scholarly journals HIGH PERFORMANCE GC/MS INSTRUMENTS THAT GET YOU THE RIGHT ANSWER.

2007 ◽  
Vol 85 (49) ◽  
pp. 10
Keyword(s):  
High Performance ◽  
The Right

Custom templates based heterogeneous resource allocation for data-intensive applications

2020 ◽  
Author(s):  
◽  
Ronny Bazan Antequera
Keyword(s):  
High Performance ◽  
Real Data ◽  
University Of Missouri ◽  
Application Performance ◽  
Data Intensive ◽  
Edge Based ◽  
The Right ◽  
Heterogeneous Cloud ◽  
Data Intensive Applications ◽  
Cloud Resources

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] The increase of data-intensive applications in science and engineering fields (i.e., bioinformatics, cybermanufacturing) demand the use of high-performance computing resources. However, data-intensive applications' local resources usually present limited capacity and availability due to sizable upfront costs. Moreover, using remote public resources presents constraints at the private edge network domain. Specifically, mis-configured network policies cause bottlenecks due to the other application cross-traffic attempting to use shared networking resources. Additionally, selecting the right remote resources can be cumbersome especially for those users who are interested in the application execution considering nonfunctional requirements such as performance, security and cost. The data-intensive applications have recurrent deployments and similar infrastructure requirements that can be addressed by creating templates. In this thesis, we handle applications requirements through intelligent resource 'abstractions' coupled with 'reusable' approaches that save time and effort in deploying new cloud architectures. Specifically, we design a novel custom template middleware that can retrieve blue prints of resource configuration, technical/policy information, and benchmarks of workflow performance to facilitate repeatable/reusable resource composition. The middleware considers hybrid-recommendation methodology (Online and offline recommendation) to leverage a catalog to rapidly check custom template solution correctness before/during resource consumption. Further, it prescribes application adaptations by fostering effective social interactions during the application's scaling stages. Based on the above approach, we organize the thesis contributions under two main thrusts: (i) Custom Templates for Cloud Networking for Data-intensive Applications: This involves scheduling transit selection, engineering at the campus-edge based upon real-time policy control. Our solution ensures prioritized application performance delivery for multi-tenant traffic profiles from a diverse set of actual data intensive applications in bioinformatics. (ii) Custom Templates for Cloud Computing for Data-intensive Applications: This involves recommending cloud resources for data-intensive applications based on a custom template catalog. We develop a novel expert system approach that is implemented as a middleware to abstracts data-intensive application requirements for custom templates composition. We uniquely consider heterogeneous cloud resources selection for the deployment of cloud architectures for real data-intensive applications in cybermanufacturing.

scholarly journals Pharmacokinetics of danofloxacin in African catfish (Clarias gariepinus) after intravenous and intramuscular administrations

2019 ◽  
Vol 67 (4) ◽  
pp. 602-609
Author(s):  
Mohamed Aboubakr ◽  
Ahmed Soliman
Keyword(s):  
Bacterial Infections ◽  
High Performance ◽  
Clarias Gariepinus ◽  
Volume Of Distribution ◽  
Pharmacokinetic Parameters ◽  
African Catfish ◽  
Caudal Vein ◽  
Group 2 ◽  
Total Body ◽  
The Right

The plasma pharmacokinetics of danofloxacin was studied in healthy African catfish (Clarias gariepinus) following a single intravenous (IV) and intramuscular (IM) administration of 10 mg/kg at 22 °C. Catfish were divided into two groups (each group containing 78 fish), then danofloxacin mesylate (10 mg/kg) was administered IV (into the caudal vein) in Group 1 and IM (into the right epaxial muscle) in Group 2, and blood was obtained from the caudal vein before (0 h) and after (0.25, 0.5, 1, 2, 4, 8, 12, 24, 36, 48, 72 and 96 h) of drug administration. High-performance liquid chromatography was used for the determination of plasma concentration, and a non-compartmental model was used for the analysis of pharmacokinetic parameters. After IV administration, elimination half-life (t1/2λz, 24.49 h), mean residence time (MRT, 30.14 h), volume of distribution at steady state (Vdss, 1.07 L/kg) and total body clearance (CLT, 0.035 L/h/kg) were determined. After IM administration, t1/2λz, MRT, peak concentration (Cmax), time to reach Cmax and bioavailability were 47.64 h, 61.06 h, 5.22 µg/mL, 1 h and 67.12%, respectively. After IM administration, danofloxacin showed good bioavailability and long t1/2λz. The favourable pharmacokinetic characteristics after IM administration support the use of danofloxacin for the treatment of susceptible bacterial infections in catfish.

