scholarly journals Zika virus epidemiology: from Uganda to world pandemic, an update

2018 ◽  
Vol 146 (6) ◽  
pp. 673-679 ◽  
Author(s):  
C. Talero-Gutiérrez ◽  
A. Rivera-Molina ◽  
C. Pérez-Pavajeau ◽  
I. Ossa-Ospina ◽  
C. Santos-García ◽  
...  
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Zika Virus ◽  
Mosquito Control ◽  
Neurological Diseases ◽  
Local Population ◽  
Public Health Problem ◽  
Control Measures ◽  
Control Treatment ◽  
Zikv Infection

AbstractZika virus (ZIKV) infection is an emergent worldwide public health problem. Historically, 84 countries have reported vector-borne ZIKV transmission, 61 of which report on-going transmission. It is a Flavivirus transmitted through arthropods belonging to the Aedes genus. Since 2015, ZIKV infections have increased dramatically; with 1.3 million people infected during 2015 in Brazil alone. This paper's objective is to highlight the conjectural epidemiological points of the virus’ dissemination. The digital archives Pubmed, MEDLINE, EMBASE and Cochrane were searched for papers that assessed aspects of ZIKV transmission and epidemiology. The first isolation occurred in Uganda in 1947. Since then, important outbreaks were documented globally. Consequently, an emergent public health problem arose from a rapidly increasing incidence and its association with the development of neurological diseases such as microcephaly and Guillain–Barré syndrome. Key factors in the successful containment of outbreaks include surveillance of mosquitos in the neighbourhood, an early mosquito control treatment, an assertive information campaign, and the involvement of the local population and healthcare workers. As such, while ZIKV seems to be spreading globally in a similar manner to other arboviruses, such as Dengue and Chikungunya viruses, it can also be rapidly contained due to the pre-existing availability of necessary resources and regulatory tools as control measures. This review aims to provide a description of those characteristics of ZIKV infection that may be useful in the construction of effective outbreak control strategies.

The reaction mechanism of Zika virus NS2B/NS3 serine protease inhibition by dipeptidyl aldehyde: a QM/MM study

2019 ◽  
Vol 21 (27) ◽  
pp. 14945-14956 ◽  
Author(s):  
Bodee Nutho ◽  
Adrian J. Mulholland ◽  
Thanyada Rungrotmongkol
Keyword(s):  
Public Health ◽  
Reaction Mechanism ◽  
Serine Protease ◽  
Health Problem ◽  
Zika Virus ◽  
Public Health Problem ◽  
Global Public Health ◽  
Protease Inhibition ◽  
Zikv Infection ◽  
Global Public Health Problem

Zika virus (ZIKV) infection has become a global public health problem, associated with microcephaly in newborns and Guillain–Barré syndrome in adults.

scholarly journals Differences in perceived severity of Zika virus infection and dengue fever and its influence on mosquito control practices in malaysia, a dengue-endemic country

2016 ◽  
Author(s):  
Li Ping Wong ◽  
Haridah Alias ◽  
Nasrin Aghamohammadi ◽  
I-Ching Sam ◽  
Sazaly Abu Bakar
Keyword(s):  
Public Health ◽  
Dengue Fever ◽  
Zika Virus ◽  
Mosquito Control ◽  
Public Health Emergency ◽  
Endemic Country ◽  
Zikv Infection ◽  
Perceived Severity ◽  
The Public ◽  
Before And After

