Sarcopenia: a clinical review

2013 ◽  
Vol 23 (4) ◽  
pp. 267-274 ◽  
Author(s):  
AJ Cruz-Jentoft
Keyword(s):  
Muscle Mass ◽  
Poor Quality ◽  
Adverse Outcomes ◽  
Life And Death ◽  
Syndromic Approach ◽  
Muscle Mass Loss ◽  
Intervention Trials ◽  
Diagnostic Work ◽  
Work Up ◽  
Near Future

SummaryAlthough sarcopenia has been used to define muscle mass loss in older subjects, muscle mass is not directly linked to muscle function. Recent definitions consider sarcopenia as a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength with a risk of adverse outcomes, such as physical disability, poor quality of life, and death. It is closely linked with physical frailty, and also with other muscle wasting disorders, including cachexia and malnutrition. This review focuses on the incorporation of sarcopenia into clinical practice, reviews case finding and diagnosis of sarcopenia, proposes a syndromic approach for the diagnostic work-up of sarcopenic patients, and looks at intervention trials with physical exercise and nutrition, as drugs to treat this condition are not expected to be available in the near future.

The Preoperative Spine: Diagnostic Work up with fMRI

2008 ◽  
Vol 21 (6) ◽  
pp. 848-854 ◽  
Author(s):  
J.P. Elsig ◽  
D.L. Kaech
Keyword(s):  
New Technology ◽  
Dynamic Mri ◽  
Signs And Symptoms ◽  
Failed Back Surgery Syndrome ◽  
Segmental Dysfunction ◽  
Failed Back Surgery ◽  
Back Surgery ◽  
Diagnostic Work ◽  
Work Up ◽  
Near Future

The advantages of the upright, open, multi-positional MRI, i.e. functional MRI (fMRI) are presented with illustrative cases and the literature is reviewed. In cases of not explained and especially in position-dependent spinal and/or neurological pain and/or dysfunction functional or dynamic MRI is able to reveal dynamic compressions/stenosis, as well as segmental dysfunction and instabilities in a noninvasive way. This new technology could become mandatory for the preoperative investigation of unexplained, mainly “dynamic, mobile or unstable” spinal pathologies. Allowing a better correlation of signs and symptoms with the imaging findings and thus a more targeted treatment, fMRI could help to decrease the rate of failed back surgery syndrome in the near future.

scholarly journals Sarcopenia, A Booming Concern of Ageing World: A Review

2015 ◽  
Vol 31 (2) ◽  
pp. 110-115
Author(s):  
Md Shahidur Rahman
Keyword(s):  
Quality Of Life ◽  
Poor Quality ◽  
Adverse Outcomes ◽  
Quality Adjusted Life Years ◽  
Life And Death ◽  
Treatment And Prevention ◽  
Life Years ◽  
Essential Components ◽  
Care Costs

Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength with a risk of adverse outcomes such as physical disability, poor quality of life and death. With the onset of advancing age, muscle tissue is gradually lost, resulting in diminished mass and strength, a condition referred to as sarcopenia. The sequelae of sarcopenia often contribute to frailty, decreased independence, and subsequently increased health care costs. This review article will introduce potential mechanisms that may contribute to sarcopenia, although no one mechanism has yet, and may not completely, define this process. Despite sarcopenia is an inevitable process of life, prevention and treatments are absolutely needed in order to improve the quality of life and quality adjusted life years. Adequate nutrition and structured exercises are essential components of treatment and prevention. However, even those individuals who maintain their fitness through exercise do not appear to be immune to sarcopenia. Bangladesh Journal of Neuroscience 2015; Vol. 31 (2): 110-115

scholarly journals Sarcopenia, Currently a Hot Topic: A Narrative Review

2021 ◽  
Vol 23 (1) ◽  
pp. 20-26
Author(s):  
JungHoon Chai ◽  
HyunJoo Kang
Keyword(s):  
Skeletal Muscle ◽  
Poor Quality ◽  
Adverse Outcomes ◽  
Narrative Review ◽  
Amino Acid Supplementation ◽  
Muscle Loss ◽  
Progressive Decline ◽  
Life And Death ◽  
And Function

Aging is associated with a progressive decline of skeletal muscle quantity and quality leading to a gradual slowing of movement, a decline in strength and power, and a condition known as sarcopenia. Sarcopenia is a syndrome a risk of adverse outcomes such as physical disability, poor quality of life and death. Agerelated losses in skeletal muscle mass and function have had a significant important in health care issue. In this study, we reviewed the recently introduced criteria for the Eastern and Western diagnosis of sarcopenia. A narrative review of evidence- and non-evidence-based papers was conducted, using a relevant methodological framework. This review is included the following: 1) definitions and diagnostic criteria over time; 2) pathophysiology of muscle loss; 3) management especially protein or amino acid supplementation, medications, and physical exercise.

