scholarly journals The Role of Axonal Transport in Neurodegenerative Disease Spread: A Meta-Analysis of Experimental and Clinical Poliomyelitis Compares with Amyotrophic Lateral Sclerosis

1991 ◽  
Vol 18 (S3) ◽  
pp. 435-438 ◽  
Author(s):  
Benjamin Rix Brooks
Keyword(s):  
Spinal Cord ◽  
Axonal Transport ◽  
Neuronal Degeneration ◽  
Meta Analysis ◽  
Gender Effects ◽  
The Other ◽  
Disease Spread ◽  
Local Spread ◽  
Other Hand ◽  
Bulbar Onset

ABSTRACT:ALS symptom spread results from local spread of the neuronal degeneration because contiguous areas are more quickly involved than non-contiguous areas. Local spread to contiguous areas of motor neuron dysfunction is faster at the brainstem, cervical and lumbar regions than spread to non-continguous areas. The time for caudal-rostral symptomatic spread of ALS to involve a distant region is a function of the distance of that region from the site of onset. The time for spread to the bulbar region is shorter following arm onset than leg onset. Spread to non-contiguous areas is faster within the spinal cord than from the spinal cord to the bulbar region. These kinetics are consistent with axonal transport of the etiological agent in a manner similar to spread of poliovirus in poliomyelitis patients. Spread from the bulbar region to the spinal cord, on the other hand, occurs faster than symptom spread from the limb region to the bulbar region in limb onset patients. This rapid limb involvement following bulbar onset is more dramatic in males compared with females. Females with leg onset, on the other hand, show more rapid involvement of the opposite leg, either arm or bulbar structures than males. Gender effects may determine the course of ALS depending on the original site of onset.

Stories and the Self

2020 ◽  
Vol 32 (2) ◽  
pp. 47-58 ◽  
Author(s):  
Stefan Krause ◽  
Markus Appel
Keyword(s):  
Meta Analysis ◽  
The Self ◽  
The Other ◽  
Lower Degree ◽  
Contrast Effects ◽  
Self Perception ◽  
Self Perceptions ◽  
Other Hand ◽  
The One ◽  
Implicit And Explicit

Abstract. Two experiments examined the influence of stories on recipients’ self-perceptions. Extending prior theory and research, our focus was on assimilation effects (i.e., changes in self-perception in line with a protagonist’s traits) as well as on contrast effects (i.e., changes in self-perception in contrast to a protagonist’s traits). In Experiment 1 ( N = 113), implicit and explicit conscientiousness were assessed after participants read a story about either a diligent or a negligent student. Moderation analyses showed that highly transported participants and participants with lower counterarguing scores assimilate the depicted traits of a story protagonist, as indicated by explicit, self-reported conscientiousness ratings. Participants, who were more critical toward a story (i.e., higher counterarguing) and with a lower degree of transportation, showed contrast effects. In Experiment 2 ( N = 103), we manipulated transportation and counterarguing, but we could not identify an effect on participants’ self-ascribed level of conscientiousness. A mini meta-analysis across both experiments revealed significant positive overall associations between transportation and counterarguing on the one hand and story-consistent self-reported conscientiousness on the other hand.

scholarly journals THE PATHOLOGIC EFFECTS OF STREPTOCOCCI FROM CASES OF POLIOMYELITIS AND OTHER SOURCES

1917 ◽  
Vol 25 (4) ◽  
pp. 557-580 ◽  
Author(s):  
Carroll G. Bull
Keyword(s):  
Spinal Cord ◽  
Guinea Pigs ◽  
The Other ◽  
Laboratory Animals ◽  
Histological Changes ◽  
Other Hand ◽  
Brain And Spinal Cord ◽  
The Brain

Streptococci cultivated from the tonsils of thirty-two cases of poliomyelitis were used to inoculate various laboratory animals. In no case was a condition induced resembling poliomyelitis clinically or pathologically in guinea pigs, dogs, cats, rabbits, or monkeys. On the other hand, a considerable percentage of the rabbits and a smaller percentage of some of the other animals developed lesions due to streptococci. These lesions consisted of meningitis, meningo-encephalitis, abscess of the brain, arthritis, tenosynovitis, myositis, abscess of the kidney, endocarditis, pericarditis, and neuritis. No distinction in the character or frequency of the lesions could be determined between the streptococci derived from poliomyelitic patients and from other sources. Streptococci isolated from the poliomyelitic brain and spinal cord of monkeys which succumbed to inoculation with the filtered virus failed to induce in monkeys any paralysis or the characteristic histological changes of poliomyelitis. These streptococci are regarded as secondary bacterial invaders of the nervous organs. Monkeys which have recovered from infection with streptococci derived from cases of poliomyelitis are not protected from infection with the filtered virus, and their blood does not neutralize the filtered virus in vitro. We have failed to detect any etiologic or pathologic relationship between streptococci and epidemic poliomyelitis in man or true experimental poliomyelitis in the monkey.

