Internal Standard Capillary Electrophoresis as a High-Throughput Method for pKa Determination in Drug Discovery and Development

2014 ◽  
Vol 16 (10) ◽  
pp. 518-525 ◽  
Author(s):  
Joan M. Cabot ◽  
Elisabet Fuguet ◽  
Martí Rosés
Keyword(s):  
Capillary Electrophoresis ◽  
Drug Discovery ◽  
High Throughput ◽  
Internal Standard ◽  
Drug Discovery And Development ◽  
High Throughput Method ◽  
Pka Determination

scholarly journals Novel Instrument for Automated pKa Determination by Internal Standard Capillary Electrophoresis

2015 ◽  
Vol 87 (12) ◽  
pp. 6165-6172 ◽  
Author(s):  
Joan M. Cabot ◽  
Elisabet Fuguet ◽  
Martí Rosés ◽  
Petr Smejkal ◽  
Michael C. Breadmore
Keyword(s):  
Capillary Electrophoresis ◽  
Internal Standard ◽  
Pka Determination

A simple and high-throughput method of ultrasonic extraction-capillary electrophoresis for determination of melamine in milk

2011 ◽  
Vol 3 (11) ◽  
pp. 2557 ◽  
Author(s):  
Yun-Kai Lv ◽  
Yue-Na Sun ◽  
Li-Min Wang ◽  
Cui-Ling Jia ◽  
Han-Wen Sun
Keyword(s):  
Capillary Electrophoresis ◽  
High Throughput ◽  
Ultrasonic Extraction ◽  
High Throughput Method

High-Throughput Method for the Production and Analysis of Large Natural Product Libraries for Drug Discovery

2002 ◽  
Vol 74 (16) ◽  
pp. 3963-3971 ◽  
Author(s):  
Gary R. Eldridge ◽  
Hélène C. Vervoort ◽  
Chris M. Lee ◽  
Peadar A. Cremin ◽  
Caroline T. Williams ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Natural Product ◽  
High Throughput ◽  
High Throughput Method

An overview of drug discovery and development

2020 ◽  
Vol 12 (10) ◽  
pp. 939-947 ◽  
Author(s):  
Nurken Berdigaliyev ◽  
Mohamad Aljofan
Keyword(s):  
Drug Discovery ◽  
High Throughput ◽  
Combinatorial Chemistry ◽  
New Technologies ◽  
Drug Repurposing ◽  
Drug Discovery And Development ◽  
Advantages And Disadvantages ◽  
High Throughput Drug Screening ◽  
The Cost ◽  
Early Drug

A new medicine will take an average of 10–15 years and more than US$2 billion before it can reach the pharmacy shelf. Traditionally, drug discovery relied on natural products as the main source of new drug entities, but was later shifted toward high-throughput synthesis and combinatorial chemistry-based development. New technologies such as ultra-high-throughput drug screening and artificial intelligence are being heavily employed to reduce the cost and the time of early drug discovery, but they remain relatively unchanged. However, are there other potentially faster and cheaper means of drug discovery? Is drug repurposing a viable alternative? In this review, we discuss the different means of drug discovery including their advantages and disadvantages.

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