AbstractBackgroundIt is important to study the concerns over the Zika virus (ZIKV) outbreak among the general public in dengue-endemic countries such as Malaysia, as both diseases are transmitted by the same vector species. Furthermore, investigation of public prevention measures for ZIKV is essential in order to identify the gaps in mosquito control practices. The aims of this study were to explore the differences in 1) the perception of severity towards ZIKV infection and dengue fever, and 2) mosquito control practices before and after the ZIKV outbreak was declared a Public Health Emergency of International Concern (PHEIC).MethodData were collected between February 2015 and May 2016 using a computer-assisted telephone interviewing system on a random sample of 567 people from the general Malaysian population aged above 18 years from randomly selected households.ResultsThe median scale score for perceived severity of ZIKV was 3 (interquartile range [IQR] 1-5) versus 4 (IQR 3-5) for dengue (P<0.001). The majority perceived dengue as being more severe than ZIKV (41.6%). Having friends or acquaintances that had died from dengue was significantly associated with higher perceived severity of ZIKV than dengue (odds ratio [OR] 1.913 [95% confidence interval (CI) 1.032-3.547]). The scores for mosquito control practices before and after ZIKV was declared a PHEIC were similar, at 4 (IQR 3-5). Multivariate analysis revealed that participants with a higher score for perception of severity of ZIKV were more likely to report greater mosquito control practices after the declaration of the PHEIC (OR 1.822 [95% CI 1.107-2.998]).ConclusionsThe emerging ZIKV pandemic requires concerted efforts to enhance mosquito control practices among the Malaysian public. Efforts to improve public mosquito control practices should focus on enhancing the perception of the severity of ZIKV.Author summaryInvestigation of the public perception of the severity of the re-emergence of Zika virus (ZIKV) in Malaysia, a dengue-endemic country, is of immense importance. It is also vital to know whether the public has heightened their mosquito prevention practices after the declaration of ZIKV as a Public Health Emergency of International Concern (PHEIC). The aim of this study was to explore the differences in 1) the perception of severity towards ZIKV infection and dengue fever, and 2) mosquito control practices before and after the ZIKV outbreak was declared a PHEIC. Findings showed that the public has a lower perception of severity of ZIKV than of dengue. Mosquito prevention practices were the same before and after the declaration of a PHEIC. People with a higher perception of severity of ZIKV reported higher mosquito control practices after the declaration of a PHEIC. The emerging ZIKV pandemic requires concerted efforts to enhance mosquito control practices among the Malaysian public. Efforts to improve public mosquito control practices should focus on enhancing the perception of severity of the ZIKV.

scholarly journals Environmental contamination by parasitic forms in a socially vulnerable community in southern Rio Grande do Sul state: a serious public health problem

2018 ◽  
Vol 55 (2) ◽  
pp. e132007
Author(s):  
Gabriela De Almeida Capella ◽  
Natália Berne Pinto ◽  
Soliane Carra Perera ◽  
Claudia Giordani ◽  
Micaele Quintana de Moura ◽  
...  
Keyword(s):  
Public Health ◽  
Environmental Contamination ◽  
Health Problem ◽  
Public Health Problem ◽  
Rio Grande ◽  
Control Measures ◽  
Parasitic Infections ◽  
Rio Grande Do Sul ◽  
Sodium Dichromate ◽  
Vulnerable Community

vulnerability. The fact that these people share the environment with animals promotes the establishment of zoonotic parasitic infections, as well as the resultant parasitic cycles. Thus, parasites present in the environment must be identified, so that control measures can be recommended. In this context, this study’s objective was to evaluate environmental contamination by parasitic forms in a socially vulnerable community in southern Rio Grande do Sul. A total of 100 soil samples collected from the community were processed by a sodium dichromate centrifuge-flotation technique and analyzed by a compound microscope (40X objective) for the identification of parasite eggs, oocysts and cysts. All points were positive for two or more parasites, with the identification of 33.59% non-identified coccidian oocysts, Strongylida (25.4%), Ascaridida (21.31%), Trichuris spp. (8.19%), Toxocara spp. (3.27%), Amoebas (4.08%), Dioctophyma renale (2.45%), and Giardia spp. (1.63%). The presence of parasitic forms in all points analyzed surpasses other studies of environmental contamination carried out in the southern region of Brazil. In addition, the identification of several parasitic forms with zoonotic potential is concerning, since it shows the possibility of parasitic transmission to humans and other animals. In view of the results, the conclusion is that the environment analyzed is contaminated by parasitic forms, constituting a serious public health problem. Therefore, implementing educational and preventive measures in the community to control parasites is of crucial importance.

scholarly journals Factors associated with soil-transmitted helminths infection in Benin: Findings from the DeWorm3 study

2021 ◽  
Vol 15 (8) ◽  
pp. e0009646
Author(s):  
Euripide F. G. A. Avokpaho ◽  
Parfait Houngbégnon ◽  
Manfred Accrombessi ◽  
Eloïc Atindégla ◽  
Elodie Yard ◽  
...  
Keyword(s):  
Public Health ◽  
Ascaris Lumbricoides ◽  
Health Problem ◽  
Infection Intensity ◽  
Public Health Problem ◽  
Current Control ◽  
Control Measures ◽  
Baseline Survey ◽  
Hookworm Infection ◽  
Factors Associated