Translocation of the neuronal cytoskeleton and axonal locomotion

1982 ◽  
Vol 299 (1095) ◽  
pp. 313-327 ◽  
Keyword(s):  
Plasma Membrane ◽  
Axonal Transport ◽  
Cell Body ◽  
Cytoskeletal Proteins ◽  
The Other ◽  
Current Understanding ◽  
Axonal Elongation ◽  
Neuronal Cytoskeleton ◽  
Other Hand ◽  
Neuron Cell Body

Recent studies of axonal transport indicate that cytoskeletal proteins are assembled into polymers in the neuron cell body and that these polymers move from the cell body toward the end of the axon. On the other hand, membranous elements appear to be inserted into the axonal plasma membrane preferentially at the end of the axon. These new observations are explored in relation to our current understanding of axonal elongation.

scholarly journals A Meta-Analysis on the Effect of Complex Training on Vertical Jump Performance

2020 ◽  
Vol 71 (1) ◽  
pp. 255-265
Author(s):  
Jeffrey Pagaduan ◽  
Haris Pojskic
Keyword(s):  
Meta Analysis ◽  
Vertical Jump ◽  
The Other ◽  
Plyometric Training ◽  
Jump Performance ◽  
Other Hand ◽  
Plyometric Exercise ◽  
Traditional Resistance Training ◽  
Complex Training ◽  
The Difference

AbstractComplex training (CT) is a strength training intervention performed by completing all the sets of a resistance exercise followed by a series of high-velocity/plyometric exercise/s. The purpose of this novel study was to conduct a meta-analysis on the effect of CT on vertical jump (VJ) performance. Five electronic databases were searched using terms related to CT and the VJ. Studies needed to include randomized trials comparing CT with traditional resistance training (RT)/plyometric training (PLYO)/control (CON) lasting ≥ 4 weeks and the VJ as a dependent variable. Seven studies qualified for the meta-analysis with two studies differentiating VJ performance from CT and RT, two studies comparing VJ performance of CT and PLYO, and two studies establishing the difference in VJ performance between CT and CON. Results indicated similar improvement in VJ performance from CT and RT (p = 0.88). On the other hand, greater VJ performance in CT than PLYO was identified (ES = 0.86; 95% CI 0.24, 1.47; p = 0.01). CT also showed significantly greater enhancement in VJ compared to CON (ES = 1.14; 95% CI 0.60, 1.68; p < 0.01). In conclusion, CT can serve as alternative training from RT in improving VJ performance. On the other hand, CT is a better option in VJ enhancement than PLYO and CON.

scholarly journals Sero-prevalence of syphilis and associated factors among pregnant women in Ethiopia: a systematic review and meta-analysis

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Habtamu Geremew ◽  
Demeke Geremew
Keyword(s):  
Systematic Review ◽  
Pregnant Women ◽  
Associated Factors ◽  
Meta Analysis ◽  
Regional Analysis ◽  
The Other ◽  
Transmitted Infection ◽  
Other Hand ◽  
Pooled Prevalence ◽  
History Of

Abstract Background Syphilis remained a major cause of reproductive morbidity and poor pregnancy outcomes in developing countries. Previously, studies showed inconsistent results and failed to show the actual picture of the diseases in Ethiopia. Thus, the aim of this meta-analysis was, first, to determine the updated pooled prevalence of syphilis among pregnant women in Ethiopia and, second, to assess its associated factors. Methods A comprehensive search was made on PubMed, Google scholar, Science Direct, and African Journals Online databases to identify relevant articles. A random effects model was used to estimate pooled syphilis prevalence and odds ratio (OR) with the respective 95% confidence intervals (CIs) using STATA 14 statistical software. I2 statistics and Egger’s regression test in conjunction with funnel plot was used to determine heterogeneity and publication bias among included studies respectively. Result We identified 13 suitable studies in this analysis. Accordingly, the pooled prevalence of syphilis among pregnant women in Ethiopia was 2.32% (95% CI, 1.68–2.97). Specifically, syphilis prevalence was 2.53% (95% CI, 1.92–3.14%) and 1.90% (95% CI, 0.40–3.40%) as per the treponemal and non-ytreponemal diagnostic test, respectively. On the other hand, regional analysis indicated that 4.06% (95% CI, 2.86–5.26) in Southern Nations Nationalities and Peoples (SNNP), 2.16% (95% CI, 1.57–2.75) in Amhara and 1.46% (95% CI, 0.69–2.23) in Oromia region. Being married (OR, 0.37 (95% CI, 0.12–0.91%)) was less likely to develop syphilis. On the other hand, women with history of multiple sexual partner (OR, 2.98 (95% CI, 1.15–7.70)) and women with history of previous sexually transmitted infection (STI) (OR, 4.88 (95% CI, 1.35–17.62)) have higher risk to develop syphilis. Besides, the pooled syphilis-HIV coinfection was 0.80% (95% CI, 0.60–1.01%). Conclusion This study provides evidence of relatively high prevalence of syphilis among pregnant women in Ethiopia. Therefore, it is recommended to further ramping up of current intervention measures to prevent future generations. Systematic review registration PROSPERO CRD42020211650

