Selective subcortical abnormalities in autism

1988 ◽  
Vol 18 (1) ◽  
pp. 39-48 ◽  
Author(s):  
R. Jacobson ◽  
A. Le Couteur ◽  
P. Howlin ◽  
M. Rutter
Keyword(s):  
Healthy Adult ◽  
Ct Scans ◽  
Computer Assisted ◽  
Careful Attention ◽  
Ventricular Size ◽  
Healthy Male ◽  
Regional Brain ◽  
Brain Scan ◽  
Interhemispheric Fissure ◽  
Ct Brain

SynopsisNine physically healthy, adult autistic men, with normal or near normal intelligence, and 13 healthy male controls were examined in a CT brain scan study. CT scans were analysed with a fully automated computer-assisted program, and regional brain radiodensities were measured with careful attention to artefacts. Autistic patients revealed significantly larger third, but not lateral, ventricular size and significantly lower mean caudate, but equivalent mean frontal and thalamic, radiodensities compared to controls. The sizes of the Sylvian fissures and interhemispheric fissure were equivalent between groups. The findings are consistent with selective subcortical abnormalities in autism.

Neurologic Sequelae in the Survivors of Neonatal Intraventricular Hemorrhage

PEDIATRICS ◽  
1979 ◽  
Vol 64 (2) ◽  
pp. 233-237
Author(s):  
K. S. Krishnamoorthy ◽  
D. C. Shannon ◽  
G. R. DeLong ◽  
I. D. Todres ◽  
K. R. Davis
Keyword(s):  
Intraventricular Hemorrhage ◽  
The Other ◽  
Neurologic Outcome ◽  
Ct Scans ◽  
Brain Scan ◽  
Neurologic Sequelae ◽  
Ct Brain

We report our experience with the neurologic sequelae (at a mean follow-up of 24 months) among the 15 surviving infants who have had neonatal intraventricular hemorrhage (IVH) documented by computerized tomographic (CT) brain scan. Neurologically six infants (40%) are normal, six infants (40%) mildly impaired, and three infants (20%) moderate to severely impaired. The neurologic outcome correlated to the degree of hemorrhage seen in the CT scans when IVH was classified into four grades. None of the other neonatal factors examined showed significant correlation with the outcome.

scholarly journals ESTIMATION OF ENTRANCE SURFACE RADIATION DOSE TO THYROID REGION IN COMPUTED TOMOGRAPHY BRAIN EXAMINATION

2019 ◽  
Vol 12 (1) ◽  
pp. 121
Author(s):  
Visakh T ◽  
Suresh Sukumar ◽  
Abhimanyu Pradhan
Keyword(s):  
Computed Tomography ◽  
Radiation Dose ◽  
Maximum Dose ◽  
Surface Radiation ◽  
Ct Scans ◽  
Surface Dose ◽  
Brain Scan ◽  
Convenience Sampling ◽  
Ct Brain ◽  
Brain Examination

Objective: The objective of this study was to estimate the entrance surface radiation dose to the thyroid region in a computed tomography (CT) brain scan.Methods: Unfors Multi-O-Meter equipment was used to measure the entrance surface at the thyroid region of adult patients ranging from 18 to 70 years of age. A total of 115 patients were included in the study based on convenience sampling. The Multi-O-Meter was kept at the thyroid region during the scan, and the values for entrance surface dose (ESD) were noted from its monitor after the scan was complete.Results: The obtained data were analyzed and violate normal distribution; therefore, the median and quartiles were computed. The overall median (Q1, Q2), ESD of the patients, was 1.335 (1.213, 1.529) mGy. The minimum and maximum dose values recorded were 1.015 mGy and 1.964 mGy, respectively.Conclusions: The result showed a significant amount of entrance surface radiation dose to the thyroid region while taking a brain scan. This data can be used for optimization of radiation protection while undergoing CT scans of brain to reduce exposure to thyroid region.

Evaluation of Neonatal Intracranial Hemorrhage by Computerized Tomography

PEDIATRICS ◽  
1977 ◽  
Vol 59 (2) ◽  
pp. 165-172
Author(s):  
K. S. Krishnamoorthy ◽  
R. A. Fernandez ◽  
K. J. Momose ◽  
G. R. DeLong ◽  
Fergus M. B. Moylan ◽  
...  
Keyword(s):  
Intensive Care ◽  
Subarachnoid Hemorrhage ◽  
Natural History ◽  
Ct Scan ◽  
Intracranial Hemorrhage ◽  
Intraventricular Hemorrhage ◽  
Ct Scans ◽  
Brain Scan ◽  
Continued Use ◽  
Ct Brain

