Association between Chlamydia trachomatis antibodies and subfertility in the Northern Finland Birth Cohort 1966 (NFBC 1966), at the age of 31 years

The objective of this study was to assess the serological association between previous Chlamydia trachomatis infection and subfertility in a general population sample. A nested case (n=493)-control (n=986) study in a population-based birth cohort consisting of 12058 live births from the year 1966 was conducted. The analysis was restricted to those 6007 cohort members who replied to a postal inquiry and participated in a health examination including blood samples at the age of 31 years. The presence of C. trachomatis-specific serum IgG antibodies was screened by a synthetic peptide-based enzyme-linked immunosorbent assay. All the positive sera were further tested by the microimmunofluorescence method using immunotype pools and individual immunotypes of C. trachomatis as antigens. An association was found between the detection of immunotype-specific C. trachomatis antibodies and subfertility both in men and women. The results of the present study confirm the serological association between past C. trachomatis infections and subfertility in male or female partners of the couple in the population-based sample.

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Population-Based Validation of a German-Language Self-Administered Headache Questionnaire

Cephalalgia ◽

10.1111/j.1468-2982.2008.01560.x ◽

2008 ◽

Vol 28 (6) ◽

pp. 605-608 ◽

Cited By ~ 35

Author(s):

M-S Yoon ◽

M Obermann ◽

G Fritsche ◽

M Slomke ◽

P Dommes ◽

...

Keyword(s):

General Population ◽

Population Sample ◽

Population Based ◽

Tension Type Headache ◽

German Language ◽

General Population Sample ◽

Trigeminal Autonomic Cephalalgia ◽

Screening Questionnaires ◽

Headache Clinic ◽

Type Headache

We validated a German-language self-administered headache questionnaire for migraine (M), tension-type headache (TTH) and trigeminal autonomic cephalalgia (TAC) in a general population sample of people with headache. Randomly selected subjects ( n = 240) diagnosed by the questionnaire as M ( n = 60), TTH ( n = 60), a combination of M and TTH (M+TTH, n = 60) and TAC ( n = 60) were invited for examination by headache specialists. One hundred and ninety-three subjects (80%) were studied. Sensitivity and specificity for M were 0.85 and 0.85, for TTH 0.6 and 0.88, for M+TTH 0.82 and 0.87, respectively. Cohen's κ was 0.6 (95% confidence interval 0.50, 0.71). Of 45 patients with TAC according to the questionnaire, physicians diagnosed cluster headache in two patients only. We conclude: (i) the questionnaire can be used to diagnose M, TTH and M+TTH, but not TAC; (ii) screening questionnaires for epidemiological research should be validated in a general population sample but not in a tertiary headache clinic.

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Long-term antipsychotic use and its association with outcomes in schizophrenia – the Northern Finland Birth Cohort 1966

European Psychiatry ◽

10.1016/j.eurpsy.2016.03.002 ◽

2016 ◽

Vol 36 ◽

pp. 7-14 ◽

Cited By ~ 10

Author(s):

J.M. Moilanen ◽

M. Haapea ◽

E. Jääskeläinen ◽

J.M. Veijola ◽

M.K. Isohanni ◽

...

Keyword(s):

Birth Cohort ◽

Population Sample ◽

Population Based ◽

Current Treatment ◽

Illness Onset ◽

Mean Lifetime ◽

Poor Outcomes ◽

Drug Free

AbstractBackgroundDue to the paucity of previous studies, we wanted to elucidate the pharmacoepidemiology of antipsychotics in schizophrenia in a general population sample, and the association between long-term antipsychotic use and outcomes.MethodsThe sample included 53 schizophrenia subjects from the Northern Finland Birth Cohort 1966 with at least ten years of follow-up (mean 18.6 years since illness onset). Data on lifetime medication and outcomes (remission, Clinical Global Impression [CGI], Social and Occupational Functioning Assessment Scale [SOFAS]) were collected from medical records, interviews, and national registers.ResultsDuring the first two years 22 (42%), between two to five years 17 (32%), and between five to ten years 14 (26%) subjects had used antipsychotics less than half of the time. Drug-free periods became rarer during the follow-up. The mean lifetime daily dose of antipsychotics was 319 mg in chlorpromazine equivalents. A high lifetime average and cumulative dose and antipsychotic polypharmacy were associated with a poorer outcome in all measures, whereas having no drug-free periods was associated with a better SOFAS score and a low proportion of time on antipsychotics with a better CGI score.ConclusionsIn our population-based sample, the use of antipsychotics increased during the first five years of illness and was relatively stable after that. Our results suggest that both low dose and proportion of use, and having no drug-free periods, are associated with better outcomes, which concords with current treatment recommendations and algorithms. High long-term doses and polypharmacy may relate to poor outcomes.

