Gemini surfactants: a new class of self-assembling molecules

1993 ◽  
Vol 115 (22) ◽  
pp. 10083-10090 ◽  
Author(s):  
F. M. Menger ◽  
C. A. Littau
Keyword(s):  
Gemini Surfactants ◽  
New Class ◽  
Self Assembling

scholarly journals Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1108
Author(s):  
Manuela Curcio ◽  
Alessandro Paolì ◽  
Giuseppe Cirillo ◽  
Sebastiano Di Pietro ◽  
Martina Forestiero ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Metastatic Cancer ◽  
Stimuli Responsive ◽  
Cancer Disease ◽  
New Class ◽  
Self Assembling ◽  
Redox Responsive ◽  
Potential Applicability ◽  
Mean Size

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

scholarly journals On the Difference between Self-Assembling Process of Monomeric and Dimeric Surfactants with the Same Head to Tail Ratio: A Lattice Monte Carlo Simulation

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Reza Behjatmanesh-Ardakani ◽  
Maryam Farsad
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Gemini Surfactants ◽  
Chain Structure ◽  
Single Chain ◽  
Lattice Monte Carlo ◽  
Self Assembling ◽  
Spacer Group ◽  
The Difference ◽  
Dimeric Surfactants

Experimental data show that gemini surfactants have critical micelle concentrations that are almost tenfold lower than the CMCs of single chain ones. It is believed that the spacer groups play an important role in this subject. Short hydrophilic or long hydrophobic spacers can reduce CMC dramatically. In this paper, self-assembling processes of double-chain and one-chain surfactants with the same head to tail ratio are compared. Dimeric chain structure is exactly double of single chain. In other words, hydrophilic-lyophilic balances of two chain models are the same. Two single chains are connected head-to-head to form a dimeric chain, without introducing extra head or tail beads as a spacer group. Premicellar, micellar, and shape/phase transition ranges of both models are investigated. To do this, lattice Monte Carlo simulation in canonical ensemble has been used. Results show that without introducing extra beads as spacer group, the CMC of (H3T3)2as a dimeric surfactant is much lower than the CMC of its similar single chain, H3T3. For dimeric case of study, it is shown that bolaform aggregates are formed.

Innovative Biomimetic Hybrid Composites to Repair Multifunctional Anatomical Region

2010 ◽  
Author(s):  
A. Tampieri ◽  
M. Sandri ◽  
T. D’Alessandro ◽  
M. Banobre-Lopez ◽  
J. Rivas
Keyword(s):  
Hybrid Composites ◽  
Osteochondral Lesions ◽  
Artificial Bone ◽  
Mineral Phase ◽  
Biologically Inspired ◽  
New Class ◽  
Self Assembling ◽  
Physico Chemical ◽  
Biomimetic Approach ◽  
Composition Structure

The development of biomimetic materials for osteochondral tissue substitution and repair can be the start for a revolution in the classical procedures of orthopaedic surgery. The persisting problems, linked to the absence of a complete functional recovery of the articulation and to the stabilization and protraction of the half-life of an articular prosthesis can be overcome by the new class of osteochondral substitutes. The characteristics of the artificial bone tissue are drastically different from those of the natural one and this is mainly due to the absence of the peculiar self-organizing interaction between apatite crystals and proteic matrix. At this purpose a biomimetic approach was used in which apatitic phases are directly nucleated on different macromolecular matrices, which act as template and induce peculiar physico-chemical features in the mineral phase to create a substitute for osteochondral lesions. In particular a biologically inspired approach was applied to nucleate bone-like hydroxyapatite (HA) nanocrystals on self-assembling collagen fibers. Biohybrid composite materials were obtained mimicking composition, structure and morphology of human osteochondral interfaces. [1–4]

scholarly journals Depsipeptide nucleic acids: prebiotic formation, oligomerization, and self-assembly of a new candidate proto-nucleic acid

