scholarly journals Insights into the dual cleavage activity of the GH16 laminarinase enzyme class on β-1,3 and β-1,4 glycosidic bonds

2021 ◽  
pp. 100385
Author(s):  
Marcelo Vizona Liberato ◽  
Erica Teixeira Prates ◽  
Thiago Augusto Gonçalves ◽  
Amanda Bernardes ◽  
Nathalia Vilela ◽  
...  
Keyword(s):  
Cleavage Activity ◽  
Glycosidic Bonds ◽  
Enzyme Class

Natural Macromolecules with Protective and Antitumor Activity

2018 ◽  
Vol 18 (5) ◽  
pp. 675-683 ◽  
Author(s):  
Cioanca Oana ◽  
Trifan Adriana ◽  
Cornelia Mircea ◽  
Scripcariu Dragos ◽  
Hancianu Monica
Keyword(s):  
Immune Response ◽  
Antitumor Activity ◽  
Tumor Cells ◽  
Biological Activities ◽  
Molecular Size ◽  
Plant Lectins ◽  
Natural Toxins ◽  
Glycosidic Bonds ◽  
Novel Drug

This review summarizes the literature data regarding plant lectins as novel drug sources in the prevention or treatment of cancer. Moreover, such compounds have been described as natural toxins that possess different biological activities (cytotoxic, antitumor, antimutagenic and anticarcinogenic properties). This activity depends greatly on their structure and affinity. Most of the mushroom heterosides are known as β-glucans with β-(1→3)-glycosidic bonds. It is thought that their conformation, bonds, molecular size can modulate the immune response by triggering different receptors. The mechanism on normal and tumor cells of various plant and mushroom polysaccharides and lectins is briefly presented in this paper.

Glucan isolated from leaves of Althaea officinalis L.

1983 ◽  
Vol 48 (7) ◽  
pp. 2082-2087 ◽  
Author(s):  
Alžbeta Kardošová ◽  
Jozef Rosík ◽  
Rudolf Toman ◽  
Peter Capek
Keyword(s):  
Medicinal Plant ◽  
Periodate Oxidation ◽  
Linear Structure ◽  
Water Soluble ◽  
Partial Hydrolysis ◽  
Methylation Analysis ◽  
Glycosidic Bonds ◽  
Nmr Data ◽  
Althaea Officinalis ◽  
C Nmr

A water-soluble low-molecular D-glucan was isolated from leaves of the medicinal plant marsh-mallow (Althaea officinalis L.). The results of methylation analysis, partial hydrolysis, periodate oxidation, and 13C NMR data indicated a virtually linear structure with α-(1→6) glycosidic bonds.

Polysaccharides from the Flowers of Malva silvestris L., ssp. mauritiana (L.) THELL.: The Structure of D-Glucan

1992 ◽  
Vol 57 (11) ◽  
pp. 2400-2406 ◽  
Author(s):  
Peter Capek
Keyword(s):  
Molecular Weight ◽  
Ion Exchange ◽  
Average Molecular Weight ◽  
Linear Structure ◽  
Gel Chromatography ◽  
Spectroscopic Investigations ◽  
Glycosidic Bonds

The neutral polysaccharide α-D-glucan was isolated from the flowers of Malva silvestris L., ssp. mauritiana (L.) THELL. using a combination of ion exchange and gel chromatography. It was homogeneous under the conditions of free electrophoresis of average molecular weight Mn 25260. The chemical and spectroscopic investigations indicated a linear structure of the polysaccharide in which the α-D-glucopyranose units were linked predominantly by 1→6 glycosidic bonds, while some saccharides were the place of branching in position C-3.

scholarly journals Plant-based fructans for increased animal welfare: provision processes and remaining challenges

2021 ◽  
Author(s):  
A. Zimmermann ◽  
C. Visscher ◽  
M. Kaltschmitt
Keyword(s):  
Animal Welfare ◽  
Dietary Fibre ◽  
Animal Feed ◽  
State Of The Art ◽  
Public Awareness ◽  
Well Being ◽  
Glycosidic Bonds ◽  
Health Promoting ◽  
Branched Structure ◽  
Stimulation Of

