Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies

2012 ◽  
Vol 42 (9) ◽  
pp. 1857-1863 ◽  
Author(s):  
I. Kelleher ◽  
D. Connor ◽  
M. C. Clarke ◽  
N. Devlin ◽  
M. Harley ◽  
...  
Keyword(s):  
Systematic Review ◽  
Psychotic Symptom ◽  
Children And Adolescents ◽  
Meta Analysis ◽  
Age Groups ◽  
Population Based ◽  
Self Report ◽  
Psychotic Symptoms ◽  
Childhood And Adolescence ◽  
Symptom Prevalence

BackgroundPsychotic symptoms occur more frequently in the general population than psychotic disorder and index risk for psychopathology. Multiple studies have reported on the prevalence of these symptoms using self-report questionnaires or clinical interviews but there is a lack of consensus about the prevalence of psychotic symptoms among children and adolescents.MethodWe conducted a systematic review of all published literature on psychotic symptom prevalence in two age groups, children aged 9–12 years and adolescents aged 13–18 years, searching through electronic databases PubMed, Ovid Medline, PsycINFO and EMBASE up to June 2011, and extracted prevalence rates.ResultsWe identified 19 population studies that reported on psychotic symptom prevalence among children and adolescents. The median prevalence of psychotic symptoms was 17% among children aged 9–12 years and 7.5% among adolescents aged 13–18 years.ConclusionsPsychotic symptoms are relatively common in young people, especially in childhood. Prevalence is higher in younger (9–12 years) compared to older (13–18 years) children.

scholarly journals Clinicopathological significance of psychotic experiences in non-psychotic young people: evidence from four population-based studies

2012 ◽  
Vol 201 (1) ◽  
pp. 26-32 ◽  
Author(s):  
I. Kelleher ◽  
H. Keeley ◽  
P. Corcoran ◽  
F. Lynch ◽  
C. Fitzpatrick ◽  
...  
Keyword(s):  
Psychotic Disorder ◽  
Early Adolescence ◽  
Longitudinal Research ◽  
Age Groups ◽  
Population Based ◽  
Diagnostic Interview ◽  
Psychotic Symptoms ◽  
Childhood And Adolescence ◽  
Wide Range ◽  
Clinicopathological Significance

BackgroundEpidemiological research has shown that hallucinations and delusions, the classic symptoms of psychosis, are far more prevalent in the population than actual psychotic disorder. These symptoms are especially prevalent in childhood and adolescence. Longitudinal research has demonstrated that psychotic symptoms in adolescence increase the risk of psychotic disorder in adulthood. There has been a lack of research, however, on the immediate clinicopathological significance of psychotic symptoms in adolescence.AimsTo investigate the relationship between psychotic symptoms and non-psychotic psychopathology in community samples of adolescents in terms of prevalence, co-occurring disorders, comorbid (multiple) psychopathology and variation across early v. middle adolescence.MethodData from four population studies were used: two early adolescence studies (ages 11–13 years) and two mid-adolescence studies (ages 13–16 years). Studies 1 and 2 involved school-based surveys of 2243 children aged 11–16 years for psychotic symptoms and for emotional and behavioural symptoms of psychopathology. Studies 3 and 4 involved in-depth diagnostic interview assessments of psychotic symptoms and lifetime psychiatric disorders in community samples of 423 children aged 11–15 years.ResultsYounger adolescents had a higher prevalence (21–23%) of psychotic symptoms than older adolescents (7%). In both age groups the majority of adolescents who reported psychotic symptoms had at least one diagnosable non-psychotic psychiatric disorder, although associations with psychopathology increased with age: nearly 80% of the mid-adolescence sample who reported psychotic symptoms had at least one diagnosis, compared with 57% of the early adolescence sample. Adolescents who reported psychotic symptoms were at particularly high risk of having multiple co-occurring diagnoses.ConclusionsPsychotic symptoms are important risk markers for a wide range of non-psychotic psychopathological disorders, in particular for severe psychopathology characterised by multiple co-occurring diagnoses. These symptoms should be carefully assessed in all patients.

