Is maternal periconceptional smoking associated with 2D:4D digit ratio in their children?

2017 ◽  
Vol 8 (5) ◽  
pp. 597-603 ◽  
Author(s):  
M. P. Velez ◽  
T. E. Arbuckle ◽  
P. Monnier ◽  
W. D. Fraser
Keyword(s):  
Smoking Prevalence ◽  
First Trimester ◽  
Ventral Surface ◽  
Environmental Chemicals ◽  
Smoking History ◽  
Androgen Exposure ◽  
Periconceptional Period ◽  
First Trimester Of Pregnancy ◽  
The Mean

The 2nd--4th finger ratio (2D:4D) has been proposed as a potential indicator of greater androgen exposure during fetal development. Maternal periconceptional smoking may alter the homeostasis of fetal androgens, which could in turn result in differential development of 2D:4Ds in utero. The aim of the present study was to assess the effect of maternal periconceptional smoking (i.e. 1 year before through the first trimester of pregnancy) on the 2D:4D of children within The Maternal-Infant Research on Environmental Chemicals (MIREC) study. Maternal smoking history was obtained through questionnaires during the first trimester of pregnancy in 2001 women from 10 cities across Canada. The periconceptional smoking prevalence was 12%. A follow-up study was conducted to measure growth and development up to 5 years of age in a subsample of some 800 MIREC children (MIREC-CD Plus), and digital pictures of the ventral surface of both hands were obtained in mothers and children (2–5 years). The 2D:4D was calculated as the ratio of the 2nd and 4th fingers of each hand. Boys had lower mean 2D:4Ds compared with girls in both hands. Age and maternal 2D:4D were strong determinants of the children’s 2D:4D, however, the mean 2D:4D did not differ among children whose mothers had smoked during the periconceptional period compared with those who had not, irrespective of sex. In conclusion, we did not find an association between maternal periconceptional smoking and children’s 2D:4D, although the smoking prevalence was low.

scholarly journals Pregnancy with adnexal masses: an institutional experience and review of the literature

2021 ◽  
Vol 10 (3) ◽  
pp. 1148
Author(s):  
Anupama Bahadur ◽  
Modalavalasa Swetha Sri ◽  
Rajlaxmi Mundhra ◽  
Latika Chawla ◽  
Megha Ajmani ◽  
...  
Keyword(s):  
Adnexal Mass ◽  
Cystic Teratoma ◽  
First Trimester ◽  
Third Trimester ◽  
Adnexal Masses ◽  
Institutional Experience ◽  
First Trimester Of Pregnancy ◽  
The Mean ◽  
Nicu Admission

Adnexal masses in pregnancy are not uncommon. We prospectively analysed all cases with adnexal masses detected during pregnancy presented to our antenatal outpatient department from January 2019 to August 2020. Herein we report six such cases with their pregnancy outcome. Among the 6 cases, 3 were diagnosed during first trimester of pregnancy, 2 in third trimester and 1 was found incidentally during caesarean section. The mean age of the cases was 25.33+2.33 years. Two cases underwent oophorectomy and rest had ovarian cystectomy. In terms of histopathological findings, one was endometriotic cyst, two were borderline tumors (mucinous and serous variety) and three were mature cystic teratomas. There was no perinatal mortality, but 2 babies required NICU admission for observation. Mature cystic teratoma was the most common adnexal mass detected in our series. Timing of surgery depends on urgency of situation. Asymptomatic/small/unilocular cyst with low suspicion should be kept under observation and follow up throughout pregnancy.

Correlations Between the Values of Maternal Glycemia from the Last Trimester of Pregnancy and Fetal Birth Weight

2013 ◽  
Vol 20 (3) ◽  
pp. 259-265
Author(s):  
Monica Vereş ◽  
Aurel Babeş ◽  
Szidonia Lacziko
Keyword(s):  
First Trimester ◽  
Mean Value ◽  
Fetal Macrosomia ◽  
Entire Group ◽  
Third Trimester ◽  
The Third ◽  
Group I ◽  
Fetal Birth Weight ◽  
First Trimester Of Pregnancy ◽  
The Mean

