Case Series With Late-Onset Psychosis Hospitalized in a Geriatric Psychiatry Unit in Turkey: Experience in 9 Years

2003 ◽  
Vol 15 (1) ◽  
pp. 69-72 ◽  
Author(s):  
Yesne Alici-Evcimen ◽  
Turan Ertan ◽  
Engin Eker
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Case Series ◽  
Geriatric Psychiatry ◽  
Delusional Disorder ◽  
Early Onset Schizophrenia ◽  
Treatment Results ◽  
Thought Insertion ◽  
Psychiatry Department ◽  
Paranoid Psychosis

In this article we report the first series of Turkish inpatients with late-onset psychosis, and describe our 9-year experience at the only inpatient geriatric psychiatry department in Turkey. Among 420 patients hospitalized between 1993 and 2002, 27 were psychotic. In this group, eight patients were diagnosed as having late-onset schizophrenia (LOS) and six very-late-onset schizophrenia-like psychosis (VLOSLP). Five patients had early-onset schizophrenia and eight had delusional disorder. Females were more frequently seen in the group with LOS and the group with VLOSLP. Except for one patient with LOS, all patients with VLOSLP and LOS had paranoid psychosis. Nihilistic delusions, delusions of poverty or guilt, thought withdrawal, thought insertion, and thought broadcasting were not seen in any of the patients. Additionally, none of the LOS or VLOSLP patients showed erotomanic delusions. Grandiose and mystic delusions were not seen in those with VLOSLP. Treatment results and antipsychotic dosages at discharge were similar to those in previous reports from other cultures.

White matter hyperintensity volume in late-onset and early-onset schizophrenia

2000 ◽  
Vol 15 (12) ◽  
pp. 1085-1089 ◽  
Author(s):  
Paul Rivkin ◽  
Michael Kraut ◽  
Patrick Barta ◽  
James Anthony ◽  
Amelia M Arria ◽  
...  
Keyword(s):  
White Matter ◽  
Early Onset ◽  
Late Onset ◽  
White Matter Hyperintensity ◽  
Early Onset Schizophrenia

scholarly journals Neuroinflammation in Late-Onset Schizophrenia: Viewing from the Standpoint of the Microglia Hypothesis

2021 ◽  
pp. 1-6
Author(s):  
Akira Monji ◽  
Yoshito Mizoguchi
Keyword(s):  
Early Onset ◽  
Genetic Factors ◽  
Late Onset ◽  
Early Onset Schizophrenia ◽  
International Consensus ◽  
Neuroimmune System ◽  
Over 40 Years

Schizophrenia develops mainly in adolescence, but late-onset schizophrenia (LOS) is not uncommon. According to the international consensus, schizophrenia which develops over 40 years old is called LOS and psychosis which develops over 60 years old is called very late-onset schizophrenia-like psychosis (VLOS). Compared to early-onset schizophrenia (EOS) that develops before the age of 40 years, LOS and VLOS are reported to be more common in women, and there are clinically clear differences such as less involvement of genetic factors than EOS. This review outlines the abnormalities of the neuroimmune system in the pathophysiology of LOS, especially focusing on the role of microglia.

scholarly journals Independent living skills and cognition in early-onset and late-onset of schizophrenia patients: a pilot study

2020 ◽  
Vol LII (1) ◽  
pp. 34-37
Author(s):  
Ekaterina G. Abdullina ◽  
Mariya A. Savina ◽  
Georgij E. Rupchev ◽  
Margarita A. Morozova ◽  
Valeriya V. Pochueva ◽  
...  
Keyword(s):  
Social Skills ◽  
Cognitive Functions ◽  
Early Onset ◽  
Independent Living ◽  
Late Onset ◽  
Early Onset Schizophrenia ◽  
Independent Living Skills ◽  
Brief Assessment ◽  
Living Skills ◽  
Sequencing Task

Aim. To evaluate cognitive functions and independent living skills in patients with late-onset schizophrenia (LOS) compared to patients with early-onset schizophrenia (EOS). Methods. The study included two clinical groups: 8 EOS patients (M=51.37.2; 7 males) and 8 LOS patients (M=67.89.9; 8 females), with comparable illness duration (22.69.1 and 19.911.9 respectively). Cognitive functions were assessed through the Brief Assessment of Cognition in Schizophrenia (BACS). The Autonomy Assessment Scale (AS) was used to measure independent living skills. The MannWhitney U-test was applied to determine differences between groups. Results. LOS group performed significantly better on Digit Sequencing Task, Verbal Fluency and Tower Test of the BACS. Composite score on AS was also significantly better in LOS group along with better scores on AS`s subscales assessing primarily social skills. Conclusion. LOS patients have milder cognitive dysfunction along with better independent living and social skills compared to AOS patients.

