Finding Ways to Relax: A Revisionistic Analysis of the Chemistry of E. coli GTP Cyclohydrolase II

Biochemistry ◽

10.1021/acs.biochem.1c00511 ◽

2021 ◽

Author(s):

Madison M. Smith ◽

Brett A. Beaupre ◽

Dariush C. Fourozesh ◽

Kathleen M. Meneely ◽

Audrey L. Lamb ◽

...

Keyword(s):

Gtp Cyclohydrolase ◽

E Coli ◽

Gtp Cyclohydrolase Ii

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A Novel Mechanism for Nitrosative Stress Tolerance Dependent on GTP Cyclohydrolase II Activity Involved in Riboflavin Synthesis of Yeast

Scientific Reports ◽

10.1038/s41598-020-62890-3 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Khairul Anam ◽

Ryo Nasuno ◽

Hiroshi Takagi

Keyword(s):

Stress Tolerance ◽

Nitrosative Stress ◽

Gtp Cyclohydrolase ◽

Gtp Cyclohydrolase Ii ◽

Riboflavin Synthesis

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Production of Sepiapterin in Escherichia coli by Coexpression of Cyanobacterial GTP Cyclohydrolase I and Human 6-Pyruvoyltetrahydropterin Synthase

Applied and Environmental Microbiology ◽

10.1128/aem.68.6.3138-3140.2002 ◽

2002 ◽

Vol 68 (6) ◽

pp. 3138-3140 ◽

Author(s):

Hyun Joo Woo ◽

Jee Yun Kang ◽

Yong Kee Choi ◽

Young Shik Park

Keyword(s):

Escherichia Coli ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Aldose Reductase ◽

High Performance ◽

Gtp Cyclohydrolase I ◽

Gtp Cyclohydrolase ◽

E Coli ◽

Sepiapterin Reductase ◽

ABSTRACT Synechocystis sp. strain PCC 6803 GTP cyclohydrolase I and human 6-pyruvoyltetrahydropterin synthase were coexpressed in Escherichia coli. The E. coli transformant produced sepiapterin, which was identified by high-performance liquid chromatography and enzymatically converted to dihydrobiopterin by sepiapterin reductase. Aldose reductase, another indispensable enzyme for sepiapterin production, may be endogenous in E. coli.

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GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase are rate-limiting enzymes in riboflavin synthesis of an industrial Bacillus subtilis strain used for riboflavin production

Journal of Industrial Microbiology & Biotechnology ◽

10.1038/sj.jim.2900590 ◽

1999 ◽

Vol 22 (1) ◽

pp. 1-7 ◽

Author(s):

M Hümbelin ◽

V Griesser ◽

T Keller ◽

W Schurter ◽

M Haiker ◽

...

Keyword(s):

Bacillus Subtilis ◽

Subtilis Strain ◽

Gtp Cyclohydrolase ◽

Riboflavin Production ◽

Gtp Cyclohydrolase Ii ◽

Rate Limiting ◽

Riboflavin Synthesis ◽

Phosphate Synthase

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II. Yeast sequencing reports. The sequence of an 8·8 kb segment on the left arm of chromosome II fromSaccharomyces cerevisiae reveals four new open reading frames including homologs of animal DNA polymerase α-primases and bacterial GTP cyclohydrolase II

Yeast ◽

10.1002/yea.320100003 ◽

1994 ◽

Vol 10 (S1994A) ◽

pp. S13-S24 ◽

Author(s):

Luc van Dyck ◽

Bénédicte Purnelle ◽

André Goffeau ◽

Jacek Skala

Keyword(s):

Dna Polymerase ◽

Open Reading Frames ◽

Gtp Cyclohydrolase ◽

Dna Polymerase Α ◽

Gtp Cyclohydrolase Ii ◽

Chromosome Ii ◽

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Assay for GTP Cyclohydrolase II Activity in Bacterial Extracts

