Age of major depression onset, depressive symptoms, and risk for subsequent dementia: results of the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe)

2012 ◽  
Vol 43 (8) ◽  
pp. 1597-1610 ◽  
Author(s):  
K. Heser ◽  
F. Tebarth ◽  
B. Wiese ◽  
M. Eisele ◽  
H. Bickel ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Sex Education ◽  
Memory Impairment ◽  
Late Onset ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
Dementia Risk ◽  
Incident Dementia ◽  
History Of ◽  
The Impact

BackgroundWhether late-onset depression is a risk factor for or a prodrome of dementia remains unclear. We investigated the impact of depressive symptoms and early- v. late-onset depression on subsequent dementia in a cohort of elderly general-practitioner patients (n = 2663, mean age = 81.2 years).MethodRisk for subsequent dementia was estimated over three follow-ups (each 18 months apart) depending on history of depression, particularly age of depression onset, and current depressive symptoms using proportional hazard models. We also examined the additive prediction of incident dementia by depression beyond cognitive impairment.ResultsAn increase of dementia risk for higher age cut-offs of late-onset depression was found. In analyses controlling for age, sex, education, and apolipoprotein E4 genotype, we found that very late-onset depression (aged ⩾70 years) and current depressive symptoms separately predicted all-cause dementia. Combined very late-onset depression with current depressive symptoms was specifically predictive for later Alzheimer's disease (AD; adjusted hazard ratio 5.48, 95% confidence interval 2.41–12.46, p < 0.001). This association was still significant after controlling for cognitive measures, but further analyses suggested that it was mediated by subjective memory impairment with worries.ConclusionsDepression might be a prodrome of AD but not of dementia of other aetiology as very late-onset depression in combination with current depressive symptoms, possibly emerging as a consequence of subjectively perceived worrisome cognitive deterioration, was most predictive. As depression parameters and subjective memory impairment predicted AD independently of objective cognition, clinicians should take this into account.

scholarly journals Differences in Subjective Memory Impairment, Depressive Symptoms, Sleep, and Physical Activity in African American and Asian American Elderly

2021 ◽  
Vol 11 (9) ◽  
pp. 1155
Author(s):  
Minsun Lee ◽  
Jin-Hyeok Nam ◽  
Elizabeth Yi ◽  
Aisha Bhimla ◽  
Julie Nelson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Depressive Symptoms ◽  
Ethnic Groups ◽  
Ethnic Differences ◽  
Asian American ◽  
Memory Impairment ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
Negative Health Outcomes ◽  
Racial Ethnic

Background: Subjective memory impairment (SMI) is associated with negative health outcomes including mild cognitive impairment and Alzheimer’s disease. However, ethnic differences in SMI and disparities in risk factors associated with SMI among minority populations are understudied. The study examined the ethnic differences in SMI, whether SMI was associated with depressive symptoms, sleep, and physical activity (PA), and whether the associations vary across racial/ethnic groups. Methods: Participants included 243 African and Asian Americans (including Chinese, Vietnamese, and Korean Americans) aged 50 or older. Demographic information, SMI, depressive symptoms, daily sleeping hours, and PA levels were assessed. Results: Vietnamese Americans reported the highest SMI score. Depressive symptoms, sleeping hours, and PA levels were significantly associated with SMI. Depressive symptoms were the only significant factor across all ethnic groups. Significant interaction effects were found between ethnicity and health behaviors in predicting SMI. In particular, Vietnamese American participants with greater depressive symptoms and physical inactivity were significantly more likely to experience SMI compared to other ethnic groups Conclusions: Our findings demonstrate ethnic differences in SMI and its association with depressive symptoms, sleep, and PA, which highlight the importance of considering the unique cultural and historical backgrounds across different racial/ethnic groups when examining cognitive functioning in elderly.

Less depressive symptoms are associated with smaller hippocampus in subjective memory impairment

2013 ◽  
Vol 57 (1) ◽  
pp. 110-115 ◽  
Author(s):  
Min-Jeong Kim ◽  
Sang Won Seo ◽  
Geon Ha Kim ◽  
Sung Tae Kim ◽  
Jong-Min Lee ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Memory Impairment ◽  
Subjective Memory ◽  
Subjective Memory Impairment

scholarly journals BMC NeurologyFactors determining recurrence in transient global amnesia

2019 ◽  
Author(s):  
Rebecca Tynas ◽  
Peter K Panegyres
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Head Injury ◽  
Memory Impairment ◽  
Transient Global Amnesia ◽  
Clinical History ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
History Of ◽  
Global Amnesia