scholarly journals ShenLian Extract Enhances TGF-β Functions in the Macrophage-SMC Unit and Stabilizes Atherosclerotic Plaques

2021 ◽  
Vol 12 ◽  
Author(s):  
Li Liu ◽  
Qi Li ◽  
Jie Yin ◽  
Zheng Zhao ◽  
Lidong Sun ◽  
...  
Keyword(s):  
High Performance ◽  
Macrophage Polarization ◽  
Neutralizing Antibody ◽  
Immunofluorescent Staining ◽  
Phenotypic Switching ◽  
Atherosclerotic Plaques ◽  
M2 Macrophage ◽  
Inflammatory Microenvironment ◽  
Phenotypic Transformation ◽  
The Right

Background/Aim: Macrophage polarization and phenotypic switching of smooth muscle cells (SMCs) are multi-faceted events dominating atherosclerosis (AS) progression. TGF-β was proved to been one of the bridge on the crosstalk between macrophage and SMC. ShenLian (SL) was extracted from a potent anti-atherosclerotic formula. However, its exact mechanism rebalancing inflammatory microenvironment of AS remain largely unknown. Within the entirety of macrophage and SMC, this study investigated the pharmacological effects of SL on stabilizing atherosclerotic plaques.Methods: The main components of SL were examined by high performance liquid chromatography. Co-culture and conditioned medium models of macrophage/SMC interactions were designed to identify the relationship between macrophage polarization and switching of SMC phenotypes. Flow cytometry, immunofluorescent staining, RT-PCR, western blotting, and ELISA were used to determine the expression of molecules relating to AS progression. An atherosclerosis animal model, established by placing a perivascular collar on the right common carotid artery in ApoE−/− mice, was used to investigate whether TGF-β is the key molecular mediator of SL in crosstalk between macrophage and SMC. Plaque size was defined by nuclear magnetic resonance imaging. Key markers related to phenotypic transformation of macrophage and SMC were determined by immunohistochemical staining.Results: Results revealed that, accompanied by rebalanced M2 macrophage polarization, SL supported SMC phenotypic transformation and functionally reconstruct the ECM of plaques specifically in macrophage-SMC co-cultural model. Molecularly, such activity of SL closely related to the activation of STAT3/SOCS3 pathway. Furthermore, in co-culture system, up-regulation of α-SMA induced by SL could neutralized by 1D11, a TGF-β neutralizing antibody, indicating that SL mediated Macrophage-SMC communication by enhancing TGF-β. In the AS model constructed by ApoE−/− mice, effects of SL on phenotypic transformation of macrophage and SMC has been well verified. Specific blocking of TGF-β largely attenuated the aforementioned effects of SL.Conclusion: Our findings highlighted that TGF-β might be the responsive factor of SL within macrophage and SMC communication. This study revealed that crosstalk between macrophage and SMC forms a holistic entirety promoting atherosclerotic plaque stability.

scholarly journals Task-based programming in COMPSs to converge from HPC to big data

2017 ◽  
Vol 32 (1) ◽  
pp. 45-60 ◽  
Author(s):  
Javier Conejero ◽  
Sandra Corella ◽  
Rosa M Badia ◽  
Jesus Labarta
Keyword(s):  
Big Data ◽  
High Performance ◽  
Programming Model ◽  
Good Alternative ◽  
Programming Models ◽  
Suitable Model ◽  
Advantages And Disadvantages ◽  
Big Data Applications ◽  
And Performance ◽  
The Right

