Prenatal maternal bereavement and mortality in the first decades of life: a nationwide cohort study from Denmark and Sweden

2016 ◽  
Vol 47 (3) ◽  
pp. 389-400 ◽  
Author(s):  
Y. Yu ◽  
S. Cnattingius ◽  
J. Olsen ◽  
E. T. Parner ◽  
M. Vestergaard ◽  
...  
Keyword(s):  
Cohort Study ◽  
Mortality Risk ◽  
Causes Of Death ◽  
Stressful Life Events ◽  
Metabolic Diseases ◽  
Population Based ◽  
Close Relative ◽  
Mortality Rate Ratio ◽  
Long Term Mortality

BackgroundThe loss of a close relative is one of the most stressful life events. In pregnancy, this experience has been associated with a higher risk of fetal death and under-five mortality, but little is known about potential effects on long-term mortality in offspring. We examined the association between prenatal maternal bereavement and mortality in a cohort of 5.3 million children followed until up to 37 years of age.MethodThe population-based cohort study included 5 253 508 live singleton births in Denmark (1973–2004) and Sweden (1973–2006). Children born to mothers who lost a child, spouse, sibling, or parent during or 1 year before pregnancy were categorized as exposed.ResultsPrenatal maternal bereavement was associated with a 10% increased all-cause mortality risk in offspring [mortality rate ratio (MRR) 1.10, 95% confidence interval (CI) 1.03–1.18]. The association was the most pronounced for children of mothers who lost a child/spouse (MRR 1.28, 95% CI 1.14–1.44) and was stronger during the first 10 years of life. Prenatal maternal bereavement may have stronger effects on natural causes of death in offspring, including infectious/parasitic disease (MRR 1.86, 95% CI 1.07–3.23), endocrine/nutritional/metabolic diseases (MRR 3.23, 95% CI 2.02–5.17), diseases of nervous system (MRR 3.36, 95% CI 2.47–4.58), and congenital malformations (MRR 1.39, 95% CI 1.08–1.80). No excess mortality risk in offspring was observed for unnatural causes of death.ConclusionPrenatal maternal bereavement was associated with an increased long-term mortality risk in offspring, particularly for selected natural causes of diseases and medical conditions. Our results support the fetal programming hypothesis that prenatal stress may contribute to ill health from physical diseases later in life.

scholarly journals Chronic osteomyelitis increases long-term mortality risk in the elderly: a nationwide population-based cohort study

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Chien-Cheng Huang ◽  
Kang-Ting Tsai ◽  
Shih-Feng Weng ◽  
Hung-Jung Lin ◽  
Hung-Sheng Huang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Mortality Risk ◽  
Chronic Osteomyelitis ◽  
The Elderly ◽  
Population Based ◽  
Long Term Mortality

scholarly journals Long-term Mortality Risk After Hyperglycemic Crisis Episodes in Geriatric Patients With Diabetes: A National Population-Based Cohort Study

Diabetes Care ◽  
2015 ◽  
Vol 38 (5) ◽  
pp. 746-751 ◽  
Author(s):  
Chien-Cheng Huang ◽  
Shih-Feng Weng ◽  
Kang-Ting Tsai ◽  
Ping-Jen Chen ◽  
Hung-Jung Lin ◽  
...  
Keyword(s):  
Cohort Study ◽  
Mortality Risk ◽  
Geriatric Patients ◽  
Population Based ◽  
National Population ◽  
Patients With Diabetes ◽  
Long Term Mortality

scholarly journals Long-term mortality in young patients with spontaneous intracerebral haemorrhage: Predictors and causes of death

2021 ◽  
Vol 6 (2) ◽  
pp. 185-193
Author(s):  
Jamie I Verhoeven ◽  
Marco Pasi ◽  
Barbara Casolla ◽  
Hilde Hénon ◽  
Frank-Erik de Leeuw ◽  
...  
Keyword(s):  
Mortality Risk ◽  
Intracerebral Haemorrhage ◽  
Causes Of Death ◽  
Cox Regression ◽  
Young Patients ◽  
University Hospital ◽  
Standardized Mortality Ratio ◽  
Excessive Alcohol Consumption ◽  
Long Term Mortality

Introduction Intracerebral haemorrhage (ICH) in young adults is rare but has devastating consequences. We investigated long-term mortality rates, causes of death and predictors of long-term mortality in young spontaneous ICH survivors. Patients and methods We included consecutive patients aged 18–55 years from the Prognosis of Intracerebral Haemorrhage cohort (PITCH), a prospective observational cohort of patients admitted to Lille University Hospital (2004–2009), who survived at least 30 days after spontaneous ICH. We studied long-term mortality with Kaplan-Meier analyses, collected causes of death, performed uni-/multivariable Cox-regression analyses for the association of baseline characteristics with long-term mortality. Results Of 560 patients enrolled in the PITCH, 75 patients (75% men) met our inclusion criteria (median age 50 years, interquartile range [IQR] 44–53 years). During a median follow-up of 8.2 years (IQR 5.0–10.1), 26 patients died (35%), with a standardized mortality ratio of 13.0 (95% confidence interval [95% CI] 8.5–18.0) compared to peers from the general population. Causes of death were vascular in 7 (27%) patients, non-vascular in 13 (50%) and unknown in 6 (23%). Global cerebral atrophy (hazard ratio [HR] 3.0, 95% CI 1.1–8.6), modified Rankin Score >2 before ICH (HR 3.4, 95% CI 1.0–11.0), and excessive alcohol consumption (HR 3.3, 95% CI 1.1–10.2) were independently associated with long-term mortality. Discussion We found a 13-fold higher mortality risk for young ICH survivors compared to the general French population. Predictors of long-term mortality were pre-existing conditions, not ICH-characteristics. Conclusion Young ICH survivors remain at increased mortality risk of vascular and non-vascular death for years after ICH.

