No Difference in Cognitive Dysfunction Among Patients with ANCA-Associated Vasculitis, Rheumatoid Arthritis or Chronic Kidney Disease

AbstractObjective: To characterize cognitive function in patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) in comparison with other chronic conditions, and to investigate its association with disease activity, and other psychological factors. Methods: Cross-sectional study including patients with AAV, rheumatoid arthritis (RA) (n = 30), and chronic kidney disease (CKD) (n = 29). Patients underwent a standardized neuropsychological battery (NEUROPSI). Sleep quality, fatigue, depression, and anxiety levels were assessed. Results: A total of 60 patients with AAV were included, median age of 54 years, and disease duration of 5.6 years. Prevalence of cognitive dysfunction (CD) in AAV patients was similar to RA and CKD (35%, 40%, and 39.3%, respectively, p = .88). When AAV patients with (n = 21) and without (n = 39) CD were compared, significantly more patients with CD had high disease activity (67% vs. 31%, p = .009). Abnormal performance was more frequent in the executive functions in the three groups (45% AAV, 51.7% RA, and 50% CKD), followed by language (25%, 13.8%, and 25%, respectively). Verbal and visual attentional tests were more frequently impaired in patients from the CKD group (p = .021), and psychomotor functions were more frequently affected in AAV patients (p < .05). Hospital Anxiety and Depression Scale (HADS) total score (especially anxiety) was higher in patients with memory impairment than in those with normal memory function (M = 6.79, SD = 4.53 vs. M = 4.5, SD = 3.6, p < .01). Neither Sleep Quality Index nor fatigue scale scores differed between those cognitively impaired and not impaired. Conclusions: No statistically significant differences were found in the frequency of CD among the three clinical populations. (JINS, 2019, 25, 595–602)

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PILL BURDEN, SLEEP QUALITY, ANXIETY, DEPRESSION IN PATIENTS WITH DIABETIC AND NON -DIABETIC CHRONIC KIDNEY DISEASE

Journal of Biomedical and Pharmaceutical Research ◽

10.32553/jbpr.v8i5.654 ◽

2019 ◽

Vol 8 (5) ◽

Author(s):

Shaik Khaja Shanawaz Basha

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Sleep Quality ◽

Sleep Disturbances ◽

Depression Scale ◽

Anxiety And Depression ◽

Pill Burden

Background: Chronic kidney disease (CKD) has a significant impact upon the quality of life of patients due to multiple factors. One of major stress is due to medication effects which may affect in patients with chronic kidney disease quality of life. In patients with chronic kidney disease, anxiety disorders are often perceived to represent the symptoms of depression and sleep disturbances. Aim and objectives: Therefore the present study evaluated the role of Pill burden, sleep quality, anxiety and depression in patients with diabetic and Non -diabetic chronic kidney disease. Materials and methods: The present study was conducted in 198 pre dialysis CKD patients of 1 to 5 stages with and without Diabetes mellitus. Sleep quality was assessed by using Pittsburgh Sleep Quality Index (PSQI) which is a standard self- reported scale for assessment of sleep quality. Anxiety and depression scores were calculated by using Hospital Anxiety and Depression scale (HADS). Results: With increasing severity of disease burden, CKD patients were found to have more increase in pill burden, reduction in sleep quality, increase in anxiety and depression. This progression was found to be more significant in diabetic CKD patients when compared to non- diabetic CKD patients. Conclusion: The present study findings conclude that patients with advanced stages of CKD experience a high symptom burden that impacts on their daily life. Diabetic CKD patients have been found to be more prone to altered sleep quality, anxiety and depression than non- diabetic CKD patients. Keywords: Chronic kidney disease, Diabetes mellitus, Pill burden, sleeps quality, anxiety and depression.

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A Multidimensional Model of Fatigue in Patients with Rheumatoid Arthritis

The Journal of Rheumatology ◽

10.3899/jrheum.111068 ◽

2012 ◽

Vol 39 (9) ◽

pp. 1807-1813 ◽

Cited By ~ 27

Author(s):

PERRY M. NICASSIO ◽

SARAH R. ORMSETH ◽

MARA K. CUSTODIO ◽

MICHAEL R. IRWIN ◽

RICHARD OLMSTEAD ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Sleep Quality ◽