2020 ◽  
Author(s):  
David M. Fialho ◽  
Suneesh C. Karunakaran ◽  
Katherine W. Greeson ◽  
Isaac Martínez ◽  
Gary B. Schuster ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Self Assembly ◽  
Rna World ◽  
Chemical Components ◽  
Early Earth ◽  
New Class ◽  
Self Assembling ◽  
World Hypothesis ◽  
Rna World Hypothesis

AbstractThe mechanism by which genetic polymers spontaneously formed on the early Earth is currently unknown. The RNA World hypothesis implies that RNA oligomers were produced prebiotically, but the demonstration of this process has proven challenging. Alternatively, RNA may be the product of evolution and some, or all, of its chemical components may have been preceded by functionally analogous moieties that were more readily accessible under plausible early-Earth conditions. We report a new class of nucleic acid analog, depsipeptide nucleic acid, which displays several properties that make it an attractive candidate for the first informational polymer to arise on the Earth. The monomers of depsipeptide nucleic acids can form under plausibly prebiotic conditions. These monomers oligomerize spontaneously when dried from aqueous solutions to form nucleobase-functionalized depsipeptides. Once formed, these depsipeptide nucleic acid oligomers are capable of complementary self-assembly, and are resistant to hydrolysis in the assembled state. These results suggest that the initial formation of primitive, self-assembling, informational polymers may have been relatively facile.

scholarly journals Lanthanide nano-drums: a new class of molecular nanoparticles for potential biomedical applications

2014 ◽  
Vol 175 ◽  
pp. 241-255 ◽  
Author(s):  
Richard A. Jones ◽  
Annie J. Gnanam ◽  
Jonathan F. Arambula ◽  
Jessica N. Jones ◽  
Jagannath Swaminathan ◽  
...  
Keyword(s):  
Total Internal Reflection ◽  
Biomedical Applications ◽  
Near Infrared ◽  
Photophysical Properties ◽  
Diagnostic Systems ◽  
Two Photon Microscopy ◽  
New Class ◽  
Two Photon ◽  
Self Assembling ◽  
Molecular Nanoparticles

We are developing a new class of lanthanide-based self-assembling molecular nanoparticles as potential reporter molecules for imaging, and as multi-functional nanoprobes or nanosensors in diagnostic systems. These lanthanide “nano-drums” are homogeneous 4d–4f clusters approximately 25 to 30 Å in diameter that can emit from the visible to near-infrared (NIR) wavelengths. Here, we present syntheses, crystal structures, photophysical properties, and comparative cytotoxicity data for six nano-drums containing either Eu, Tb, Lu, Er, Yb or Ho. Imaging capabilities of these nano-drums are demonstrated using epifluorescence, total internal reflection fluorescence (TIRF), and two-photon microscopy. We discuss how these molecular nanoparticles can to be adapted for a range of assays, particularly by taking advantage of functionalization strategies with chemical moieties to enable conjugation to protein or nucleic acids.

Wedge-Shaped Molecules with a Sulfonate Group at the Tip—A New Class of Self-Assembling Amphiphiles

2004 ◽  
Vol 10 (16) ◽  
pp. 3871-3878 ◽  
Author(s):  
Xiaomin Zhu ◽  
Bernd Tartsch ◽  
Uwe Beginn ◽  
Martin Möller
Keyword(s):  
Sulfonate Group ◽  
New Class ◽  
Self Assembling

scholarly journals pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1899 ◽  
Author(s):  
Evgeny Apartsin ◽  
Nadezhda Knauer ◽  
Valeria Arkhipova ◽  
Ekaterina Pashkina ◽  
Alina Aktanova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Drug Carriers ◽  
Ph Sensitive ◽  
Cancer Drug ◽  
Smart Vehicles ◽  
New Class ◽  
Self Assembling ◽  
Anti Cancer ◽  
Cancer Drug Delivery

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

Sign in / Sign up

Export Citation Format

Share Document