Use of oral reading to estimate premorbid intellectual and neuropsychological functioning

1999 ◽  
Vol 5 (3) ◽  
pp. 247-254 ◽  
Author(s):  
JULIE AKIKO GLADSJO ◽  
ROBERT K. HEATON ◽  
BARTON W. PALMER ◽  
MICHAEL J. TAYLOR ◽  
DILIP V. JESTE

Judgment of neuropsychological decline is typically made by comparing a patient's current cognitive performance to data from demographically similar normal individuals. Even within narrowly defined demographic categories, however, there is variability in level of performance, approximating the normal curve. The present study explored the degree to which oral reading scores on the American National Adult Reading Test (ANART) could more accurately predict a person's test performance relative to other demographically similar individuals. In a sample of 141 neurologically healthy participants, the ANART added modestly to the precision of WAIS–R Verbal and Full Scale IQ and Learning score predictions, beyond that achieved by demographics alone; however, ANART score did not significantly improve estimation of Performance IQ, Average Impairment Rating, or Memory score. Use of the ANART tended to improve demographic predictions primarily with “outlier” participants whose oral reading skills were relatively poor. For Verbal IQ, ANART helped with participants who had both poor ANART and relatively high education. Oral reading can be useful for estimating premorbid verbal intelligence and learning in combination with demographic variables, but it does not appear to improve estimates of other neurocognitive abilities. (JINS, 1999, 5, 247–254.)

1995 ◽  
Vol 25 (3) ◽  
pp. 263-276 ◽  
Author(s):  
Eileen J. Burker ◽  
James A. Blumenthal ◽  
Michelle Feldman ◽  
Elizabeth Thyrum ◽  
Elizabeth Mahanna ◽  
...  

Objective: The present longitudinal study was designed to: 1) determine the ability of the Mini Mental State Exam (MMSE) to predict neuropsychologic impairment based on neuropsychologic testing five to seven days and six weeks after cardiac surgery; and 2) to determine whether the traditional or the education-related MMSE norms are more appropriate to use for this purpose. Method: The day before surgery (T1), before hospital discharge (T2), and six weeks after surgery (T3), 247 subjects completed a battery of five neuropsychologic tests. Subjects also completed the Center for Epidemiological Studies Depression Scale and the Speilberger State-Trait Anxiety Inventory. Subjects completed the MMSE two to three days after surgery. Results: Stepwise regression analyses revealed that the MMSE significantly predicted only a small portion of the variance in neuropsychologic test performance at T2, and to an even lesser extent at T3, over and above the demographic variables. In assessing the association between an impairment score (derived from the neuropsychologic test battery) and the MMSE, we found that the traditional MMSE cut-off score maximized specificity (number of true negatives) while the education-adjusted MMSE cut-off scores maximized sensitivity (number of true positives). Conclusions: These results suggest that although the MMSE is widely used to assess cognitive mental status, it may have limited value in identifying patients with cognitive impairment post-cardiac surgery, and special attention must be paid to the cut-off scores used in interpreting the MMSE.


2002 ◽  
Vol 8 (6) ◽  
pp. 847-854 ◽  
Author(s):  
PETER BRIGHT ◽  
ELI JALDOW ◽  
MICHAEL D. KOPELMAN