Rapidly progressive glomerulonephritis as presenting feature of systemic lupus erythematosus in a Bangladeshi male patient: a rare case report

2020 ◽  
Vol 10 (2) ◽  
pp. 137-138
Author(s):  
Samiha Haque ◽  
Ishrat Jahan ◽  
Tufayel Ahmed Chowdhury ◽  
Muhammad Abdur Rahim ◽  
Mehruba Alam Ananna ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Venous Pressure ◽  
Rapidly Progressive Glomerulonephritis ◽  
Initial Response ◽  
Systemic Lupus ◽  
Renal Manifestation ◽  
Rare Case Report ◽  
Diagnostic Work ◽  
Work Up

Rapidly progressive glomerulonephritis is one of the most dramatic and tragic presentations of lupus nephritis (LN) or renal manifestation of systemic lupus erythematosus (SLE). A 35-year-old Bangladeshi gentleman presented with worsening oedema, scanty, high colored, frothy urine and deteriorating renal function. He had puffy face, anaemia, oedema, normal jugular venous pressure (JVP), high blood pressure (150/90 mm Hg), ascites and bilateral pleural effusions. Diagnostic work-up confirmed SLE with class IV LN. His initial response to specific therapy showed improvement Birdem Med J 2020; 10(2): 137-138

Jiangnan Dietary Pattern Actively Prevents Muscle Mass Loss: Based on a Cohort Study

2021 ◽  
Author(s):  
Zhengyuan Wang ◽  
Xinyi Dong ◽  
Qi Song ◽  
Xueying Cui ◽  
Zehuan Shi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Mass Loss ◽  
Muscle Mass ◽  
Dietary Pattern ◽  
Muscle Mass Loss

scholarly journals Stroke masquerading as cardiac arrest: the artery of Percheron

2021 ◽  
Vol 14 (1) ◽  
pp. e238681
Author(s):  
Megan Quetsch ◽  
Sureshkumar Nagiah ◽  
Stephen Hedger
Keyword(s):  
Cardiac Arrest ◽  
Clinical Assessment ◽  
Altered Consciousness ◽  
Cognitive Changes ◽  
Consciousness Level ◽  
Artery Of Percheron ◽  
Conscious Level ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

The artery of Percheron (AOP) is a rare arterial variant of the thalamic blood supply. Due to the densely packed collection of nuclei it supplies, an infarction of the AOP can be devastating. Here we highlight a patient who had an AOP stroke in the community, which was initially managed as cardiac arrest. AOP strokes most often present with vague symptoms such as reduced conscious level, cognitive changes and confusion without obvious focal neurology, and therefore are often missed at the initial clinical assessment. This case highlights the importance of recognising an AOP stroke as a cause of otherwise unexplained altered consciousness level and the use of MRI early in the diagnostic work-up.

scholarly journals Etiological Work-Up for Adults with Bronchiectasis: A Predictive Diagnostic Score for Primary Ciliary Dyskinesia and Cystic Fibrosis

2021 ◽  
Vol 10 (16) ◽  
pp. 3478
Author(s):  
Frederic Schlemmer ◽  
Agnes Hamzaoui ◽  
Sonia Zebachi ◽  
Aurelie Le Thuaut ◽  
Gilles Mangiapan ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Primary Ciliary Dyskinesia ◽  
Clinical Score ◽  
Adult Patients ◽  
Operating Characteristics ◽  
Diagnostic Score ◽  
Receiver Operating Characteristics Curve ◽  
Diagnostic Work ◽  
Work Up ◽  
Ciliary Dyskinesia

Background: etiological investigations are not done for all adult patients with bronchiectasis because of the availability and interpretation of tests. The aim of the study was to elaborate a score to identify patients at high risk of having cystic fibrosis or primary ciliary dyskinesia (CF/PCD), which require appropriate management. Methods: diagnostic work-ups were carried out on a French monocenter cohort, and results were subjected to logistic-regression analyses to identify the independent factors associated with CF/PCD diagnosis and, thereby, elaborate a score to validate in a second cohort. Results: among 188 patients, 158 had no obvious diagnosis and were enrolled in the algorithm-construction group. In multivariate analyses, age at symptom onset (8.69 (2.10–35.99); p = 0.003), chronic ENT symptoms or diagnosed sinusitis (10.53 (1.26–87.57); p = 0.03), digestive symptoms or situs inversus (5.10 (1.23–21.14); p = 0.025), and Pseudomonas. aeruginosa and/or Staphylococcus aureus isolated from sputum (11.13 (1.34–92.21); p = 0.02) are associated with CF or PCD. Receiver operating characteristics curve analysis, using a validation group of 167 patients with bronchiectasis, confirmed the score’s performance with AUC 0.92 (95% CI: 0.84–0.98). Conclusions: a clinical score may help identify adult patients with bronchiectasis at higher risk of having CF or PCD.

scholarly journals Death of unknown cause? Post-mortem diagnosis of fulminant course of an EBV-associated secondary hemophagocytic lymphohistiocytosis

2021 ◽  
Author(s):  
Josia Fauser ◽  
Stefan Köck ◽  
Eberhard Gunsilius ◽  
Andreas Chott ◽  
Andreas Peer ◽  
...  
Keyword(s):  
Immune Response ◽  
Case Report ◽  
Macrophage Activation ◽  
Post Mortem ◽  
Life Threatening ◽  
Appropriate Therapy ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up ◽  
Secondary Hemophagocytic Lymphohistiocytosis

SummaryHLH is a life-threatening disease, which is characterized by a dysregulated immune response with uncontrolled T cell and macrophage activation. The often fulminant course of the disease needs a fast diagnostic work-up to initiate as soon as possible the appropriate therapy. We present herein the case of a 71-year-old patient with rapidly progressive hyperinflammatory syndrome, which post mortem resulted in the diagnosis of EBV-associated HLH. With this case report, we intend to highlight the relevance of the HScore in the diagnosis of HLH, to create a greater awareness for EBV as a trigger of HLH, and to demonstrate the importance of treating EBV-associated HLH as early as possible.

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