P22 c2 Repressor−Operator Complex:  Mechanisms of Direct and Indirect Readout‡

Biochemistry ◽  
2008 ◽  
Vol 47 (8) ◽  
pp. 2325-2338 ◽  
Author(s):  
Derrick Watkins ◽  
Chiaolong Hsiao ◽  
Kristen Kruger Woods ◽  
Gerald B. Koudelka ◽  
Loren Dean Williams
Keyword(s):  
Complex Mechanisms ◽  
Indirect Readout

Exneriana – II – The Scientific Legacy of John E. Exner, Jr. 1Part of this paper was presented at the XIXth International Congress of Rorschach and Projective Methods, July 22–26, 2008, Louvain, Belgium.

2008 ◽  
Vol 29 (2) ◽  
pp. 81-107 ◽  
Author(s):  
Anne Andronikof
Keyword(s):  
Clinical Studies ◽  
Experimental Studies ◽  
Scientific Work ◽  
International Congress ◽  
Response Process ◽  
Scientific Legacy ◽  
Projective Test ◽  
Projective Methods ◽  
Comprehensive Picture ◽  
Complex Mechanisms

Based on an analysis of John Exner’s peer-reviewed published work from 1959 to 2007, plus a brief comment for an editorial in Rorschachiana, the author draws a comprehensive picture of the scientific work of this outstanding personality. The article is divided into three sections: (1) the experimental studies on the Rorschach, (2) the clinical studies using the Rorschach, and (3) Exner’s “testament,” which we draw from the last paper he saw published before his death (Exner, 2001/2002). The experimental studies were aimed at better understanding the nature of the test, in particular the respective roles of perception and projection in the response process. These fundamental studies led to a deeper understanding of the complex mechanisms involved in the Rorschach responses and introduced some hypotheses about the intentions of the author of the test. The latter were subsequently confirmed by the preparatory sketches and documents of Hermann Rorschach, which today can be seen at the H. Rorschach Archives and Museum in Bern (Switzerland). Exner’s research has evidenced the notion that the Rorschach is a perceptive-cognitive-projective test.

Structural and Static Analysis of the Mechanisms Used in Car Mechanical Jacks

2016 ◽  
Vol 823 ◽  
pp. 277-282
Author(s):  
Viorica Velișcu ◽  
Dan Mesarici ◽  
Păun Antonescu
Keyword(s):  
Structural Analysis ◽  
Static Analysis ◽  
Kinematic Chain ◽  
Gravity Force ◽  
Complex Mechanisms

The paper presents a structural analysis of the complex mechanisms type screw-jack. The mechanism mobilityanalysis using various generally applicable formulas has been performed. A newkinematic scheme of the jack linkage has been proposed. Besides the actuatorscrew, it has a planar kinematic chain with articulated bars. With regard tothis new mechanism, an algorithm for static calculus has been developed, inwhich the automobile gravity force is the main exterior force.

Complex Mechanisms Underlying Impaired Activation of Cdk4 and Cdk2 in Replicative Senescence: Roles of p16, p21, and Cyclin D1

1999 ◽  
Vol 253 (2) ◽  
pp. 503-510 ◽  
Author(s):  
Hirobumi Morisaki ◽  
Akikazu Ando ◽  
Yoshiho Nagata ◽  
Olivia Pereira-Smith ◽  
James R. Smith ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Replicative Senescence ◽  
Complex Mechanisms

Direct molecular targets of resveratrol: identifying key interactions to unlock complex mechanisms

2015 ◽  
Vol 1348 (1) ◽  
pp. 124-133 ◽  
Author(s):  
Robert G. Britton ◽  
Christina Kovoor ◽  
Karen Brown
Keyword(s):  
Molecular Targets ◽  
Complex Mechanisms

Creutzfeldt-Jakob Disease

2021 ◽  
pp. 42-58
Author(s):  
Sadeeq Muhammad Sheshe
Keyword(s):  
Nervous System ◽  
Rare Disease ◽  
Prion Proteins ◽  
Diagnosis And Treatment ◽  
Misfolded Proteins ◽  
Jakob Disease ◽  
Complex Mechanisms ◽  
The Brain

Creutzfeldt-Jakob disease (CJD) is a rare disease associated with neurodegeneration mostly characterized by damage to the neurons. CJD is caused by aggregation of misfolded proteins known as prions; thus, CJD is said to be a prion-related illness. CJD and other prion-related illnesses such as Kuru and Gerstmann-Sträussler-Scheinker disease (GSS) have been reported to have complex mechanisms due to their association with the brain and the nervous system in general. A lot of questions have been raised about the mechanism, diagnosis, and pathogenesis of this disease. The complexity of prion proteins themselves have contributed to more questions about the complications of CJD, whether misfolding of the prions are responsible for neurodegeneration or the misfolding are mere symptoms of the disease. This chapter attempts to explore some details about CJD and answers most related questions about the disease's mechanism. The author finally attempts to explore recent development in pathogenesis, diagnosis, and treatment of CJD.

Full focus on calcium

2019 ◽  
Vol 12 (599) ◽  
pp. eaaz0961 ◽  
Author(s):  
Jan B. Parys ◽  
Andreas H. Guse
Keyword(s):  
Intracellular Calcium ◽  
Binding Proteins ◽  
Cellular Function ◽  
Complex Mechanisms ◽  
And Behavior

Intracellular calcium (Ca2+) signals are of prime importance for cellular function and behavior and are underpinned by a plethora of Ca2+ channels, pumps, transporters, and binding proteins that are regulated in complex ways. A series of biennial meetings, the International Meetings of the European Calcium Society (ECS), focuses on a better understanding of these complex mechanisms in the framework of cellular and organismal (patho)physiology.

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