scholarly journals Depressive symptoms and C-reactive protein: The Cardiovascular Risk in Young Finns Study

2006 ◽  
Vol 36 (6) ◽  
pp. 797-805 ◽  
Author(s):  
MARKO ELOVAINIO ◽  
LIISA KELTIKANGAS-JÄRVINEN ◽  
LAURA PULKKI-RÅBACK ◽  
MIKA KIVIMÄKI ◽  
SAMPSA PUTTONEN ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Depressive Symptoms ◽  
Cardiovascular Risk ◽  
Contraceptive Use ◽  
Depressive Symptomatology ◽  
Smoking Status ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Young Finns Study

Background. We tested the hypothesis that depressive symptoms in healthy young adults would be associated with elevated levels of C-reactive proteins (CRP).Method. We studied the association between depressive symptoms and CRP in 1201 young adults, as a part of the on-going population-based Cardiovascular Risk in Young Finns Study. Depressive symptoms were determined by responses to a revised version of Beck's Depression Inventory in 1992 and 2001. CRP and other known cardiac risk factors were measured in 2001.Results. Higher depressive symptomatology in 1992 and in 2001 and their means score were related to higher CRP levels (B's range from 0·24 to 0·21, p<0·001). These relationships persisted after separate adjustments for various risk factors including sex, age, education, oral contraceptive use, dietary fat, physical activity, alcohol consumption, smoking status, LDL-cholesterol, HDL-cholesterol, systolic blood pressure and history of acute infectious disease. Adjustments for obesity and triglycerides levels, however, somewhat attenuated the relationship between depressive symptoms and CRP.Conclusions. We concluded that higher levels of depressive symptoms are associated with higher levels of CRP, but this association may largely be attributable to obesity or triglycerides.

scholarly journals Relative Telomere Length and Cardiovascular Risk Factors

Biomolecules ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 192 ◽  
Author(s):  
Moritz Koriath ◽  
Christian Müller ◽  
Norbert Pfeiffer ◽  
Stefan Nickels ◽  
Manfred Beutel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Telomere Length ◽  
Ldl Cholesterol ◽  
Smoking Status ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Relative Telomere Length

(1) Background: Telomeres are repetitive DNA sequences located at the extremities of chromosomes that maintain genetic stability. Telomere biology is relevant to several human disorders and diseases, specifically cardiovascular disease. To better understand the link between cardiovascular disease and telomere length, we studied the effect of relative telomere length (RTL) on cardiovascular risk factors in a large population-based sample. (2) Methods: RTL was measured by a real-time quantitative polymerase chain reaction in subjects of the population-based Gutenberg Health Study (n = 4944). We then performed an association study of RTL with known cardiovascular risk factors of smoking status as well as systolic and diastolic blood pressure, body mass index (BMI), LDL cholesterol, HDL cholesterol, and triglycerides. (3) Results: A significant correlation was shown for RTL, with age as a quality control in our study (effect = −0.004, p = 3.2 × 10−47). Analysis of the relation between RTL and cardiovascular risk factors showed a significant association of RTL in patients who were current smokers (effect = −0.016, p = 0.048). No significant associations with RTL were seen for cardiovascular risk factors of LDL cholesterol (p = 0.127), HDL cholesterol (p = 0.713), triglycerides (p = 0.359), smoking (p = 0.328), diastolic blood pressure (p = 0.615), systolic blood pressure (p = 0.949), or BMI (p = 0.903). In a subsequent analysis, we calculated the tertiles of RTL. No significant difference across RTL tertiles was detectable for BMI, blood pressure, lipid levels, or smoking status. Finally, we studied the association of RTL and cardiovascular risk factors stratified by tertiles of age. We found a significant association of RTL and LDL cholesterol in the oldest tertile of age (effect = 0.0004, p = 0.006). (4) Conclusions: We determined the association of relative telomere length and cardiovascular risk factors in a population setting. An association of telomere length with age, current smoking status, as well as with LDL cholesterol in the oldest tertile of age was found, whereas no associations were observed between telomere length and triglycerides, HDL cholesterol, blood pressure, or BMI.

scholarly journals Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study

2010 ◽  
Vol 31 (14) ◽  
pp. 1745-1751 ◽  
Author(s):  
M. Juonala ◽  
J. S. A. Viikari ◽  
M. Kahonen ◽  
L. Taittonen ◽  
T. Laitinen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Cardiovascular Risk ◽  
Carotid Atherosclerosis ◽  
Life Time ◽  
Young Finns Study

Gender differences in cardiovascular risk assessment in elderly adults in Ecuador: evidence from a national survey

2018 ◽  
Vol 67 (4) ◽  
pp. 736-742
Author(s):  
Ivan Sisa
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Cardiovascular Risk ◽  
Rural Areas ◽  
Risk Model ◽  
Smoking Status ◽  
Population Based ◽  
Cvd Risk ◽  
Serum Triglycerides ◽  
Traditional Risk Factors

The present study aimed to predict the risk of developing cardiovascular disease (CVD) over a 5-year period and how it might vary by sex in an ethnically diverse population of older adults. We used a novel CVD risk model built and validated in older adults named the Systematic Coronary Risk Evaluation in Older Persons (SCORE OP). A population-based study analyzed a total of 1307 older adults. Analyses were done by various risk categories and sex. Of the study population, 54% were female with a mean age of 75±7.1 years. According to the SCORE OP model, individuals were classified as having low (9.8%), moderate (48.1%), and high or very high risk (42.1%) of CVD-related mortality. Individuals at higher risk of CVD were more likely to be male compared with females, 53.9% vs 31.8%, respectively (p<0.01). Males were more likely to be younger, living in rural areas, had higher levels of schooling, and with the exception of smoking status and serum triglycerides, had lower values of traditional risk factors than females. In addition, males were less likely to require blood pressure-lowering therapy and statin drugs than females. This gender inequality could be driven by sociocultural determinants and a risk factor paradox in which lower levels of the cardiovascular risk factors are associated with an increase rather than a reduction in mortality. These data can be used to tailor primary prevention strategies such as lifestyle counseling and therapeutic measures in order to improve male elderly health, especially in low-resource settings.

