Simple Link Atom Saccharide Hybrid (SLASH) Treatment for Glycosidic Bonds at the QM/MM Boundary

2014 ◽  
Vol 10 (4) ◽  
pp. 1727-1738 ◽  
Author(s):  
Werner Crous ◽  
Martin J. Field ◽  
Kevin J. Naidoo
Keyword(s):  
Glycosidic Bonds ◽  
Link Atom ◽  
Simple Link

Natural Macromolecules with Protective and Antitumor Activity

2018 ◽  
Vol 18 (5) ◽  
pp. 675-683 ◽  
Author(s):  
Cioanca Oana ◽  
Trifan Adriana ◽  
Cornelia Mircea ◽  
Scripcariu Dragos ◽  
Hancianu Monica
Keyword(s):  
Immune Response ◽  
Antitumor Activity ◽  
Tumor Cells ◽  
Biological Activities ◽  
Molecular Size ◽  
Plant Lectins ◽  
Natural Toxins ◽  
Glycosidic Bonds ◽  
Novel Drug

This review summarizes the literature data regarding plant lectins as novel drug sources in the prevention or treatment of cancer. Moreover, such compounds have been described as natural toxins that possess different biological activities (cytotoxic, antitumor, antimutagenic and anticarcinogenic properties). This activity depends greatly on their structure and affinity. Most of the mushroom heterosides are known as β-glucans with β-(1→3)-glycosidic bonds. It is thought that their conformation, bonds, molecular size can modulate the immune response by triggering different receptors. The mechanism on normal and tumor cells of various plant and mushroom polysaccharides and lectins is briefly presented in this paper.

Glucan isolated from leaves of Althaea officinalis L.

1983 ◽  
Vol 48 (7) ◽  
pp. 2082-2087 ◽  
Author(s):  
Alžbeta Kardošová ◽  
Jozef Rosík ◽  
Rudolf Toman ◽  
Peter Capek
Keyword(s):  
Medicinal Plant ◽  
Periodate Oxidation ◽  
Linear Structure ◽  
Water Soluble ◽  
Partial Hydrolysis ◽  
Methylation Analysis ◽  
Glycosidic Bonds ◽  
Nmr Data ◽  
Althaea Officinalis ◽  
C Nmr

A water-soluble low-molecular D-glucan was isolated from leaves of the medicinal plant marsh-mallow (Althaea officinalis L.). The results of methylation analysis, partial hydrolysis, periodate oxidation, and 13C NMR data indicated a virtually linear structure with α-(1→6) glycosidic bonds.

Polysaccharides from the Flowers of Malva silvestris L., ssp. mauritiana (L.) THELL.: The Structure of D-Glucan

1992 ◽  
Vol 57 (11) ◽  
pp. 2400-2406 ◽  
Author(s):  
Peter Capek
Keyword(s):  
Molecular Weight ◽  
Ion Exchange ◽  
Average Molecular Weight ◽  
Linear Structure ◽  
Gel Chromatography ◽  
Spectroscopic Investigations ◽  
Glycosidic Bonds

The neutral polysaccharide α-D-glucan was isolated from the flowers of Malva silvestris L., ssp. mauritiana (L.) THELL. using a combination of ion exchange and gel chromatography. It was homogeneous under the conditions of free electrophoresis of average molecular weight Mn 25260. The chemical and spectroscopic investigations indicated a linear structure of the polysaccharide in which the α-D-glucopyranose units were linked predominantly by 1→6 glycosidic bonds, while some saccharides were the place of branching in position C-3.

scholarly journals Plant-based fructans for increased animal welfare: provision processes and remaining challenges

2021 ◽  
Author(s):  
A. Zimmermann ◽  
C. Visscher ◽  
M. Kaltschmitt
Keyword(s):  
Animal Welfare ◽  
Dietary Fibre ◽  
Animal Feed ◽  
State Of The Art ◽  
Public Awareness ◽  
Well Being ◽  
Glycosidic Bonds ◽  
Health Promoting ◽  
Branched Structure ◽  
Stimulation Of

AbstractFructans are carbohydrates consisting of fructose monomers linked by β-2,1- and/or β-2,6-glycosidic bonds with linear or branched structure. These carbohydrates belong to the group of prebiotic dietary fibre with health-promoting potential for humans and mammals due to their indigestibility and selective stimulation of microorganisms in the gastrointestinal tract. This makes fructans interesting mainly for healthy food as well as animal feed applications. As a consequence of a growing public awareness for animal welfare, dietary fibre and thus fructans move into the focus as a fibre-rich feeding improving not only animals’ health but also their well-being. Against this background, this paper summarises the known effects of fructans focusing on pigs and highlights the state of the art in fructan production processes from plant material as well as selected current research lines. Additionally, an attempt is made to assess the potential of European fructan production for an application as animal feed. Based on this, challenges in the field of fructan production are addressed and alternative substrates for fructans are discussed and pointed out.

