Effects of Platelet-Activating Factor on Leukocyte Adhesion in the Guinea Pig Aorta
1985 ◽
Vol 43
◽
pp. 684-685
Keyword(s):
Platelet-activating factor (PAF) is a potent mediator of immune anaphylaxis. In a dose-dependent manner, PAF can induce such effects as thrombocytopenia, neutropenia, hypotension, bronchoconstriction, hemoconcentration, and negative inotropic cardiac effects. By intradermal or intravenous injection, PAF has been shown to induce blood vessel hyperpermeability resulting in extravasation of plasma, leukocyte adhesion and subsequent diapedesis. However, most studies of endothelial-leukocyte interactions have been limited to small vessels. We have examined the effects of PAF on endothelial structure and leukocyte involvement in the guinea pig aorta.
1996 ◽
Vol 270
(3)
◽
pp. L368-L375
◽
1984 ◽
Vol 52
(01)
◽
pp. 034-036
◽
Keyword(s):
2019 ◽
Vol 18
(1)
◽
pp. 34-38
1992 ◽
Vol 1
(6)
◽
pp. 375-377
◽
1990 ◽
Vol 259
(1)
◽
pp. H62-H67
◽
1994 ◽
Vol 267
(4)
◽
pp. G523-G528
Keyword(s):