Abstract Background and aims: Gestational diabetes represents a form of diabetes diagnosed during pregnancy that is not clearly overt diabetes. In the last trimester of gestation the growth of fetoplacental unit takes place, thus maternal hyperglycemia will determine an increased transplacental passage, hyperinsulinemia and fetal macrosomia. The aim of our study was that o analyzing the effect of maternal glycemia from the last trimester of pregnancy over fetal weight. Material and method: We run an observational study on a group of 46 pregnant women taken into evidence from the first trimester of pregnancy, separated in two groups according to blood glucose determined in the third trimester (before birth): group I normoglycemic and group II with hyperglycemia (>92mg/dl). Results: The mean value of third trimester glycemia for the entire group was of 87.13±22.03. The mean value of the glycemia determined in the third trimester of pregnancy was higher in the second group (109.17 mg/dl) in comparison to the first group (74.,21 mg/dl). The ROC curve for third trimester glycemia as fetal macrosomia appreciation test has an AUC of 0.517. Conclusions: Glycemia determined in the last trimester of pregnancy cannot be used alone as the predictive factor for fetal macrosomia.

Evaluation of Normal Heart Rate in Early Pregnancy Corresponding to Gestational Age between Six to Eight Weeks

Med Phoenix ◽  
2017 ◽  
Vol 2 (1) ◽  
pp. 34-37
Author(s):  
Akhilesh Kumar Jha ◽  
Bikranta Rimal ◽  
Tarannum Khatun
Keyword(s):  
Heart Rate ◽  
Early Pregnancy ◽  
Well Being ◽  
Clinical Decision ◽  
First Trimester ◽  
Normal Heart ◽  
Normal Heart Rate ◽  
First Trimester Of Pregnancy ◽  
Singleton Pregnancies

Background: Ultrasonography is the reliable and safe way for the evaluation of pregnancy. Heart rate can be detected more confidently from the Ultrasonography. Heart rate is an important parameter for the evaluation of early pregnancy. The purpose of this study was to evaluate the normal heart rate in embryos/fetuses between 6 and 8 weeks of gestation.Method: In our region people are poor and most of them do not know the benefit of regular follow up examination during pregnancy. So most of pregnant women come to our centre at late stage of pregnancy. The number of pregnancy cases is good in our centre but the number of early pregnancy cases coming to regular follow up examination is low. Thus the study was conducted in 51 normal singleton pregnancies undergoing routine ultrasound examination during the first trimester of pregnancy. The duration of study was 6 weeks.Result: Out of 51 singleton pregnancies, 20 cases (39.2%) heart rate were between 131-150 beat per minute and 25 cases (49.0 %) heart rate were between 151-170 beat per minute. However 4 cases (7.8%) were between 110-120 beat per minute and 2 cases (3.9%) were more than 171 beat per minute. There were zero cases above the 180 beat per minute.Conclusion: The result of this study will help to evaluate abnormal and normal fetal heart rate so that early clinical decision whether to continue the pregnancy or terminate it can be taken, as Ultrasonography is only the method used in screening fetal well being in most of the region of our country.Med Phoenix Vol.2(1) July 2017, 34-37

scholarly journals Umbilical Cord Entanglement: Diagnostic and Clinical Repercussions

2012 ◽  
Vol 6 (3) ◽  
pp. 225-232 ◽  
Author(s):  
Francisco Raga ◽  
Newton G Osborne ◽  
Luiz E Machado ◽  
Francisco Bonilla ◽  
Fernando Bonilla-Musoles ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Three Dimensional ◽  
First Trimester ◽  
Delivery Outcome ◽  
Entire Pregnancy ◽  
Pregnancy And Delivery ◽  
First Trimester Of Pregnancy ◽  
3D Ultrasonography ◽  
Umbilical Cord Entanglement

ABSTRACT The use of three-dimensional (3D) ultrasonography since the first trimester of pregnancy allows the diagnosis and follow-up of cord entanglement throughout the entire pregnancy and delivery. This technology permits a more accurate diagnosis when compared with two-dimensional (2D) ultrasonography or Doppler The vast majority of cord entanglements observed at the end of the first-trimester will persist during the entire pregnancy; delivery outcome is usually not affected by this finding except for cases in which multiple cord entanglement is diagnosed. How to cite this article Martínez-Aspas A, Raga F, Machado LE, Bonilla F Jr, Castillo JC, Osborne NG, Bonilla-Musoles F. Umbilical Cord Entanglement: Diagnostic and Clinical Repercussions. Donald School J Ultrasound Obstet Gynecol 2012;6(3):225-232.

