Cognitive performance norms from the Korean genome and epidemiology study (KoGES)

2017 ◽  
Vol 29 (11) ◽  
pp. 1909-1924
Author(s):  
Hyun Kim ◽  
Rhoda Au ◽  
Robert J. Thomas ◽  
Chang-Ho Yun ◽  
Seung Ku Lee ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Visual Memory ◽  
Normative Data ◽  
Neuropsychological Test ◽  
Population Sample ◽  
Cognitive Test ◽  
Health Examination ◽  
Epidemiology Study ◽  
Study Population ◽  
And Gender

ABSTRACTBackground:While normative data on neuropsychological performance provide baseline metrics for the assessment and diagnosis of mild cognitive impairment and dementia, a lack of comparative normative data in non-Caucasian populations makes it difficult to conduct similar evaluations and studies in individuals from diverse backgrounds. The current paper aims to provide normative data on a range of cognitive measures in a Korean general population sample and investigate various demographic and health variables associated with cognitive performance in this representative population.Method(s):The study population was 1,528 stroke and dementia-free individuals who participated in the Korean Genome and Epidemiology study (KoGES) (mean age 60.43 ± 7.30, 52.42% female). All participants underwent a comprehensive neuropsychological test battery that included verbal and visual memory, language, attention, and executive function measures. A health examination and a questionnaire-based interview were also administered.Results:The majority of cognitive test results were associated with age, education, and gender. In general, higher education and younger age was associated with better cognitive performance. Explained variance increased modestly in models that included measures of general health and depressive symptoms.Conclusion:Normative data of cognitive performance in a community based Korean population are presented. These norms provide reference values in a non-Caucasian middle to older aged sample.

scholarly journals The Relation Between Cognitive Performance and Symptom Factors Following Concussion

2019 ◽  
Vol 34 (5) ◽  
pp. 764-764
Author(s):  
E Whitley ◽  
R Gerkin ◽  
A Kontos ◽  
C Quintana ◽  
B Nalepa ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Verbal Memory ◽  
Visual Memory ◽  
Injury Severity ◽  
Clinical Importance ◽  
Retrospective Chart Review ◽  
Symptom Assessment ◽  
Cognitive Outcomes ◽  
Motor Speed ◽  
And Gender

Abstract Purpose The purpose of this study was to explore if symptom factors are related to cognitive outcomes. Prior studies have examined the relationship of individual symptoms to cognition. However, the relation between empirically-derived symptom factors and cognitive outcomes has yet to be explored. Methods Data were extracted via retrospective chart review of 691 patients (aged 10–24, mean: 14.99±2.63). Participants completed ImPACT and the PCSS within 14 days of injury (mean: 9.27±3.37). Predictors were PCSS factor scores of Cognitive-Fatigue-Migraine (CFM), Affective (AFF), Somatic (SOM), and Sleep (SLP) (Kontos et al., 2012). Outcomes examined were ImPACT composite scores. Univariate analyses were performed and values with p < 0.10 were entered into stepwise linear regression (LR) models. Retained predictors in each LR model had p values <.05. Results Verbal memory was predicted by CFM, SOM, age, and gender. Visual memory was predicted by CFM and SOM. Visual motor speed was predicted by age, gender, CFM, SOM, and AFF. Reaction time was best predicted by SOM, CFM, and age. The variance explained was fairly small (0.08 to 0.21). SLP was not a significant predictor in any LR. Conclusion CFM and SOM factors were most predictive of lower cognitive performance, similar to prior studies linking dizziness to longer recovery and post-traumatic migraine to worse cognitive performance. These findings underscore the clinical importance of diverse symptom assessment and injury education. Higher CFM and SOM scores may also serve as proxy for injury severity, which we would expect to be associated with worse cognitive performance.

scholarly journals Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): Normative Data for Older Adults

2019 ◽  
Vol 34 (8) ◽  
pp. 1356-1366 ◽  
Author(s):  
Michelle Olaithe ◽  
Michael Weinborn ◽  
Talitha Lowndes ◽  
Amanda Ng ◽  
Erica Hodgson ◽  
...  
Keyword(s):  
Normative Data ◽  
Neuropsychological Test ◽  
Female Gender ◽  
Frequency Distributions ◽  
Neuropsychological Status ◽  
Three Samples ◽  
Regression Techniques ◽  
Repeatable Battery ◽  
Standard Deviations ◽  
And Gender

