Brain substrates of perceived spatial separation between speech sources under simulated reverberant listening conditions in schizophrenia

2015 ◽  
Vol 46 (3) ◽  
pp. 477-491 ◽  
Author(s):  
Y. Zheng ◽  
C. Wu ◽  
J. Li ◽  
H. Wu ◽  
S. She ◽  
...  
Keyword(s):  
Speech Recognition ◽  
Inferior Frontal Gyrus ◽  
Spatial Separation ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Precedence Effect ◽  
Informational Masking ◽  
Reverberant Environments ◽  
The Brain ◽  
Perceived Spatial Separation

BackgroundPeople with schizophrenia recognize speech poorly under multiple-people-talking (informational masking) conditions. In reverberant environments, direct-wave signals from a speech source are perceptually integrated with the source reflections (the precedence effect), forming perceived spatial separation (PSS) between different sources and consequently improving target-speech recognition against informational masking. However, the brain substrates underlying the schizophrenia-related vulnerability to informational masking and whether schizophrenia affects the unmasking effect of PSS are largely unknown.MethodUsing psychoacoustic testing and functional magnetic resonance imaging, respectively, the speech recognition under either the PSS or perceived spatial co-location (PSC) condition and the underlying brain substrates were examined in 20 patients with schizophrenia and 16 healthy controls.ResultsSpeech recognition was worse in patients than controls. Under the PSS (but not PSC) condition, speech recognition was correlated with activation of the superior parietal lobule (SPL), and target speech-induced activation of the SPL, precuneus, middle cingulate cortex and caudate significantly declined in patients. Moreover, the separation (PSS)-against-co-location (PSC) contrast revealed (1) activation of the SPL, precuneus and anterior cingulate cortex in controls, (2) suppression of the SPL and precuneus in patients, (3) activation of the pars triangularis of the inferior frontal gyrus and middle frontal gyrus in both controls and patients, (4) activation of the medial superior frontal gyrus in patients, and (5) impaired functional connectivity of the SPL in patients.ConclusionsIntroducing the PSS listening condition efficiently reveals both the brain substrates underlying schizophrenia-related speech-recognition deficits against informational masking and the schizophrenia-related neural compensatory strategy for impaired SPL functions.

scholarly journals Common Brain Substrates Underlying Auditory Speech Priming and Perceived Spatial Separation

2021 ◽  
Vol 15 ◽  
Author(s):  
Junxian Wang ◽  
Jing Chen ◽  
Xiaodong Yang ◽  
Lei Liu ◽  
Chao Wu ◽  
...  
Keyword(s):  
Inferior Frontal Gyrus ◽  
Critical Role ◽  
Spatial Separation ◽  
Anterior Cingulate ◽  
Cocktail Party ◽  
Brain Areas ◽  
Motor Representation ◽  
Auditory Speech ◽  
Perceived Spatial Separation

Under a “cocktail party” environment, listeners can utilize prior knowledge of the content and voice of the target speech [i.e., auditory speech priming (ASP)] and perceived spatial separation to improve recognition of the target speech among masking speech. Previous studies suggest that these two unmasking cues are not processed independently. However, it is unclear whether the unmasking effects of these two cues are supported by common neural bases. In the current study, we aimed to first confirm that ASP and perceived spatial separation contribute to the improvement of speech recognition interactively in a multitalker condition and further investigate whether there exist intersectant brain substrates underlying both unmasking effects, by introducing these two unmasking cues in a unified paradigm and using functional magnetic resonance imaging. The results showed that neural activations by the unmasking effects of ASP and perceived separation partly overlapped in brain areas: the left pars triangularis (TriIFG) and orbitalis of the inferior frontal gyrus, left inferior parietal lobule, left supramarginal gyrus, and bilateral putamen, all of which are involved in the sensorimotor integration and the speech production. The activations of the left TriIFG were correlated with behavioral improvements caused by ASP and perceived separation. Meanwhile, ASP and perceived separation also enhanced the functional connectivity between the left IFG and brain areas related to the suppression of distractive speech signals: the anterior cingulate cortex and the left middle frontal gyrus, respectively. Therefore, these findings suggest that the motor representation of speech is important for both the unmasking effects of ASP and perceived separation and highlight the critical role of the left IFG in these unmasking effects in “cocktail party” environments.

scholarly journals Neurophysiology of Ethnicity (based on foreign literature)