scholarly journals The Wuhan Twin Birth Cohort (WTBC)

2017 ◽  
Vol 20 (4) ◽  
pp. 355-362
Author(s):  
Jinzhu Zhao ◽  
Shaoping Yang ◽  
Anna Peng ◽  
Zhengmin Qian ◽  
Hong Xian ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Medical Information ◽  
First Trimester ◽  
Population Based ◽  
Health Examination ◽  
Birth Registry ◽  
Twin Birth ◽  
First Trimester Of Pregnancy

The Wuhan Pre/Post-Natal Twin Birth Registry (WPTBR) is one of the largest twin birth registries with comprehensive medical information in China. It recruits women from the first trimester of pregnancy and their twins from birth. From January 2006 to May 2016, the total number of twins enrolled in WPTBR is 13,869 twin pairs (27,553 individuals). The WPTBR initiated the Wuhan Twin Birth Cohort (WTBC). The WTBC is a prospective cohort study carried out through incorporation of three samples. The first one comprises 6,920 twin pairs, and the second one, 6,949 twin pairs. Both are population-based samples linked to the WPTBR and include pre- and post-natal information from WPTBR. The second sample includes neonatal blood spots as well. Using a hospital-based approach, we recently developed a third sample with a target enrolment of 1,000 twin pairs and their mothers. These twins are invited, via their parents, to participate in a periodic health examination from the first trimester of pregnancy to 18 years. Biological samples are collected initially from the mother, including blood, urine, cord blood, cord, amniotic fluid, placenta, breast milk and meconium, and vaginal secretions, and later from the twins, including meconium, stool, urine, and blood. This article describes the design, recruitment, follow-up, data collection, and measures, as well as ongoing and planned analyses at the WTBC. The WTBC offers a unique opportunity to follow women from prenatal to postnatal, as well as follow-up of their twins. This cohort study will expand the understanding of genetic and environmental influences on pregnancy and twins’ development in China.

scholarly journals A comparative study of oral, sublingual and vaginal route of misoprostol as cervical ripening agent before surgical method of termination of first-trimester pregnancy

2017 ◽  
Vol 6 (4) ◽  
pp. 1295 ◽  
Author(s):  
Divya Sinha ◽  
Sourabh Shrivastava ◽  
Swati Shrivastava
Keyword(s):  
Blood Loss ◽  
First Trimester ◽  
Cervical Ripening ◽  
Vaginal Route ◽  
Surgical Method ◽  
First Trimester Pregnancy ◽  
Medical Termination ◽  
First Trimester Of Pregnancy ◽  
The Mean ◽  
Vaginal Misoprostol

Background: Cervical ripening is a critical step for surgical method of termination of first trimester of pregnancy. Misoprostol, PGE1 analogue have promising role as cervical ripening agent. The present study aimed to compare the efficacy and side effects of oral, sublingual and vaginal misoprostol at dosage of 400mcg for cervical priming before surgical method of termination in first-trimester pregnancy.Methods: It was a prospective hospital based randamosied study. Total 150 patients at 6-12 weeks gestation requesting for medical termination of pregnancy were divided equally in to 3 groups. Every group was advised to have single dose of 400 mcg misoprostol either oral, sublingual or vaginal route respectively 4 hour before suction and evacuation.Results: The sublingual group had highly significant cervical dilatation (P<0.001) and the duration of suction and evacuation was less as compared to the vaginal and oral routes (p<0.000). However, the mean intraoperative blood loss was more in sublingual as compared to the vaginal and oral groups. Loose motions and nausea/vomiting were more with oral routes while blood loss was more in the vaginal route.Conclusions: Thus, it can be concluded from present study that sublingual route of misoprostol is more preferable than oral or vaginal route as pro-abortion cervical ripening agent.

scholarly journals Frequency of subclinical hypothyroidism and mean serum TSH level in first trimester of pregnancy.