Since its publication in 1982, the National Adult Reading Test (NART; Revised Version, NART–R) has become a widely accepted method for estimating premorbid levels of intelligence in neuropsychological research. However, the assumption that NART/NART–R performance is relatively independent of brain damage has been increasingly challenged in recent years. In a number of conditions, including Alzheimer dementia and Korsakoff's syndrome, studies have indicated a deterioration in reading ability, leading to an underestimated premorbid IQ. In a reaction to these studies, some researchers have advocated the use of demographic variables as a more suitable foundation for accurately predicting premorbid intelligence. We addressed this issue by calculating IQ estimates on the basis of NART/NART–R, demographic variables, and a combination of the two approaches and by comparing these with current WAIS/WAIS–R IQ in patients with Korsakoff's syndrome, Alzheimer dementia, frontal or temporal lobe lesions, and in healthy controls. Estimated premorbid IQs did not differ across groups, whether derived from NART/NART–R or demographic variables. Those based on NART/NART–R demonstrated higher correlations with current WAIS/WAIS–R IQ in controls and patients than those derived from demographic variables. An equation combining NART scores with demographic variables did not significantly increase the amount of variance in IQ explained by NART only, either in patients or controls. The data offer reassurance regarding the continued use of NART as a valid estimate of premorbid intelligence in a number of conditions. (JINS, 2002, 8, 847–854.)


2020 ◽  
Author(s):  
Sarah E Dubner ◽  
Michal Ben-Shachar ◽  
Aviv Mezer ◽  
Heidi M Feldman ◽  
Katherine E Travis

ABSTRACTAIMChildren born preterm (PT) experience perinatal white matter injury and later reading deficits at school age. We used two complementary neuroimaging modalities to determine if reading skills would be associated with contemporaneous white matter properties in school-aged PT children.METHODIn 8-year-old PT children (N=29), we measured diffusivity (fractional anisotropy, FA), from diffusion MRI, and myelin content (relaxation rate, R1) from quantitative relaxometry. We assessed reading (Gray’s Oral Reading Test, Fifth Edition) in each child. Whole-brain deterministic tractography coupled with automatic segmentation and quantification were applied to extract FA and R1 along four tracts and assess their statistical association with reading scores.RESULTSReading-FA correlations were not significant along the four analyzed tracts. Reading-R1 correlations were significantly positive in portions of the left superior longitudinal fasciculus, right uncinate fasciculus, and left inferior longitudinal fasciculus. FA positively correlated with R1 in limited areas of reading-R1 associations, but did not contribute to the variance in reading scores.INTERPRETATIONCombining complementary neuroimaging approaches identified relations between reading and white matter properties not found using a single MRI measure. Associations of reading skills and white matter properties may vary across white matter tracts and metrics in PT children.What this paper adds▪Preterm children’s reading was associated with white matter myelin content.▪Preterm children’s reading was not associated with white matter diffusivity.


2021 ◽  
Author(s):  
Edith Brignoni-Perez ◽  
Sarah Dubner ◽  
Michal Ben-Shachar ◽  
Shai Berman ◽  
Aviv A. Mezer ◽  
...  

Diffusion magnetic resonance imaging (dMRI) studies find differences in associations between reading and white matter fractional anisotropy (FA) in children born full term (FT) versus preterm (PT). Use of complementary neuroimaging modalities may reveal neurobiological factors driving these associations. We used two MRI methods to interpret associations of reading abilities and white matter properties in FT and PT children. Participants (N=79; 36 FT; 43 PT) were administered Gray’s Oral Reading Test at age 8 years. We segmented two dorsal and two ventral white matter tracts associated with reading skills and quantified (1) FA from dMRI and (2) R1 from quantitative relaxometry, as a proxy for myelin content. We examined correlations between reading scores and imaging metrics, assessing trajectories along the tracts. Mean reading scores fell in the typical range in both groups. Reading positively correlated with FA in segments of the left arcuate and the left and right superior longitudinal fasciculi, but only in FT children, not in PT children. Reading positively correlated with R1 in segments of the left superior longitudinal, right uncinate, and left inferior longitudinal fasciculi, but only in PT children, not in FT children. The significantly different patterns of associations between reading abilities and white matter properties across FT and PT groups suggest variations in the neurobiology of typical reading abilities.


