Degradable Carbon Dots from Cigarette Smoking with Broad-Spectrum Antimicrobial Activities against Drug-Resistant Bacteria

2018 ◽  
Vol 1 (6) ◽  
pp. 1871-1879 ◽  
Author(s):  
Yuxiang Song ◽  
Fang Lu ◽  
Hao Li ◽  
Huibo Wang ◽  
Mengling Zhang ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Broad Spectrum ◽  
Carbon Dots ◽  
Antimicrobial Activities ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Drug Resistant Bacteria

scholarly journals Nanoparticles Enable Efficient Delivery of Antimicrobial Peptides for the Treatment of Deep Infections

2021 ◽  
Author(s):  
Yingxue Deng ◽  
Rui Huang ◽  
Songyin Huang ◽  
Menghua Xiong
Keyword(s):  
Antimicrobial Peptides ◽  
Broad Spectrum ◽  
Antimicrobial Properties ◽  
Therapeutic Index ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Efficient Delivery ◽  
Delivery Vehicles

Antimicrobial peptides (AMPs) have emerged as promising alternatives of traditional antibiotics against drug-resistant bacteria owing to their broad-spectrum antimicrobial properties and low tendency to drugresistance. However, their therapeutic efficacy in vivo, especially for infections in deep organs, is limited owing to their systemic toxicity and low bioavailability. Nanoparticles-based delivery systems offer a strategy to increase the therapeutic index of AMPs by preventing proteolysis, increasing the accumulation at infection sites, and reducing toxicity. Herein, we will discuss the current progress of using nanoparticles as delivery vehicles for AMPs for the treatment of deep infections.

scholarly journals Potential of Novel Antimicrobial Peptide P3 from Bovine Erythrocytes and Its Analogs To Disrupt Bacterial MembranesIn Vitroand Display Activity against Drug-Resistant Bacteria in a Mouse Model

2015 ◽  
Vol 59 (5) ◽  
pp. 2835-2841 ◽  
Author(s):  
Qinghua Zhang ◽  
Yanzhao Xu ◽  
Qing Wang ◽  
Bolin Hang ◽  
Yawei Sun ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Body Weight ◽  
Mouse Model ◽  
Antimicrobial Activities ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Drug Resistant Bacteria ◽  
Resistant Strains ◽  
Bovine Erythrocytes

ABSTRACTWith the emergence of many antibiotic-resistant strains worldwide, antimicrobial peptides (AMPs) are being evaluated as promising alternatives to conventional antibiotics. P3, a novel hemoglobin peptide derived from bovine erythrocytes, exhibited modest antimicrobial activityin vitro. We evaluated the antimicrobial activities of P3 and an analog, JH-3, bothin vitroandin vivo. The MICs of P3 and JH-3 ranged from 3.125 μg/ml to 50 μg/ml when a wide spectrum of bacteria was tested, including multidrug-resistant strains. P3 killed bacteria within 30 min by disrupting the bacterial cytoplasmic membrane and disturbing the intracellular calcium balance. Circular dichroism (CD) spectrometry showed that P3 assumed an α-helical conformation in bacterial lipid membranes, which was indispensable for antimicrobial activity. Importantly, the 50% lethal dose (LD50) of JH-3 was 180 mg/kg of mouse body weight after intraperitoneal (i.p.) injection, and no death was observed at any dose up to 240 mg/kg body weight following subcutaneous (s.c.) injection. Furthermore, JH-3 significantly decreased the bacterial count and rescued infected mice in a model of mouse bacteremia. In conclusion, P3 and an analog exhibited potent antimicrobial activities and relatively low toxicities in a mouse model, indicating that they may be useful for treating infections caused by drug-resistant bacteria.

scholarly journals Microwave assisted synthesis of negative-charge carbon dots with potential antibacterial activity against multi-drug resistant bacteria

RSC Advances ◽  
2020 ◽  
Vol 10 (67) ◽  
pp. 41202-41208
Author(s):  
Jung-Chang Kung ◽  
I-Ting Tseng ◽  
Chi-Sheng Chien ◽  
Sheng-Hui Lin ◽  
Chun-Chi Wang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Carbon Dots ◽  
Negative Charge ◽  
Resistant Bacteria ◽  
Microwave Assisted Synthesis ◽  
Drug Resistant ◽  
Antibacterial Ability ◽  
Microwave Assisted ◽  
Drug Resistant Bacteria ◽  
One Step