2021 ◽  
Vol 28 (12) ◽  
pp. 1763-1767
Author(s):  
Fouzia Perveen ◽  
Lubna Ali ◽  
Afshan Hasan
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Subclinical Hypothyroidism ◽  
Maternal Age ◽  
Age Groups ◽  
First Trimester ◽  
Level Data ◽  
First Trimester Of Pregnancy ◽  
The Mean ◽  
Serum Tsh

Objective: To find out the frequency of subclinical hypothyroidism (SCH) in our pregnant population during 1st Trimester and the mean TSH level in first trimester of pregnancy. Study Design: Cross Sectional Descriptive study. Setting: Dow University Hospital and Dr Ruth KM Pfau CHK. Period: June 2015 to May 2016. Material & Methods: All Pregnant women with <14 weeks gestation were screened for Serum TSH level. Data were recorded after informed consent and institutional ethical approval. Variables recorded were age, parity, gestational age and serum TSH level. Data were analyzed on SPSS version 16. Mean and SD were calculated for quantitative variables ie. Age, parity, gestational age, serum TSH level and serum free T4 level. Mean TSH level according to age group, parity and gestational age groups were determined by applying ANOVA test. Correlation of Serum TSH level with the maternal age, parity and gestational age groups were also assessed by Pearson Correlation test. Significant P-value was taken as <0.05. Results: The frequency of SCH found was 19.35% by taking cut off limit of <2.5 IU/L and 3.55% by taking cut off limit of <4.5 IU/L among total of 310 pregnant women. Mean TSH level was 1.84±1.36 IU/L. The mean maternal age was 27.22 ± 4.43 yrs. while median parity was 1. Mean gestational age of these patients were 9.41 ± 2.748 weeks and out of these 160 (51.61%) were between 4-9 weeks and 150(48.38%) between 10-14 weeks. Majority (74%) of these women belonged to lower middle socioeconomic class. Mean TSH level coorelation between different age groups, parity groups and gestational age groups were found to be insignificant. Conclusion: The prevalence of SCH is not so high and mean TSH level in our population was 1.84 IU/L. But to establish reference range for Pakistani population, further studies in population of different backgrounds and geographical distribution needs to be evaluated.

scholarly journals A Pragmatic Intervention Using Financial Incentives for Pregnancy Weight Management: Feasibility Randomized Controlled Trial (Preprint)

2021 ◽  
Author(s):  
Rebecca Krukowski ◽  
Brandi Johnson ◽  
Hyeonju Kim ◽  
Saunak Sen ◽  
Riad Homsi
Keyword(s):  
Physical Activity ◽  
Data Collection ◽  
Financial Incentives ◽  
Financial Incentive ◽  
Controlled Trial ◽  
Treatment Engagement ◽  
First Trimester ◽  
Adult Women ◽  
First Trimester Of Pregnancy

BACKGROUND Excessive gestational weight gain (GWG) is common and can result in maternal and child health complications. Pragmatic behavioral interventions that can be incorporated into standard obstetric care are needed, and financial incentives are a promising approach. OBJECTIVE The aim of this study is to evaluate the feasibility of recruitment, randomization, and retention, as well as treatment engagement and intervention satisfaction, in a behavioral program. The program provided small incentives for meeting behavioral goals of self-weighing and physical activity as well as larger outcome incentives for meeting GWG goals. METHODS We recruited 40 adult women in their first trimester of pregnancy from February 2019 to September 2019 at an obstetric clinic. Participants were randomized to 3 intervention components using a 2×2×2 factorial design: daily incentives for self-weighing (lottery vs certain loss), incentives for adhering to the Institute of Medicine’s GWG guidelines based on BMI category (monthly vs overall), and incentives for reaching physical activity goals (yes vs no). Participants were asked to complete daily weigh-ins using the Withings Body wireless scale provided by the study, as well as wear a physical activity tracker (Fitbit Flex 2). Feasibility outcomes of recruitment, randomization, and retention, as well as treatment engagement and intervention satisfaction, were assessed. Weight assessments were conducted at baseline, 32-week gestation, and 36-week gestation. RESULTS Participants were enrolled at, on average, 9.6 (SD 1.8) weeks’ gestation. Of the 39 participants who were oriented to their condition and received the intervention, 24 (62%) were Black or African American, 30 (77%) were not married, and 29 (74%) had an annual household income of less than US $50,000. Of the 39 participants, 35 (90%) completed the follow-up data collection visit. Participants were generally quite positive about the intervention components, with a particular emphasis on the helpfulness of, and the enjoyment of using, the e-scale in both the quantitative and qualitative feedback. Participants who received the loss incentive, on average, had 2.86 times as many days of self-weighing as those who received the lottery incentive. Participants had a relatively low level of activity, with no difference between those who received a physical activity incentive and those who did not. CONCLUSIONS A financial incentive–based pragmatic intervention was feasible and acceptable for pregnant women for promoting self-weighing, physical activity, and healthy GWG. Participants were successfully recruited early in their first trimester of pregnancy and retained for follow-up data collection in the third trimester. Participants demonstrated promising engagement in self-weighing, particularly with loss-based incentives, and reported finding the self-weighing especially helpful. This study supports further investigation of pragmatic, clinic-based financial incentive–based interventions for healthy GWG behaviors. CLINICALTRIAL ClinicalTrials.gov NCT03834194; https://clinicaltrials.gov/ct2/show/NCT03834194

