On the Significance of Acheulean Biface Variability in Southern Britain

1998 ◽  
Vol 64 ◽  
pp. 15-44 ◽  
Author(s):  
Mark J. White

The significance of morphological variation in Acheulean bifaces has been a central issue in Palaeolithic research for well over a century. For much of that period interpretation has been dominated by culture-historical models and it is only in the past 20 years that other explanatory factors have received adequate attention. This paper examines the combined role of several of these factors – namely raw materials, reduction intensity, and function – on biface variability in the British Isles, with special reference to the two major shaped-based ‘tradition’ devised by Roe (1967; 1968). First-hand examination of bifaces from 19 assemblages suggests that final biface shape depends largely on the dimensions of the original raw materials and the technofunctional strategies designed to deal with them. Through these observations a new model is generated and tested. This suggests that the patterning in the British Acheulean simply reflects the nature of the resources available at a site and the hominid procurement and technological strategies used to exploit them. According to this model, well-worked ovates with all-round edges were preferentially produced wherever raw materials were large and robust enough to frequently support intensive reduction procedures, usually when obtained from primary flint sources. Assemblages characterised by partially-edged, moderately-reduced pointed forms were only manufactured when smaller, narrower blanks, that imposed restrictions on human technological actions regarding the location and extent of working, were exploited. Such blanks were usually obtained from a secondary flint source, such as river gravel. Thus, Roe's pointed and ovate ‘traditions’ are seen not as the products of different biface making populations, but as the same broad populations coping with the exigencies of a heterogeneous environment, using different resources in an adaptive, flexible manner.

2021 ◽  
Vol 12 ◽  
Author(s):  
Diego Catalán ◽  
Miguel Andrés Mansilla ◽  
Ashley Ferrier ◽  
Lilian Soto ◽  
Kristine Oleinika ◽  
...  

Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing immune responses and reestablishing immune homeostasis. The important role of Bregs in restraining the pathology associated with exacerbated inflammatory responses in autoimmunity and graft rejection has been consistently demonstrated, while more recent studies have suggested a role for this population in other immune-related conditions, such as infections, allergy, cancer, and chronic metabolic diseases. Initial studies identified IL-10 as the hallmark of Breg function; nevertheless, the past decade has seen the discovery of other molecules utilized by human and murine B cells to regulate immune responses. This new arsenal includes other anti-inflammatory cytokines such IL-35 and TGF-β, as well as cell surface proteins like CD1d and PD-L1. In this review, we examine the main suppressive mechanisms employed by these novel Breg populations. We also discuss recent evidence that helps to unravel previously unknown aspects of the phenotype, development, activation, and function of IL-10-producing Bregs, incorporating an overview on those questions that remain obscure.


1998 ◽  
Vol 89 (1) ◽  
pp. 47-61 ◽  
Author(s):  
Robin Trotter

Museums are currently undergoing a number of changes as a repercussion of their histories and professional developments, and of new social and cultural contexts, not to mention as a result of pressure from competition and economic forces. This article explores the current ‘reinvention’ of museums — in particular, national museums — by examining some of the factors of change — some of the major internal pressures that have been the result of museological initiatives and also various exogenous influences. New museology and postcolonialism represent not only separate forces, but also a synthesis of pressures that are not only changing the face, but also the role, of museums, whilst also transforming relationships between museums and their users. A concern of this study is to look at those museums which have a ‘nationalising’ function, and to determine whether changing policies and practices are inhibiting or advance a renegotiation of the relationships between museums and their constituencies. In the last two decades, we have seen some trends confirmed. There has been a move from material culture studies to concern with the ideas contained in objects, whilst the older notion of the museum as a treasure house has given way to a stronger educative role and, more recently, an information centre and also a site of leisure, entertainment and identity-formation. These ‘reinventive’ processes, it is suggested, are closely allied to a postcolonial imperative.


Author(s):  
Brian A. Mc Ardle ◽  
Jennifer M. Renaud ◽  
Robert A. deKemp ◽  
Rob S. B. Beanlands

Cardiac PET enables evaluation of multiple aspects of myocardial perfusion, metabolism, cell signaling and function that are of value both for diagnosis and prognostication in patients with known or suspected CAD and its use has increased in the past three decades. PET myocardial perfusion imaging (MPI) offers several technological advantages over SPECT including; higher photon energy, higher count sensitivity, more consistent attenuation correction and the ability to measure myocardial blood flow in absolute terms. These result in faster imaging times, lower patient radiation exposure and increased diagnostic accuracy. However the availability of PET MPI remains limited, predominantly due to expense. Efforts are underway to expand the use of PET MPI beyond larger centers, with lower-cost scanners and more widely available radiotracers. In this chapter we describe the latest advances in PET camera technology and image reconstruction as well as potential image artifacts specific to PET MPI. We go on to discuss diagnostic accuracy and prognostic value of PET MPI as well as its role in clinical practice.


Endocrinology ◽  
2020 ◽  
Vol 161 (9) ◽  
Author(s):  
Eric Lazartigues ◽  
Mirza Muhammad Fahd Qadir ◽  
Franck Mauvais-Jarvis

Abstract The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and thyroid diseases.


