Near-infrared Imaging in Stroke Research

1997 ◽  
Vol 3 (S2) ◽  
pp. 829-830
Author(s):  
R.J. Dempsey ◽  
R.G. Buice ◽  
W.C. Symons ◽  
R.A. Lodder
Keyword(s):  
Near Infrared ◽  
Carotid Atherosclerosis ◽  
Infrared Imaging ◽  
Disease Process ◽  
Stroke Research ◽  
Collateral Growth ◽  
Life Threatening ◽  
Long Term Prognosis ◽  
Lipoprotein Composition

Accurate and nondestructive measurement of different lipoproteins simultaneously in carotid plaque in stroke patients using near-infrared (IR) imaging spectrometry seems possible for research. The lipoprotein composition of the plaque appears to have an impact on the outcome of the disease process. Carotid atherosclerosis without associated thrombosis is frequently a benign disease that is asymptomatic, although TIAs may be present in other cases. Many patients with carotid atherosclerosis can be treated surgically by endarterectomy with high initial success and favorable long-term prognosis. The acute manifestation of carotid atherosclerosis - stroke - arises when thrombus or ulceration develop. This potentially life-threatening complication probably develops at the site of plaque fissure or rupture. Recent research by others indicates that it is not the severity of stenosis (plaque volume) that determines the outcome: it is the type of stenosis (plaque chemical composition) and the extent of collateral growth.

scholarly journals Can newborn screening be cost benefit procedure if preventing serious complications of cystic fibrosis?

2021 ◽  
pp. 020-023
Author(s):  
Šubat-Dežulović Mirna ◽  
Pelčić Gordana ◽  
Valković Ana ◽  
Flajšman-Raspor Sanja ◽  
Pelčić Goran ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Newborn Screening ◽  
Metabolic Alkalosis ◽  
Cost Benefit ◽  
Inherited Disease ◽  
Eu Countries ◽  
Life Threatening ◽  
Long Term Prognosis ◽  
The Cost

Cystic Fibrosis (CF) is a common inherited disease with reported mean prevalence of 0.737/10,000 in 27 EU countries (Farrell J Cyst Fibros. 2008). Still, many EU countries have not implemented CF in the Newborn Screening (NBS) programme, including our country. We report the case of a 7-month-old boy whose presenting signs of CF were life-threatening neurological symptoms caused by severe metabolic alkalosis and hypoelectrolytemia. By presenting this case, we argue hoping to persuade the authorities in any country that the available newborn screening for CF is the cost benefit procedure in preventing life treating consequences with the obvious impact on the long-term prognosis of this chronic disease.

Cholesterol Embolism in Intensive Care Patients

1993 ◽  
Vol 8 (2) ◽  
pp. 91-102 ◽  
Author(s):  
Lisa L. Kirkland
Keyword(s):  
Case Reports ◽  
Supportive Therapy ◽  
Hemodynamic Instability ◽  
Cholesterol Embolism ◽  
Intensive Care Patients ◽  
Major Organ ◽  
Life Threatening ◽  
Perineal Gangrene ◽  
Long Term Prognosis

Four case reports are presented, followed by a discussion of the acute, potentially life-threatening manifestations of the cholesterol embolism syndromes. Every major organ system except the lungs may be directly affected by cholesterol emboli; devastating consequences encompass cerebral, myocardial, spinal cord, intestinal, renal, and other visceral organ infarction, as well as peripheral and perineal gangrene. Additional complications include severe hypertension, gastrointestinal bleeding, and hemodynamic instability. Anticoagulants and thrombolytic therapy may exacerbate atheromatous embolism and are relatively contraindicated. Aggressive supportive therapy may improve chances of survival, but long-term prognosis is poor. Prevention remains the most important aspect in this devastating disorder.

scholarly journals Long-term prognosis of patients with life-threatening ventricular arrhythmias induced by coronary artery spasm

EP Europace ◽  
2017 ◽  
Vol 20 (5) ◽  
pp. 851-858 ◽  
Author(s):  
Moisés Rodríguez-Mañero ◽  
Teresa Oloriz ◽  
Jean-Benoit le Polain de Waroux ◽  
Haran Burri ◽  
Bahij Kreidieh ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Ventricular Arrhythmias ◽  
Coronary Artery Spasm ◽  
Life Threatening ◽  
Long Term Prognosis

scholarly journals The correlation between traditional risk factors and the severity of acute coronary syndrome and long-term prognosis