Congenital Rubella and Thrombocytopenia: Report of Two Cases with Initial and Follow-up Viral Cultures

PEDIATRICS ◽  
1965 ◽  
Vol 36 (2) ◽  
pp. 268-270
Author(s):  
WILLIAM D. COCHRAN ◽  
MICHAEL CORNFIELD ◽  
DAVID FRIEDBERG
Keyword(s):  
Tissue Culture ◽  
Kidney Tissue ◽  
Clinical History ◽  
First Trimester ◽  
Clinical Findings ◽  
Congenital Rubella ◽  
Echo Virus ◽  
History Of ◽  
First Trimester Of Pregnancy

Recent advances have made it possible to isolate rubella virus from affected persons and to propagate the virus in tissue culture. The virus may be identified by the unique cytopathogenic changes in human amnion tissue culture by interference with ECHO virus type 11 in monkey kidney tissue culture. Thus an even closer correlation between an active rubella infection in the mother in the first trimester of pregnancy and the clinical findings of the rubella syndrome is now feasible. The rubella epidemic of 1964 can be expected to produce significant numbers of infants with the congenital rubella syndrome. This paper reports the clinical history of two cases of rubella associated with thrombocytopenia in the newborn.

The Value of Targeted Ultrasound for the Primary Evaluation of Breast Symptoms in Pregnant Women of All Ages

2021 ◽  
Vol 3 (5) ◽  
pp. 556-563
Author(s):  
Jamie N Holtz ◽  
Genevieve A Woodard ◽  
Jessica H Hayward ◽  
Kimberly M Ray ◽  
Neeta Kannan ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Breast Imaging ◽  
Imaging Modality ◽  
First Trimester ◽  
Study Cohort ◽  
Targeted Ultrasound ◽  
First Trimester Of Pregnancy ◽  
Primary Evaluation ◽  
Common Malignancy

Abstract Objective Data on breast imaging in symptomatic pregnant women are limited. Our aim was to assess the value of targeted breast US for the primary evaluation of breast symptoms in pregnant women of all ages. Methods This IRB-approved retrospective study included all pregnant patients who underwent targeted US for focal breast symptoms at an academic imaging facility over an 18-year period (2000–2018). Clinical, imaging, and pathology results were reviewed. Malignant outcomes were determined by histology. Benign outcomes were confirmed by pathology or ≥2 years of follow-up. Descriptive statistics and 2 × 2 contingency table analyses were performed at the presentation level. Results The study cohort comprised 178 presentations in 175 pregnant women. Mean age was 34.7 years (standard deviation, 5.2). The majority (153/178, 86.0%) were more than 30 years old. At presentation, 42.1% (75/178) were in the first trimester of pregnancy, 27.0% (48/178) in the second, and 29.8% (53/178) in the third. The most common presenting symptom was a palpable lump (162/178, 91.0%), followed by focal pain (7/178, 3.9%). The vast majority (174/178, 97.8%) of cases were non-malignant. However, targeted US detected all 4 malignancies (cancer detection rate, 22/1000; negative predictive value 136/136, 100%). Sensitivity and specificity were 100% (4/4) and 78.2% (136/174), respectively. Conclusion Benign causes of symptoms in pregnant women were far more common; malignancy was rare, accounting for only 2.2% (4/178) of cases. Targeted breast US detected all malignancies, supporting US as the primary imaging modality for evaluating symptomatic pregnant women, regardless of age.

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