Computerized tomographic (CT) brain scan was performed on 28 infants with unexplained cardiorespiratory and neurologic deterioration and bloody lumbar cerebrospinal spinal fluid. Fourteen of 20 with intraventricular hemorrhage (IVH) died; the six infants with lesser degrees of IVH survived. Significant subarachnoid hemorrhage (SAH) was demonstrable in three infants and three had negative scans despite bloody CSF. We have found that CT scans provide useful information about the size and extent of neonatal IVH and distinguishes it from SAH. It also confirms the diagnosis of post-hemorrhagic hydrocephalus in these infants. Continued use of the CT scan will help us to understand the natural history and the effects of neonatal intracranial hemorrhage among the survivors of intensive care.

Immunobiology of primary intracranial tumors

1985 ◽  
Vol 63 (5) ◽  
pp. 719-725 ◽  
Author(s):  
M. Stephen Mahaley ◽  
Mary B. Urso ◽  
Robert A. Whaley ◽  
Maxine Blue ◽  
Thomas E. Williams ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
The Other ◽  
Response To Treatment ◽  
Ct Scans ◽  
Intracranial Tumors ◽  
Content Type ◽  
Anaplastic Gliomas ◽  
Brain Scan ◽  
Ct Brain ◽  
Fine Print

✓ Human lymphoblastoid alpha-interferon was administered intravenously or intramuscularly to 19 patients with recurrent gliomas. Each patient had previously undergone surgery and radiation therapy. The treatment course consisted of 8 weeks of therapy with an escalating daily dosage and number of days of treatment per week to a total dose of 900 × 106 U/sq m. Response to treatment was determined by serial computerized tomography (CT) scans. Seven of the 17 evaluable patients were determined to be treatment responders at 12 weeks (1 month after completion of treatment), and the other 10 patients exhibited tumor progression during this period. Median survival time was 511 days for the responders versus 147 days for the non-responding patients. Interferon appears to be efficacious in the treatment of recurrent anaplastic gliomas as defined by CT brain scan responses following therapy.

scholarly journals ESTIMATION OF ENTRANCE SURFACE RADIATION DOSE TO THYROID REGION IN COMPUTED TOMOGRAPHY BRAIN EXAMINATION

2019 ◽  
Vol 12 (1) ◽  
pp. 121
Author(s):  
Visakh T ◽  
Suresh Sukumar ◽  
Abhimanyu Pradhan
Keyword(s):  
Computed Tomography ◽  
Radiation Dose ◽  
Maximum Dose ◽  
Surface Radiation ◽  
Ct Scans ◽  
Surface Dose ◽  
Brain Scan ◽  
Convenience Sampling ◽  
Ct Brain ◽  
Brain Examination

Objective: The objective of this study was to estimate the entrance surface radiation dose to the thyroid region in a computed tomography (CT) brain scan.Methods: Unfors Multi-O-Meter equipment was used to measure the entrance surface at the thyroid region of adult patients ranging from 18 to 70 years of age. A total of 115 patients were included in the study based on convenience sampling. The Multi-O-Meter was kept at the thyroid region during the scan, and the values for entrance surface dose (ESD) were noted from its monitor after the scan was complete.Results: The obtained data were analyzed and violate normal distribution; therefore, the median and quartiles were computed. The overall median (Q1, Q2), ESD of the patients, was 1.335 (1.213, 1.529) mGy. The minimum and maximum dose values recorded were 1.015 mGy and 1.964 mGy, respectively.Conclusions: The result showed a significant amount of entrance surface radiation dose to the thyroid region while taking a brain scan. This data can be used for optimization of radiation protection while undergoing CT scans of brain to reduce exposure to thyroid region.

A fully-automated computer-assisted method of CT brain scan analysis for the measurement of cerebrospinal fluid spaces and brain absorption density

1986 ◽  
Vol 28 (2) ◽  
pp. 109-117 ◽  
Author(s):  
R. E. Baldy ◽  
G. S. Brindley ◽  
I. Ewusi-Mensah ◽  
R. R. Jacobson ◽  
M. A. Reveley ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Computer Assisted ◽  
Brain Scan ◽  
Ct Brain

Clinical and etiological evaluation of secondary seizures by computed tomography and electroencephalogram

2016 ◽  
Vol 5 (10) ◽  
pp. 4982
Author(s):  
Archana Aher* ◽  
Satish Gore
Keyword(s):  
Meta Analysis ◽  
Temporal Region ◽  
Government Medical College ◽  
Occipital Region ◽  
Parietal Region ◽  
Medical College ◽  
Mri Brain ◽  
Brain Scan ◽  
Ct Brain ◽  
Clonic Convulsions

