Depressed mood and anxiety as risk factors for hypertensive disorders of pregnancy: a systematic review and meta-analysis

2020 ◽  
Vol 50 (13) ◽  
pp. 2128-2140 ◽  
Author(s):  
Matthew Shay ◽  
Anna L. MacKinnon ◽  
Amy Metcalfe ◽  
Gerald Giesbrecht ◽  
Tavis Campbell ◽  
...  
Keyword(s):  
English Language ◽  
Meta Analysis ◽  
Hypertensive Disorders Of Pregnancy ◽  
Case Control Studies ◽  
Pregnancy Anxiety ◽  
Relative Risks ◽  
Hypertensive Disorders ◽  
Study Characteristics ◽  
Anxious Group ◽  
In Pregnancy

AbstractBackgroundPsychosocial factors have been implicated as both a cause and consequence of hypertension in the general population but are less understood in relation to hypertensive disorders of pregnancy (HDP). The aims of this review were to (1) synthesize the existing literature examining associations between depression and/or anxiety in pregnancy and HDP and (2) assess if depression and/or anxiety in early pregnancy was a risk factor for HDP.MethodsA comprehensive search of Medline, Embase, CINAHL, and PsycINFO was conducted from inception to March 2020 using terms related to ‘pregnancy’, ‘anxiety’, ‘depression’, and ‘hypertensive disorders’. English-language cohort and case-control studies were included if they reported: (a) the presence or absence of clinically significant symptoms of depression/anxiety, or a medical record diagnosis of depression or an anxiety disorder in pregnancy; (b) diagnosis of HDP; and/or (c) data comparing the depressed/anxious group to the non-depressed/anxious group on HDP. Data related to depression/anxiety, HDP, study characteristics, and aspects related to study quality were extracted independently by two reviewers. Random-effects meta-analyses of estimated pooled relative risks (RRs) were conducted for depression/anxiety in pregnancy and HDP.ResultsIn total, 6291 citations were retrieved, and 44 studies were included across 61.2 million pregnancies. Depression and/or anxiety were associated with HDP [RR = 1.39; 95% confidence interval (CI) 1.25–1.54].ConclusionsWhen measurement of anxiety or depression preceded diagnosis of hypertension, the association remained (RR = 1.27; 95% CI 1.07–1.50). Women experiencing depression or anxiety in pregnancy have an increased prevalence of HDP compared to their non-depressed or non-anxious counterparts.

scholarly journals P.076 Hypertensive disorders in pregnancy are strongly associated with future stroke and hypertension: A systematic review and meta-analysis

2021 ◽  
Vol 48 (s3) ◽  
pp. S40-S41
Author(s):  
AR Switzer ◽  
EE Smith ◽  
A Ganesh
Keyword(s):  
Gestational Hypertension ◽  
Meta Analysis ◽  
Stroke Mortality ◽  
Case Control Studies ◽  
Stroke Subtype ◽  
Stroke Incidence ◽  
Hypertensive Disorders ◽  
Hazard Ratios ◽  
Hypertensive Disorders In Pregnancy ◽  
In Pregnancy

Background: We aimed to evaluate the association between hypertensive disorders in pregnancy (HDP) and future risk of stroke, stroke death, and hypertension. Methods: Systematic searches were performed in MEDLINE and EMBASE up to April 27th, 2020. Exposure of interest included the different types of HDP. Outcomes of interest included hypertension incidence, stroke incidence, stroke subtype, and stroke mortality. Results: Eighteen cohort and 1 case-control studies involving >10 million women were included in the meta-analysis. Pooled hazard ratios with 95% confidence interval generally adjusted for age at delivery, ethnicity, and vascular risk factors are listed in table 1. Conclusions: Increasing severities of HDP carry higher hazards of hypertension and stroke years later. HDP, including gestational hypertension alone, are also associated with future stroke mortality.

scholarly journals Hypertensive disorders of pregnancy and risk of asthma in offspring: protocol for a systematic review and meta-analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. e035145 ◽  
Author(s):  
Ping Li ◽  
Tao Xiong ◽  
Yong Hu
Keyword(s):  
Systematic Review ◽  
English Language ◽  
Data Extraction ◽  
Meta Analysis ◽  
Published Data ◽  
Hypertensive Disorders Of Pregnancy ◽  
Cross Sectional ◽  
Random Effects Models ◽  
Hypertensive Disorders ◽  
Increased Risk

IntroductionHypertensive disorders of pregnancy (HDP), one of the most common obstetrical complications, has been reported to have a controversial relationship with the increased risk of asthma in offspring. No systematic review of this topic has been performed. The aim of this systematic review will be to summarise the available evidence examining the association between HDP and the risk of asthma in offspring.Methods and analysisWe will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Meta-analysis of Observational Studies in Epidemiology guidelines. A systematic search of the PubMed, Embase, Cochrane and Web of Science databases will be performed using a detailed search strategy from database inception through 31 December 2019. Cohort, case-control and cross-sectional studies that report a diagnosis of maternal HDP and asthma in offspring will be included. Studies will be limited to the English language and include only human participants. Two independent reviewers will conduct the study selection, data extraction and risk of bias assessments using a standardised data extraction form. A meta-analysis will be performed to calculate overall pooled estimates using the generic inverse variance method. The data will be synthesised by either fixed-effect or random effects models according to heterogeneity tests. All analyses will be performed in Stata 14 and RevMan 5.3. High-quality evidence of the relationship between HDP and the risk of asthma in exposed offspring will be identified through the synthesis of current studies. In addition, the results of subgroup analyses and related secondary outcomes will be reported. The following will be concluded: (i) whether HDP increases the risk of asthma in offspring, (ii) whether HDP affects the severity of asthma in exposed offspring and (iii) whether possible differences in the risk of asthma among different HDP subgroups exist.Ethics and disseminationThere is no requirement for ethics approval because the meta-analysis and systematic review will be based on published data. It is anticipated that the dissemination of results will take place at conferences and through publication in a peer-reviewed journal.