2015 ◽  
Vol 6 (4) ◽  
pp. 6-10
Author(s):  
I. S Skopets ◽  
N. N Vezikova ◽  
I. M Marusenko ◽  
O. Yu Barysheva
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Family History ◽  
Coronary Syndrome ◽  
Increased Risk ◽  
Life Threatening ◽  
Traditional Risk Factors ◽  
Long Term Prognosis

A number of studies demonstrate that patients with traditional risk factors (TRF) have not only increases primary risk of atherothrombotic events, but are also associated with many complicates and poor prognosis.Purpose: assessment of TRF effect on the incidence of complications and outcomes in patients with acute coronary syndrome (ACS).Materials and methods: in 255 patients hospitalized with ACS were retrospective determined the TRF prevalence, frequency of the complications and correlation between the presence of TRF and the risk of complications and long-term prognosis (follow-up 1 year).Results: patients had TRF very often, 80% patients had more than 3 TRFs. The presence of some TRFs (smoking, abdominal obesity, family history) was associated with a significantly increased risk of complications in patients with ACS, including life-threatening. Effect of TRF on long-term prognosis was not determined.Conclusion: the findings suggest the need to evaluation TRF not only in primary preventive and also to improve the effectiveness of risk stratification in patients with ACS.

scholarly journals Novel Treatment Pathways in Pulmonary Arterial Hypertension

2021 ◽  
Vol 17 (2) ◽  
pp. 106-114
Author(s):  
Kanza N Qaiser ◽  
Adriano R Tonelli
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Disease Process ◽  
Ongoing Research ◽  
Treatment Pathways ◽  
Pulmonary Vascular Remodeling ◽  
Pulmonary Arterial ◽  
Long Term Prognosis ◽  
New Treatments

Pulmonary arterial hypertension (PAH) is a severe and progressive vascular disease characterized by pulmonary vascular remodeling, proliferation, and inflammation. Despite the availability of effective treatments, PAH may culminate in right ventricular failure and death. Currently approved medications act through three well-characterized pathways: the nitric oxide, endothelin, and prostacyclin pathways. Ongoing research efforts continue to expand our understanding of the molecular pathogenesis of this complex and multifactorial disease. Based on recent discoveries in the pathobiology of PAH, several new treatments are being developed and tested with the goal of modifying the disease process and ultimately improving the long-term prognosis.

Craniectomy in severe, life-threatening encephalitis: a report on outcome and long-term prognosis of four cases

2001 ◽  
Vol 27 (8) ◽  
pp. 1426-1428 ◽  
Author(s):  
E. Taferner ◽  
B. Pfausler ◽  
A. Kofler ◽  
H. Spiss ◽  
K. Engelhardt ◽  
...  
Keyword(s):  
Life Threatening ◽  
Long Term Prognosis

scholarly journals Tricarbocyanine N-triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells in vivo

2018 ◽  
Vol 9 (36) ◽  
pp. 7261-7270 ◽  
Author(s):  
Richard J. Mellanby ◽  
Jamie I. Scott ◽  
Iris Mair ◽  
Antonio Fernandez ◽  
Louise Saul ◽  
...  
Keyword(s):  
Immune Cells ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Near Infrared Imaging ◽  
Nir Dyes

Tricarbocyanine N-triazoles are first described as rationally-designed structures to overcome the limitations of NIR dyes for long-term in vivo imaging.

Verbal Dyspraxia in Treated Galactosemia

PEDIATRICS ◽  
1991 ◽  
Vol 88 (2) ◽  
pp. 346-350
Author(s):  
C. Donald Nelson ◽  
Diane D. Waggoner ◽  
Judith M. Tuerck ◽  
George N. Donnell ◽  
Neil R. M. Buist
Keyword(s):  
Biochemical Control ◽  
Speech Defect ◽  
Rapid Improvement ◽  
Speech Characteristics ◽  
Life Threatening Illness ◽  
Life Threatening ◽  
Iq Scores ◽  
Long Term Prognosis ◽  
Rare Metabolic Disorder

Galactosemia is an inborn error of metabolism that causes life-threatening illness a few days after galactose-containing milk is fed to a newborn. Early treatment with a strict lactose-free diet results in rapid improvement, and, until recently, it was thought that the long-term prognosis in such infants was usually good. The speech characteristics of 24 patients treated for galactosemia were examined. Fifty-four percent had the specific speech disorder, verbal dyspraxia. This finding was not related to age at diagnosis, severity of symptoms in the newborn period, or to biochemical control. There may be, however, a relation between dyspraxia and diminished IQ scores observed in the group of patients with dyspraxia judged as "severe." The findings indicate the association of a specific and unusual speech defect with a specific and rare metabolic disorder.

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