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The Wuhan Twin Birth Cohort (WTBC)

Twin Research and Human Genetics ◽

10.1017/thg.2017.24 ◽

2017 ◽

Vol 20 (4) ◽

pp. 355-362

Author(s):

Jinzhu Zhao ◽

Shaoping Yang ◽

Anna Peng ◽

Zhengmin Qian ◽

Hong Xian ◽

...

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Medical Information ◽

First Trimester ◽

Population Based ◽

Health Examination ◽

Birth Registry ◽

Twin Birth ◽

First Trimester Of Pregnancy

The Wuhan Pre/Post-Natal Twin Birth Registry (WPTBR) is one of the largest twin birth registries with comprehensive medical information in China. It recruits women from the first trimester of pregnancy and their twins from birth. From January 2006 to May 2016, the total number of twins enrolled in WPTBR is 13,869 twin pairs (27,553 individuals). The WPTBR initiated the Wuhan Twin Birth Cohort (WTBC). The WTBC is a prospective cohort study carried out through incorporation of three samples. The first one comprises 6,920 twin pairs, and the second one, 6,949 twin pairs. Both are population-based samples linked to the WPTBR and include pre- and post-natal information from WPTBR. The second sample includes neonatal blood spots as well. Using a hospital-based approach, we recently developed a third sample with a target enrolment of 1,000 twin pairs and their mothers. These twins are invited, via their parents, to participate in a periodic health examination from the first trimester of pregnancy to 18 years. Biological samples are collected initially from the mother, including blood, urine, cord blood, cord, amniotic fluid, placenta, breast milk and meconium, and vaginal secretions, and later from the twins, including meconium, stool, urine, and blood. This article describes the design, recruitment, follow-up, data collection, and measures, as well as ongoing and planned analyses at the WTBC. The WTBC offers a unique opportunity to follow women from prenatal to postnatal, as well as follow-up of their twins. This cohort study will expand the understanding of genetic and environmental influences on pregnancy and twins’ development in China.

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Beyond resilients, undercontrollers, and overcontrollers? an extension of personality prototype research

European Journal of Personality ◽

10.1002/per.557 ◽

2006 ◽

Vol 20 (1) ◽

pp. 5-28 ◽

Cited By ~ 52

Author(s):

Philipp Yorck Herzberg ◽

Marcus Roth

Keyword(s):

General Population ◽

Big Five ◽

Population Sample ◽

Population Based ◽

Cluster Solution ◽

General Population Sample ◽

Discriminant Functions ◽

Cluster Approach

Prototypes of personality were investigated in two studies. In study I, clusters of Big‐Five‐based prototypes were examined using a general population sample of 1908 German adults. Convergent evidence suggested the appropriateness of a five‐cluster solution, which corresponds to previously identified temperament based prototypes. In study II, the five‐cluster solution was cross‐validated in a sample of 256 prisoners. Moreover, it was shown that a population‐based approach (using discriminant functions derived from study I) was superior over the traditional sample‐based cluster approach (using Ward followed by k‐means). The authors argue that future typological research can be sufficiently grounded on a five‐prototype conception rather than on a three‐prototype conception, and suggest a new and flexible assignment procedure. Copyright © 2006 John Wiley & Sons, Ltd.