2017 ◽  
Vol 8 (4) ◽  
pp. 43-54
Author(s):  
E.A. Varshaver
Keyword(s):  
Cognitive Science ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Fusiform Face Area ◽  
Foreign Literature ◽  
Face Area ◽  
The Brain

This article contains a review of research in the realm of neurophysiology of ethnicity. According to this body of research, there are zones of the brain which get active in response to demonstration of ethnic stimuli. Among these zones are amygdala, anterior cingulate cortex, fusiform face area and others. The article describes the research focused on each of these zones, discusses their weaknesses and projects further research on the crossroads of neurophysiology, cognitive science, psychology and sociology.

scholarly journals Framing and Self-Responsibility Modulate Brain Activities in Decision Escalation

2021 ◽  
Author(s):  
Ting-Peng Liang ◽  
Yuwen Li ◽  
Nai-Shing Yen ◽  
Ofir Turel ◽  
Sen-Mou Hsu
Keyword(s):  
Anterior Cingulate Cortex ◽  
Contextual Factors ◽  
Inferior Frontal Gyrus ◽  
Cingulate Cortex ◽  
Brain Regions ◽  
Anterior Cingulate ◽  
Imaging Data ◽  
Two Factors ◽  
Human Decision

Abstract Background: Escalation of commitment is a common bias in human decision making. The present study examined (1) differences in neural recruitment for escalation and de-escalation decisions of prior investments, and (2) how the activations of these brain networks are modulated by two factors that are often argued to modulate the behavior: (i) self-responsibility, and (ii) framing of the success probabilities. Results: Imaging data were obtained from functional magnetic resonance imaging (fMRI) applied to 29 participants. A whole-brain analysis was conducted to compare brain activations between conditions. ROI analysis, then, was used to examine if these significant activations were modulated by two contextual factors. Finally, mediation analysis was applied to explore how the contextual factors affect escalation decisions through brain activations. The findings showed that (1) escalation decisions are faster than de-escalation decisions, (2) the corresponding network of brain regions recruited for escalation (anterior cingulate cortex, insula and precuneus) decisions differs from this recruited for de-escalation decisions (inferior and superior frontal gyri), (3) the switch from escalation to de-escalation is primarily frontal gyri dependent, and (4) activation in the anterior cingulate cortex, insula and precuneus were further increased in escalation decisions, when the outcome probabilities of the follow-up investment were positively framed; and activation in the inferior and superior frontal gyri in de-escalation decisions were increased when the outcome probabilities were negatively framed. Conclusions: Escalation and de-escalation decisions recruit different brain regions. Framing of possible outcomes as negative leads to escalation decisions through recruitment of the inferior frontal gyrus. Responsibility for decisions affects escalation decisions through recruitment of the superior (inferior) gyrus, when the decision is framed positively (negatively).

scholarly journals When honest people cheat, and cheaters are honest: Cognitive control processes override our moral default

2020 ◽  
Author(s):  
Sebastian P.H. Speer ◽  
Ale Smidts ◽  
Maarten A.S. Boksem
Keyword(s):  
Cognitive Control ◽  
Inferior Frontal Gyrus ◽  
Neural Mechanism ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Anterior Cingulate ◽  
Temporoparietal Junction ◽  
Self Image ◽  
Trial Basis

AbstractEvery day, we are faced with the conflict between the temptation to cheat for financial gains and maintaining a positive image of ourselves as being a ‘good person’. While it has been proposed that cognitive control is needed to mediate this conflict between reward and our moral self-image, the exact role of cognitive control in (dis)honesty remains elusive. Here, we identify this role, by investigating the neural mechanism underlying cheating. We developed a novel task which allows for inconspicuously measuring spontaneous cheating on a trial-by-trial basis in the MRI scanner. We found that activity in the Nucleus Accumbens promotes cheating, particularly for individuals who cheat a lot, while a network consisting of Posterior Cingulate Cortex, Temporoparietal Junction and Medial Prefrontal Cortex promotes honesty, particularly in individuals who are generally honest. Finally, activity in areas associated with Cognitive Control (Anterior Cingulate Cortex and Inferior Frontal Gyrus) helped dishonest participants to be honest, whereas it promoted cheating for honest participants. Thus, our results suggest that cognitive control is not needed to be honest or dishonest per se, but that it depends on an individual’s moral default.