The time course of psychotic symptom side effects of ketamine in the treatment of depressive disorders: a systematic review and meta-analysis

2020 ◽  
pp. 103985622096164
Author(s):  
Maryam Tashakkori ◽  
Andrew Ford ◽  
Milan Dragovic ◽  
Laura Gabriel ◽  
Flavie Waters
Keyword(s):  
Systematic Review ◽  
Side Effects ◽  
Psychotic Symptom ◽  
Repeated Measures ◽  
Time Course ◽  
Meta Analysis ◽  
Psychotic Symptoms ◽  
Positive Symptoms ◽  
Symptom Change ◽  
Repeated Measures Design

Objective: Ketamine is a potential rapid-acting treatment for depression. Studies have suggested that the side effects are minimal and temporary, but the psychotic symptom side effects have yet to be fully examined. This study investigated whether ketamine infusion in the treatment of mood disorders is associated with increases in positive symptoms and whether these symptom effects endure over time. Methods: A systematic review and meta-analysis of studies of ketamine in the treatment of depression. Embase and Medline databases were searched for studies including (a) participants with major affective disorders, (b) 0.4 or 0.5 mg intravenously administered ketamine, (c) measurement of positive symptoms using BPRS+, and (d) a within-subject repeated-measures design with participants serving as their own baseline. Results: Seventeen studies met the inclusion criteria, comprising 458 participants. The meta-analyses examined symptom change occurring within the first 4 h, after 1 day, and after 3 days. Results showed significant BPRS+ increases within the first 30–60 min in 72% of studies, followed by a return to baseline levels. Conclusion: Peak symptom change occurred within the first hour post infusion. There are limited data to determine if ketamine is safe in the longer term, but there were no indications that psychotic symptoms re-occurred after the first hour and in the days following administration.

scholarly journals Systematic review of childhood and adolescence sedentary behavior: analysis of the Report Card Brazil 2018

2018 ◽  
Vol 20 (4) ◽  
pp. 415-445 ◽  
Author(s):  
Kelly Samara da Silva ◽  
Alexsandra Da Silva Bandeira ◽  
Priscila Cristina dos Santos ◽  
Luís Eduardo Argenta Malheiros ◽  
Ana Caroline F. C. de Sousa ◽  
...  
Keyword(s):  
Systematic Review ◽  
Children And Adolescents ◽  
Sedentary Behavior ◽  
Population Based ◽  
Original Research ◽  
Childhood And Adolescence ◽  
Tv Viewing ◽  
Age Range ◽  
Watching Tv ◽  
Brazilian Children

The aim of this study was to summarize studies examining the prevalence of sedentary behavior among Brazilian children and adolescents. A systematic review conducted on eight databases (PubMed, Scopus, Web of Science, LILACS, SPORTDiscus, BIREME, Scielo, and Google Scholar). The criteria applied were: original research; samples including Brazilian children and adolescents; to be a school- or population-based survey; observational studies using different measures of sedentary behavior; studies showing the prevalence of at least one component of sedentary behavior. Of the 205 studies included, 104 were analyzed. There was a greater concentration of studies in the southern (n=41) and northeastern (n=18) regions. The components more frequently investigated were watching TV (n=36) and screen time (n=32). Only three studies included children under seven years, and the age range more investigated was 10 to 19 years. Most of the studies used a self-reported questionnaire and showed variability in the cut-off point applied (from 2 to 4 hours/day). The prevalence of adolescents who met recommendations ranged from 9.4% to 68.0% for sedentary behavior (<2 hours/day) and from 16.8% to 67.2% for TV viewing (<2 hours/day). The prevalence ranged from 39.1% to 97.7% for computer use and from 47.7% to 98.0% for videogame use. Most of the studies reported that less than half of the adolescents met the recommendations of sedentary behavior and TV viewing. On the other hand, more than half of them devoted less than two hours a day to computer and videogame use.

scholarly journals Prevalence and trends of thinness, overweight and obesity among children and adolescents aged 3–18 years across Europe: a protocol for a systematic review and meta-analysis