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The detection of specific antibody formation to recall antigens after human bone marrow transplantation

Blood ◽

10.1182/blood.v67.3.582.582 ◽

1986 ◽

Vol 67 (3) ◽

pp. 582-587 ◽

Cited By ~ 53

Author(s):

LG Lum ◽

NA Munn ◽

MS Schanfield ◽

R Storb

Keyword(s):

Measles Virus ◽

Chronic Gvhd ◽

Enzyme Linked Immunosorbent Assay ◽

Igg Antibodies ◽

Short Term ◽

Specific Serum ◽

Antibody Titers ◽

One Year ◽

Long Term Survivors

Abstract The results of this study show that donor-derived immunity can be detected and persists in long-term survivors with and without chronic graft-v-host disease (GVHD) after human marrow grafting. Seventy-one marrow recipients (60 long-term and 11 short-term survivors) were studied for the presence of specific serum IgG antibodies to tetanus toxoid (TT), and 46 marrow recipients (35 long-term and 11 short-term) were tested for antibodies to diphtheria toxoid (DT) and measles virus after marrow grafting using an enzyme-linked immunosorbent assay. Of the 60 long-term survivors, 31 were healthy and 29 had chronic GVHD. None of the recipients were immunized to the test antigens postgrafting. Most long-term healthy recipients exhibited antibody titers to the recall test antigens, whereas only a minority of those with chronic GVHD had antibody titers to recall antigens. In healthy long-term recipients (greater than or equal to one year postgrafting) whose donors were immune to the test antigens, 25 of 31 had titers to TT, 11 of 17 had titers to DT, and 12 of 20 had titers to measles. In recipients with C-GVHD, 13 of 29 had titers to TT, six of 15 had titers to DT, and six of 15 had titers to measles virus. Within 100 days postgrafting, 11 of 11 had anti-TT titers, ten of ten had anti-DT titers, and seven of eight had antimeasles virus titers.

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Chlamydia trachomatisSerology in Women with and without Ovarian Cancer

Infectious Diseases in Obstetrics and Gynecology ◽

10.1155/2008/219672 ◽

2008 ◽

Vol 2008 ◽

pp. 1-5 ◽

Cited By ~ 15

Author(s):

Roberta B. Ness ◽

Caixia Shen ◽

Debra Bass ◽

Carlynn Jackson ◽

Kristen Moysich ◽

...

Keyword(s):

Ovarian Cancer ◽

Chlamydia Trachomatis ◽

Pelvic Inflammatory Disease ◽

Inflammatory Disease ◽

Surrogate Marker ◽

Population Based ◽

Elisa Assay ◽

Igg Antibodies

Pelvic inflammation has been implicated in the genesis of ovarian cancer. We conducted serologic measurements ofChlamydia trachomatisantibodies as a surrogate marker of chlamydial pelvic inflammatory disease. Women with ovarian cancer (n=521) and population-based controls (n=766) were tested. IgG antibodies to serovar D of chlamydia elementary bodies (EBs) were detected using an ELISA assay. The odds of having ovarian cancer among women with the highest titers (≥0.40 OD units) were 0.6 (95% CI 0.4–0.9). These data do not support our earlier finding of elevated titers for antibodies toC. trachomatisamong women with ovarian cancer.

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Serological Investigation of Chlamydia trachomatis Heat Shock Protein 10

Infection and Immunity ◽

10.1128/iai.67.10.5243-5246.1999 ◽

1999 ◽

Vol 67 (10) ◽

pp. 5243-5246 ◽

Cited By ~ 9

Author(s):

Fotini Betsou ◽

Jean Marie Sueur ◽

Jeanne Orfila

Keyword(s):

Heat Shock ◽

Chlamydia Trachomatis ◽

Heat Shock Protein ◽

Genital Tract ◽

Chlamydia Pneumoniae ◽

Enzyme Linked Immunosorbent Assay ◽

Igg Antibodies ◽

Genital Tract Infection ◽

Humoral Immune ◽

Tract Infections

ABSTRACT The humoral immune response to Chlamydia trachomatis10-kDa heat shock protein (Chsp10) in populations of Russian and French origin was studied by using a recombinant Chsp10 enzyme-linked immunosorbent assay. A physiological but not a serological correlation of Chsp10 exposure with Chsp60 exposure was observed in the Russian population. In the French population studied, there was a significant association between detection of anti-r-Chsp10 immunoglobulin G (IgG) antibodies and chronic genital tract infections. Chsp10 residues 50 to 67 were found to contain an immunodominant although not universal B epitope. Cross-reactions with Chlamydia pneumoniae orEscherichia coli GroES protein are limited but may occur. Our study suggests that detection of anti-Chsp10 IgG antibodies is associated with chronicity of C. trachomatis genital tract infection and does not parallel that of anti-Chsp60 IgG antibodies.