scholarly journals Spatial Release from Masking Using Clinical Corpora: Sentence Recognition in a Colocated or Spatially Separated Speech Masker

2020 ◽  
Vol 31 (04) ◽  
pp. 271-276
Author(s):  
Grant King ◽  
Nicole E. Corbin ◽  
Lori J. Leibold ◽  
Emily Buss
Keyword(s):  
Hearing Loss ◽  
Speech Recognition ◽  
Spatial Separation ◽  
Speech Corpus ◽  
Sentence Recognition ◽  
Spatial Release ◽  
The Mean ◽  
Release From Masking ◽  
Perceived Spatial Separation ◽  
Separation Conditions

Abstract Background Speech recognition in complex multisource environments is challenging, particularly for listeners with hearing loss. One source of difficulty is the reduced ability of listeners with hearing loss to benefit from spatial separation of the target and masker, an effect called spatial release from masking (SRM). Despite the prevalence of complex multisource environments in everyday life, SRM is not routinely evaluated in the audiology clinic. Purpose The purpose of this study was to demonstrate the feasibility of assessing SRM in adults using widely available tests of speech-in-speech recognition that can be conducted using standard clinical equipment. Research Design Participants were 22 young adults with normal hearing. The task was masked sentence recognition, using each of five clinically available corpora with speech maskers. The target always sounded like it originated from directly in front of the listener, and the masker either sounded like it originated from the front (colocated with the target) or from the side (separated from the target). In the real spatial manipulation conditions, source location was manipulated by routing the target and masker to either a single speaker or to two speakers: one directly in front of the participant, and one mounted in an adjacent corner, 90° to the right. In the perceived spatial separation conditions, the target and masker were presented from both speakers with delays that made them sound as if they were either colocated or separated. Results With real spatial manipulations, the mean SRM ranged from 7.1 to 11.4 dB, depending on the speech corpus. With perceived spatial manipulations, the mean SRM ranged from 1.8 to 3.1 dB. Whereas real separation improves the signal-to-noise ratio in the ear contralateral to the masker, SRM in the perceived spatial separation conditions is based solely on interaural timing cues. Conclusions The finding of robust SRM with widely available speech corpora supports the feasibility of measuring this important aspect of hearing in the audiology clinic. The finding of a small but significant SRM in the perceived spatial separation conditions suggests that modified materials could be used to evaluate the use of interaural timing cues specifically.

scholarly journals Functional MRI Investigation of Ultrasound Stimulation at ST 36

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Yarui Wei ◽  
Ling Mei ◽  
Xiaojing Long ◽  
Xiaoxiao Wang ◽  
Yanjun Diao ◽  
...  
Keyword(s):  
Block Design ◽  
Brain Activation ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Anterior Cingulate ◽  
Activation Patterns ◽  
Lentiform Nucleus ◽  
Ultrasound Stimulation ◽  
Postcentral Gyrus ◽  
The Brain

Background. Clinical and experimental data suggest that ultrasound stimulation (US) at acupoints can produce similar effective treatment compared to manual acupuncture (MA). Although the brain activation to MA at acupoints is investigated by numerous studies, the brain activation to US at acupoints remains unclear. Methods. In the present work, we employed task state functional magnetic resonance imaging (fMRI) to explore the human brain’s activation to US and MA at ST 36 (Zusanli) which is one of the most commonly used acupoints in acupuncture-related studies. 16 healthy subjects underwent US and MA procedures in an interval of more than one week. On-off block design stimulation was used for the recording of fMRI-related brain patterns. Results. Both US and MA at ST 36 produced activations in somatosensory and limbic/paralimbic regions (postcentral gyrus, insula, middle prefrontal cortex, and anterior cingulate cortex). Only US at ST 36 produced a significant signal increase in the inferior parietal lobule and decrease in the posterior cingulate cortex, whereas MA at ST 36 produced a significant signal increase in the lentiform nucleus and cerebellum. Conclusions. Our results indicate that US may be a possible noninvasive alternative method to MA due to its similar activation patterns.

scholarly journals A neural network for information seeking

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
J. Kael White ◽  
Ethan S. Bromberg-Martin ◽  
Sarah R. Heilbronner ◽  
Kaining Zhang ◽  
Julia Pai ◽  
...  
Keyword(s):  
Neural Network ◽  
Basal Ganglia ◽  
Anterior Cingulate Cortex ◽  
Information Seeking ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Information Seeking Behavior ◽  
Seeking Behavior ◽  
The Moment ◽  
The Brain