This study was conducted to determine the clinical evaluation and various etiological factors of secondary seizures in patients admitted to Government Medical College, Nagpur. We evaluated 58 patients of secondary seizures from Dec 2011 to Oct 2013. Secondary seizures were defined as case of seizure with CT (brain) or MRI (brain) abnormality1. Out of 58 cases 35 were males and 23 were females. Mean age of study subjects was 34.85. The commonest presenting feature was generalized tonic clonic convulsions (42 patients) followed by focal seizures (16 patients).  Todd’s palsy was observed in 4 cases. Aura was present in 24 cases. According to CT brain scan the aetiology was – neurocysticercosis (34.48%), post stroke (27.59%), tuberculoma (24.14%). Space occupying lesions(SOLs) were present in 8 patients, out of whom 4 had brain tumour, 2 patients had brain abscess, 1 had hydatid cyst and 1 had metastasis. Majority of lesions were located in frontal region (58.62%), followed by in parietal region (44.83%), in temporal region (25.86%) and in occipital region (13.79 % patients). In our study neurocysticercosis was found to be the commonest cause of secondary seizures. As in a meta-analysis it was found that cysticidal drugs result in better outcome in patients of neurocysticecosis, we recommend that the patients of secondary seizures should be identified for the aetiology and treated at the earliest2.

scholarly journals Improving Spleen Volume Estimation Via Computer-assisted Segmentation on Clinically Acquired CT Scans

2016 ◽  
Vol 23 (10) ◽  
pp. 1214-1220 ◽  
Author(s):  
Zhoubing Xu ◽  
Adam L. Gertz ◽  
Ryan P. Burke ◽  
Neil Bansal ◽  
Hakmook Kang ◽  
...  
Keyword(s):  
Volume Estimation ◽  
Ct Scans ◽  
Computer Assisted ◽  
Spleen Volume

A Phase 1 Study to Evaluate the Safety and Pharmacokinetics following Administration of Single and Multiple Doses of the Anti-Staphylococcal Lysin, LSVT-1701, in Healthy Adult Subjects

2022 ◽  
Author(s):  
Mary Beth Wire ◽  
Soo Youn Jun ◽  
In-Jin Jang ◽  
Seung-Hwan Lee ◽  
Jun Gi Hwang ◽  
...  
Keyword(s):  
Healthy Adult ◽  
Phase 1 ◽  
Infusion Site ◽  
Healthy Male ◽  
C Reactive Protein ◽  
Phase 1 Study ◽  
Reactive Protein ◽  
Male Subjects ◽  
Common Teaes ◽  
Dose Proportional

Thirty-two healthy male subjects (8 per cohort) were randomized 6:2 to active:placebo. LSVT-1701, an anti-staphylococcal lysin, was administered intravenously as a 6 mg/kg single dose and as 1.5, 3, and 4.5 mg/kg twice daily for 4 days. LSVT-1701 exposure increased in a greater than dose proportional manner and did not accumulate. Treatment-emergent adverse events (TEAEs) were predominantly of mild intensity. The most common TEAEs were chills, pyrexia, headache, infusion site events, cough, rhinorrhea, and increases in C-reactive protein.

Ventricular Enlargement in Schizophrenia

1985 ◽  
Vol 147 (3) ◽  
pp. 233-240 ◽  
Author(s):  
Michael A. Reveley
Keyword(s):  
Ct Scans ◽  
Ventricular Enlargement ◽  
Ventricular Size ◽  
Validity And Reliability ◽  
Computerised Tomography ◽  
Twin Birth ◽  
Chronic Schizophrenics ◽  
Level Of Significance ◽  
Considerable Range ◽  
Age And Sex

SummaryThere has been a considerable range in both the prevalence of ventricular enlargement and values for ventricular size of both schizophrenics and controls, in studies using computerised tomography (CT). The CT scans of 19 unrelated chronic schizophrenics, all of monozygotic (MZ) twin birth, and 36 age-and-sex-matched normal twins from 18 MZ pairs were examined by linear, planimetric, and semi-automated computerised methods. All methods distinguished schizophrenics from controls at approximately the same level of significance, but partial volume artefact led to a greater than two-fold variation in apparent ventricular size, and significantly reduced the validity and reliability of mechanical planimetric and linear measures. Measurement error may be an important source of artefact in uncontrolled studies using those techniques, and when comparing absolute values across studies, but the use of computerised methods should significantly reduce this source of artefact and allow more meaningful comparison.

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