Angiostrongylus cantonensis in urban populations of terrestrial gastropods and rats in an impoverished region of Brazil

Parasitology ◽  
2021 ◽  
pp. 1-34
Author(s):  
Fábio Neves Souza ◽  
Maísa Aguiar Santos ◽  
Daniele Almeida Alves ◽  
Leyva Cecília Vieira de Melo ◽  
Dan Jessé Gonçalves da Mota ◽  
...  
Keyword(s):  
Angiostrongylus Cantonensis ◽  
Urban Populations ◽  
Terrestrial Gastropods

scholarly journals Autochthonous Angiostrongylus cantonensis, Angiostrongylus vasorum and Aelurostrongylus abstrusus infections in native terrestrial gastropods from the Macaronesian Archipelago of Spain

2021 ◽  
Author(s):  
Lisa Segeritz ◽  
Alejandro Cardona ◽  
Anja Taubert ◽  
Carlos Hermosilla ◽  
Antonio Ruiz
Keyword(s):  
Epidemiological Study ◽  
Current Data ◽  
Angiostrongylus Cantonensis ◽  
Angiostrongylus Vasorum ◽  
Intermediate Hosts ◽  
Aelurostrongylus Abstrusus ◽  
El Hierro ◽  
Terrestrial Gastropods ◽  
Total Prevalence ◽  
Macaronesian Archipelago

AbstractThe presence of zoonotic relevant Angiostrongylus cantonensis infections has recently been reported in rat final hosts and gastropod intermediate hosts in Tenerife, Spain. However, data on A. cantonensis, Angiostrongylus vasorum and Aelurostrongylus abstrusus prevalences in endemic gastropods for other islands of the Macaronesian Archipelago are still missing. In order to fill this gap, we conducted an epidemiological study on terrestrial native slug (Plutonia lamarckii) and snail (Cornu aspersum, Theba pisana, Rumina decollata) species in 27 selected locations of Tenerife, Gran Canaria, El Hierro, Lanzarote, La Palma and Fuerteventura. Overall, 131 terrestrial gastropods were collected in winter/spring season 2018/2019 and examined for the presence of metastrongyloid lungworm larvae via artificial digestion. The current data revealed a total prevalence of 4.6% for A. vasorum, 3.8% for A. abstrusus and 0.8% for A. cantonensis. In Tenerife, three lungworm species were detected, thereby re-confirming A. cantonensis endemicity for this island. Prevalences of snails (C. aspersum) originating from El Hierro were 5% for A. abstrusus and 15% for A. vasorum, respectively, with larval burdens up to 290 larvae per specimen. This epidemiological study indicates the presence of human, canine and feline lungworm species in Macaronesia, Spain. The current data—particularly those on anthropozoonotic A. cantonensis—call for a regular large-scale monitoring on intermediate hosts, paratenic hosts and definitive hosts to prevent further spread of lungworm-related diseases in humans and animals.

Activación y biosíntesis intratecal de C3c en niños con meningoencefalitis eosinofílica por Angiostrongylus cantonensis

2009 ◽  
Vol 48 (12) ◽  
pp. 632
Author(s):  
Bárbara Padilla Docal ◽  
Alberto Juan Dorta Contreras ◽  
Raisa Bu-Coifiú Fanego
Keyword(s):  
Angiostrongylus Cantonensis

scholarly journals The structure of Brazilian Amazonian gut microbiomes in the process of urbanisation

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Ana Paula Schaan ◽  
Dionison Sarquis ◽  
Giovanna C. Cavalcante ◽  
Leandro Magalhães ◽  
Eliene R. P. Sacuena ◽  
...  
Keyword(s):  
Native American ◽  
Ribosomal Rna ◽  
Gut Microbiome ◽  
Brazilian Amazon ◽  
American People ◽  
South American ◽  
Subsistence Strategy ◽  
Urban Populations ◽  
Gradual Loss ◽  
Agricultural Societies

AbstractShifts in subsistence strategy among Native American people of the Amazon may be the cause of typically western diseases previously linked to modifications of gut microbial communities. Here, we used 16S ribosomal RNA sequencing to characterise the gut microbiome of 114 rural individuals, namely Xikrin, Suruí and Tupaiú, and urban individuals from Belém city, in the Brazilian Amazon. Our findings show the degree of potential urbanisation occurring in the gut microbiome of rural Amazonian communities characterised by the gradual loss and substitution of taxa associated with rural lifestyles, such as Treponema. Comparisons to worldwide populations indicated that Native American groups are similar to South American agricultural societies and urban groups are comparable to African urban and semi-urban populations. The transitioning profile observed among traditional populations is concerning in light of increasingly urban lifestyles. Lastly, we propose the term “tropical urban” to classify the microbiome of urban populations living in tropical zones.

scholarly journals TNF-α Triggers RIP1/FADD/Caspase-8-Mediated Apoptosis of Astrocytes and RIP3/MLKL-Mediated Necroptosis of Neurons Induced by Angiostrongylus cantonensis Infection

2021 ◽  
Author(s):  
Hongli Zhou ◽  
Minyu Zhou ◽  
Yue Hu ◽  
Yanin Limpanon ◽  
Yubin Ma ◽  
...  
Keyword(s):  
Cell Death ◽  
Enrichment Analysis ◽  
Angiostrongylus Cantonensis ◽  
Gene Set Enrichment Analysis ◽  
Caspase 8 ◽  
Cns Injury ◽  
Vitro Assay ◽  
Tnf Α

