Inhalable Nanocomposite Microparticles with Enhanced Dissolution and Superior Aerosol Performance

Promethazine.HCl is a potent anti-emetic. The central antimuscarinic actions of antihistamines are probably responsible for their anti-emetic effects. Promethazine is also believed to inhibit the medullary chemoreceptor trigger zone, and antagonize apomorphine -induced vomiting. Fast dissolving tablets of Promethazine.HCl were prepared using five superdisintegrants viz; sodium starch glycolate, crospovidone, croscarmellose, L-HPC and pregelatinised starch. The precompression blend was tested for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The tablets were evaluated for weight variation, hardness, friability, disintegration time (1 min), dissolution rate, content uniformity, and were found to be within standard limit. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrating with enhanced dissolution can be made using selected superdisintegrants. Among the different formulations of Promethazine.HCl was prepared and studied and the formulation S2 containing crospovidone, mannitol and microcrystalline cellulose combination was found to be the fast dissolving formulation. In the present study an attempt has been made to prepare fast dissolving tablets of Promethazine.HCl, by using different superdisintegrants with enhanced disintegration and dissolution rate.

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Improved Dissolution Properties of Ketoconazole through Application of Liquisolid Techniques

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2015.8.4.9 ◽

2015 ◽

Vol 8 (4) ◽

pp. 3053-3059

Author(s):

Sudarshan Singh ◽

S S Shyale ◽

H G Sandip

Keyword(s):

Drug Release ◽

Immediate Release ◽

Water Soluble ◽

Wet Granulation ◽

Wetting Properties ◽

Enhanced Dissolution ◽

Water Soluble Drug ◽

Drug Concentrations ◽

Water Soluble Drugs ◽

Liquisolid Compacts

In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Ketoconazole. The liquisolid tablets were formulated with liquid medications, namely Propylene Glycol (PG) drug concentrations, 60% w/w, 70% w/w and 80% w/w. Avicel pH102 was used as a carrier material, Aerosil 200 as a coating material and Sodium starch glycollate as a super-disintegrant. Quality control tests, such as uniformity of tablet weight, uniformity of drug content, tablet hardness, friability test, disintegration and dissolution tests were performed to evaluate prepared tablets. For further confirmation of results the liquisolid compacts were evaluated by XRD and FTIR studies to prove that, solubility of Ketoconazole has been increased by liquisolid compact technique. From the results obtained, it was be speculated that such systems exhibit enhanced drug release profiles due to increased wetting properties and surface of drug available for dissolution. As liquisolid compacts demonstrated significantly higher drug release rates, in PG as compared to directly compressible tablets and conventional wet granulation, we lead to conclusion that it could be a promising strategy in improving the dissolution of poor water soluble drugs and formulating immediate release solid dosage forms.

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Design and Characterization of Microcrystals for Enhanced Dissolution Rate of Celecoxib

Current Drug Discovery Technologies ◽

10.2174/15701638113109990035 ◽

2013 ◽

Vol 10 (4) ◽

pp. 305-314 ◽

Cited By ~ 4

Author(s):

Lakshmi K ◽

M Reddy ◽

Rajesh Kaza

Keyword(s):

Dissolution Rate ◽

Enhanced Dissolution

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Enhanced Dissolution and Antioxidant Activity of Chrysin Nanoparticles Employing Co-Precipitation as a Technique

Pharmaceutical Nanotechnology ◽

10.2174/2211738504666151127192541 ◽

2016 ◽

Vol 3 (3) ◽

pp. 205-218 ◽

Cited By ~ 6

Author(s):

Harkiran Kaur ◽

Deepinder Malik ◽

Gurpreet Kaur

Keyword(s):

Antioxidant Activity ◽

Enhanced Dissolution ◽

Co Precipitation

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Enhanced Dissolution of Naproxen by Combining Cocrystallization and Eutectic Formation

Pharmaceutics ◽

10.3390/pharmaceutics13050618 ◽

2021 ◽

Vol 13 (5) ◽

pp. 618

Author(s):

Hakyeong Kim ◽

Soeun Jang ◽

Il Won Kim

Keyword(s):

Model System ◽

Dissolution Behavior ◽

Active Pharmaceutical Ingredients ◽

Biorelevant Media ◽

Biologically Relevant ◽

Pharmaceutical Ingredients ◽

Enhanced Dissolution ◽

Dissolution Properties ◽

Eutectic Formation ◽

Combined Strategy

Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step in drug development with the increasing occurrence of sparingly soluble APIs. Cocrystal formation is one of the methods to alter the physicochemical properties of APIs, but its dissolution behavior in biorelevant media has been scrutinized only in recent years. We investigated the combined strategy of cocrystallization and eutectic formation in this regard and utilized the cocrystal model system of naproxen and three pyridinecarboxamide isomers. Binary melting diagrams were constructed to discover the eutectic compositions of the three cocrystals with excess amounts of pyridinecarboxamides. The melt–crystallized eutectics and cocrystals were compared in their dissolution behaviors with respect to neat naproxen. The eutectics enhanced the early dissolution rates of the cocrystals in both the absence and presence of biologically relevant bile salt and phospholipid components, whereas the cocrystal dissolution was expedited and delayed, respectively. The combined strategy in the present study will be advantageous in maximizing the utility of the pharmaceutical cocrystals.

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Effects of Concurrent Co or Ti Silicidation on Transient Diffusion and End-of-Range Damage in Phosphorus Implanted Silicon

MRS Proceedings ◽

10.1557/proc-262-701 ◽

1992 ◽

Vol 262 ◽

Cited By ~ 1

Author(s):

J.W. Honeycutt ◽

J. Ravi ◽

G. A. Rozgonyi

Keyword(s):

Secondary Ion Mass Spectrometry ◽

Complete Removal ◽

Dislocation Loops ◽

Enhanced Diffusion ◽

Depth Profiles ◽

Enhanced Dissolution ◽

Implantation Damage ◽

Transmission Electron ◽

Defect Behavior ◽

Secondary Ion

ABSTRACTThe effects of Ti and Co silicidation on P+ ion implantation damage in Si have been investigated. After silicidation of unannealed 40 keV, 2×1015 cm-2 P+ implanted junctions by rapid thermal annealing at 900°C for 10–300 seconds, secondary ion mass spectrometry depth profiles of phosphorus in suicided and non-silicided junctions were compared. While non-silicided and TiSi2 suicided junctions exhibited equal amounts of transient enhanced diffusion behavior, the junction depths under COSi2 were significantly shallower. End-of-range interstitial dislocation loops in the same suicided and non-silicided junctions were studied by planview transmission electron microscopy. The loops were found to be stable after 900°C, 5 minute annealing in non-silicided material, and their formation was only slightly effected by TiSi2 or COSi2 silicidation. However, enhanced dissolution of the loops was observed under both TiSi2 and COSi2, with essentially complete removal of the defects under COSi2 after 5 minutes at 900°C. The observed diffusion and defect behavior strongly suggest that implantation damage induced excess interstitial concentrations are significantly reduced by the formation and presence of COSi2, and to a lesser extent by TiSi2. The observed time-dependent defect removal under the suicide films suggests that vacancy injection and/or interstitial absorption by the suicide film continues long after the suicide chemical reaction is complete.

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