scholarly journals Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to vasculitis: a meta-analysis

2012 ◽  
Vol 13 (1) ◽  
pp. 196-201 ◽  
Author(s):  
Young Ho Lee ◽  
Sung Jae Choi ◽  
Jong Dae Ji ◽  
Gwan Gyu Song
Keyword(s):  
Kawasaki Disease ◽  
Confidence Interval ◽  
Angiotensin Converting Enzyme ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Wegener's Granulomatosis ◽  
The Other ◽  
Converting Enzyme ◽  
Deletion Polymorphism ◽  
Other Hand

Introduction: To explore whether the insertion (I) and deletion (D) polymorphism of angiotensin-converting enzyme ( ACE) confers susceptibility to vasculitis. Materials and methods: A meta-analysis was conducted on the associations between the ACE I/D polymorphism and vasculitis. Results: Twelve studies, including four on Behçet’s disease (BD), four on Henoch–Schenlein purpura (HSP), three on Kawasaki disease (KD), and one on Wegener’s granulomatosis, were available for the meta-analysis. Meta-analysis showed that the DD + ID genotype was associated with susceptibility to vasculitis (odds ratio [OR] 1.468, 95% confidence interval [CI] 1.214–1.468, p = 7.4 × 10−5). The overall OR for the D allele was significantly increased in BD (OR 1.313, 95% CI 1.017–1.695). Meta-analysis of the DD+ID genotype, the DD genotype and the DD vs. II genotype showed marginal associations with BD, but meta-analysis of the D allele, and the DD+ID genotype showed significant associations with HSP (OR 1.446, 95% CI 1.021–2.049, p = 0.038; OR 1.881, 95% CI 1.385–2.595, p = 6.6 × 10−5). On the other hand, meta-analysis showed no association between KD and the ACE I/D polymorphism. Conclusions: This meta-analysis shows that the ACE I/D polymorphism is associated with vasculitis susceptibility, especially in BD and HSP.

scholarly journals Radiation therapy and breast reconstruction

2020 ◽  
pp. 10-14
Author(s):  
V. I. Apanasevich ◽  
I. S. Gulian ◽  
N. O. Nikiforova ◽  
Y. Y. Petukhova ◽  
O. V. Korshunova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Breast Reconstruction ◽  
Meta Analysis ◽  
The Other ◽  
Acellular Matrix ◽  
Other Hand ◽  
Integral Component ◽  
Capsular Contractures

Radiation therapy is an integral component of the treatment of breast cancer. Although its implementing after breast reconstruction sufficiently increases the number of complications, particularly capsular contractures. After having analyzed published materials and meta-analysis research the authors made a conclusion – if a patient is planned to have a breast reconstruction, it’s better to make it with her own tissue. On the other hand the risk of capsular contractures development significantly decreases when using acellular matrix and polyurethane shell to cover the implant. This fact gives hope that conflict between breast reconstruction and the necessity of the radiation therapy can be solved.

scholarly journals Associations of Dietary and Circulating Vitamin E Level With Metabolic Syndrome. A Meta-Analysis of Observational Studies

2021 ◽  
Vol 8 ◽  
Author(s):  
Yi Zhang ◽  
Jun Ding ◽  
Hongbin Guo ◽  
Ze Liu ◽  
Qi Liu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin E ◽  
Observational Studies ◽  
Meta Analysis ◽  
The Other ◽  
Dietary Vitamin ◽  
Current Evidence ◽  
Control Subjects ◽  
Other Hand ◽  
Standard Mean Difference