AbstractFructans are carbohydrates consisting of fructose monomers linked by β-2,1- and/or β-2,6-glycosidic bonds with linear or branched structure. These carbohydrates belong to the group of prebiotic dietary fibre with health-promoting potential for humans and mammals due to their indigestibility and selective stimulation of microorganisms in the gastrointestinal tract. This makes fructans interesting mainly for healthy food as well as animal feed applications. As a consequence of a growing public awareness for animal welfare, dietary fibre and thus fructans move into the focus as a fibre-rich feeding improving not only animals’ health but also their well-being. Against this background, this paper summarises the known effects of fructans focusing on pigs and highlights the state of the art in fructan production processes from plant material as well as selected current research lines. Additionally, an attempt is made to assess the potential of European fructan production for an application as animal feed. Based on this, challenges in the field of fructan production are addressed and alternative substrates for fructans are discussed and pointed out.

scholarly journals The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Wenjing Qi ◽  
Erika D. V. Gromoff ◽  
Fan Xu ◽  
Qian Zhao ◽  
Wei Yang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Small Rnas ◽  
C Elegans ◽  
Cleavage Activity ◽  
Response To Temperature ◽  
Multicellular Organisms ◽  
Cell Immortality ◽  
Mature Mrnas ◽  
Endoribonuclease Activity

AbstractMulticellular organisms coordinate tissue specific responses to environmental information via both cell-autonomous and non-autonomous mechanisms. In addition to secreted ligands, recent reports implicated release of small RNAs in regulating gene expression across tissue boundaries. Here, we show that the conserved poly-U specific endoribonuclease ENDU-2 in C. elegans is secreted from the soma and taken-up by the germline to ensure germline immortality at elevated temperature. ENDU-2 binds to mature mRNAs and negatively regulates mRNA abundance both in the soma and the germline. While ENDU-2 promotes RNA decay in the soma directly via its endoribonuclease activity, ENDU-2 prevents misexpression of soma-specific genes in the germline and preserves germline immortality independent of its RNA-cleavage activity. In summary, our results suggest that the secreted RNase ENDU-2 regulates gene expression across tissue boundaries in response to temperature alterations and contributes to maintenance of stem cell immortality, probably via retaining a stem cell specific program of gene expression.

Exploring the trans-cleavage activity of CRISPR-Cas12a for the development of a Mxene based electrochemiluminescence biosensor for the detection of Siglec-5

2021 ◽  
Vol 178 ◽  
pp. 113019
Author(s):  
Kai Zhang ◽  
Zhenqiang Fan ◽  
Bo Yao ◽  
Yuedi Ding ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Cleavage Activity

DNA-cleavage activity of the iron(II) complex with optically active ligands, meta- and para-xylyl-linked N’,N’-dipyridylmethyl-cyclohexane-1,2-diamine

2021 ◽  
Vol 36 ◽  
pp. 127834
Author(s):  
Koichi Kato ◽  
Yoshimi Ichimaru ◽  
Yoshinori Okuno ◽  
Yoshihiro Yamaguchi ◽  
Wanchun Jin ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Optically Active ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

scholarly journals CRISPR/Cas12a-mediated gold nanoparticle aggregation for colorimetric detection of SARS-CoV-2

2021 ◽  
Author(s):  
Yiren Cao ◽  
Jinjun Wu ◽  
Bo Pang ◽  
Hongquan Zhang ◽  
X. Chris Le
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanoparticle ◽  
Colorimetric Detection ◽  
Isothermal Amplification ◽  
Nanoparticle Aggregation ◽  
Cleavage Activity ◽  
Gold Nanoparticle Aggregation

The trans-cleavage activity of the target-activated CRISPR-Cas12a liberated an RNA crosslinker from a molecular transducer, which facilitated assembly of gold nanoparticles. Integration of the molecular transducer with isothermal amplification and...

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