Abstract Objective Provide updated older adult (ages 60+) normative data for the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Form A, using regression techniques, and corrected for education, age, and gender. Method Participants (aged 60–93 years; N = 415) were recruited through the Healthy Ageing Research Program (HARP), University of Western Australia, and completed Form A of the RBANS as part of a wider neuropsychological test battery. Regression-based techniques were used to generate normative data rather than means-based methods. This methodology allows for the control of demographic variables using continuous data. To develop norms, the data were assessed for: (1) normality; (2) associations between each subtest score and age, education, and gender; (3) the effect of age, education, and gender on subtest scores; and (4) residual scores which were converted to percentile distributions. Results Differences were noted between the three samples, some of which were small and may not represent a clinically meaningful difference. Younger age, more years of education, and female gender were associated with better scores on most subtests. Frequency distributions, means, and standard deviations were produced using unstandardized residual scores to remove the effects of age, education, and gender. Conclusions These normative data expand upon past work by using regression-based techniques to generate norms, presenting percentiles, as well as means and standard deviations, correcting for the effect of gender, and providing a free-to-use Excel macro to calculate percentiles.

EXPLORING THE RELEVANCE OF GENDER AND AGE DIFFERENCES IN THE ASSESSMENT OF SOCIAL FEARS IN ADOLESCENCE

2008 ◽  
Vol 36 (3) ◽  
pp. 385-390 ◽  
Author(s):  
Luis-Joaquin Garcia Lopez ◽  
Candido J. Ingles ◽  
Jose M. Garcia-Fernandez
Keyword(s):  
Normative Data ◽  
Common Mental Disorders ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Age And Gender ◽  
Socially Anxious ◽  
Developmental Theories ◽  
Gender And Age ◽  
Study Population ◽  
And Gender

Although social phobia is one of the most common mental disorders in adolescents, information on the need for normative data is missing. For this reason, this cross-sectional study was aimed at determining if there is a need to have normative data according to age and gender in socially anxious adolescents. Furthermore, we analyzed whether or not boys and girls differ in the nature of their social fears. The study population comprised 2,543 Spanish-speaking adolescents randomly recruited from 10 schools. The results indicate that there is no need for different normative data based on age and gender. Moreover, our data also indicate that even though there are quantitative differences between boys and girls, i.e., girls report a higher percentage, a qualitative analysis revealed that boys and girls experience the same social fears and, therefore, the nature of the social-anxiety provoking situations is the same across gender. Implications for developmental theories and assessment are discussed as well.

Normative Data for the Spanish Version of the Addenbrooke's Cognitive Examination III

2016 ◽  
Vol 41 (5-6) ◽  
pp. 243-250 ◽  
Author(s):  
Jordi A. Matías-Guiu ◽  
Ramón Fernández-Bobadilla ◽  
Aníbal Fernández-Oliveira ◽  
María Valles-Salgado ◽  
Teresa Rognoni ◽  
...  
Keyword(s):  
Normative Data ◽  
Cognitive Disorders ◽  
Demographic Factors ◽  
Spanish Version ◽  
Cognitive Test ◽  
Test Results ◽  
Cognitive Domains ◽  
Visuospatial Skills ◽  
And Gender ◽  
Addenbrooke’S Cognitive Examination

Background: Addenbrooke's Cognitive Examination III (ACE-III) is a cognitive test that has been validated for the diagnosis of cognitive disorders. The aim of this study was to provide normative data for the ACE-III for age, education and gender. Methods: The Spanish version of the ACE-III was administered to a group of 273 healthy subjects in a multicenter study in Spain. Correlation and determination coefficients for age, education and gender were estimated. The overlapping interval strategy and linear regression analyses were used to provide adjusted norms for demographic factors and to explore the potential influence of these factors in the performance of the test. Results: Age and education correlated significantly with the total score and with all the domains. Gender correlated only with the domains of attention and visuospatial skills. Norms for the total score and for cognitive domains (attention, memory, fluency, language, and visuospatial skills) are provided. Conclusion: This study confirms the influence of demographic factors (especially age and education) on the performance in the ACE-III and provides normative data for the Spanish version of the ACE-III.