Background Despite several years of school-based MDA implementation, STH infections remain an important public health problem in Benin, with a country-wide prevalence of 20% in 2015. The DeWorm3 study is designed to assess the feasibility of using community-based MDA with albendazole to interrupt the transmission of STH, through a series of cluster-randomized trials in Benin, India and Malawi. We used the pre-treatment baseline survey data to describe and analyze the factors associated with STH infection in Comé, the study site of the DeWorm3 project in Benin. These data will improve understanding of the challenges that need to be addressed in order to eliminate STH as a public health problem in Benin. Methods Between March and April 2018, the prevalence of STH (hookworm spp., Ascaris and Trichuris trichiura) was assessed by Kato-Katz in stool samples collected from 6,153 residents in the community of Comé, Benin using a stratified random sampling procedure. A standardized survey questionnaire was used to collect information from individual households concerning factors potentially associated with the presence and intensity of STH infections in pre-school (PSAC, aged 1–4), school-aged children (SAC, aged 5–14) and adults (aged 15 and above). Multilevel mixed-effects models were used to assess associations between these factors and STH infection. Results The overall prevalence of STH infection was 5.3%; 3.2% hookworm spp., 2.1% Ascaris lumbricoides and 0.1% Trichuris. Hookworm spp. were more prevalent in adults than in SAC (4.4% versus 2.0%, respectively; p = 0.0001) and PSAC (4.4% versus 1.0%, respectively; p<0.0001), whilst Ascaris lumbricoides was more prevalent in SAC than in adults (3.0% versus 1.7%, respectively; p = 0.004). Being PSAC (adjusted Odds Ratio (aOR) = 0.2, p< 0.001; adjusted Infection Intensity Ratio (aIIR) = 0.1, p<0.001) or SAC (aOR = 0.5, p = 0.008; aIIR = 0.3, p = 0.01), being a female (aOR = 0.6, p = 0.004; aIIR = 0.3, p = 0.001), and having received deworming treatment the previous year (aOR = 0.4, p< 0.002; aIIR = 0.2, p<0.001) were associated with a lower prevalence and intensity of hookworm infection. Lower income (lowest quintile: aOR = 5.0, p<0.001, 2nd quintile aOR = 3.6, p = 0.001 and 3rd quintile aOR = 2.5, p = 0.02), being a farmer (aOR = 1.8, p = 0.02), medium population density (aOR = 2.6, p = 0.01), and open defecation (aOR = 0.5, p = 0.04) were associated with a higher prevalence of hookworm infection. Lower education—no education, primary or secondary school- (aIIR = 40.1, p = 0.01; aIIR = 30.9, p = 0.02; aIIR = 19.3, p = 0.04, respectively), farming (aIIR = 3.9, p = 0.002), natural flooring (aIIR = 0.2, p = 0.06), peri-urban settings (aIIR = 6.2, 95%CI 1.82–20.90, p = 0.003), and unimproved water source more than 30 minutes from the household (aIIR = 13.5, p = 0.02) were associated with a higher intensity of hookworm infection. Improved and unshared toilet was associated with lower intensity of hookworm infections (aIIR = 0.2, p = 0.01). SAC had a higher odds of Ascaris lumbricoides infection than adults (aOR = 2.0, p = 0.01) and females had a lower odds of infection (aOR = 0.5, p = 0.02). Conclusion Hookworm spp. are the most prevalent STH in Comé, with a persistent reservoir in adults that is not addressed by current control measures based on school MDA. Expanding MDA to target adults and PSAC is necessary to substantially impact population prevalence, particularly for hookworm. Trial registration ClinicalTrials.gov NCT03014167.

scholarly journals Zika virus: a new arboviral public health problem

2016 ◽  
Vol 61 (6) ◽  
pp. 523-527 ◽  
Author(s):  
Tulin Demir ◽  
Selcuk Kilic
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Zika Virus ◽  
Public Health Problem

ENTOMOLOGICAL INVESTIGATIONS IN MOULAY YAACOUB, LEISHMANIASIS FOCUS IN THE CENTR OF MOROCCO

2016 ◽  
Vol 9 (6) ◽  
pp. 340 ◽  
Author(s):  
Abdelhakim El Ouali Lalami
Keyword(s):  
Public Health ◽  
Spatial Distribution ◽  
Sex Ratio ◽  
Health Problem ◽  
Public Health Problem ◽  
Control Measures ◽  
Eastern Province ◽  
North Central ◽  
Health Authorities ◽  
Cutaneous Form