Abstract Aetiology of transient global amnesia (TGA) remains uncertain, though many have been proposed, including ischaemic, migrainous or epileptic pathologies. We attempted to determine risk factors for TGA, as well as prognostic factors that may cause recurrence. We evaluated clinical history, family history and magnetic resonance diffusion-weighted imaging (DWI) studies of 93 prospective patients with TGA. Patients were followed from 2004-2016. Fifteen of 93 (16%) patients experienced a recurrence of TGA. Among precipitating events, physical activities inducing Valsalva-like manoeuvres were most common, followed by emotional stress. Eighty-four patients had possible comorbidities or risk factors for TGA, though no single risk factor was ubiquitous. Risk factors associated with recurrence were head injury (isolated vs. recurrent, 16.7% vs. 53.5%, p < 0.01), depression (isolated vs. recurrent, 15.4% vs 46.7%, p = 0.01) and family history of dementia (isolated vs. recurrent, 20.5% vs. 46.7%, p = 0.03). Of 15 patients with confirmed recurrent TGA, two developed dementia and four subjective memory impairment. DWI lesions were observed in 24 patients and were located anywhere within the hippocampus. DWI lesions were not significantly associated with outcomes (recurrence, subjective memory impairment, dementia). We have found that depression, previous head injury and family history of dementia may predict TGA recurrence.

scholarly journals Factors determining recurrence in transient global amnesia

2020 ◽  
Author(s):  
Rebecca Tynas ◽  
Peter K Panegyres
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Head Injury ◽  
Memory Impairment ◽  
Transient Global Amnesia ◽  
Clinical History ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
History Of ◽  
Global Amnesia

Abstract Background: Aetiology of transient global amnesia (TGA) remains uncertain, though many have been proposed, including ischaemic, migrainous or epileptic pathologies. Methods: We attempted to determine risk factors for TGA, as well as prognostic factors that may cause recurrence. We evaluated clinical history, family history and magnetic resonance diffusion-weighted imaging (DWI) studies of 93 prospective patients with TGA. Patients were followed from 2004-2016. Fifteen of 93 (16%) patients experienced a recurrence of TGA. Results: Among precipitating events, physical activities inducing Valsalva-like manoeuvres were most common, followed by emotional stress. Eighty-four patients had possible comorbidities or risk factors for TGA, though no single risk factor was ubiquitous. Risk factors associated with recurrence were head injury (isolated vs. recurrent, 16.7% vs. 53.5%, p < 0.01), depression (isolated vs. recurrent, 15.4% vs 46.7%, p = 0.01) and family history of dementia (isolated vs. recurrent, 20.5% vs. 46.7%, p = 0.03). Of 15 patients with confirmed recurrent TGA, two developed dementia and four subjective memory impairment. DWI lesions were observed in 24 patients and were located anywhere within the hippocampus. Conclusions: DWI lesions were not significantly associated with outcomes (recurrence, subjective memory impairment, dementia). We have found that depression, previous head injury and family history of dementia may predict TGA recurrence.

scholarly journals Factors determining recurrence in transient global amnesia

2019 ◽  
Author(s):  
Rebecca Tynas ◽  
Peter K Panegyres
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Family History ◽  
Head Injury ◽  
Memory Impairment ◽  
Transient Global Amnesia ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
History Of ◽  
Global Amnesia

Abstract Aetiology of transient global amnesia (TGA) remains uncertain, though many have been proposed, including ischaemic, migrainous or epileptic pathologies. We attempted to determine risk factors for TGA, as well as prognostic factors that may cause recurrence. We evaluated clinical history, family history and magnetic resonance diffusion-weighted imaging (DWI) studies of 93 prospective patients with TGA. Patients were followed up regarding recurrence and prognostic factors. Fifteen of 93 (16%) patients experienced a recurrence of TGA. Among precipitating events, physical activities inducing Valsalva-like manoeuvres were most common, followed by emotional stress. Eighty-four patients had possible comorbidities or risk factor for TGA, though no single risk factor was ubiquitous. Risk factors associated with recurrence were head injury (isolated vs. recurrent, 16,7% vs. 53.5%, p < 0.01), depression (isolated vs. recurrent, 15.4% vs 46.7%, p = 0.01) and family history of dementia (isolated vs. recurrent, 20.5% vs 46.7%, p = 0.03). Of 15 patients with confirmed recurrent TGA, two developed dementia and four subjective memory impairment. DWI lesions were observed in 24 patients and located anywhere within the hippocampus. DWI lesions were not significantly associated with outcomes (recurrence, subjective memory impairment, dementia). Findings suggest TGA is a heterogeneous syndrome. Among those with recurrence, depression, previous head injury and family history of dementia may be predictive factors. Encouraging primary prevention of head injury, managing depression and assisting in development of adequate coping mechanisms may decrease incidence. Education of healthcare works will also increase diagnostic rates, allowing for improved education and comfort for patients and families.

Determinants of incident dementia in different old age groups: results of the prospective AgeCoDe/AgeQualiDe study

2019 ◽  
Vol 32 (5) ◽  
pp. 645-659
Author(s):  
Tobias Luck ◽  
Alexander Pabst ◽  
Susanne Roehr ◽  
Birgitt Wiese ◽  
Marion Eisele ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Old Age ◽  
Age Groups ◽  
Least Square ◽  
Subjective Memory ◽  
Ordinary Least Square ◽  
Dementia Risk ◽  
Incident Dementia ◽  
The Impact ◽  
Dementia Onset