BMJ Open ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. e018241 ◽  
Author(s):  
Miriam Garrido-Miguel ◽  
Iván Cavero-Redondo ◽  
Celia Álvarez-Bueno ◽  
Fernando Rodriguez-Artalejo ◽  
Luis Moreno Aznar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Children And Adolescents ◽  
Weight Status ◽  
Task Force ◽  
Meta Analysis ◽  
Overweight And Obesity ◽  
European Region ◽  
Cochrane Library ◽  
Public Health Issue ◽  
Childhood And Adolescence

IntroductionIncreasing prevalence of both thinness and excess weight during childhood and adolescence is a significant public health issue because of short-term health consequences and long-term tracking of weight status. Monitoring weight status in Europe may serve to identify countries and regions where rates of these disorders are either slowing down or increasing to evaluate recent policies aimed at appropriate body weight, and to direct future interventions. This study protocol provides a standardised and transparent methodology to improve estimating trends of thinness, overweight and obesity in children aged 3–18 years and adolescents across the European region between 2000 and 2017.Methods and analysisThis protocol is guided by the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) and the Cochrane Collaboration Handbook. To identify relevant studies, a search will be conducted in MEDLINE, EMBASE, Cochrane Library, CINAHL and Web of Science databases. From the selected studies, relevant references will be screened as supplemental sources. Finally, open search in websites from health institutions will be conducted to identify weight status data not published in scientific journals. Cross-sectional, follow-up studies and panel surveys reporting weight status (objectively measured height and weight) according to the International Obesity Task Force criteria, and written in English or Spanish will be included. Subgroup analyses will be carried out by gender, age, study year and country or European region.DiscussionThis study will provide a comprehensive description of weight status of children and adolescents across Europe from 2000 to 2017. The results will be disseminated in a peer-reviewed journal. This study will use data exclusively from published research or institutional literature, so institutional ethical approval is not required.PROSPERO registration numberCRD42017056917.

scholarly journals Clinical manifestations in primary ciliary dyskinesia: systematic review and meta-analysis

2016 ◽  
Vol 48 (4) ◽  
pp. 1081-1095 ◽  
Author(s):  
Myrofora Goutaki ◽  
Anna Bettina Meier ◽  
Florian S. Halbeisen ◽  
Jane S. Lucas ◽  
Sharon D. Dell ◽  
...  
Keyword(s):  
Systematic Review ◽  
Primary Ciliary Dyskinesia ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Explanatory Factors ◽  
Symptom Prevalence ◽  
Meta Analyses ◽  
Ciliary Dyskinesia

Few original studies have described the prevalence and severity of clinical symptoms of primary ciliary dyskinesia (PCD). This systematic review and meta-analysis aimed to identify all published studies on clinical manifestations of PCD patients, and to describe their prevalence and severity stratified by age and sex.We searched PubMed, Embase and Scopus for studies describing clinical symptoms of ≥10 patients with PCD. We performed meta-analyses and meta-regression to explain heterogeneity.We included 52 studies describing a total of 1970 patients (range 10–168 per study). We found a prevalence of 5% for congenital heart disease. For the rest of reported characteristics, we found considerable heterogeneity (I2 range 68–93.8%) when calculating the weighted mean prevalence. Even after taking into account the explanatory factors, the largest part of the between-studies variance in symptom prevalence remained unexplained for all symptoms. Sensitivity analysis including only studies with test-proven diagnosis showed similar results in prevalence and heterogeneity.Large differences in study design, selection of study populations and definition of symptoms could explain the heterogeneity in symptom prevalence. To better characterise the disease, we need larger, multicentre, multidisciplinary, prospective studies that include all age groups, use uniform diagnostics and report on all symptoms.

scholarly journals A systematic review with meta-analysis of the role of anxiety and depression in irritable bowel syndrome onset

2016 ◽  
Vol 46 (15) ◽  
pp. 3065-3080 ◽  
Author(s):  
A. Sibelli ◽  
T. Chalder ◽  
H. Everitt ◽  
P. Workman ◽  
S. Windgassen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Meta Analysis ◽  
Population Based ◽  
Self Report ◽  
Anxiety And Depression ◽  
Gastrointestinal Infection ◽  
Case Control Studies ◽  
Irritable Bowel

