
pp. 561-564
Author(s):  
Michael W. Riley ◽  
David J. Cochran ◽  
Arthur J. Soundy
Keyword(s):  
Heart Rate ◽  
Oxygen Consumption ◽  
Young Adult ◽  
Skin Temperature ◽  
Body Fat ◽  
Bicycle Ergometer ◽  
The Body ◽  
Lean Body Weight ◽  
Adult Males ◽  
Young Adult Males

The physiological responses of heart rate, oxygen consumption, sweat loss, rectal temperature and mean skin temperature were monitored as eight well-conditioned young adult males were exposed to effective temperatures of 70°F, 80°F and 90°F. The body fat contents of the subjects ranged from 11.3% to 34%. The subjects pedalled a 300 kilopond meters/minute load on a bicycle ergometer for 25 minutes. Results indicate that body fat or the percent of body fat squared have a statistically significant effect on the dependent variables of oxygen consumption/lean body weight, change in heart rate, core-skin temperature gradient, and oxygen consumption/maximum oxygen consumption.

Comparative studies of body mass, body measurements and organ weights of wild-derived and laboratory golden hamsters (Mesocricetus auratus)

2002 ◽  
Vol 36 (4) ◽  
pp. 445-454 ◽  
Author(s):  
R. Gattermann ◽  
P. Fritzsche ◽  
R. Weinandy ◽  
K. Neumann
Keyword(s):  
Food Consumption ◽  
Body Mass ◽  
Body Fat ◽  
Social Stress ◽  
Adrenal Glands ◽  
The Body ◽  
Body Measurements ◽  
Housing Conditions ◽  
Golden Hamsters ◽  
Stress Symptoms

All laboratory golden hamsters originate from a sibling pairing back in 1930. To investigate possible differences between domesticated and wild conspecifics, descendants of both strains were maintained under standardized laboratory conditions individually and in unisexual groups. Body mass and food consumption were monitored from birth to 22 weeks of age. The animals were subsequently sacrificed, and body measurements and body composition were analysed. In addition, the absolute and relative masses of different organs were measured. Laboratory hamsters gained more body mass through higher food consumption. However, they did not get fatter, since relative fat values were the same for both strains. Body measurements revealed only minor differences (in body and ear lengths). As deducible from the body mass, the organs (spleen, kidneys, adrenal glands, testes, epididymis and ovaries) were seen to be heavier in laboratory hamsters. Furthermore, with the exception of the kidneys, the same went for the relative values. There were distinct sexual specific differences in both strains only for body fat (♂♂↑) and adrenal glands (♂♂↑). In females, group housing induced an elevated level of aggression. In general, these housing conditions led to social stress symptoms, such as heavier adrenal glands. Additionally, spleen, kidneys, ovaries, body length and mass, body water and body fat were increased in group-housed hamsters. In conclusion, no major differences between laboratory and wild-derived hamsters were observed.

The Rubber Hand Illusion in Healthy Younger and Older Adults

2018 ◽  
Vol 31 (6) ◽  
pp. 537-555 ◽  
Author(s):  
Jennifer L. Campos ◽  
Graziella El-Khechen Richandi ◽  
Babak Taati ◽  
Behrang Keshavarz
Keyword(s):  
Skin Temperature ◽  
Subjective Experience ◽  
Age Groups ◽  
Objective Measure ◽  
The Body ◽  
Rubber Hand Illusion ◽  
Body Ownership ◽  
Rubber Hand ◽  
Age Related ◽  
Body Change

Percepts about our body’s position in space and about body ownership are informed by multisensory feedback from visual, proprioceptive, and tactile inputs. The Rubber Hand Illusion (RHI) is a multisensory illusion that is induced when an observer sees a rubber hand being stroked while they feel their own, spatially displaced, and obstructed hand being stroked. When temporally synchronous, the visual–tactile interactions can create the illusion that the rubber hand belongs to the observer and that the observer’s real hand is shifted in position towards the rubber hand. Importantly, little is understood about whether these multisensory perceptions of the body change with older age. Thus, in this study we implemented a classic RHI protocol (synchronous versus asynchronous stroking) with healthy younger (18–35) and older (65+) adults and measured the magnitude of proprioceptive drift and the subjective experience of body ownership. As an adjunctive objective measure, skin temperature was recorded to evaluate whether decreases in skin temperature were associated with illusory percepts, as has been shown previously. The RHI was observed for both age groups with respect to increased drift and higher ratings of ownership following synchronous compared to asynchronous stroking. Importantly, no effects of age and no interactions between age and condition were observed for either of these outcome measures. No effects were observed for skin temperature. Overall, these results contribute to an emerging field of research investigating the conditions under which age-related differences in multisensory integration are observed by providing insights into the role of visual, proprioceptive, and tactile inputs on bodily percepts.

Sign in / Sign up

Export Citation Format

Share Document