Disease Activity ◽

Structural Equation ◽

Mood Disturbance ◽

Equation Modeling ◽

Poor Sleep ◽

Direct Effects ◽

Multidimensional Model ◽

Poor Sleep Quality

Objective.To evaluate a multidimensional model testing disease activity, mood disturbance, and poor sleep quality as determinants of fatigue in patients with rheumatoid arthritis (RA).Method.The data of 106 participants were drawn from baseline of a randomized comparative efficacy trial of psychosocial interventions for RA. Sets of reliable and valid measures were used to represent model constructs. Structural equation modeling was used to test the direct effects of disease activity, mood disturbance, and poor sleep quality on fatigue, as well as the indirect effects of disease activity as mediated by mood disturbance and poor sleep quality.Results.The final model fit the data well, and the specified predictors explained 62% of the variance in fatigue. Higher levels of disease activity, mood disturbance, and poor sleep quality had direct effects on fatigue. Disease activity was indirectly related to fatigue through its effects on mood disturbance, which in turn was related to poor sleep quality. Mood disturbance also indirectly influenced fatigue through poor sleep quality.Conclusion.Our findings confirmed the importance of a multidimensional framework in evaluating the contribution of disease activity, mood disturbance, and sleep quality to fatigue in RA using a structural equation approach. Mood disturbance and poor sleep quality played major roles in explaining fatigue along with patient-reported disease activity.

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MO529PREVALENCE AND DETERMINANT FACTORS OF DEPRESSION AND ANXIETY IN PEOPLE WITH CHRONIC KIDNEY DISEASE : A MOROCCAN CROSS-SECTIONAL STUDY

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfab087.0049 ◽

2021 ◽

Vol 36 (Supplement_1) ◽

Author(s):

Amina Chrifi Alaoui ◽

Mohammed Omari ◽

Noura Qarmiche ◽

Omar Kouiri ◽

Basmat Amal Chouhani ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Depression Scale ◽

Clinical Information ◽

Cross Sectional Study ◽

University Hospital ◽

Depression And Anxiety ◽

Cross Sectional ◽

Determinant Factors ◽

Before And After

Abstract Background and Aims The Chronic kidney disease (CKD), like many chronic illnesses, is invariably associated with various psychiatric conditions and poorer quality of life. This study aims to assess the prevalence of depression and anxiety among CKD patient and their determinant factors. Method this is a cross sectional single center study in a Moroccan university hospital. Patients aged ≥ 18 years old and followed for more than one year were included. The data was collected using a questionnaire for sociodemographic and clinical information and the Hospital anxiety and depression scale (HADS) to assess depression and anxiety prevalence. After the description of the population’s characteristics, the statistical analysis aimed to assess the association between depression and anxiety disorders and the estimated glomerular filtration rate before and after adjustment on several confounding factors. Results 88 patients were included (63.6% of them were women, the mean age was 61.8±14.0 years), 21 were on stage 3, 46 were on stage 4, and 21 were on stage 5 of the CKD. The median of depression sub-score was 5.00[2.00; 10.0], the median of anxiety sub-score was 6.00[4.00; 9.00], and the median of the global score was 11.0[7.00; 20.0], 22.0% of included patients had depression and 22.0% had anxiety. Both depression and anxiety scores were associated to eGFR before and after adjustment (p= 0.001, p<0.001and p=0.04, p=0.03 respectively). Conclusion This study showed that depression and anxiety are strongly related to the CKD progression, which should motivate both doctors and nurses to improve their psychological care toward CKD patients.

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TINJAUAN SISTEMATIK: KECEMASAN PASIEN PENYAKIT GINJAL KRONIK DENGAN TINDAKAN HEMODIALISIS

Jurnal Kesehatan Mesencephalon ◽

10.36053/mesencephalon.v4i2.74 ◽

2018 ◽

Vol 4 (2) ◽

Author(s):

May Dwi Yuri Santoso

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Depression Scale ◽

Pharmacological Action ◽

Spiritual Intelligence ◽

Anxiety And Depression ◽

Hospital Anxiety ◽

Factors Affecting ◽

Social Demographic ◽

Keywords Anxiety

The action of hemodialysis in patients with chronic kidney disease can trigger anxiety due to situational crisis, death threat and not know the final result of hemodialysis action. The purpose of this systematic review is to gain an understanding of the anxiety of patients with chronic kidney disease with hemodialysis action. The results of a review of 15 journals that have been selected suggest that patients with chronic kidney disease with hemodialysis actions mostly experience anxiety. The most widely used instruments are (HADS) Hospital Anxiety And Depression Scale (n = 5). Factors affecting anxiety of chronic kidney disease patients with hemodialysis action are social demographic factors such as sex, age, occupation, duration of hemodialysis and education. Other factors are psychological, social perception, non pharmacological action (progressive muscular), (aroma therapy) and spiritual intelligence. The conclusion that anxiety disorder is very important, and appropriate Instrument will affect patient objective anxiety results. The need for a team collaborative approach to reduce anxiety of patients with chronic kidney disease by hemodialysis. Keywords : Anxiety, Chronic Kidney Disease, Hemodialysis

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