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Health-related quality of life and IGF-1 in GH-deficient adult patients on GH replacement therapy: analysis of the German KIMS data and the Study of Health in Pomerania

Acta Endocrinologica ◽

10.1530/eje-08-0738 ◽

2009 ◽

Vol 160 (1) ◽

pp. 17-24 ◽

Cited By ~ 27

Author(s):

Joern Moock ◽

Christin Albrecht ◽

Nele Friedrich ◽

Henry Völzke ◽

Matthias Nauck ◽

...

Keyword(s):

Quality Of Life ◽

General Population ◽

Gh Deficiency ◽

Population Sample ◽

Population Based ◽

General Population Sample ◽

Gh Replacement ◽

Related Quality ◽

Health Related

ObjectiveTo analyse 12-month response to GH treatment in a single-country cohort of hypopituitary adult patients with GH deficiency (GHD) in regards to health-related quality of life (HRQoL) and insulin-like growth factor-1 (IGF-1) compared with values from general population sample. Moreover, association between the response in HRQoL and the IGF-1 values in patients and in the background population was investigated.DesignHRQoL was assessed by quality of life assessment of GH deficiency in adults (QoL-AGHDA) in 651 patients retrieved from the German KIMS (Pfizer International Metabolic Database) before and after 12 months of GH replacement and in a sample drawn from a cross-sectional study in Germany (n=2734). IGF-1 was measured in KIMS patients and in the population-based study with the same assay technique.ResultsIn KIMS patients, mean QoL-AGHDA scores before GH replacement were 9.2±6.8 (8.7±6.8) in women (men) and in the general population sample 4.5±5.3 (4.3±5.0) in women (men). Mean differences in QoL-AGHDA scores were statistically significant for all age categories (P<0.05). The mean IGF-1 SDS of KIMS patients before GH replacement was −1.1±1.4 (−0.8±1.4) in women (men). After GH replacement, a significant increase of IGF-1 concentration and a significant decrease of QoL-AGHDA scores near to age- and gender-specific population-based values were observed.ConclusionsThis study confirms an improvement in HRQoL and an increase of IGF-1 SDS in GH-replaced adults, which approximated the values of general population. However, there was no association between IGF-1 values and HRQoL assessment as one of the important treatment outcomes.

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The detection of specific antibody formation to recall antigens after human bone marrow transplantation

Blood ◽

10.1182/blood.v67.3.582.bloodjournal673582 ◽

1986 ◽

Vol 67 (3) ◽

pp. 582-587 ◽

Cited By ~ 1

Author(s):

LG Lum ◽

NA Munn ◽

MS Schanfield ◽

R Storb

Keyword(s):

Measles Virus ◽

Chronic Gvhd ◽

Enzyme Linked Immunosorbent Assay ◽

Igg Antibodies ◽

Short Term ◽

Specific Serum ◽

Antibody Titers ◽

One Year ◽

Long Term Survivors

The results of this study show that donor-derived immunity can be detected and persists in long-term survivors with and without chronic graft-v-host disease (GVHD) after human marrow grafting. Seventy-one marrow recipients (60 long-term and 11 short-term survivors) were studied for the presence of specific serum IgG antibodies to tetanus toxoid (TT), and 46 marrow recipients (35 long-term and 11 short-term) were tested for antibodies to diphtheria toxoid (DT) and measles virus after marrow grafting using an enzyme-linked immunosorbent assay. Of the 60 long-term survivors, 31 were healthy and 29 had chronic GVHD. None of the recipients were immunized to the test antigens postgrafting. Most long-term healthy recipients exhibited antibody titers to the recall test antigens, whereas only a minority of those with chronic GVHD had antibody titers to recall antigens. In healthy long-term recipients (greater than or equal to one year postgrafting) whose donors were immune to the test antigens, 25 of 31 had titers to TT, 11 of 17 had titers to DT, and 12 of 20 had titers to measles. In recipients with C-GVHD, 13 of 29 had titers to TT, six of 15 had titers to DT, and six of 15 had titers to measles virus. Within 100 days postgrafting, 11 of 11 had anti-TT titers, ten of ten had anti-DT titers, and seven of eight had antimeasles virus titers.

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