BackgroundIt is well established that people with irritable bowel syndrome (IBS) have higher levels of anxiety and depression compared with controls. However, the role of these as risk factors is less clearly established. The aims of this systematic review were to investigate: (1) whether anxiety and/or depression predict IBS onset; (2) the size of the relative risk (RR) of anxiety versus depression in IBS onset. Subgroup analyses explored if methodological factors affected the overall findings.MethodProspective cohort or case–control studies were included if they: (1) focused on the development of IBS in population-based or gastroenteritis cohorts; (2) explored the effects of anxiety and/or depression at baseline as predictors of IBS onset at a future point. In all, 11 studies were included of which eight recruited participants with a gastrointestinal infection. Meta-analyses were conducted.ResultsThe risk of developing IBS was double for anxiety cases at baseline compared with those who were not [RR 2.38, 95% confidence interval (CI) 1.58–3.60]. Similar results were found for depression (RR 2.06, 95% CI 1.44–2.96). Anxiety and depression seemed to play a stronger role in IBS onset in individuals with a gastrointestinal infection although this could be attributed to other differences in methodology, such as use of diagnostic interviews rather than self-report.ConclusionsThe findings suggest that self-reported anxiety and depression provide a twofold risk for IBS onset. There is less support for the role of anxiety or depressive disorder diagnosed using clinical interview. These findings may have implications for the development of interventions focused on IBS prevention and treatment.

scholarly journals ADHD symptoms and diagnosis in adult preterms: systematic review, IPD meta-analysis, and register-linkage study

2022 ◽  
Author(s):  
Rachel Robinson ◽  
Polina Girchenko ◽  
Anna Pulakka ◽  
Kati Heinonen ◽  
Anna Lähdepuro ◽  
...  
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Meta Analysis ◽  
Population Based ◽  
Linkage Study ◽  
Self Report ◽  
List Type ◽  
Adhd Symptoms ◽  
Adhd Diagnosis ◽  
Preterm Born

Abstract Background This study examined differences in ADHD symptoms and diagnosis between preterm and term-born adults (≥18 years), and tested if ADHD is related to gestational age, birth weight, multiple births, or neonatal complications in preterm borns. Methods (1) A systematic review compared ADHD symptom self-reports and diagnosis between preterm and term-born adults published in PubMed, Web of Science, and PROQUEST until April 2021; (2) a one-stage Individual Participant Data(IPD) meta-analysis (n = 1385 preterm, n = 1633 term; born 1978–1995) examined differences in self-reported ADHD symptoms[age 18–36 years]; and (3) a population-based register-linkage study of all live births in Finland (01/01/1987–31/12/1998; n = 37538 preterm, n = 691,616 term) examined ADHD diagnosis risk in adulthood (≥18 years) until 31/12/2016. Results Systematic review results were conflicting. In the IPD meta-analysis, ADHD symptoms levels were similar across groups (mean z-score difference 0.00;95% confidence interval [95% CI] −0.07, 0.07). Whereas in the register-linkage study, adults born preterm had a higher relative risk (RR) for ADHD diagnosis compared to term controls (RR = 1.26, 95% CI 1.12, 1.41, p < 0.001). Among preterms, as gestation length (RR = 0.93, 95% CI 0.89, 0.97, p < 0.001) and SD birth weight z-score (RR = 0.88, 95% CI 0.80, 0.97, p < 0.001) increased, ADHD risk decreased. Conclusions While preterm adults may not report higher levels of ADHD symptoms, their risk of ADHD diagnosis in adulthood is higher. Impact Preterm-born adults do not self-report higher levels of ADHD symptoms, yet are more likely to receive an ADHD diagnosis in adulthood compared to term-borns. Previous evidence has consisted of limited sample sizes of adults and used different methods with inconsistent findings. This study assessed adult self-reported symptoms across 8 harmonized cohorts and contrasted the findings with diagnosed ADHD in a population-based register-linkage study. Preterm-born adults may not self-report increased ADHD symptoms. However, they have a higher risk of ADHD diagnosis, warranting preventive strategies and interventions to reduce the presentation of more severe ADHD symptomatology in adulthood.