scholarly journals Schizophrenia, neuroleptic medication and mortality

2006 ◽  
Vol 188 (2) ◽  
pp. 122-127 ◽  
Author(s):  
Matti Joukamaa ◽  
Markku Heliövaara ◽  
Paul Knekt ◽  
Arpo Aromaa ◽  
Raimo Raitasalo ◽  
...  
Keyword(s):  
Population Sample ◽  
Premature Death ◽  
Baseline Survey ◽  
Health Examination ◽  
Prediction Of Mortality ◽  
Comprehensive Health ◽  
Death From Natural Causes ◽  
Potential Risk Factors ◽  
And Gender ◽  
Somatic Diseases

BackgroundThere is an excess of death from natural causes among people with schizophrenia.AimsSchizophrenia and its treatment with neuroleptics were studied for their prediction of mortality in a representative population sample of 7217 Finns aged ⩾30 years.MethodA comprehensive health examination was carried out at baseline. Schizophrenia was determined using the Present State Examination and previous medical records.ResultsDuring a 17-year follow-up, 39 of the 99 people with schizophrenia died. Adjusted for age and gender, the relative mortality risk between those with schizophrenia and others was 2.84 (95% CI 2.06–3.90), and was2.25 (95%CI1.61–3.15) after further adjusting for somatic diseases, blood pressure, cholesterol, body mass index, smoking, exercise, alcohol intake and education. The number of neuroleptics used at the time of the baseline survey showed a graded relation to mortality. Adjusted for age, gender, somatic diseases and other potential risk factors for premature death, the relative risk was 2.50 (95% CI1.46–4.30) per increment of one neuroleptic.ConclusionsThere is an urgent need to ascertain whether the high mortality in schizophrenia is attributable to the disorder itself or the antipsychotic medication.

scholarly journals An Examination of Adolescent Athletes and Nonathletes on Baseline Neuropsychological Test Scores

2018 ◽  
Vol 53 (4) ◽  
pp. 404-409 ◽  
Author(s):  
Christopher P. Tomczyk ◽  
Megan Mormile ◽  
Megan S. Wittenberg; ◽  
Jody L. Langdon ◽  
Tamerah N. Hunt
Keyword(s):  
High School ◽  
High School Students ◽  
High Schools ◽  
Reaction Time ◽  
Verbal Memory ◽  
Visual Memory ◽  
Neuropsychological Test ◽  
Test Battery ◽  
Cognitive Test ◽  
High School Athletes

Context:  An estimated 15.3 million adolescent students are enrolled in US high schools, with approximately 7.8 million participating in athletics. Researchers have examined various demographics in high school athletes; however, athletic participation may play a larger role in test performance than previously thought. Currently, investigations of concussion assessment may rely on uninjured athletes as controls. However, due to the intense nature of athletics, this may not be an appropriate practice. Objective:  To examine differences between athletes and nonathletes using a common computerized neuropsychological test. Design:  Retrospective cross-sectional study. Setting:  High schools from a school district in Columbus, Ohio. Patients or Other Participants:  A total of 662 adolescent high school students (athletes: n = 383, female n = 18; nonathletes: n = 279, female n = 193). Main Outcome Measure(s):  Participants were administered a computerized neuropsychological test battery (Immediate Post-Concussion Assessment and Cognitive Test [ImPACT]) during baseline concussion assessment. Differences between groups were established for output composite scores. Results:  Differences were found between athletes and nonathletes in composite reaction time (F1,522 = 14.855, P &lt; .001) and total symptom score (F1,427 = 33.770, P &lt; .001). Nonathletes reported more symptoms, whereas athletes had faster reaction times. No differences were present in composite verbal memory, composite visual memory, composite visual motor speed, or composite impulse control (P &gt; .05). Conclusions:  Symptom reporting and reaction time differed between high school athletes and nonathletes. Participation in extracurricular activities may lead to cognitive differences in adolescents that can influence performance on the Immediate Post-Concussion Assessment and Cognitive Test battery. Researchers should account for these differences in baseline performance when making concussion diagnostic and management decisions.

scholarly journals Cognitive Performance among Cognitively Healthy Adults Aged 30–100 Years

