Determination of Endocrine Disruption Potential of Bisphenol A Alternatives in Food Contact Materials Using In Vitro Assays: State of the Art and Future Challenges

2019 ◽  
Vol 67 (46) ◽  
pp. 12613-12625 ◽  
Author(s):  
Ying Peng ◽  
Jieliang Wang ◽  
Changqing Wu
Keyword(s):  
Bisphenol A ◽  
Endocrine Disruption ◽  
State Of The Art ◽  
In Vitro Assays ◽  
Contact Materials ◽  
Food Contact Materials ◽  
Food Contact ◽  
Future Challenges

scholarly journals Evaluation of the Suitability of Mammalian In Vitro Assays to Assess the Genotoxic Potential of Food Contact Materials

Foods ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 237
Author(s):  
Elisabeth Pinter ◽  
Bernhard Rainer ◽  
Thomas Czerny ◽  
Elisabeth Riegel ◽  
Benoît Schilter ◽  
...  
Keyword(s):  
Standard Test ◽  
In Vitro Assays ◽  
Contact Materials ◽  
Food Contact Materials ◽  
Additional Information ◽  
Food Contact ◽  
Low Concentrations ◽  
Direct Acting ◽  
Threshold Criteria

Background: Non-targeted screening of food contact materials (FCM) for non-intentionally added substances (NIAS) reveals a great number of unknown and unidentified substances present at low concentrations. In the absence of toxicological data, the application of the threshold of toxicological concern (TTC) or of EU Regulation 10/2011 requires methods able to fulfill safety threshold criteria. In this review, mammalian in vitro genotoxicity assays are analyzed for their ability to detect DNA-damaging substances at limits of biological detection (LOBD) corresponding to the appropriate safety thresholds. Results: The ability of the assays to detect genotoxic effects varies greatly between substance classes. Especially for direct-acting mutagens, the assays lacked the ability to detect most DNA reactive substances below the threshold of 10 ppb, making them unsuitable to pick up potential genotoxicants present in FCM migrates. However, suitability for the detection of chromosomal damage or investigation of other modes of action makes them a complementary tool as part of a standard test battery aimed at giving additional information to ensure safety. Conclusion: improvements are necessary to comply with regulatory thresholds to consider mammalian genotoxicity in vitro assays to assess FCM safety.

Effects of Processing Temperature on Release of Bisphenol A from PC: A Multi-Technique Analytical Study

2016 ◽  
Vol 850 ◽  
pp. 137-141
Author(s):  
Zhuo Jun Sun ◽  
Chun Ping Li ◽  
Jian Gao ◽  
Shu Zhen Pan ◽  
Shu Li Zhang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
High Temperatures ◽  
Endocrine Disruptor ◽  
Analytical Study ◽  
Processing Temperature ◽  
Contact Materials ◽  
Food Contact Materials ◽  
Food Contact

The degradation of polycarbonate (PC) food contact materials was studied based on analysis with GC-MS, FTIR, UV-Vis and TG techniques. It was evident that the processing temperature of the materials significantly enhanced the release of bisphenol A, an endocrine disruptor. Investigation of the redshift of UV band also revealed that high temperatures accelerated the aging degradation of PC.

Direct analysis in real time coupled with quadrupole-Orbitrap high-resolution mass spectrometry for rapid analysis of pyrethroid preservatives in wooden food contact materials

The Analyst ◽  
2020 ◽  
Vol 145 (8) ◽  
pp. 2892-2896
Author(s):  
Xianshuang Meng ◽  
Yueguang Lv ◽  
Qing Lv ◽  
Yulin Deng ◽  
Hua Bai ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Direct Analysis ◽  
Rapid Analysis ◽  
Contact Materials ◽  
Food Contact Materials ◽  
Food Contact ◽  
Resolution Mass

A methodology is presented for the determination of pyrethroid preservatives in wooden food contact materials using DART coupled with quadrupole-Orbitrap HRMS.

Determination of Bisphenols and Related Compounds in Honey and Their Migration from Selected Food Contact Materials

2016 ◽  
Vol 64 (46) ◽  
pp. 8866-8875 ◽  
Author(s):  
Marjeta Česen ◽  
Dimitra Lambropoulou ◽  
Maria Laimou-Geraniou ◽  
Tina Kosjek ◽  
Urška Blaznik ◽  
...  
Keyword(s):  
Contact Materials ◽  
Food Contact Materials ◽  
Food Contact ◽  
Related Compounds
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