Objective: In Morocco leishmaniasis represent entities of great clinical and epidemiological diversity and thus constitute a public health problem. The area of Moulay Yaâcoub, North central of Morocco. This study was conducted in all localities of the province of Moulay Yaâcoub to understand the epidemiology and spatial distribution of sandflies in this region. Nine among eleven localities of the province of Moulay Yaâcoub have never been studied and the phlebotomy fauna of the region remains unknown until now. Methods: Trapping was done using sticky traps once a month during the period of activity of sandfly from April to October. Results: A total of 3287 specimens of sandflies were collected. 8 species belonging to two genera Phlebotomus (94.3%) and Sergentomyia (5.7%). The study of sex ratio showed an advantage of males to females for all species. However, for the species S. falax, S. antennata, S. minuta we have not collected females. The highest sex ratio was determined for Ph. Perniciosus and lowest among S. dreyfussi. The results show a difference in the distribution of species between different localities. Conclusion: it was possible to distinguish two major entities; a dominant sub-genre Phlebotomus and Paraphlébotomus, responsible for the cutaneous form in the center and northwest of the province, and a sub-genre dominated Larroussius entity responsible for the visceral form the northeast of the province with a small entity in the south-eastern province. The results of this study will help undoubtedly health authorities to establish appropriate monitoring and anti-vectorial control measures.

scholarly journals ZIKATracker: A mobile App for reporting cases of ZIKV worldwide

2016 ◽  
Vol 10 (02) ◽  
pp. 113-115 ◽  
Author(s):  
Alyson Ann Kelvin ◽  
David Banner ◽  
Luciano Pamplona ◽  
Carlos Alencar ◽  
Salvatore Rubino ◽  
...  
Keyword(s):  
North America ◽  
Zika Virus ◽  
Mosquito Control ◽  
Mobile App ◽  
Control Measures ◽  
Zikv Infection ◽  
Developmental Defects ◽  
Neurological Sequelae ◽  
South Central

We have developed a mobile App called ZIKATracker (zikatracker.net) to voluntarily be used to report ZIKV cases on a public or private level. As the Zika virus (ZIKV) infection zones are rapidly expanding across South, Central, and North America, and reports have emerged linking ZIKV infection with developmental defects and neurological sequelae, reporting the movement and sequelae of ZIKV is essential. ZIKATracker is a multi-lingual App (English, French, Spanish, and Portuguese) freely available to anyone worldwide wishing to report a suspected or confirmed case of Zika virus and related symptoms. Knowledge gained from the use of this App will help direct the implementation of mosquito control measures in needed areas, bring aid to those affected by the Zika virus, and understand the movement and sequelae of ZIKV as it spreads through communities and across continents.

Kindesmisshandlung und deren Langzeitfolgen – Analyse einer repräsentativen deutschen Stichprobe

2019 ◽  
Vol 67 (2) ◽  
pp. 100-111 ◽  
Author(s):  
Andreas Witt ◽  
Rebecca Brown ◽  
Paul L. Plener ◽  
Elmar Brähler ◽  
Jörg M. Fegert ◽  
...  
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Public Health Problem ◽  
Nachhaltige Entwicklung

Zusammenfassung. Kindesmisshandlung stellt einen bedeutenden Risikofaktor für die Entwicklung dar. Einzelne Formen von Kindesmisshandlung treten häufig nicht isoliert auf, sondern das gemeinsame Auftreten verschiedener Formen von Kindesmisshandlung stellt eher die Regel als die Ausnahme dar. Neben den langfristigen und vielfältigen individuellen Folgen führt Kindesmisshandlung jährlich zu einer hohen gesamtgesellschaftlichen Belastung. Die WHO hat Kindesmisshandlung als großes Public Health Problem identifiziert und die Vereinten Nationen haben den Kampf gegen Kindesmisshandlung zum Ziel in ihrer Agenda für nachhaltige Entwicklung gemacht. In dem vorliegenden Beitrag werden die Häufigkeit sowie das gemeinsame Auftreten unterschiedlicher Formen von Kindesmisshandlung sowie deren Assoziation mit psychischen und somatischen Folgen auf Basis einer bevölkerungsrepräsentativen Stichprobe untersucht und dargestellt. Die Ergebnisse verdeutlichen den Zusammenhang zwischen der Kumulation verschiedener Formen von Misshandlung und negativen Folgen für die Betroffenen. So ist das Risiko für negative Konsequenzen beim Erleben von vier oder mehr Formen von Misshandlung um das bis zu 10-fache erhöht. Viel zu selten werden die kumulativen Effekte von mehreren Belastungen berücksichtigt. Gerade weil die Wirkweisen über die Misshandlung, die Gesundheit beeinflusst, zunehmend gut untersucht sind, muss dieses Wissen im Gesundheitswesen stärker bei der Konzeption von Präventions- und Interventionsmaßnahmen berücksichtigt werden.

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