Task-based programming has proven to be a suitable model for high-performance computing (HPC) applications. Different implementations have been good demonstrators of this fact and have promoted the acceptance of task-based programming in the OpenMP standard. Furthermore, in recent years, Apache Spark has gained wide popularity in business and research environments as a programming model for addressing emerging big data problems. COMP Superscalar (COMPSs) is a task-based environment that tackles distributed computing (including Clouds) and is a good alternative for a task-based programming model for big data applications. This article describes why we consider that task-based programming models are a good approach for big data applications. The article includes a comparison of Spark and COMPSs in terms of architecture, programming model, and performance. It focuses on the differences that both frameworks have in structural terms, on their programmability interface, and in terms of their efficiency by means of three widely known benchmarking kernels: Wordcount, Kmeans, and Terasort. These kernels enable the evaluation of the more important functionalities of both programming models and analyze different work flows and conditions. The main results achieved from this comparison are (1) COMPSs is able to extract the inherent parallelism from the user code with minimal coding effort as opposed to Spark, which requires the existing algorithms to be adapted and rewritten by explicitly using their predefined functions, (2) it is an improvement in terms of performance when compared with Spark, and (3) COMPSs has shown to scale better than Spark in most cases. Finally, we discuss the advantages and disadvantages of both frameworks, highlighting the differences that make them unique, thereby helping to choose the right framework for each particular objective.

scholarly journals Tolerability, kinetics, and efficacy of subconjunctival pefloxacin in pigmented rabbits.

1995 ◽  
Vol 39 (4) ◽  
pp. 834-838 ◽  
Author(s):  
S Marrakchi-Benjaafar ◽  
I Cochereau ◽  
F D'Hermies ◽  
J J Pocidalo
Keyword(s):  
Half Life ◽  
Maximum Concentration ◽  
High Performance ◽  
Histopathological Examination ◽  
Vitreous Humor ◽  
Subconjunctival Injection ◽  
Corneal Ulcers ◽  
Drug Concentrations ◽  
Pigmented Rabbits ◽  
The Right

Pefloxacin has been shown to have good intraocular penetration when given systemically. In order to extend its clinical use, we have assessed the tolerability, kinetics, and efficacy of subconjunctival pefloxacin in phakic pigmented rabbits. The tolerability of a single subconjunctival injection of pefloxacin (0.8, 1.6, 8, or 16 mg in 0.2 ml) in the right eyes of eight rabbits was evaluated by clinical and histopathological examination. The 0.8-mg dose of pefloxacin was well tolerated. The kinetics was evaluated after a single subconjunctival injection of 0.8 mg in 18 rabbits. Animals were sacrificed at 1, 3, 5, 7, 12, or 18 h postinjection. Drug concentrations were measured by high-performance liquid chromatography. Pefloxacin was found in the cornea (maximum concentration, 18.13 micrograms/ml; half-life, 3.92 h) and in the aqueous humor (maximum concentration, 3.40 micrograms/ml; half-life, 2.14 h). Pefloxacin did not penetrate into the vitreous humor by this route. The efficacy was evaluated in an experimental model of staphylococcal corneal ulcers in eight rabbits which received two subconjunctival injections of 0.8 mg of pefloxacin at 16 and 24 h after intrastromal inoculation. The results (expressed as mean log10 CFU per milliliter +/- standard deviation) showed that pefloxacin significantly (P < 0.001) reduced the bacterial counts (4.39 +/- 0.97) compared with those in control eyes (6.46 +/- 0.69). For phakic eyes, subconjunctival pefloxacin might be of value for the treatment of corneal ulcers. Further studies are required to determine its penetration into the vitreous humor of aphakic eyes.

The Combinatorial BLAS: design, implementation, and applications

2011 ◽  
Vol 25 (4) ◽  
pp. 496-509 ◽  
Author(s):  
Aydın Buluç ◽  
John R Gilbert
Keyword(s):  
Data Mining ◽  
High Performance ◽  
Web Search ◽  
Sparse Matrix ◽  
Ease Of Use ◽  
Coarse Grained ◽  
Matrix Methods ◽  
The Right ◽  
Traditional Approaches ◽  
Combinatorial Graphs