Late-Onset and Early-Onset Schizophrenia

1990 ◽  
Vol 147 (10) ◽  
pp. 1382-b-1383
Author(s):  
RAYMOND LEVY
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Early Onset Schizophrenia

scholarly journals CNVs and Chromosomal Aneuploidy in Patients With Early-Onset Schizophrenia and Bipolar Disorder: Genotype-Phenotype Associations

2021 ◽  
Vol 11 ◽  
Author(s):  
Hojka Gregoric Kumperscak ◽  
Danijela Krgovic ◽  
Maja Drobnic Radobuljac ◽  
Nina Senica ◽  
Andreja Zagorac ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Early Onset ◽  
Late Onset ◽  
Copy Number Variations ◽  
Molecular Karyotyping ◽  
Early Onset Schizophrenia ◽  
Chromosomal Aneuploidy ◽  
Standards And Guidelines ◽  
Genetic Loading ◽  
Or Genes

Introduction: Early-onset schizophrenia (EOS) and bipolar disorder (EOB) start before the age of 18 years and have a more severe clinical course, a worse prognosis, and a greater genetic loading compared to the late-onset forms. Copy number variations (CNVs) are an important genetic factor in the etiology of psychiatric disorders. Therefore, this study aimed to analyze CNVs in patients with EOS and EOB and to establish genotype-phenotype relationships for contiguous gene syndromes or genes affected by identified CNVs.Methods: Molecular karyotyping was performed in 45 patients, 38 with EOS and seven with EOB hospitalized between 2010 and 2017. The exclusion criteria were medical or neurological disorders or IQ under 70. Detected CNVs were analyzed according to the standards and guidelines of the American College of Medical Genetics.Result: Molecular karyotyping showed CNVs in four patients with EOS (encompassing the PAK2, ADAMTS3, and ADAMTSL1 genes, and the 16p11.2 microduplication syndrome) and in two patients with EOB (encompassing the ARHGAP11B and PRODH genes). In one patient with EOB, a chromosomal aneuploidy 47, XYY was found.Discussion: Our study is the first study of CNVs in EOS and EOB patients in Slovenia. Our findings support the association of the PAK2, ARHGAP11B, and PRODH genes with schizophrenia and/or bipolar disorder. To our knowledge, this is also the first report of a multiplication of the ADAMTSL1 gene and the smallest deletion of the PAK2 gene in a patient with EOS, and one of the few reports of the 47, XYY karyotype in a patient with EOB.

scholarly journals Dementia in schizophrenia

2012 ◽  
Vol 18 (2) ◽  
pp. 144-153 ◽  
Author(s):  
Raghavakurup Radhakrishnan ◽  
Robert Butler ◽  
Laura Head
Keyword(s):  
Cognitive Impairment ◽  
Old Age ◽  
Early Onset ◽  
Late Onset ◽  
Evidence Base ◽  
Common Type ◽  
Future Research ◽  
Early Onset Schizophrenia ◽  
Growing Body ◽  
Diagnosis Of Dementia

SummaryA growing body of evidence suggests that the most common type of dementia in schizophrenia differs from Alzheimer's disease in its clinical features, natural course, neuropathology, neuroanatomical substrates and prognosis. Furthermore, there is some evidence that the risk of developing cognitive impairment and its progression in early-onset schizophrenia differ compared with late- or very-late-onset schizophrenia. The diagnosis and management of dementia in schizophrenia is challenging for both general adult and old age psychiatrists. This article reviews the evidence base regarding dementia in schizophrenia. It discusses the diagnosis of dementia in schizophrenia, its management and prognosis, and identifies some future research opportunities.

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