AbstractHumans and other animals often show a strong desire to know the uncertain rewards their future has in store, even when they cannot use this information to influence the outcome. However, it is unknown how the brain predicts opportunities to gain information and motivates this information-seeking behavior. Here we show that neurons in a network of interconnected subregions of primate anterior cingulate cortex and basal ganglia predict the moment of gaining information about uncertain rewards. Spontaneous increases in their information prediction signals are followed by gaze shifts toward objects associated with resolving uncertainty, and pharmacologically disrupting this network reduces the motivation to seek information. These findings demonstrate a cortico-basal ganglia mechanism responsible for motivating actions to resolve uncertainty by seeking knowledge about the future.

scholarly journals Partially dissociable roles of OFC and ACC in stimulus-guided and action-guided decision making

2014 ◽  
Vol 111 (9) ◽  
pp. 1717-1720 ◽  
Author(s):  
Abbas Khani
Keyword(s):  
Decision Making ◽  
Anterior Cingulate Cortex ◽  
Orbitofrontal Cortex ◽  
Single Neuron ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Functional Specialization ◽  
Complex Picture ◽  
Lesion Studies ◽  
The Brain

Recently, the functional specialization of prefrontal areas of the brain, and, specifically, the functional dissociation of the orbitofrontal cortex (OFC) and the anterior cingulate cortex (ACC), during decision making have become a particular focus of research. A number of neuropsychological and lesion studies have shown that the OFC and ACC have dissociable functions in various dimensions of decision making, which are supported by their different anatomical connections. A recent single-neuron study, however, described a more complex picture of the functional dissociation between these two frontal regions during decision making. Here, I discuss the results of that study and consider alternative interpretations in connection with other findings.

scholarly journals Neural Changes in Borderline Personality Disorder After Dialectical Behavior Therapy–A Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Adam Iskric ◽  
Emily Barkley-Levenson
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Anterior Cingulate Cortex ◽  
Behavior Therapy ◽  
Dialectical Behavior Therapy ◽  
Emotional Reactivity ◽  
Inferior Frontal Gyrus ◽  
Cingulate Cortex ◽  
Borderline Personality ◽  
Anterior Cingulate

The biological component of the biosocial theory of emotion regulation stipulates that borderline personality disorder (BPD) arises from biological vulnerabilities to heightened emotional reactivity. Comprehensive reviews have consistently implicated abnormalities in the amygdala, anterior cingulate cortex, and hippocampus in the neurobiology of BPD. While Dialectical Behavior Therapy (DBT) is the leading evidence-based psychotherapy for the treatment of BPD, there remains a paucity of literature examining changes in the neurobiology of BPD following DBT treatment. Nine studies were identified that examined neurobiological changes in BPD after the completion of DBT. Results indicated that there was significant deactivation of amygdala activity as well as the anterior cingulate cortex in patients with BPD after DBT treatment. As well, several studies found after DBT treatment, BPD patients had a decreased activity in the inferior frontal gyrus in response to arousing stimuli and increased activity in response to inhibitory control. Future research on the neurobiological change after DBT treatment can help clarify biological mechanisms of change in BPD.

scholarly journals A neural network for information seeking

2019 ◽  
Author(s):  
J. Kael White ◽  
Ethan S. Bromberg-Martin ◽  
Sarah R. Heilbronner ◽  
Kaining Zhang ◽  
Julia Pai ◽  
...  
Keyword(s):  
Neural Network ◽  
Basal Ganglia ◽  
Anterior Cingulate Cortex ◽  
Information Seeking ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Information Seeking Behavior ◽  
Seeking Behavior ◽  
The Moment ◽  
The Brain

ABSTRACTHumans and other animals often show a strong desire to know the uncertain rewards their future has in store, even when they cannot use this information to influence the outcome. However, it is unknown how the brain predicts opportunities to gain information and motivates this information seeking behavior. Here we show that neurons in a network of interconnected subregions of primate anterior cingulate cortex and basal ganglia predict the moment of gaining information about uncertain rewards. Spontaneous increases in their information prediction signals are followed by gaze shifts toward objects associated with resolving uncertainty, and pharmacologically disrupting this network reduces the motivation to seek information. These findings demonstrate a cortico-basal ganglia mechanism responsible for motivating actions to resolve uncertainty by seeking knowledge about the future.

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