Soy Consumption with Risk of Coronary Heart Disease and Stroke: A Meta-Analysis of Observational Studies

2016 ◽  
Vol 46 (4) ◽  
pp. 242-252 ◽  
Author(s):  
Danfei Lou ◽  
Yuehua Li ◽  
Guoliang Yan ◽  
Jianhong Bu ◽  
Haihui Wang
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cohort Studies ◽  
Observational Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Inverse Association ◽  
Case Control Studies ◽  
Relative Risks ◽  
Product Consumption

Background: The association of soy product consumption with the relative risk of cardiovascular disease remains controversial. This meta-analysis aimed at investigating whether an association exists between soy consumption and the risk of stroke and coronary heart disease (CHD) in observational studies. Methods: A systematic search of the PubMed and EMBASE databases was performed for case-control and cohort studies that assessed soy consumption and the risk of stroke and CHD. Summary relative risks (SRRs) and 95% CIs were combined by using a random-effects model. Results: Of a total of 1,266 abstracts, 5 prospective cohort and 6 case-control studies met our inclusion criteria, and comprised 4,954 stroke and 7,616 CHD events. Based on the high vs. low analyses, combining cohort studies showed no association between soy intake and risk of stroke (SRR 0.92; 95% CI 0.70-1.10; Pheterogeneity = 0.236; I2 = 29.4%) or CHD (SRR 0.97; 95% CI 0.74-1.27; Pheterogeneity = 0.020; I2 = 62.7%), although a significantly inverse association between soy intake and the risk of stroke (SRR 0.54; 95% CI 0.34-0.87; Pheterogeneity = 0.001; I2 = 79.3%) and CHD (SRR 0.66; 95% CI 0.56-0.77; Pheterogeneity = 0.421; I2 = 0) was observed in case-control studies. No association between soy isoflavone intake and the risk of stroke and CHD was identified. Conclusion: There was limited evidence to indicate that soy consumption was inversely associated with the risk of stroke and CHD, although further studies, with prospective designs that use validated questionnaires and control for important confounders, are warranted.

scholarly journals Maternal dietary patterns and risk of adverse pregnancy (hypertensive disorders of pregnancy and gestational diabetes mellitus) and birth (preterm birth and low birth weight) outcomes: a systematic review and meta-analysis

2018 ◽  
Vol 22 (3) ◽  
pp. 506-520 ◽  
Author(s):  
Kelemu Tilahun Kibret ◽  
Catherine Chojenta ◽  
Ellie Gresham ◽  
Teketo K Tegegne ◽  
Deborah Loxton
Keyword(s):  
Diabetes Mellitus ◽  
Birth Outcomes ◽  
Dietary Patterns ◽  
Meta Analysis ◽  
Whole Grains ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Pregnancy And Birth Outcomes ◽  
Adverse Pregnancy ◽  
Pregnancy And Birth

AbstractObjectiveEpidemiological studies have indicated that dietary patterns during pregnancy are associated with adverse pregnancy and birth outcomes such as hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), preterm birth (PTB) and low birth weight (LBW). However, the results of these studies are varied and inconsistent. The present study aimed to assess the association between dietary patterns and the risk of adverse pregnancy and birth outcomes.DesignSystematic review and meta-analysis. Seven databases were searched for articles. Two reviewers performed the study selection and data extraction. A random-effects model was used to estimate pooled effect sizes of eligible studies.SettingStudies conducted all over the world were incorporated.SubjectsThe review focused on pregnant women.ResultsA total of twenty-one studies were identified. Adherence to a healthy dietary pattern (intake of vegetables, fruits, legumes, whole grains) was significantly associated with lower odds (OR; 95 % CI) of pre-eclampsia (0·78; 0·70, 0·86; I2=39·0 %, P=0·178), GDM (0·78; 0·56, 0·99; I2=68·6 %, P=0·013) and PTB (0·75; 0·57, 0·93; I2=89·6 %, P=0·0001).ConclusionsOur review suggests that dietary patterns with a higher intake of fruits, vegetables, legumes, whole grains and fish are associated with a decreased likelihood of adverse pregnancy and birth outcomes. Further research should be conducted in low-income countries to understand the impact of limited resources on dietary intake and adverse pregnancy and birth outcomes.

scholarly journals Benzodiazepine use in pregnancy and major malformations or oral cleft: meta-analysis of cohort and case-control studies

BMJ ◽  
1998 ◽  
Vol 317 (7162) ◽  
pp. 839-843 ◽  
Author(s):  
L. R Dolovich ◽  
A. Addis ◽  
J M R. Vaillancourt ◽  
J D B. Power ◽  
G. Koren ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Oral Cleft ◽  
Benzodiazepine Use ◽  
In Pregnancy
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