1992 ◽  
Vol 22 (4) ◽  
pp. 903-909 ◽  
Author(s):  
R. E. O'Carroll ◽  
A. Moffoot ◽  
K. P. Ebmeier ◽  
G. M. Goodwin

SynopsisThe National Adult Reading Test (NART) is widely used in clinical and research settings to estimate pre-morbid intellectual levels. The validity of the NART in estimating pre-morbid ability in Alcoholic Korsakoff Syndrome (AKS) is examined in the present study. Twenty AKS subjects were compared with 40 healthy controls. The validity of the NART as a pre-morbid measure in AKS was examined using four methods. AKS subjects made more NART errors than controls, had lower NART predicted IQ than demographically predicted IQ, made more NART errors than predicted by demographic variables and demonstrated NART performance which correlated with degree of memory impairment. It is concluded that NART performance is detrimentally affected by the AKS and that estimating pre-morbid intellectual level in Korsakoff's psychosis using the NART may be invalid. Furthermore, it is postulated that the impaired ability to pronounce correctly irregular words in AKS may reflect a failure in cognitive ‘error checking’ which may represent a consequence of frontal lobe dysfunction.


2013 ◽  
Author(s):  
David G. Wall ◽  
Jeremy J. Davis ◽  
Jacqueline H. Remondet Wall

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Valerie H. Balldin ◽  
James R. Hall ◽  
Robert C. Barber ◽  
Linda Hynan ◽  
Ramon Diaz-Arrastia ◽  
...  

Background. Considerable research documents an association between pro- and anti-inflammatory markers and Alzheimer's disease (AD), yet the differential relation between these markers and neuropsychological functioning in AD and nondemented controls has received less attention. The current study sought to evaluate the relationship between peripheral markers of inflammation (both pro- and anti-inflammatory) and neuropsychological functioning through the Texas Alzheimer's Research and Care Consortium (TARCC) cohort.Methods. There were 320 participants (Probable ADn=124, Controlsn=196) in the TARCC Longitudinal Research Cohort available for analysis. Regression analyses were utilized to examine the relation between proinflammatory and anti-inflammatory markers and neuropsychological functioning. Follow-up analyses were conducted separately by case versus control status.Results. Proinflammatory and anti-inflammatory markers were found to be associated with neuropsychological testing. Third tertile proinflammatory markers were negatively associated with measures of attention and language, and anti-inflammatory markers were positively associated with measures of immediate verbal memory and delayed verbal and visual memory.Conclusions. These findings support the link between peripheral inflammatory markers and neuropsychological functioning and suggest the utility of examining profiles of inflammatory markers in the future.


2009 ◽  
Vol 13 (S1) ◽  
Author(s):  
L.L. Larsen ◽  
Ø. Øistensen Holthe ◽  
N.I. Landrø ◽  
T.C. Stiles ◽  
P.C. Borchgrevink

2006 ◽  
Vol 12 (5) ◽  
pp. 707-735 ◽  
Author(s):  
ELIZABETH W. TWAMLEY ◽  
SUSAN A. LEGENDRE ROPACKI ◽  
MARK W. BONDI

Alzheimer's disease (AD) is a common, devastating form of dementia. With the advent of promising symptomatic treatment, the importance of recognizing AD at its very earliest stages has increased. We review the extant neuropsychological and neuroimaging literature on preclinical AD, focusing on longitudinal studies of initially nondemented individuals and cross-sectional investigations comparing at-risk with normal individuals. We systematically reviewed 91 studies of neuropsychological functioning, structural neuroimaging, or functional neuroimaging in preclinical AD. The neuropsychological studies indicated that preclinical AD might be characterized by subtle deficits in a broad range of neuropsychological domains, particularly in attention, learning and memory, executive functioning, processing speed, and language. Recent findings from neuroimaging research suggest that volume loss and cerebral blood flow or metabolic changes, particularly in the temporal lobe, may be detected before the onset of dementia. There exist several markers of a preclinical period of AD, in which specific cognitive and biochemical changes precede the clinical manifestations. The preclinical indicators of AD reflect early compromise of generalized brain integrity and temporal lobe functioning in particular. (JINS, 2006,12, 707–735.)


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