ABSTRACTObjectives:To examine the impact of determinants of incident dementia in three different old age groups (75–79, 80–84, 85+years) in Germany.Design:Multicenter prospective AgeCoDe/AgeQualiDe cohort study with baseline and nine follow-up assessments at 1.5-year intervals.Setting:Primary care medical record registry sample.Participants:General practitioners’ (GPs) patients aged 75+years at baseline.Measurements:Conduction of standardized interviews including neuropsychological assessment and collection of GP information at each assessment wave. We used age-stratified competing risk regression models (accounting for the competing event of mortality) to assess determinants of incident dementia and age-stratified ordinary least square regressions to quantify the impact of identified determinants on the age at dementia onset.Results:Among 3027 dementia-free GP patients, n = 704 (23.3%) developed dementia during the 13-year study period. Worse cognitive performance and subjective memory decline with related worries at baseline, and the APOE ε4 allele were associated independently with increased dementia risk in all three old age groups. Worse cognitive performance at baseline was also associated with younger age at dementia onset in all three age groups. Other well-known determinants were associated with dementia risk and age at dementia onset only in some or in none of the three old age groups.Conclusions:This study provides further evidence for the age-specific importance of determinants of incident dementia in old age. Such specifics have to be considered more strongly particularly with regard to potential approaches of early detection and prevention of dementia.

scholarly journals Family History of Alzheimer’s Disease and Subjective Memory Performance

2018 ◽  
Vol 33 (7) ◽  
pp. 458-462 ◽  
Author(s):  
Robert Haussmann ◽  
Steffi Ganske ◽  
Antonia Gruschwitz ◽  
Annett Werner ◽  
Antje Osterrath ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Family History ◽  
Cognitive Deficits ◽  
Memory Impairment ◽  
Subjective Memory ◽  
Healthy Older Adults ◽  
Subjective Memory Impairment ◽  
History Of

People with a first-degree family history of Alzheimer’s disease are at an increased risk of developing dementia. Subjective memory impairment among individuals with no measurable cognitive deficits may also indicate elevated dementia risk. It remains unclear whether nondemented people with a positive family history of Alzheimer’s disease are more likely to experience cognitive deficits and whether such an association reflects underlying neuropathology. We therefore investigated subjective memory impairment and hippocampal cortical thickness in 40 healthy older adults and 35 patients with amnestic mild cognitive impairment. We found greater subjective memory impairment and left hemispheric hippocampal cortical thinning associated with a first-degree family history of Alzheimer’s disease in healthy older adults. This suggests that subjective memory impairment could reflect preclinical stage neurodegeneration among individuals with the family history risk factor.

scholarly journals EXAMINING THE TEMPORAL ASSOCIATIONS BETWEEN SUBJECTIVE MEMORY IMPAIRMENT AND DEPRESSIVE SYMPTOMS IN OLDER ADULTS

2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 778-778
Author(s):  
I Bhang ◽  
J Mogle ◽  
N Hill ◽  
E Whitaker ◽  
S Bhargava ◽  
...  
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Memory Impairment ◽  
Subjective Memory ◽  
Subjective Memory Impairment

scholarly journals Embarking on a memory assessment voices of older persons living with memory impairment

Dementia ◽  
2020 ◽  
pp. 147130122091063
Author(s):  
Marie Tyrrell ◽  
Dorota Religa ◽  
Bjöörn Fossum ◽  
Ragnhild Hedman ◽  
Kirsti Skovdahl ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Older Persons ◽  
Neuropsychiatric Symptoms ◽  
Structured Interviews ◽  
Subjective Memory ◽  
Memory Assessment ◽  
Subjective Memory Impairment ◽  
Initial Symptoms ◽  
The Impact ◽  
With Memory

Aim To describe older persons who had commenced a memory assessment, experiences of living with memory impairment and related symptoms. Background Persons with subjective memory impairment are two times more likely to develop dementia over the years than their peers. Older persons seldom seek help from primary health care clinics solely for subjective memory impairment. Of those who seek help, it can take up to 35 months from the person experiencing initial symptoms to referral to a memory clinic. Further research is needed regarding how older persons live with memory impairment with related symptoms before they receive a memory diagnosis. Method A qualitative study with 23 participants who had commenced a memory assessment in primary care. Semi-structured interviews were held. During the interviews, the Neuropsychiatric Inventory was completed and discussed with the participants. Interview data were analysed using Interpretive Description. Results The results are presented under four themes: Conflicting views about the situation, Unveiling the presence of neuropsychiatric symptoms, Compensating with external and internal strategies to recall and Worrying about self and future. Persons with memory impairment were encouraged by family members or others to seek a memory assessment. Few persons were self-referred as memory impairment was often seen as a part of aging. Polarised viewpoints existed within the families regarding the impact of memory impairment on daily life. The presence of neuropsychiatric symptoms appeared unexplored in the participants seeking a memory assessment. In this study, the majority of participants experienced neuropsychiatric symptoms at the time of contact for a memory assessment. Conclusions Memory problems experienced were often viewed by the person as being part of an aging process. The presence of neuropsychiatric symptoms was not acknowledged as being connected to memory impairment. Contextualising ‘memory impairment’ as a part of a ‘cognitive process’ may help the person in identifying the presence of neuropsychiatric symptoms.

Sign in / Sign up

Export Citation Format

Share Document