The effect of vitamin E and long-chain polyunsaturated fatty acid supplementation of pregnant and lactating ewes on the transfer of vitamin E to the lamb

2003 ◽  
Vol 2003 ◽  
pp. 61-61
Author(s):  
J. L. Capper ◽  
R. G. Wilkinson ◽  
E. Kasapidou ◽  
S. E. Pattinson ◽  
A. M. Mackenzie ◽  
...  
Keyword(s):  
Vitamin E ◽  
Maternal Diet ◽  
Dietary Vitamin ◽  
Chain Polyunsaturated Fatty Acid ◽  
Biochemical Mechanism ◽  
Pufa Supplementation ◽  
Fatty Acid Supplementation ◽  
Chain Pufa ◽  
Vitamin E Status ◽  
Long Chain

It is reported that supplementing pregnant ewes with supra-optimal levels of vitamin E improves neonatal lamb vigour and growth rate (Merrell, 1998). The biochemical mechanism behind these observations has yet to be elucidated as several studies report negligible placental vitamin E transfer in ruminants (Van Saun et al., 1989); consequently, lambs may be clinically deficient in this nutrient at birth and achieve a satisfactory vitamin E status via colostrum ingestion. Lamb vitamin E status may be further diminished by the addition of polyunsaturated fatty acids (PUFAs) to the maternal diet. However, PUFA supplementation demonstrably enhances foetal and neonatal development in human studies (Morley, 1998) although these effects have not been investigated in ruminants to any depth. The objective of this experiment was to investigate the effects of dietary vitamin E in combination with long-chain PUFA supplementation of ewes on ewe and lamb performance.

The effect of long-chain polyunsaturated fatty acid and vitamin E supplementation of ewes on neonatal lamb vigour, lamb growth and colostrum parameters

2002 ◽  
Vol 2002 ◽  
pp. 7-7 ◽  
Author(s):  
J. L. Capper ◽  
R. G. Wilkinson ◽  
L. A. Sinclair ◽  
S. E. Pattinson ◽  
A. M. Mackenzie
Keyword(s):  
Fatty Acids ◽  
Vitamin E ◽  
Chain Polyunsaturated Fatty Acid ◽  
Alpha Linolenic Acid ◽  
Chain Pufa ◽  
Ruminant Diets ◽  
The Brain ◽  
Lamb Growth ◽  
Long Chain ◽  
Vitamin E Supplementation

The long-chain polyunsaturated fatty acids (PUFA) docosahexaenoic acid (DHA) and arachidonic acid (AA) are the most abundant fatty acids in the brain and are vital for its correct development and for that of the nervous system (Huang and Craig-Schmidt, 1996). Ruminant diets are low in DHA and its precursor alpha-linolenic acid. In addition, dietary PUFAs are substantially hydrogenated in the rumen. Consequently, it may be argued that the diets of pregnant and lactating ewes may be deficient in DHA and that a response to supplementation may be observed. Studies involving the supplementation of pregnant ewes with supraoptimal levels of vitamin E have shown that lambs born to supplemented dams are more vigorous immediately after birth and have higher liveweight gains (Merrell, 1998). The objective of this experiment was to investigate the effects of dietary long-chain PUFA in combination with vitamin E supplementation of ewes on ewe and lamb performance.

Influence of long-chain polyunsaturated fatty acid on vitamin E status of pregnant women

2005 ◽  
Vol 30 (03) ◽  
Author(s):  
C Franke ◽  
H Demmelmair ◽  
T Decsi ◽  
C Campoy ◽  
K Müller ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Vitamin E ◽  
Pregnant Women ◽  
Polyunsaturated Fatty Acid ◽  
Chain Polyunsaturated Fatty Acid ◽  
Vitamin E Status ◽  
Long Chain

scholarly journals The effect of dietary vitamin E and fatty acid supplementation of pregnant and lactating ewes on placental and mammary transfer of vitamin E to the lamb

2005 ◽  
Vol 93 (4) ◽  
pp. 549-557 ◽  
Author(s):  
Judith L. Capper ◽  
Robert G. Wilkinson ◽  
Eleni Kasapidou ◽  
Sandra E. Pattinson ◽  
Alexander M. Mackenzie ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Vitamin E ◽  
Fish Oil ◽  
Plasma Concentrations ◽  
Dietary Vitamin ◽  
Blood Samples ◽  
Fatty Acid Supplementation ◽  
Fish Oil Supplementation ◽  
Vitamin E Status ◽  
Vitamin E Supplementation

The present study investigated the effect of maternal vitamin E and fatty acid supplementation on lamb antioxidant status. Forty-eight ewes were fed one of four concentrate diets supplemented with a basal (50 mg/kg) or supranutritional (500 mg/kg) level of vitamin E plus a source of either saturated fat (Megalac®; Volac Ltd, Royston, Hertfordshire, UK) or long-chain PUFA (fish oil) from 6 weeks prepartum until 4 weeks postpartum. Blood samples were taken from ewes and lambs at intervals throughout the experiment and, at parturition, muscle, brain and blood samples were obtained from twelve lambs (three per treatment). Colostrum and milk samples were obtained at 12 h and 21 d after parturition, respectively. Supranutritional vitamin E supplementation of the ewe significantly increased concentrations of vitamin E in neonatal lamb tissues although plasma concentrations were undetectable. A significant increase in lamb birth weight resulted from increasing the dietary vitamin E supply to the ewe. Furthermore, maternal plasma, colostrum and milk vitamin E concentrations were increased by vitamin E supplementation, as were lamb plasma concentrations at 14 d of age. Neonatal vitamin E status was not significantly affected by fat source although plasma vitamin E concentrations in both ewes and suckling lambs were reduced by fish oil supplementation of the ewe. Fish oil supplementation reduced vitamin E concentrations in colostrum and milk and the activity of glutathione peroxidase in suckling lambs. The data suggest that the vitamin E status of the neonatal and suckling lamb may be manipulated by vitamin E supplementation of the ewe during pregnancy and lactation.

scholarly journals No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial – reply by Rogers et al.

2008 ◽  
Vol 100 (6) ◽  
pp. 1349-1351 ◽  
Author(s):  
Peter J. Rogers ◽  
Katherine M. Appleton ◽  
David Kessler ◽  
Tim J. Peters ◽  
David Gunnell ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cognitive Function ◽  
Randomised Controlled Trial ◽  
Depressed Mood ◽  
Controlled Trial ◽  
Chain Polyunsaturated Fatty Acid ◽  
Pufa Supplementation ◽  
Chain Pufa ◽  
Randomised Controlled ◽  
Long Chain

We recently reported a null outcome from a study of n-3 long-chain PUFA supplementation in depressed mood(1).

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Meta Analysis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Inflammation Markers ◽  
Pufa Supplementation ◽  
Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

scholarly journals n‐3 PUFA Supplementation Alters Retinal Very‐Long‐Chain‐PUFA Levels and Ratios in Diabetic Animal Models

2019 ◽  
Vol 63 (15) ◽  
pp. 1801058 ◽  
Author(s):  
Aruna Gorusupudi ◽  
Fu‐Yen Chang ◽  
Kelly Nelson ◽  
Gregory S. Hageman ◽  
Paul S. Bernstein
Keyword(s):  
Animal Models ◽  
Diabetic Animal ◽  
Pufa Supplementation ◽  
Chain Pufa ◽  
Long Chain
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