scholarly journals Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tak Kyu Oh ◽  
Eun Sun Jang ◽  
In-Ae Song
Keyword(s):  
Cohort Study ◽  
Liver Enzymes ◽  
Adult Population ◽  
Population Based ◽  
Study Data ◽  
Point Increase ◽  
Elevated Liver Enzymes ◽  
Glutamyl Transpeptidase ◽  
Long Term Mortality

AbstractWe aimed to investigate whether elevated liver enzymes in the adult population were associated with mortality due to infection. As a population-based cohort study, data from the National Health Insurance Service Health Screening Cohort were used. Adult individuals (aged ≥ 40 years) who underwent standardized medical examination between 2002 and 2003 were included, and infectious mortality was defined as mortality due to infection between 2004 and 2015. Aspartate transaminase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (γ-GTP), AST/ALT ratio, and dynamic AST/ALT ratio (dAAR) were included in multivariable Cox modeling. A total of 512,746 individuals were included in this study. Infectious mortality occurred in 2444 individuals (0.5%). In the multivariable model, moderate and severe elevation in AST was associated with 1.94-fold [hazard ratio (HR):1.94, 95% confidence interval (CI) 1.71–2.19; P < 0.001] and 3.93-fold (HR: 3.93, 95% CI 3.05–5.07; P < 0.001) higher infectious mortality respectively, compared with the normal AST group. Similar results were observed for moderate and severe elevation in ALT and mild, moderate, and severe elevation in γ-GTP. Additionally, a 1-point increase in the AST/ALT ratio and dAAR was associated with higher infection mortality. Elevated liver enzymes (AST, ALT, AST/ALT ratio, γ-GTP, and dAAR) were associated with increased infectious mortality.

Erratum to “Long-term mortality after Staphylococcus aureus spondylodiscitis: A Danish nationwide population-based cohort study” [J Infect 69 (2014) 252–258]

2015 ◽  
Vol 70 (2) ◽  
pp. 211
Author(s):  
Theis Aagaard ◽  
Casper Roed ◽  
Anders R. Larsen ◽  
Andreas Petersen ◽  
Benny Dahl ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cohort Study ◽  
Population Based ◽  
Long Term Mortality

Long-term mortality and incidence of cancer after pregnancy-related venous thrombosis: Results of a population-based cohort study

2013 ◽  
Vol 131 (6) ◽  
pp. 497-501 ◽  
Author(s):  
Hilde S. Wik ◽  
Anne F. Jacobsen ◽  
Morten W. Fagerland ◽  
Leiv Sandvik ◽  
Per Morten Sandset
Keyword(s):  
Cohort Study ◽  
Venous Thrombosis ◽  
Population Based ◽  
Incidence Of Cancer ◽  
Long Term Mortality

scholarly journals Effect of AIDS-defining events at initiation of antiretroviral therapy on long-term mortality of HIV/AIDS patients in southwestern China: a cohort study

2020 ◽  
Author(s):  
Yunxuan Huang ◽  
Oulu Zhou ◽  
Zhigang Zheng ◽  
Yuexiang Xu ◽  
Yi Shao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Antiretroviral Therapy ◽  
Mortality Risk ◽  
Hiv Positive ◽  
Aids Patients ◽  
Death Risk ◽  
Long Term Mortality ◽  
Hiv Aids

Abstract Objective To evaluate the impact of AIDS-defining events (ADE) on long-term mortality of HIV positive individuals on antiretroviral therapy (ART), a retrospective HIV/AIDS treatment cohort study was performed in southwestern China. Methods The cohort was established based on HIV/AIDS patients on ART recruited in Guigang city, Guangxi, China, from January 2004 to December 2018. Participants were divided into ADE and non-ADE groups, and were followed-up every six months to observe treatment outcomes. Comparison of mortality between groups was performed using the log-rank test and Kaplan-Meier analysis. Cox proportional hazard regression was used to explore the risk factors of mortality. 1:1 propensity score matching (PSM) was used to balance confounding factors and adjust the mortality risk. Results Of 6,757 participants with 29,096.06 person-years of follow-up, 16.86% (1,139/6,757) belonged to ADE group while the others (83.14%) belonged to the non-ADE group. The most common cause of death by ADE was disseminated mycosis (31.65%), followed by recurrent severe bacterial pneumonia (28.48%), herpes zoster(17.72%), and extra-pulmonary tuberculosis (8.86%). The mortality of the ADE group was significantly higher than that of the non-ADE group [3.45/100 person-years (95% CI: 2.92-3.97) vs. 2.34/100 person-years (95%CI: 2.15-2.52), P<0.001]. The death risk of the ADE group was also higher than that of the non- ADE group [adjusted hazard ratio (aHR) =1.291, 95% CI: 1.061-1.571, P =0.011], which was confirmed by PSM analysis (aHR=1.581, 95% CI: 1.192-2.099, P =0.002). Cox analysis indicated that ADE, older age, male gender, previous non-use of cotrimoxazole, advanced WHO clinical stage, and low baseline CD4+ cell count were the risk factors for death. Conclusions Even on ART, the mortality risk of HIV positive individuals with ADE was higher than those without ADE. Active testing, earlier diagnosis, and timely therapy with ART may reduce the death risk of ADE.

Sign in / Sign up

Export Citation Format

Share Document