scholarly journals Impact of uncomplicated traumatic dental injuries on the quality of life of children and adolescents: a systematic review and meta-analysis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Diego Lopez ◽  
Nilakshi Waidyatillake ◽  
Carlos Zaror ◽  
Rodrigo Mariño
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Children And Adolescents ◽  
Negative Impact ◽  
Meta Analysis ◽  
Age Groups ◽  
Narrative Synthesis ◽  
Traumatic Dental Injuries ◽  
Dental Injuries

Abstract Background Traumatic dental injuries (TDIs) are highly prevalent during childhood and adolescence and have a significant effect on their oral health related quality of life (OHRQoL). Uncomplicated TDIs, dental trauma involving enamel, enamel and dentin and tooth discolorations, account for approximately two-thirds of all diagnosed TDIs in children and adolescents. Hence, it may be important to understand the impact of uncomplicated TDIs on OHRQoL, by synthesizing the available literature. Methods Medline, Embase, Web of Science and Scopus databases were systematically searched from January 1966 to April 2018. Studies that evaluated the effect of TDIs on the OHRQoL of children and adolescents using validated methods were selected for analysis. A narrative synthesis and a meta-analysis were performed. The studies were pooled according to age groups and OHRQoL questionnaire used. A random-effect model was applied to calculate the pooled odds ratios (OR) and their respective 95% confidence intervals. Results There were 712 identified studies. Of these, 26 articles were selected for the review and included in the narrative synthesis, 20 of these articles concluded that uncomplicated TDIs were not associated with a negative impact in OHRQoL. Seventeen were included in the meta-analysis. The estimates were pooled by age groups: children (OR: 1.01; 95%CI; 0.85–1.19; I2 = 51.9%) and adolescents (OR: 1.07; 95%CI; 0.91, 1.26; I2 = 50.2%).When pooling all estimates the OR was 0.96 (95% CI: 0.85–1.10; I2 = 61.4%). Conclusions Uncomplicated TDIs do not have a negative impact on the OHRQoL of children and adolescents. Further prospective studies are needed to confirm the results of this review. The majority of the studies included were of cross-sectional design, which may have limited the ability to reach conclusions on the nature of this association. The PROSPERO systematic review registry is CRD42018110471.

Homocysteine levels and cardiovascular risk factors in children and adolescents: systematic review and meta-analysis

2020 ◽  
Author(s):  
Luana de Oliveira Leite ◽  
Jacqueline Costa Dias Pitangueira ◽  
Nadjane Ferreira Damascena ◽  
Priscila Ribas de Farias Costa
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Cardiovascular Risk ◽  
Children And Adolescents ◽  
Cardiovascular Risk Factors ◽  
Latin American ◽  
Meta Analysis ◽  
Childhood And Adolescence ◽  
Cross Sectional ◽  
Cross Sectional Studies

Abstract Context Studies have indicated that homocysteine levels are nontraditional markers for cardiovascular disease. The onset of atherosclerotic disease begins in childhood and adolescence; thus, prevention of its risk factors should occur early. Objective This systematic review and meta-analysis was conducted to summarize the association between high homocysteine levels and traditional cardiovascular risk factors in children and adolescents. Data Sources This systematic review and meta-analysis were developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the protocol was submitted to PROSPERO. Only observational studies in children and adolescents with homocysteine levels as an exposure variable and cardiovascular risk factors as outcome variables were included and searched in the following electronic bibliographic databases: PubMed/MEDLINE, Web of Science, Embase, Latin American and Caribbean Literature in Health Sciences, Ovid and Scopus. Data Extraction Two authors independently extracted data from eligible studies. The methodological quality of the studies was assessed using the Newcastle-Ottawa scale. Data Analysis Seven studies were included in the systematic review; they were published from 1999 to 2017, predominantly were of a cross-sectional design, and mainly evaluated adolescents. In the meta-analysis (n = 6), cross-sectional studies (n = 3) identified that high homocysteine levels were positive and weakly correlated with overweight in children and adolescents (odds ratio, 1.08; 95%CI, 1.04–1.11). Conclusion High homocysteine levels were weakly associated with overweight in children and adolescents in the reviewed cross-sectional studies. However, for the other traditional cardiovascular risk factors, the findings, although important, were inconclusive. Additional robust longitudinal studies are recommended to be conducted to better identify these associations. Systematic Review Registration: PROSPERO registration no. CRD42018086252.

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