Objective: The associations of dietary and circulating vitamin E level with metabolic syndrome (MetS) remains conflicting. This meta-analysis of observational study was therefore employed to investigate the issue above.Methods: The PubMed, Web of Science and Embase database were searched up to April 2021. The observational studies on the associations of dietary and circulating vitamin E level with MetS were specified. The pooled relative risk (RR) of MetS for the highest vs. lowest dietary and circulating vitamin E level, and the standard mean difference (SMD) of dietary and circulating vitamin E level for MetS vs. control subjects, were calculated.Results: A total of 25 observational studies with 51,276 participants, were included in this meta-analysis. The overall multi-variable adjusted RR demonstrated that the dietary vitamin E level was inversely associated with MetS (RR = 0.92, 95%CI: 0.85–1.00; P = 0.044). In addition, the dietary vitamin E level in MetS was also lower than that in control subjects according to the overall combined SMD (SMD = −0.08, 95%CI: −0.14 to −0.02; P = 0.024). On the other hand, the overall multi-variable adjusted RR showed no significant relationship between the circulating vitamin E level and MetS (RR = 1.46, 95%CI: 0.85–2.48; P = 0.17). However, the circulating vitamin E level in MetS was lower than that in control subjects according to the overall combined SMD (SMD = −0.58, 95%CI: −1.04 to −0.13; P = 0.013).Conclusions: The results of this meta-analysis suggest that the dietary vitamin E level is inversely associated with MetS. On the other hand, current evidence is still insufficient to conclude a relationship between the circulating vitamin E level and MetS. More well-designed prospective cohort studies are needed to address the issues further.

scholarly journals COVID – 19: a test for globalization

2021 ◽  
pp. 289-306
Keyword(s):  
Public Health ◽  
World Order ◽  
The Other ◽  
Disease Spread ◽  
Conceptual Approach ◽  
Wuhan City ◽  
Other Hand ◽  
The Future ◽  
The Moment ◽  
The One

In the last days of 2019, when the whole world was waiting for the moment to enter a new decade, a strange kind of unexplained pneumonia appeared in Wuhan city, China. From the little information as well as attention initially, this epidemic has turned into a pandemic worldwide. The quick-fire coronavirus spread and the response of different countries to it highlight immediate concerns about public health and have a significant impact on the evolving world order and the values that underpin it. This pandemic is unprecedented in its capacity to take advantage of modern globalization, allowing for massive disease spread at a surprising speed. It can say that COVID-19 is an additional blow to the vision and practices of the globalization process that is already under strain. Using the conceptual approach, the article, on the one hand, tried to analyze the challenges that globalization is facing because of COVID-19. On the other hand, the study want to affirm that globalization will still be an irreplaceable trend in the future.

scholarly journals Better pain control with 8-gray single fraction palliative radiotherapy for skeletal metastases: a Bayesian network meta-analysis

2021 ◽  
Author(s):  
Filippo Migliorini ◽  
Jörg Eschweiler ◽  
Andromahi Trivellas ◽  
Arne Driessen ◽  
Matthias Knobe ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bayesian Network ◽  
Pain Control ◽  
Meta Analysis ◽  
Cord Compression ◽  
The Other ◽  
Skeletal Metastases ◽  
Pain Response ◽  
Pathological Fractures ◽  
Single Fraction

AbstractExternal Beam Radiotherapy (EBRT) allows remarkable pain control in patients with skeletal metastases. We performed a Bayesian network meta-analysis comparing the most commonly used radiotherapy regimens for palliative management in patients with skeletal metastases. The main online databases were accessed in October 2020. All randomized clinical trials evaluating the irradiation of painful bone metastases were considered. The following irradiation patterns were analysed and included in the present network meta-analysis: 8 Gy- and 10 Gy/single fraction, 20 Gy/5 fractions, 30 Gy/10 fractions. The Bayesian hierarchical random-effect model analysis was adopted in all comparisons. The Log Odds-Ratio (LOR) statistical method for dichotomic data was adopted for analysis. Data from 3595 patients were analysed. The mean follow-up was 9.5 (1 to 28) months. The cumulative mean age was 63.3 ± 2.9. 40.61% (1461 of 3595 patients) were female. The 8Gy/single fraction protocol detected reduced rate of “no pain response” (LOR 3.39), greater rate of “pain response” (LOR-5.88) and complete pain remission (LOR-7.05) compared to the other dose patterns. The 8Gy group detected a lower rate of pathological fractures (LOR 1.16), spinal cord compression (LOR 1.31) and re-irradiation (LOR 2.97) compared to the other dose patterns. Palliative 8Gy/single fraction radiotherapy for skeletal metastases shows outstanding results in terms of pain control, re-irradiations, pathological fractures and spinal cord compression, with no differences in terms of survivorship compared to the other multiple dose patterns.Level of evidence: I, Bayesian network meta-analysis of RCTs.

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