BIO-PROTOCOL ◽

10.21769/bioprotoc.1198 ◽

2014 ◽

Vol 4 (15) ◽

Author(s):

Svetlana Yurgel ◽

Na Sa ◽

Jennifer Rice ◽

Sanja Roje

Keyword(s):

Gtp Cyclohydrolase ◽

Gtp Cyclohydrolase Ii

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Hemolytic properties and riboflavin synthesis of Helicobacter pylori: cloning and functional characterization of the rib A gene encoding GTP-cyclohydrolase II that confers hemolytic activity to Escherichia coli

Medical Microbiology and Immunology ◽

10.1007/s004300050062 ◽

1998 ◽

Vol 186 (4) ◽

pp. 177-187 ◽

Author(s):

S. Bereswill ◽

F. Fassbinder ◽

C. Völzing ◽

A. Covacci ◽

R. Haas ◽

...

Keyword(s):

Escherichia Coli ◽

Helicobacter Pylori ◽

Hemolytic Activity ◽

Functional Characterization ◽

Gtp Cyclohydrolase ◽

Gene Encoding ◽

Gtp Cyclohydrolase Ii ◽

Riboflavin Synthesis

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Structural and functional analysis of the riboflavin synthesis genes encoding GTP cyclohydrolase II (ribA), DHBP synthase (ribBA), riboflavin synthase (ribC), and riboflavin deaminase/reductase (ribD) fromHelicobacter pyloristrain P1

FEMS Microbiology Letters ◽

10.1111/j.1574-6968.2000.tb09339.x ◽

2000 ◽

Vol 191 (2) ◽

pp. 191-197 ◽

Author(s):

Frank Fassbinder ◽

Manfred Kist ◽

Stefan Bereswill

Keyword(s):

Functional Analysis ◽

Gtp Cyclohydrolase ◽

Genes Encoding ◽

Gtp Cyclohydrolase Ii ◽

Riboflavin Synthesis

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Molecular and structural characterization of GTP-cyclohydrolase II in Eremothecium ashbyi NRRL Y-1363: cDNA cloning, comparative sequence analysis and molecular modeling

Fungal Biology ◽

10.1016/j.funbio.2010.06.006 ◽

2010 ◽

Vol 114 (9) ◽

pp. 731-738 ◽

Author(s):

Sudeshna Sengupta ◽

T.S. Chandra

Keyword(s):

Molecular Modeling ◽

Sequence Analysis ◽

Cdna Cloning ◽

Structural Characterization ◽

Comparative Sequence Analysis ◽

Gtp Cyclohydrolase ◽

Comparative Sequence ◽

Eremothecium Ashbyi ◽

Gtp Cyclohydrolase Ii

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Biosynthesis of riboflavin in plants. The ribA gene of Arabidopsis thaliana specifies a bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase

Phytochemistry ◽

10.1016/s0031-9422(00)00013-3 ◽

2000 ◽

Vol 53 (7) ◽

pp. 723-731 ◽

Author(s):

Stefan Herz ◽

Sabine Eberhardt ◽

Adelbert Bacher

Keyword(s):

Arabidopsis Thaliana ◽

Gtp Cyclohydrolase ◽

Gtp Cyclohydrolase Ii ◽

Phosphate Synthase

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The crystal structure reveals the molecular mechanism of bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II (Rv1415) fromMycobacterium tuberculosis

Acta Crystallographica Section D Biological Crystallography ◽

10.1107/s0907444913011402 ◽

2013 ◽

Vol 69 (9) ◽

pp. 1633-1644 ◽

Author(s):

Mirage Singh ◽

Pankaj Kumar ◽

Savita Yadav ◽

Ruchi Gautam ◽

Nidhi Sharma ◽

...

Keyword(s):

Crystal Structure ◽

Molecular Mechanism ◽

Gtp Cyclohydrolase ◽

Gtp Cyclohydrolase Ii ◽

Phosphate Synthase

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