scholarly journals Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma

2019 ◽  
Vol 62 (9) ◽  
pp. 4772-4778 ◽  
Author(s):  
Christopher R. M. Asquith ◽  
Kaleb M. Naegeli ◽  
Michael P. East ◽  
Tuomo Laitinen ◽  
Tammy M. Havener ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Egfr Inhibitor ◽  
Epidermal Growth ◽  
Cyclin G ◽  
Relationship Of ◽  
The Relationship

scholarly journals Design of a GAK/EGFR inhibitor set to interrogate the relationship of EGFR and GAK in chordoma

2018 ◽  
Author(s):  
Christopher R. M. Asquith ◽  
Kaleb M. Naegeli ◽  
Michael P. East ◽  
Tuomo Laitinen ◽  
Tammy M. Havener ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Egfr Inhibitor ◽  
Target Engagement ◽  
Cell Target ◽  
Epidermal Growth ◽  
Cyclin G ◽  
Relationship Of ◽  
The Relationship

ABSTRACTWe describe the design of a set of inhibitors to investigate the relationship between cyclin G associated kinase (GAK) and epidermal growth factor receptor (EGFR) in chordoma bone cancers. These compounds were characterized both in vitro and using in cell target engagement assays. The most potent chordoma inhibitors were further characterized in a kinome-wide screen demonstrating narrow spectrum profiles.

Exploring Epidermal Growth Factor Receptor (EGFR) Inhibitor Features: The Role of Fused Dioxygenated Rings on the Quinazoline Scaffold

2010 ◽  
Vol 53 (4) ◽  
pp. 1862-1866 ◽  
Author(s):  
Adriana Chilin ◽  
Maria Teresa Conconi ◽  
Giovanni Marzaro ◽  
Adriano Guiotto ◽  
Luca Urbani ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Egfr Inhibitor ◽  
Epidermal Growth

scholarly journals Epidermal growth factor receptor (EGFR) inhibitor induced purpuric drug eruption

Medicine ◽  
2019 ◽  
Vol 98 (47) ◽  
pp. e18112 ◽  
Author(s):  
Szu-Yun Fang ◽  
Chieh-Shan Wu ◽  
Yi-Shan Liu ◽  
Kai-Che Wei
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Drug Eruption ◽  
Growth Factor Receptor ◽  
Egfr Inhibitor ◽  
Epidermal Growth
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