This paper presents a scalable high-performance software library to be used for graph analysis and data mining. Large combinatorial graphs appear in many applications of high-performance computing, including computational biology, informatics, analytics, web search, dynamical systems, and sparse matrix methods. Graph computations are difficult to parallelize using traditional approaches due to their irregular nature and low operational intensity. Many graph computations, however, contain sufficient coarse-grained parallelism for thousands of processors, which can be uncovered by using the right primitives. We describe the parallel Combinatorial BLAS, which consists of a small but powerful set of linear algebra primitives specifically targeting graph and data mining applications. We provide an extensible library interface and some guiding principles for future development. The library is evaluated using two important graph algorithms, in terms of both performance and ease-of-use. The scalability and raw performance of the example applications, using the Combinatorial BLAS, are unprecedented on distributed memory clusters.

scholarly journals Rational Design, Synthesis, Characterization and Evaluation of Iodinated 4,4′-Bipyridines as New Transthyretin Fibrillogenesis Inhibitors

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2213 ◽  
Author(s):  
Alessandro Dessì ◽  
Paola Peluso ◽  
Roberto Dallocchio ◽  
Robin Weiss ◽  
Giuseppina Andreotti ◽  
...  
Keyword(s):  
High Performance ◽  
Rational Design ◽  
Halogen Bond ◽  
Coupling Reaction ◽  
Docking Studies ◽  
Binding Modes ◽  
Design Synthesis ◽  
In Silico Docking ◽  
Amyloid Fibril Formation ◽  
The Right

The 3,3′,5,5′-tetrachloro-2-iodo-4,4′-bipyridine structure is proposed as a novel chemical scaffold for the design of new transthyretin (TTR) fibrillogenesis inhibitors. In the frame of a proof-of-principle exploration, four chiral 3,3′,5,5′-tetrachloro-2-iodo-2′-substituted-4,4′- bipyridines were rationally designed and prepared from a simple trihalopyridine in three steps, including a Cu-catalysed Finkelstein reaction to introduce iodine atoms on the heteroaromatic scaffold, and a Pd-catalysed coupling reaction to install the 2′-substituent. The corresponding racemates, along with other five chiral 4,4′-bipyridines containing halogens as substituents, were enantioseparated by high-performance liquid chromatography in order to obtain pure enantiomer pairs. All stereoisomers were tested against the amyloid fibril formation (FF) of wild type (WT)-TTR and two mutant variants, V30M and Y78F, in acid mediated aggregation experiments. Among the 4,4′-bipyridine derivatives, interesting inhibition activity was obtained for both enantiomers of the 3,3′,5,5′-tetrachloro-2′-(4-hydroxyphenyl)-2-iodo-4,4′-bipyridine. In silico docking studies were carried out in order to explore possible binding modes of the 4,4′-bipyridine derivatives into the TTR. The gained results point out the importance of the right combination of H-bond sites and the presence of iodine as halogen-bond donor. Both experimental and theoretical evidences pave the way for the utilization of the iodinated 4,4′-bipyridine core as template to design new promising inhibitors of TTR amyloidogenesis.

Study shows psychological capital and work engagement mediate the impact of high-performance work systems (HPWS) on intentions to quit, creativity and extra-role performance

2019 ◽  
Vol 27 (7) ◽  
pp. 7-8
Keyword(s):  
Work Engagement ◽  
High Performance ◽  
Psychological Capital ◽  
Black Box ◽  
Role Performance ◽  
Employee Outcomes ◽  
Customer Contact ◽  
Content Type ◽  
The Right ◽  
The Impact

Purpose The researchers wanted to examine the mediating factors operating in the “black box” between HPWS and employee outcomes. Design/methodology/approach The authors obtained their data from a variety of customer-contact employees, such as front desk agents, food servers and concierges, in four and five-star hotels in the Romanian cities of Sibiu and Bucharest. They sent out questionnaires measuring psychological capital, such as self-reliance, hope, resilience and optimism, as well as work engagement, creative performance and extra-role performance. Supervisors were also asked their opinions. Findings The analysis of customer-contact employees and their supervisors in the Romanian hotel industry suggested that psychological capital and work engagement were the two most important factors operating in the “black box” between HPWS and employee outcomes. Originality/value There is great value for businesses in the conclusions of the research. It shows how critical it is to establish various HPWS programs that boost engagement, as well as indicating the importance of providing job security and designing recruitment processes that root out people with the right skills.

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