scholarly journals Measles virus-specific antibody levels in Sudanese infants: a prospective study using filter-paper blood samples

2005 ◽  
Vol 134 (1) ◽  
pp. 79-85 ◽  
Author(s):  
S. A. IBRAHIM ◽  
A. ABDALLAH ◽  
E. A. SALEH ◽  
A. D. M. E. OSTERHAUS ◽  
R. L. DE SWART
Keyword(s):  
Cord Blood ◽  
Specific Antibody ◽  
Filter Paper ◽  
Measles Virus ◽  
Dried Blood Spots ◽  
Birth Cohort Study ◽  
Blood Samples ◽  
Heel Prick ◽  
A Prospective Study ◽  
Antibody Levels

SUMMARYWe conducted a prospective birth cohort study in rural Sudan to assess measles virus (MV)-specific antibody levels at different time points in infancy. Dried blood spots were collected on filter paper at birth (cord blood) and at ages 6, 12 and 24 months (heel-prick). Maternally derived MV-specific antibody levels were high in cord blood samples, but at the age of 6 months had dropped below cut-off values in half of the infants. By extrapolation it was concluded that the current Expanded Programme of Immunization (EPI) target age for measles vaccination of 9 months was an appropriate choice for this area. At the age of 24 months acquired MV-specific antibodies were detected in 65–85% of the cohort, which corresponded well with the 79% of infants reported to be vaccinated by this age. This study demonstrates the usefulness of filter paper blood samples for seroepidemiological studies in developing countries.

scholarly journals Prevalence of Protective Measles Virus Antibody Levels in Umbilical Cord Blood Samples and Sera of Mothers and Transplacental Transport Ratio in Turkey

2019 ◽  
Vol 72 (3) ◽  
pp. 185-192 ◽  
Author(s):  
Serap CETIN COBAN ◽  
Fehminaz TEMEL ◽  
Pinar DUMAN ◽  
Yasemin COSGUN ◽  
Fatma OZARSLAN ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Measles Virus ◽  
Virus Antibody ◽  
Blood Samples ◽  
Antibody Levels

scholarly journals Prevalence of Protective Measles Virus Antibody Levels in Umbilical Cord Blood Samples in Catalonia, Spain

2010 ◽  
Vol 17 (4) ◽  
pp. 691-694 ◽  
Author(s):  
Pedro Plans ◽  
Josep Costa ◽  
Angela Domínguez ◽  
Núria Torner ◽  
Eva Borras ◽  
...  
Keyword(s):  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord Blood ◽  
Measles Virus ◽  
Maternal Age ◽  
Virus Antibody ◽  
Blood Samples ◽  
Measles Vaccination ◽  
The Mean ◽  
Antibody Levels

ABSTRACT The prevalence of protective antibody levels (>160 mIU/ml) in neonates was 98.5%. The mean measles virus antibody level was 3,406 mIU/ml and increased with maternal age. Measles vaccination was reported by 42% of pregnant women and decreased with age.

scholarly journals Measles Virus-Specific Antibody Levels in Individuals in Argentina Who Received a One-Dose Vaccine

2006 ◽  
Vol 44 (8) ◽  
pp. 2733-2738 ◽  
Author(s):  
M. H. Arguelles ◽  
M. L. Orellana ◽  
A. A. Castello ◽  
G. A. Villegas ◽  
M. Masini ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Measles Virus ◽  
Virus Specific Antibody ◽  
Antibody Levels ◽  
Dose Vaccine

scholarly journals IgM Anti PGL-1 Antibody Level in Patients with Leprosy: A Comparative Study between Ear Lobes Capillary and Median Cubital Vein Blood Samples

2018 ◽  
Vol 6 (8) ◽  
pp. 1346-1348
Author(s):  
Khairina Nasution ◽  
Kristina Nadeak ◽  
Syahril Rahmat Lubis
Keyword(s):  
Blood Sample ◽  
Filter Paper ◽  
Cross Sectional Study ◽  
Mean Value ◽  
Cross Sectional ◽  
Blood Samples ◽  
Significant Difference ◽  
Median Cubital Vein ◽  
The Mean ◽  
Antibody Levels

BACKGROUND: To establish the diagnosis of leprosy accurately, additional examination such as serologic examination with ELISA is required. There are considerations about taking a blood sample from the earlobe region.AIM: To determine the differences in IgM anti-PGL-1 antibody levels from earlobe capillary and median cubital vein blood sample in leprosy patients.METHODS: An observational analytic study using a cross-sectional study involving 30 patients with leprosy. ELISA examination of earlobe blood samples with filter paper, and the median cubital vein blood samples with filter paper and conventional methods were performed to determine IgM anti-PGL-1 antibody levels.RESULTS: The mean value of IgM anti PGL-1 antibody levels from earlobe blood samples with filter paper (1476.62 μ/ml) was relatively similar with median cubital vein blood samples with conventional method (1476.77 μ/ml), but the mean value of IgM anti PGL-1 antibody levels from median cubital vein blood samples with filter paper (1210.37 μ/ml) was lower from other methods. However, there was no statistically significant difference between them.CONCLUSION: There are no significant differences between the mean levels of IgM anti-PGL-1 antibody from earlobe and the median cubital vein blood samples.