2019 ◽  
Vol 9 (1) ◽  
pp. 11-23 ◽  
Author(s):  
Minna Alenius ◽  
Sanna Koskinen ◽  
Ilona Hallikainen ◽  
Tiia Ngandu ◽  
Jari Lipsanen ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Verbal Memory ◽  
Test Performance ◽  
Verbal Fluency ◽  
Word List ◽  
Education Level ◽  
Healthy Adults ◽  
Cognitive Test ◽  
Normative Values ◽  
And Gender

Background/Aims: To detect cognitive decline in older adults, measures of verbal fluency and verbal memory are widely used. Less is known about performance in these measures in younger persons or according to education level and gender. We investigated cognitive performance according to age, education and gender among cognitively healthy adults aged 30–100 years. Methods: The study population comprised 4,174 cognitively healthy persons participating in the nationally representative Finnish Health 2011 survey. Cognitive assessment included verbal fluency, word list memory, word list recall and word list savings from the Consortium to Establish a Registry for Alzheimer’s Disease neuropsychological battery. Results: Total variance in the cognitive test performance explained by age, education and gender varied from 12.3 to 31.2%. A decreasing trend in cognitive performance existed in all subtests by advancing age, with differences appearing between 50 and 55 years. Persons with the highest-education level performed best for all measures. For the participants < 55 years, education explained part of the variance, while age and gender did not. Conclusions: When assessing cognition, age and education should be accounted for in more detail in research and clinical practice. Additionally, the cohort effect and its potential impact on the renewal cycle of future normative values for cognitive tests should be considered.

Relationship Between PET-Assessed Amyloid Burden and Visual and Verbal Episodic Memory Performance in Elderly Subjects

2020 ◽  
Vol 78 (1) ◽  
pp. 229-244
Author(s):  
Paula Squarzoni ◽  
Daniele de Paula Faria ◽  
Mônica Sanches Yassuda ◽  
Fábio Henrique de Gobbi Porto ◽  
Artur Martins Coutinho ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Cognitive Performance ◽  
Verbal Memory ◽  
Test Scores ◽  
Visual Memory ◽  
Memory Performance ◽  
Amyloid Β ◽  
Standard Uptake Value ◽  
Cognitive Test ◽  
Elderly Subjects

Background: Studies of elderly subjects using biomarkers that are proxies for Alzheimer’s disease (AD) pathology have the potential to document meaningful relationships between cognitive performance and biomarker changes along the AD continuum. Objective: To document cognitive performance differences across distinct AD stages using a categorization based on the presence of PET-assessed amyloid-β (Aβ) burden and neurodegeneration. Methods: Patients with mild dementia compatible with AD (n = 38) or amnestic mild cognitive impairment (aMCI; n = 43) and a cognitively unimpaired group (n = 27) underwent PET with Pittsburgh compound-B (PiB) assessing Aβ aggregation (A+) and [18F]FDG-PET assessing neurodegeneration ((N)+). Cognitive performance was assessed with verbal and visual episodic memory tests and the Mini-Mental State Examination. Results: The A+(N)+ subgroup (n = 32) showed decreased (p < 0.001) cognitive test scores compared to both A+(N)–(n = 18) and A–(N)–(n = 49) subjects, who presented highly similar mean cognitive scores. Despite its modest size (n = 9), the A–(N)+ subgroup showed lower (p < 0.043) verbal memory scores relative to A–(N)–subjects, and trend lower (p = 0.096) scores relative to A+(N)–subjects. Continuous Aβ measures (standard uptake value ratios of PiB uptake) were correlated most significantly with visual memory scores both in the overall sample and when analyses were restricted to dementia or (N)+ subjects, but not in non-dementia or (N)–groups. Conclusion: These results demonstrate that significant Aβ-cognition relationships are highly salient at disease stages involving neurodegeneration. The fact that findings relating Aβ burden to memory performance were detected only at (N)+ stages, together with the similarity of test scores between A+(N)–and A–(N)–subjects, reinforce the view that Aβ-cognition relationships during early AD stages may remain undetectable unless substantially large samples are evaluated.

scholarly journals Institutionally Based ImPACT Test® Normative Values May Differ from Manufacturer-Provided Normative Values