scholarly journals Insights into the dual cleavage activity of the GH16 laminarinase enzyme class on β-1,3 and β-1,4 glycosidic bonds

2021 ◽  
pp. 100385
Author(s):  
Marcelo Vizona Liberato ◽  
Erica Teixeira Prates ◽  
Thiago Augusto Gonçalves ◽  
Amanda Bernardes ◽  
Nathalia Vilela ◽  
...  
Keyword(s):  
Cleavage Activity ◽  
Glycosidic Bonds ◽  
Enzyme Class

A Simple Link between Hydrocarbon and Borohydride Chemistries

2013 ◽  
Vol 19 (13) ◽  
pp. 4169-4175 ◽  
Author(s):  
Jordi Poater ◽  
Miquel Solà ◽  
Clara Viñas ◽  
Francesc Teixidor
Keyword(s):  
Simple Link

scholarly journals Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Gloria Gamiz-Arco ◽  
Luis I. Gutierrez-Rus ◽  
Valeria A. Risso ◽  
Beatriz Ibarra-Molero ◽  
Yosuke Hoshino ◽  
...  
Keyword(s):  
Sequence Space ◽  
Conformational Flexibility ◽  
Allosteric Modulation ◽  
Heme Binding ◽  
Optimum Temperature ◽  
Glycosidic Bonds ◽  
Glycosidase Activity ◽  
Tim Barrel ◽  
Crystallographic Structures ◽  
Ancestral Protein

AbstractGlycosidases are phylogenetically widely distributed enzymes that are crucial for the cleavage of glycosidic bonds. Here, we present the exceptional properties of a putative ancestor of bacterial and eukaryotic family-1 glycosidases. The ancestral protein shares the TIM-barrel fold with its modern descendants but displays large regions with greatly enhanced conformational flexibility. Yet, the barrel core remains comparatively rigid and the ancestral glycosidase activity is stable, with an optimum temperature within the experimental range for thermophilic family-1 glycosidases. None of the ∼5500 reported crystallographic structures of ∼1400 modern glycosidases show a bound porphyrin. Remarkably, the ancestral glycosidase binds heme tightly and stoichiometrically at a well-defined buried site. Heme binding rigidifies this TIM-barrel and allosterically enhances catalysis. Our work demonstrates the capability of ancestral protein reconstructions to reveal valuable but unexpected biomolecular features when sampling distant sequence space. The potential of the ancestral glycosidase as a scaffold for custom catalysis and biosensor engineering is discussed.

scholarly journals Residual Brewing Yeast as Substrate for Co-Production of Cell Biomass and Biofilm Using Candida maltosa SM4

Fermentation ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 84
Author(s):  
Vidal Flores-Copa ◽  
Luis Romero-Soto ◽  
Danitza Romero-Calle ◽  
María Teresa Alvarez-Aliaga ◽  
Felipe Orozco-Gutierrez ◽  
...  
Keyword(s):  
Logistic Model ◽  
Water Retention ◽  
Candida Maltosa ◽  
Brewing Yeast ◽  
Cell Biomass ◽  
Glycosidic Bonds ◽  
Biofilm Production ◽  
High Degree ◽  
Maximal Production ◽  
Different Levels

Candida maltosa was cultivated in the liquid phase of residual brewing yeast, a major brewery residue, to produce biomass and biofilm. Using response surface methodology, the effect of two variables at two different levels was investigated. The independent variables were agitation speed (at 100 and 200 rpm), and aeration (at 1 and 3 L min−1). Aeration was identified to be important for the production of both biomass and biofilm, while agitation was the only factor significantly affecting biofilm production. The maximal production of biofilm (2.33 g L−1) was achieved for agitation of 200 rpm and aeration of 1 L min−1, while the maximum for biomass (16.97 g L−1) was reached for 100 rpm agitation and 3 L min−1 air flow. A logistic model applied to predict the growth of C. maltosa in the exponential phase and the biofilm production, showed a high degree of agreement between the prediction and the actual biomass measured experimentally. The produced biofilms were further characterized using Fourier-transform infrared spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Thermogravimetric Analysis (TGA). FTIR allowed the identification of methyl, carbonyl ester and sulfate groups, and revealed the presence of uronic acid moieties and glycosidic bonds. Water-retention ability up to relatively high temperatures was revealed by TGA, and that makes the produced biofilm suitable for production of hydrogels. SEM also gave indications on the hydrogel-forming potential of the biofilm.

ChemInform Abstract: SPECIFIC CLEAVAGE OF O-GLYCOSIDIC BONDS TO L-SERINE AND L-THREONINE BY TRIFLUOROACETOLYSIS

1979 ◽  
Vol 10 (37) ◽  
Author(s):  
B. LINDBERG ◽  
B. NILSSON ◽  
T. NORBERG ◽  
S. SVENSSON
Keyword(s):  
Glycosidic Bonds
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