scholarly journals Use of Quantitative Dried Blood Spots to Evaluate the Post-Vaccination Level of Neutralizing Antibodies against SARS-CoV-2

Life ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1125
Author(s):  
Alexandre Marchand ◽  
Ingrid Roulland ◽  
Florian Semence ◽  
Olof Beck ◽  
Magnus Ericsson
Keyword(s):  
Neutralizing Antibodies ◽  
Immune Status ◽  
Clinical Chemistry ◽  
Venous Blood ◽  
Dried Blood Spots ◽  
Post Vaccination ◽  
Blood Samples ◽  
Antibody Levels ◽  
Blood Spot ◽  
Over Time

To combat the COVID-19 pandemic, vaccines against SARS-CoV-2 are now given to protect populations worldwide. The level of neutralizing antibodies following the vaccination will evolve with time and vary between individuals. Immunoassays quantifying immunoglobulins against the viral spike (S) protein in serum/plasma have been developed, but the need for venous blood samples could limit the frequency and scale of control in populations. The use of a quantitative dried blood spot (DBS) that can be self-collected would simplify this monitoring. The objective of this study was to determine whether a quantitative DBS device (Capitainer qDBS 10 µL) could be used in combination with an Elecsys anti-SARS-CoV-2 S immunoassay from Roche to follow the development and persistence of anti-S antibodies. This objective was carried out through two clinical studies. The first study investigated 14 volunteers who received two doses of the Comirnaty (Pfizer) vaccine. The levels of anti-S antibodies and the progression over time post-vaccination were studied for three months. The level of produced antibodies varied between subjects, but a similar trend was observed. The anti-S antibodies were highly stimulated by the second dose (×100) and peaked two weeks later. The antibody levels subsequently decreased and three months later were down to 65%. DBS proved to be sufficiently sensitive for use in evaluating the immune status against SARS-CoV-2 over a prolonged time. The second cohort was composed of 200 random patients from a clinical chemistry department in Stockholm. In this cohort, we had no information on previous COVID-19 infections or vaccination. Nevertheless, 87% of the subjects had anti-S immunoglobulins over 0.8 U/mL, and the bias between plasma and DBS proved to be variable, as was also seen in the first vaccination study.

scholarly journals Iron status in pregnant women in the Republic of Seychelles

2009 ◽  
Vol 13 (3) ◽  
pp. 331-337 ◽  
Author(s):  
Emeir M Duffy ◽  
Maxine P Bonham ◽  
Julie MW Wallace ◽  
Chin-Kuo Chang ◽  
Paula J Robson ◽  
...  
Keyword(s):  
Cord Blood ◽  
Pregnant Women ◽  
Iron Status ◽  
Fe Deficiency ◽  
Blood Samples ◽  
Normal Ranges ◽  
Multiparous Women ◽  
Negative Effect ◽  
The Republic ◽  
A Prospective Study

AbstractObjectiveTo establish the Fe status of pregnant women and their neonates in the Republic of Seychelles.DesignA prospective study.SettingRepublic of Seychelles.SubjectsPregnant women were recruited and blood samples taken at enrolment and post-delivery along with cord blood samples. Ferritin and soluble transferrin receptor (sTfR) were measured in maternal (n220) and cord blood (n123) samples.ResultsMaternal Fe deficiency (ferritin < 15 ng/ml, sTfR > 28 nmol/l) was present in 6 % of subjects at enrolment and in 20 % at delivery. There was no significant decrease in maternal ferritin. A significant increase in sTfR was observed between enrolment and delivery (P< 0·001). Maternal BMI and use of Fe supplements at 28 weeks’ gestation were associated with improved maternal Fe status at delivery, whereas parity had a negative effect on sTfR and ferritin at delivery.ConclusionsFe status of pregnant Seychellois women was, on average, within normal ranges. The incidence of Fe deficiency throughout pregnancy in this population was similar to that in a Westernised population. Increased awareness of the importance of adequate Fe intake during pregnancy, particularly in multiparous women, is warranted.

scholarly journals Low Pertussis Toxin Antibody Levels in Maternal and Cord Blood Samples

2015 ◽  
Vol 2 (suppl_1) ◽  
Author(s):  
Zafer Kurugol ◽  
Ebru Turkoglu ◽  
Nilay Coplu ◽  
Esra Ozer ◽  
Cemile Sonmez
Keyword(s):  
Cord Blood ◽  
Pertussis Toxin ◽  
Blood Samples ◽  
Antibody Levels

Vaccinated students with negative enzyme immunoassay results show positive measles virus-specific antibody levels by immunofluorescence and plaque neutralisation tests

2007 ◽  
Vol 38 (3) ◽  
pp. 204-209 ◽  
Author(s):  
Annedore Tischer ◽  
Markus Gassner ◽  
Jean-Luc Richard ◽  
Franziska Suter-Riniker ◽  
Annette Mankertz ◽  
...  
Keyword(s):  
Enzyme Immunoassay ◽  
Specific Antibody ◽  
Measles Virus ◽  
Virus Specific Antibody ◽  
Antibody Levels
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