2019 ◽  
Vol 35 (3) ◽  
pp. 275-282 ◽  
Author(s):  
Samuel R Walton ◽  
Donna K Broshek ◽  
Jason R Freeman ◽  
Jay Hertel ◽  
J Patrick Meyer ◽  
...  
Keyword(s):  
Normative Data ◽  
Goodness Of Fit ◽  
National Collegiate Athletic Association ◽  
Cognitive Test ◽  
Normative Values ◽  
Motor Speed ◽  
Average Performance ◽  
Increased Risk ◽  
Chi Squared ◽  
And Gender

Abstract Objective The necessity for pre-injury baseline computerized neurocognitive assessments versus comparing post-concussion outcomes to manufacturer-provided normative data is unclear. Manufacturer-provided norms may not be equivalent to institution-specific norms, which poses risks for misclassifying the presence of impairment when comparing individual post-concussion performance to manufacturer-provided norms. The objective of this cohort study was to compare institutionally derived normative data to manufacturer-provided normative values provided by ImPACT® Applications, Incorporated. Method National Collegiate Athletic Association Division 1 university student athletes (n = 952; aged 19.2 ± 1.4 years, 42.5% female) from one university participated in this study by completing pre-injury baseline Immediate Post-Concussion Assessment and Cognitive Test (ImPACT) assessments. Participants were separated into 4 groups based on ImPACT’s age and gender norms: males &lt;18 years old (n = 186), females &lt;18 years old (n = 165), males &gt;19 years old (n = 361) or females &gt;19 years old (n = 240). Comparisons were made between manufacturer-provided norms and institutionally derived normative data for each of ImPACT’s clinical composite scores: Verbal (VEM) and Visual (VIM) Memory, Visual Motor Speed (VMS), and Reaction Time (RT). Outcome scores were compared for all groups using a Chi-squared goodness of fit analysis. Results Institutionally derived normative data indicated above average performance for VEM, VIM, and VMS, and slightly below average performance for RT compared to the manufacturer-provided data (χ2 ≥ 20.867; p &lt; 0.001). Conclusions Differences between manufacturer- and institution-based normative value distributions were observed. This has implications for an increased risk of misclassifying impairment following a concussion in lieu of comparison to baseline assessment and therefore supports the need to utilize baseline testing when feasible, or otherwise compare to institutionally derived norms rather than manufacturer-provided norms.

Up to a Third of Renal Transplant Recipients Have Deficiencies in Cognitive Functioning

2017 ◽  
Vol 27 (4) ◽  
pp. 329-338 ◽  
Author(s):  
Lisa Stoessel ◽  
Katharina Schieber ◽  
Sabine Jank ◽  
Sandra Reber ◽  
Franziska Grundmann ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Cognitive Functioning ◽  
Cognitive Performance ◽  
Cognitive Abilities ◽  
Normative Data ◽  
Deceased Donor ◽  
Cognitive Test ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Number Of Patients

Introduction: Kidney transplantation is beneficial in improving cognitive abilities in patients with chronic kidney disease; however, there is still uncertainty concerning which cognitive domains benefit and to what extent. Aim: In the present study, cognitive functioning of renal transplant recipients was compared to normative data. Sociodemographic and clinical parameters that were associated with low cognitive performance were identified. Design: A total of 109 renal transplant recipients (63% men) participated in the study, with a mean age of 51.8 (standard deviation [SD] = 14.2) years. The cognitive test battery consisted of measurements assessing memory, attention, executive function, reproductive, and deductive ability. Results: In all tests, participants showed mean scores ranging within 1 SD of the population means. However, except for tests measuring memory, the percentage of participants scoring more than 1 SD below normed means was higher than expected in a normal distribution of performance. In certain tests, up to a third of the participants scored below average. Participants with continuous low performance (11%) showed higher age, poorer education, a longer time since transplantation, higher serum levels of urea and creatinine, and were more likely to have a deceased donor allograft. Discussion: Altough cognitive performance in renal transplant recipients matches normative data and confirms former findings, the amount of patients scoring more than 1 SD below average suggests that there are a considerable number of patients whose cognitive performance in certain domains lies below those of the general population. The identified sociodemographic and biochemical factors might be helpful to identify renal transplant recipients at risk.

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