scholarly journals Increased awareness, inadequate treatment, and poor control of cardiovascular risk factors in American young adults: 2005–2016

2020 ◽  
pp. 204748732090519 ◽  
Author(s):  
Rajat Kalra ◽  
Vibhu Parcha ◽  
Nirav Patel ◽  
Anirudh Bhargava ◽  
Katherine S Booker ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Smoking Status ◽  
Cross Sectional ◽  
Income Insurance ◽  
Hypertension Awareness ◽  
Males And Females ◽  
And Control

Introduction There are little contemporary data about cardiovascular risk factors among young adults. We defined trends in diabetes mellitus (DM), hypertension, and hypercholesterolemia in American adults aged 18–44 years. Methods The National Health and Nutrition Examination Study serial cross-sectional surveys were used to define three time periods: 2005–2008, 2009–2012, and 2013–2016. Age-adjusted weighted trends of prevalence, awareness, treatment, and control of DM, hypertension, and hypercholesterolemia were calculated by linear regression modelling in the overall sample, males, and females. Trends were calculated after adjustment for age, race, body mass index, smoking status, education attainment, income, insurance status, and number of healthcare visits. Results From 2005–2008 to 2013–2016, 15,171 participants were identified. DM prevalence was stable ∼3%, hypertension prevalence was stable ∼11.0%, and hypercholesterolemia prevalence declined from 11.5% to 9.0% (ptrend = 0.02). DM awareness stayed stable between 61.1 and 74.1%, hypertension awareness increased from 68.7 to 77.7% (ptrend = 0.05), and hypercholesterolemia awareness was stable between 46.8 and 54.1%. DM and hypertension treatment improved markedly (ptrend < 0.001 and 0.05, respectively) but the hypercholesterolemia treatment was stable ∼30%. DM control improved across survey periods (7.7–17.4%, ptrend = 0.04) but hypertension control (∼50%) and hypercholesterolemia control (∼13%) remained stable. Prevalence, awareness, treatment, and control trends also differed between males and females. Conclusions There is a stable prevalence of DM, high and stable prevalence of hypertension, and declining prevalence of hypercholesterolemia among young Americans. Despite stable or increasing awareness of diabetes and hypertension, there are inadequate treatment and control trends for DM, hypertension, and hypercholesterolemia.

Abstract 14193: Depression Worsens Cardiovascular Health: A Population-based Cohort Study (NHANES, 2015-16)

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Brent Medoff ◽  
Andrew Baird ◽  
Brandon Herbert ◽  
Jared W Magnani
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Health ◽  
Smoking Status ◽  
Population Based ◽  
Mild Depression ◽  
Health And Nutrition ◽  
Patient Health ◽  
Cardiovascular Health Promotion

Introduction: Depression increases cardiovascular risk, but associations between depression and cardiovascular risk profiles have had limited investigation. We hypothesized that depression is associated with cardiovascular risk factors in a population-based cohort. Methods: We selected participants from the 2015-16 National Health and Nutrition Examination Survey (NHANES) and age ≥25 years. Participants completed the Patient Health Questionnaire (PHQ), a 9-item, validated instrument categorizing minimal (0-4), mild (5-9) or moderate-to-severe (≥10) depression. We employed the American Heart Association’s assessment of cardiovascular health, Life’s Simple 7 (LS7) which uses risk factors (smoking status, BMI, physical activity, diet, cholesterol, blood pressure, and glycohemoglobin) to categorize cardiovascular health as poor (0-1), intermediate (5-9) or ideal (10-14). We related PHQ scores to cardiovascular health as measured by LS7 in regression analyses adjusted for relevant covariates (age, sex, race, education, health insurance and poverty-income level). Results: Among 5053 NHANES participants, 4003 (79%) had data for the PHQ and determination of LS7 scores (age 51±16; 52% female; 67% white race). Individuals with mild depression (PHQ 5-9) had 1.4-times greater likelihood (95% CI, 1.07-1.92) of lower cardiovascular health compared to those without depression in multivariable-adjusted models. Likewise, individuals with moderate depression (PHQ≥10) had 3-times greater likelihood (95% CI, 1.90-4.97) of lower cardiovascular health compared to those without depression. Conclusions: In a socially diverse cohort, individuals with depression were more likely to have significantly lower cardiovascular health compared to those without depression. Our findings show that depression may be a barrier to cardiovascular health promotion. Addressing depression appears essential to improve cardiovascular health.

Depressive Symptoms and Carotid Artery Intima-Media Thickness in Young Adults: The Cardiovascular Risk in Young Finns Study

2005 ◽  
Vol 67 (4) ◽  
pp. 561-567 ◽  
Author(s):  
Marko Elovainio ◽  
Liisa Keltikangas-Järvinen ◽  
Mika Kivimäki ◽  
Laura Pulkki ◽  
Sampsa Puttonen ◽  
...  
Keyword(s):  
Young Adults ◽  
Depressive Symptoms ◽  
Cardiovascular Risk ◽  
Carotid Artery ◽  
Intima Media Thickness ◽  
Media Thickness ◽  
Young Finns Study
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