In this research, negative-charge carbon dots (CDs) were synthesized in one-step using a microwave and found to have potential antibacterial ability against multi-drug resistant bacteria.

scholarly journals Identification of antibiotic-producing Bacillus sensu lato isolated from national parks of Hoang Lien and Phu Quoc in Vietnam

2014 ◽  
Vol 6 (1) ◽  
pp. 77-83
Author(s):  
Thi Tuyet Van Dinh ◽  
Nguyen Hai Linh Bui ◽  
Van Hop Duong ◽  
Mai Phuong Doan ◽  
Thanh Trung Trinh
Keyword(s):  
National Parks ◽  
Broad Spectrum ◽  
Antibiotic Production ◽  
Antagonistic Activity ◽  
Bacillus Species ◽  
Resistant Bacteria ◽  
Viet Nam ◽  
Drug Resistant ◽  
E Coli ◽  
Drug Resistant Bacteria

Many lipopeptide antibiotics produced from Bacillus sensu lato (Bacillus s. l.) against drug-resistant bacteria have been recently reported. To explore the potential production of the antibiotics from this group of bacteria in Vietnam, we collected 38 soil samples from two national parks of Hoang Lien and Phu Quoc and isolated 411Bacillus s. l. strains. Of those, 22 strains had antagonistic activity against both susceptible S. aureus and E. coli. The strains were further tested on drug-resistant bacteria collected at Bach Mai hospital and 20 strains demonstrated antagonistic activity against at least 2 of 18 drug-resistant bacteria K. pneumoniae, E. coli, A. baumannii and S. aureus. Analysis of 16S rDNA sequence showed that most of the broad spectrum antibiotic producers were Paenibacillus species whereas narrow spectrum antibiotic producers were Bacillus species. Strains PQH 0103 and PQH 0410 were probably produced novel antibiotic agents as they suspected to be novel taxa in Paenibacillus genus. Moreover, strains PQH 1509 and PQH 1702 produced broad spectrum antibiotics were identified as P. chitinolyticus. To our best knowledge, there is no report on antibiotic production from this species. Further elucidation of chemical structure of antibiotics produced from Bacillus s. l. isolated in soils of Vietnam is needed. Gần đây, nhiều kháng sinh lipopeptide từ vi khuẩn Bacillus sensu lato (Bacillus s. l.) có khả năng sinh kháng sinh kháng vi khuẩn kháng thuốc đã được phát hiện và công bố. Để tìm hiểu khả năng sinh kháng sinh của nhóm vi khuẩn này ở Việt Nam, chúng tôi tiến hành thu thập 38 mẫu đất tại vườn Quốc gia Hoàng Liên và vườn Quốc gia Phú Quốc và phân lập được 411 chủng vi khuẩn Bacillus s. l.. Trong số đó, 22 chủng có khả năng sinh kháng sinh kháng 2 chủng vi khuẩn S. aureus và E. coli nhậy cảm thuốc. 20 trong số 22 chủng này có hoạt tính kháng ít nhất từ 2 đến 18 chủng kiểm định kháng thuốc thuộc các loài K. pneumoniae, E. coli, A. baumannii và S. aureus. Dựa trên kết quả phân loại bằng trình tự gene 16S rRNA, các chủng Bacillus s. l. sinh kháng sinh phổ rộng là các loài Paenibacillus trong khi đó các loài sinh kháng sinh phổ hẹp là Bacillus. Trên cây phát sinh chủng loại, chủng PQH 0103 và PQH 0410 có thể là những loài mới và có tiềm năng sinh các chất kháng sinh mới. Hơn nữa, chủng PQH 1509 và PQH 1702 sinh kháng sinh phổ rộng được phân loại vào loài P. chitinolyticus. Đây là loài chưa có công bố nào về khả năng sinh chất kháng sinh và có thể là loài sinh chất kháng sinh mới. Nghiên cứu giải mã cấu trúc chất kháng sinh từ các loài Bacillus s. l. phân lập tại Việt Nam cần được làm rõ trong tương lai.

scholarly journals An Exceptional Broad-Spectrum Nanobiocide for Multimodal and Synergistic Inactivation of Drug-Resistant Bacteria

CCS Chemistry ◽  
2021 ◽  
pp. 1-32
Author(s):  
Ke Xue ◽  
Cuihong Yang ◽  
Chun Wang ◽  
Yang Liu ◽  
Jianfeng Liu ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Drug Resistant Bacteria
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