Additive Manufacturing of Bioactive Poly(trimethylene carbonate)/β-Tricalcium Phosphate Composites for Bone Regeneration

Bone preservation and primary regeneration is a daily challenge in the field of dental medicine. In recent years, bioresorbable metals based on magnesium (Mg) have been widely investigated due to their bone-like modulus of elasticity, their high biocompatibility, antimicrobial, and osteoconductive properties. Synthetic Mg-based biomaterials are promising candidates for bone regeneration in comparison with other currently available pure synthetic materials. Different alloys based on Mg were developed to fit clinical requirements. In parallel, advances in additive manufacturing offer the possibility to fabricate experimentally bioresorbable metallic porous scaffolds. This review describes the promising clinical results of resorbable Mg-based biomaterials for bone repair in osteosynthetic application and discusses the perspectives of use in oral bone regeneration.

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Design and 3D bioprinting of interconnected porous scaffolds for bone regeneration. An additive manufacturing approach

Journal of Manufacturing Processes ◽

10.1016/j.jmapro.2021.01.057 ◽

2021 ◽

Vol 64 ◽

pp. 655-663

Author(s):

Renan Roque ◽

Gustavo Franco Barbosa ◽

Antônio Carlos Guastaldi

Keyword(s):

Additive Manufacturing ◽

Bone Regeneration ◽

Porous Scaffolds ◽

3D Bioprinting

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Enhanced bone regeneration using poly(trimethylene carbonate)/vancomycin hydrochloride porous microsphere scaffolds in presence of the silane coupling agent modified hydroxyapatite nanoparticles

Journal of Industrial and Engineering Chemistry ◽

10.1016/j.jiec.2021.04.021 ◽

2021 ◽

Author(s):

Jian He ◽

Xulin Hu ◽

Luyao Xing ◽

Dongliang Chen ◽

Lijun Peng ◽

...

Keyword(s):

Bone Regeneration ◽

Coupling Agent ◽

Silane Coupling Agent ◽

Trimethylene Carbonate ◽

Hydroxyapatite Nanoparticles ◽

Vancomycin Hydrochloride ◽

Silane Coupling ◽

Porous Microsphere

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3D Plotting of Silica/Collagen Xerogel Granules in an Alginate Matrix for Tissue-Engineered Bone Implants

Materials ◽

10.3390/ma14040830 ◽

2021 ◽

Vol 14 (4) ◽

pp. 830

Author(s):

Sina Rößler ◽

Andreas Brückner ◽

Iris Kruppke ◽

Hans-Peter Wiesmann ◽

Thomas Hanke ◽

...

Keyword(s):

Additive Manufacturing ◽

Bone Regeneration ◽

Material Properties ◽

Viscoelastic Properties ◽

Viscoelastic Behavior ◽

Matrix Phase ◽

Patient Specific ◽

Active Player ◽

Alginate Concentration ◽

Alginate Matrix

Today, materials designed for bone regeneration are requested to be degradable and resorbable, bioactive, porous, and osteoconductive, as well as to be an active player in the bone-remodeling process. Multiphasic silica/collagen Xerogels were shown, earlier, to meet these requirements. The aim of the present study was to use these excellent material properties of silica/collagen Xerogels and to process them by additive manufacturing, in this case 3D plotting, to generate implants matching patient specific shapes of fractures or lesions. The concept is to have Xerogel granules as active major components embedded, to a large proportion, in a matrix that binds the granules in the scaffold. By using viscoelastic alginate as matrix, pastes of Xerogel granules were processed via 3D plotting. Moreover, alginate concentration was shown to be the key to a high content of irregularly shaped Xerogel granules embedded in a minimum of matrix phase. Both the alginate matrix and Xerogel granules were also shown to influence viscoelastic behavior of the paste, as well as the dimensionally stability of the scaffolds. In conclusion, 3D plotting of Xerogel granules was successfully established by using viscoelastic properties of alginate as matrix phase.

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Additive manufacturing to assist prosthetically guided bone regeneration of atrophic maxillary arches

Rapid Prototyping Journal ◽

10.1108/rpj-12-2013-0127 ◽

2015 ◽

Vol 21 (6) ◽

pp. 705-715 ◽

Cited By ~ 6

Author(s):

M. Fantini ◽

F. De Crescenzio ◽

L. Ciocca ◽

F. Persiani

Keyword(s):

Additive Manufacturing ◽

Bone Regeneration ◽

Dental Implants ◽

Surgical Intervention ◽

Guided Bone Regeneration ◽

Autogenous Bone ◽

Bone Augmentation ◽

Virtual Planning ◽

Content Type ◽

Fused Deposition

Purpose – The purpose of this paper is to describe two different approaches for manufacturing pre-formed titanium meshes to assist prosthetically guided bone regeneration of atrophic maxillary arches. Both methods are based on the use of additive manufacturing (AM) technologies and aim to limit at the minimal intervention the bone reconstructive surgery by virtual planning the surgical intervention for dental implants placement. Design/methodology/approach – Two patients with atrophic maxillary arches were scheduled for bone augmentation using pre-formed titanium mesh with particulate autogenous bone graft and alloplastic material. The complete workflow consists of four steps: three-dimensional (3D) acquisition of medical images and virtual planning, 3D modelling and design of the bone augmentation volume, manufacturing of biomodels and pre-formed meshes, clinical procedure and follow up. For what concerns the AM, fused deposition modelling (FDM) and direct metal laser sintering (DMLS) were used. Findings – For both patients, a post-operative control CT examination was scheduled to evaluate the progression of the regenerative process and verify the availability of an adequate amount of bone before the surgical intervention for dental implants placement. In both cases, the regenerated bone was sufficient to fix the implants in the planned position, improving the intervention quality and reducing the intervention time during surgery. Originality/value – A comparison between two novel methods, involving AM technologies are presented as viable and reproducible methods to assist the correct bone augmentation of atrophic patients, prior to implant placement for the final implant supported prosthetic rehabilitation.

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Additive manufacturing of PLA-based scaffolds intended for bone regeneration and strategies to improve their biological properties

e-Polymers ◽

10.1515/epoly-2020-0046 ◽

2020 ◽

Vol 20 (1) ◽

pp. 571-599

Author(s):

Ricardo Donate ◽

Mario Monzón ◽

María Elena Alemán-Domínguez

Keyword(s):

Mechanical Properties ◽

Tissue Engineering ◽

Additive Manufacturing ◽

Bone Regeneration ◽

Polylactic Acid ◽

State Of The Art ◽

Biological Properties ◽

Design Stage ◽

Bone Scaffolds ◽

Regeneration Of Bone

AbstractPolylactic acid (PLA) is one of the most commonly used materials in the biomedical sector because of its processability, mechanical properties and biocompatibility. Among the different techniques that are feasible to process this biomaterial, additive manufacturing (AM) has gained attention recently, as it provides the possibility of tuning the design of the structures. This flexibility in the design stage allows the customization of the parts in order to optimize their use in the tissue engineering field. In the recent years, the application of PLA for the manufacture of bone scaffolds has been especially relevant, since numerous studies have proven the potential of this biomaterial for bone regeneration. This review contains a description of the specific requirements in the regeneration of bone and how the state of the art have tried to address them with different strategies to develop PLA-based scaffolds by AM techniques and with improved biofunctionality.

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