AbstractAngiostrongylus cantonensis (AC) can cause severe eosinophilic meningitis or encephalitis in non-permissive hosts accompanied by apoptosis and necroptosis of brain cells. However, the explicit underlying molecular basis of apoptosis and necroptosis upon AC infection has not yet been elucidated. To determine the specific pathways of apoptosis and necroptosis upon AC infection, gene set enrichment analysis (GSEA) and protein–protein interaction (PPI) analysis for gene expression microarray (accession number: GSE159486) of mouse brain infected by AC revealed that TNF-α likely played a central role in the apoptosis and necroptosis in the context of AC infection, which was further confirmed via an in vivo rescue assay after treating with TNF-α inhibitor. The signalling axes involved in apoptosis and necroptosis were investigated via immunoprecipitation and immunoblotting. Immunofluorescence was used to identify the specific cells that underwent apoptosis or necroptosis. The results showed that TNF-α induced apoptosis of astrocytes through the RIP1/FADD/Caspase-8 axis and induced necroptosis of neurons by the RIP3/MLKL signalling pathway. In addition, in vitro assay revealed that TNF-α secretion by microglia increased upon LSA stimulation and caused necroptosis of neurons. The present study provided the first evidence that TNF-α was secreted by microglia stimulated by AC infection, which caused cell death via parallel pathways of astrocyte apoptosis (mediated by the RIP1/FADD/caspase-8 axis) and neuron necroptosis (driven by the RIP3/MLKL complex). Our research comprehensively elucidated the mechanism of cell death after AC infection and provided new insight into targeting TNF-α signalling as a therapeutic strategy for CNS injury.

scholarly journals Mining chemical information in Swedish wastewaters for simultaneous assessment of population consumption, treatment efficiency and environmental discharge of illicit drugs

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Inga Haalck ◽  
Paul Löffler ◽  
Christine Baduel ◽  
Karin Wiberg ◽  
Lutz Ahrens ◽  
...  
Keyword(s):  
Illicit Drugs ◽  
Emerging Contaminants ◽  
Chemical Information ◽  
Treatment Efficiency ◽  
Daily Consumption ◽  
Urban Populations ◽  
The Public ◽  
Target Drug ◽  
Similar Drug ◽  
Almost All

AbstractConsumption of illicit drugs poses health risks to the public and environment. Knowledge on their usage helps better implementations of intervention strategies to reduce drug-related harms in the society and also policies to limit their releases as emerging contaminants to recipient environments. This study aimed to investigate from the daily consumption to treatment efficiency and subsequent discharge of illicit drugs by the Swedish urban populations based on simultaneous collection and analysis of influent and effluent wastewater. Two different weekly monitoring campaigns showed similar drug prevalence in Stockholm and Uppsala, with amphetamine as the most popular drug. Almost all target drug residues were still measurable in effluent wastewater. High removal efficiencies (> 94%) were observed for amphetamine, cocaine and benzoylecgonine, whereas ketamine, 3,4-methylenedioxymethamphetamine (MDMA), mephedrone and methamphetamine were the least removed substances (< 64%), with the highest discharge observed for MDMA in both catchments (~ 3.0 g/day in Uppsala; ~ 18 g/day in Stockholm). Our study provides new insights into short-term changes in the use and related discharge of illicit drugs by urban populations. Such wastewater monitoring can provide useful information to public health, forensic and environmental authorities in planning future intervention and regulation policies.

scholarly journals Will Peri-Urban Cydia pomonella (Lepidoptera: Tortricidae) Challenge Local Eradication?

Insects ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 207 ◽  
Author(s):  
Rachael Horner ◽  
Georgia Paterson ◽  
James T.S. Walker ◽  
George L.W. Perry ◽  
Rodelyn Jaksons ◽  
...  
Keyword(s):  
New Zealand ◽  
Spatial Interpolation ◽  
Spatial Clustering ◽  
Cydia Pomonella ◽  
Codling Moth ◽  
Catch Rate ◽  
Trap Catch ◽  
Urban Populations ◽  
Host Trees ◽  
The City

Codling moth, Cydia pomonella (Lepidoptera: Tortricidae), is a phytosanitary pest of New Zealand’s export apples. The sterile insect technique supplements other controls in an eradication attempt at an isolated group of orchards in Hawke’s Bay, New Zealand. There has been no attempt in New Zealand to characterize potential sources of uncontrolled peri-urban populations, which we predicted to be larger than in managed orchards. We installed 200 pheromone traps across Hastings city, which averaged 0.32 moths/trap/week. We also mapped host trees around the pilot eradication orchards and installed 28 traps in rural Ongaonga, which averaged 0.59 moths/trap/week. In Hastings, traps in host trees caught significantly more males than traps in non-host trees, and spatial interpolation showed evidence of spatial clustering. Traps in orchards operating the most stringent codling moth management averaged half the catch rate of Hastings peri-urban traps. Orchards with less rigorous moth control had a 5-fold higher trap catch rate. We conclude that peri-urban populations are significant and ubiquitous, and that special measures to reduce pest prevalence are needed to achieve area-wide suppression and reduce the risk of immigration into export orchards. Because the location of all host trees in Hastings is not known, it could be more cost-effectively assumed that hosts are ubiquitous across the city and the area treated accordingly.

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