scholarly journals Evaluation of the Suitability of Mammalian In Vitro Assays to Assess the Genotoxic Potential of Food Contact Materials

Foods ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 237
Author(s):  
Elisabeth Pinter ◽  
Bernhard Rainer ◽  
Thomas Czerny ◽  
Elisabeth Riegel ◽  
Benoît Schilter ◽  
...  
Keyword(s):  
Standard Test ◽  
In Vitro Assays ◽  
Contact Materials ◽  
Food Contact Materials ◽  
Additional Information ◽  
Food Contact ◽  
Low Concentrations ◽  
Direct Acting ◽  
Threshold Criteria

Background: Non-targeted screening of food contact materials (FCM) for non-intentionally added substances (NIAS) reveals a great number of unknown and unidentified substances present at low concentrations. In the absence of toxicological data, the application of the threshold of toxicological concern (TTC) or of EU Regulation 10/2011 requires methods able to fulfill safety threshold criteria. In this review, mammalian in vitro genotoxicity assays are analyzed for their ability to detect DNA-damaging substances at limits of biological detection (LOBD) corresponding to the appropriate safety thresholds. Results: The ability of the assays to detect genotoxic effects varies greatly between substance classes. Especially for direct-acting mutagens, the assays lacked the ability to detect most DNA reactive substances below the threshold of 10 ppb, making them unsuitable to pick up potential genotoxicants present in FCM migrates. However, suitability for the detection of chromosomal damage or investigation of other modes of action makes them a complementary tool as part of a standard test battery aimed at giving additional information to ensure safety. Conclusion: improvements are necessary to comply with regulatory thresholds to consider mammalian genotoxicity in vitro assays to assess FCM safety.

scholarly journals Nontargeted Multicomponent Analytical Screening of Plastic Food Contact Materials Using Fast Interpretation of Deliverables via Expert Structure-Activity Relationship Software

2009 ◽  
Vol 92 (3) ◽  
pp. 941-950 ◽  
Author(s):  
Thorsten Rothenbacher ◽  
Wolfgang Schwack
Keyword(s):  
Capillary Column ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Contact Materials ◽  
Food Contact Materials ◽  
Toxicological Effects ◽  
Multilayer Foils ◽  
Food Contact ◽  
Structure Activity ◽  
Low Concentrations

Abstract Plastic packaging materials may release compounds into packed foodstuffs. To identify potential migrants of toxicological concern, resins, and multilayer foils (mainly polyethylene) intended for the production of food contact materials were extracted and analyzed by GC/mass spectrometry. To identify even compounds of low concentrations, AMDIS software was used and data evaluation was safeguarded by the Kovats retention index (RI) system. In this way, 46 compounds were identified as possible migrants. The expert structure-activity relationship software DEREK for Windows was utilized to evaluate all identified substances in terms of carcinogenicity, genotoxicity, thyroid toxicity, and miscellaneous endpoints for humans. Additionally, a literature search for these compounds was performed with Sci-Finder<sup/>, but relevant data were missing for 28 substances. Seven compounds with adverse toxicological effects were identified. In addition, the RIs of 24 commercial additive standards, measured with a GC capillary column of intermediate polarity, are given.

scholarly journals Characterization of Estrogen and Androgen Activity of Food Contact Materials by Different In Vitro Bioassays (YES, YAS, ERα and AR CALUX) and Chromatographic Analysis (GC-MS, HPLC-MS)

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e100952 ◽  
Author(s):  
Johannes Mertl ◽  
Christian Kirchnawy ◽  
Veronica Osorio ◽  
Angelika Grininger ◽  
Alexander Richter ◽  
...  
Keyword(s):  
Chromatographic Analysis ◽  
Contact Materials ◽  
Food Contact Materials ◽  
Food Contact ◽  
In Vitro Bioassays

scholarly journals Nano-enhanced food contact materials and the in vitro toxicity to human intestinal cells of nano-ZnO at low dose

2011 ◽  
Vol 304 ◽  
pp. 012038
Author(s):  
Niall Ó Claonadh ◽  
Alan Casey ◽  
Sean Lyons ◽  
Clement Higginbotham ◽  
Sanchali Gupta Mukherjee ◽  
...  
Keyword(s):  
Low Dose ◽  
In Vitro Toxicity ◽  
Intestinal Cells ◽  
Nano Zno ◽  
Contact Materials ◽  
Food Contact Materials ◽  
Food Contact ◽  
Human Intestinal Cells

β-Glucan, a Promising Polysaccharide for Bio-based Films Developments for Food Contact Materials and Medical Applications

2018 ◽  
Vol 22 (12) ◽  
pp. 1249-1254 ◽  
Author(s):  
Mercedes Peltzer ◽  
Juan F. Delgado ◽  
Andres G. Salvay ◽  
Jorge R. Wagner
Keyword(s):  
Medical Applications ◽  
Contact Materials ◽  
Food Contact Materials ◽  
Food Contact

Effect of high pressure processing on migration characteristics of polypropylene used in food contact materials

2021 ◽  
Vol 38 (3) ◽  
pp. 513-531
Author(s):  
Yoon S. Song ◽  
John L. Koontz ◽  
Rima O. Juskelis ◽  
Eduardo Patazca ◽  
William Limm ◽  
...  
Keyword(s):  
High Pressure ◽  
High Pressure Processing ◽  
Contact Materials ◽  
Food Contact Materials ◽  
Food Contact

scholarly journals Presence of Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) In Food Contact Materials (FCM) and Its Migration to Food

Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1443
Author(s):  
Arabela Ramírez Carnero ◽  
Antía Lestido-Cardama ◽  
Patricia Vazquez Loureiro ◽  
Letricia Barbosa-Pereira ◽  
Ana Rodríguez Bernaldo de Quirós ◽  
...  
Keyword(s):  
Fast Food ◽  
Food Packaging ◽  
Health Concern ◽  
Contact Materials ◽  
Food Contact Materials ◽  
Food Contact ◽  
Contaminated Food ◽  
Polyfluoroalkyl Substances ◽  
And Storage ◽  
Perfluoroalkyl And Polyfluoroalkyl Substances

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are synthetic chemical compounds widely used in different industry fields including food contact materials (FCM), providing resistance to fat and humidity, and non-stick properties. PFAS enter into the food chain directly from the intake of contaminated food or indirectly from the migration of the FCM into the food. This exposure published in different research highlights a public health concern. Therefore, it is necessary to perform analysis of the content of different FCM and evaluate the migration from the FCM under normal conditions of use and storage. This bibliographical review proves that different perfluoroalkyl and polyfluoroalkyl compounds are detected in fast food packaging, microwave popcorn bags, and frying pans, among others. Furthermore, it shows the conditions or factors that favor the migration of the PFAS from the FCM into the food.

scholarly journals Food contact materials: an effect-based evaluation of the presence of hazardous chemicals in paper and cardboard packaging

2021 ◽  
pp. 1-14
Author(s):  
Erica Selin ◽  
Kettil Svensson ◽  
Erik Gravenfors ◽  
Georgios Giovanoulis ◽  
Mitsura Iida ◽  
...  
Keyword(s):  
Hazardous Chemicals ◽  
Contact Materials ◽  
Food Contact Materials ◽  
Food Contact
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