2020 ◽  
Vol 9 (1) ◽  
pp. 83-102 ◽  
Author(s):  
Kiera Lindsey

This article discusses a recent art project created by the Wiradjuri and Kamilaroi artist Jonathon Jones, which was commissioned to commemorate the opening of the revitalized Hyde Park Barracks in Sydney in early 2020. Jones’ work involves a dramatic installation of red and white crushed stones laid throughout the grounds of the barracks, merging the image of the emu footprint with that of the English broad convict arrow to ‘consider Australia’s layered history and contemporary cultural relations’. This work was accompanied by a ‘specially-curated programme’ of performances, workshops, storytelling and Artist Talks. Together, these elements were designed to unpack how certain ‘stories determine the ways we came together as a nation’. As one of the speakers of the Artist Talk’s programme, I had a unique opportunity to experiment with what colleagues and I have been calling ‘Creative histories’ in reference to the way some artists and historians are choosing to communicate their research about the past in ways that experiment with form and function and push disciplinary or generic boundaries. This article reflects upon how these two distinct creative history projects – one visual art, the other performative – renegotiate the complex and contested pasts of the Hyde Park Barracks. I suggest that both examples speak to the role of memory and creativity in shaping cultural responses to Australia’s colonial past, while Jones' programme illustrates how Indigenous artists and academics are making a profound intervention into contemporary understandings of how history is ‘done’ in Australia.


2013 ◽  
Vol 27 (1) ◽  
pp. 1-10 ◽  
Author(s):  
CARSTEN STAHN ◽  
ERIC DE BRABANDERE

Like international legal scholarship, LJIL is in transition. Our colleagues, Larissa van den Herik and Jean d'Aspremont, who have shaped much of the role and plural identity of the journal over the past decade, in collaboration with our different sections, have passed leadership on to us, the new team of (co-)editors-in-chief. This editorial reflects on the changing role and function of scholarship in international law, a theme important to our predecessors and ourselves. This is to some extent a niche area. It has not received much attention in discourse. With some notable exceptions, legal journals are typically reluctant to address overarching meta-issues of discourse, i.e. issues of production of scholarship, the role of journals vis-à-vis other media, or the broader direction of the development of international legal scholarship. Such issues might be perceived as non-scientific by some. We feel that it is important to include such dimensions, including critical self-reflection on our discipline, in international legal discourse.


2019 ◽  
Vol 13 ◽  
pp. 117906951984644 ◽  
Author(s):  
Jessica McFadyen

Over the past few decades, evidence has come to light that there is a rapid subcortical shortcut that transmits visual information to the amygdala, effectively bypassing the visual cortex. This pathway purportedly runs from the superior colliculus to the amygdala via the pulvinar, and thus presents a methodological challenge to study noninvasively in the human brain. Here, we present our recent work where we reliably reconstructed the white matter structure and directional flow of neural signal along this pathway in over 600 healthy young adults. Critically, we found structure-function relationships for the pulvinar-amygdala connection, where people with greater fibre density had stronger functional neural coupling and were also better at recognising fearful facial expressions. These results tie together recent anatomical evidence from other visual primates with very recent optogenetic research on rodents demonstrating a functional role of this pathway in producing fear responses. Here, we discuss how this pathway might operate alongside other thalamo-cortical circuits (such as pulvinar to middle temporal area) and how its structure and function may change according to the sensory input it receives. This newly established circuit might play a potentially important role in autism and/or anxiety disorders.


Author(s):  
Edward G. Fey

In the past few years, considerable advances have been made regarding the structure and function of the nuclear matrix. In the first half of this presentation, the field of nuclear matrix research will be summarized. Emphasis will be placed on those studies where molecular interactions are demonstrated in situ utilizing high resolution light and/or electron microscopy. Studies demonstrating the role of the nuclear matrix in DNA synthesis and replication, RNA transcription and processing, and the binding of matrix attachment regions to specific nuclear matrix proteins will be summarized.


Author(s):  
Kenneth M. Holland

Over the past five years the Supreme Court of Canada has addressed on three occasions the implications of the 1982Charter of Rights and Freedomsfor the principle of judicial independence. The justices agree that the Court's new role as guardian of constitutionally entrenched civil rights and liberties demands an expansion in its immunity from legislative and executive influence. The hoary principle of judicial independence can no longer be confined to such individual elements as security of salary and tenure but must encompass an institutional element, “reflected in [a court's] institutional or administrative relationships to the executive and legislative branches of government.” The “modern understanding of judicial independence,” according to Chief Justice Brian Dickson, recognizes that the Canadian judiciary is no longer confined to the resolution of disputes in individual cases but plays the role of “protector of theConstitutionand the fundamental values embodied in it—rule of law, fundamental justice, equality, preservation of the democratic process, to name perhaps the most important.” It is not enough, therefore, to ensure the impartiality of judges in individual cases. Courts must “be completely separate in ‘authority and function’ from all other branches of government.” Accordingly, the Court ruled in a 1989 case that a royal commission of inquiry cannot compel judges involved in a matter being investigated to testify as to the reasons for their judicial decision.


1982 ◽  
Vol 57 (3) ◽  
pp. 301-308 ◽  
Author(s):  
W. Kemp Clark

✓ The President of the American Association of Neurological Surgeons concentrates on the problems facing the specialty, the achievements of the past, and the mechanisms designed to foster the advancement and role of neurosurgery. To counter the difficult days ahead, he emphasizes the need for concerted effort and action on the part of neurosurgeons within the umbrella of the Association as spokesman for the specialty and advocate for the patients' welfare.


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