scholarly journals Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1108
Author(s):  
Manuela Curcio ◽  
Alessandro Paolì ◽  
Giuseppe Cirillo ◽  
Sebastiano Di Pietro ◽  
Martina Forestiero ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Metastatic Cancer ◽  
Stimuli Responsive ◽  
Cancer Disease ◽  
New Class ◽  
Self Assembling ◽  
Redox Responsive ◽  
Potential Applicability ◽  
Mean Size

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

scholarly journals Dual-Targeted Hyaluronic Acid/Albumin Micelle-Like Nanoparticles for the Vectorization of Doxorubicin

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 304
Author(s):  
Manuela Curcio ◽  
Luis Diaz-Gomez ◽  
Giuseppe Cirillo ◽  
Fiore Pasquale Nicoletta ◽  
Antonella Leggio ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Metastatic Cancer ◽  
Specific Interaction ◽  
Membrane Receptors ◽  
Natural Polymers ◽  
Environmental Signals ◽  
Self Assembling ◽  
Potential Applicability ◽  
Mean Size

Drug targeting of tumor cells is one of the great challenges in cancer therapy; nanoparticles based on natural polymers represent valuable tools to achieve this aim. The ability to respond to environmental signals from the pathological site (e.g., altered redox potential), together with the specific interaction with membrane receptors overexpressed on cancer cells membrane (e.g., CD44 receptors), represent the main features of actively targeted nanoparticles. In this work, redox-responsive micelle-like nanoparticles were prepared by self-assembling of a hyaluronic acid–human serum albumin conjugate containing cystamine moieties acting as a functional spacer. The conjugation procedure consisted of a reductive amination step of hyaluronic acid followed by condensation with albumin. After self-assembling, nanoparticles with a mean size of 70 nm and able to be destabilized in reducing media were obtained. Doxorubicin-loaded nanoparticles modulated drug release rate in response to different redox conditions. Finally, the viability and uptake experiments on healthy (BALB-3T3) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a drug vector in cancer therapy.

AIE/FRET-based versatile PEG-Pep-TPE/DOX nanoparticles for cancer therapy and real-time drug release monitoring

2020 ◽  
Vol 8 (1) ◽  
pp. 118-124 ◽  
Author(s):  
Tian-Tian Wang ◽  
Qi-Chun Wei ◽  
Zhen-Tao Zhang ◽  
Meng-Ting Lin ◽  
Jie-Jian Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Cancer Therapy ◽  
Drug Release ◽  
Immune Responses ◽  
Real Time ◽  
Biological Significance ◽  
Stimuli Responsive ◽  
Self Assembling ◽  
Program Cell Death

Based on the biological significance of self-assembling peptides in program cell death, promoting proliferation of stem cells and suppressing immune responses, stimuli-responsive polypeptide nanoparticles have attracted more and more attention.

The Smart Dual-Stimuli Responsive Nanoparticles for Controlled AntiTumor Drug Release and Cancer Therapy

2020 ◽  
Vol 20 ◽  
Author(s):  
Feng Wu ◽  
Fei Qiu ◽  
Siew Anthony Wai-Keong ◽  
Yong Diao
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Targeted Delivery ◽  
Relevant Information ◽  
Therapeutic Effects ◽  
Stimuli Responsive ◽  
Control Effect ◽  
Chemotherapy Drugs ◽  
Excellent Control

Background: In recent years, the emergence of stimuli-responsive nanoparticles makes drug delivery more efficient. As an intelligent and effective targeted delivery platform, it can reduce the side effects generated during drug transportation while enhancing the treatment efficacy. The stimuli-responsive nanoparticles can respond to different stimuli at corresponding times and locations to deliver and release their drugs and associated therapeutic effects. Objective: This review aims to inform researchers on the latest advances in the application of dual-stimuli responsive nanoparticles in precise drug delivery, with special attention to their design, drug release properties, and therapeutic effects. Syntheses of nanoparticles with simultaneous or sequential responses to two or more stimuli (pH-redox, pH-light, redoxlight, temperature-magnetic, pH-redox-temperature, redox-enzyme-light, etc.) and the applications of such responsivity properties for drugs control and release have become a hot topic of recent research. Methods: A database of relevant information for the production of this review was sourced, screened and analyzed from Pubmed, Web of Science, SciFinder by searching for the following keywords: “dual-stimuli responsive”, “controlled release”, “cancer therapy”, “synergistic treatment”. Results: Notably, the nanoparticles with dual-stimuli responsive function have an excellent control effect on drug delivery and release, playing a crucial part in the treatment of tumors. They can improve the encapsulation and delivery efficiency of hydrophobic chemotherapy drugs, combine chemo-photothermal therapies, apply imaging function in the diagnosis of tumors and even conduct multi-drugs delivery to overcome multi-drugs resistance (MDR). Conclusion: With the development of smart dual-stimuli responsive nanoparticles, cancer treatment methods will become more diverse and effective. All the stimuli-responsive nanoparticles functionalities exhibited their characteristics individually within the single nanosystem.

Redox-responsive degradable honeycomb manganese oxide nanostructures as effective nanocarriers for intracellular glutathione-triggered drug release

2015 ◽  
Vol 51 (4) ◽  
pp. 776-779 ◽  
Author(s):  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
Xue Yang ◽  
Xiaoxiao Yang ◽  
...  
Keyword(s):  
Drug Release ◽  
Manganese Oxide ◽  
Drug Carriers ◽  
New Class ◽  
Oxide Nanostructures ◽  
Redox Responsive ◽  
Intracellular Glutathione ◽  
Triggered Drug Release

Redox-responsive degradable honeycomb manganese oxide (hMnO2) nanostructures consisting of some lamellar MnO2 platelets were established as a new class of drug carriers for efficient intracellular GSH-triggered drug release.

scholarly journals Magnetic hyperthermia-induced drug release from ureasil-PEO-γ-Fe2O3 nanocomposites

RSC Advances ◽  
2016 ◽  
Vol 6 (68) ◽  
pp. 63291-63295 ◽  
Author(s):  
B. L. Caetano ◽  
C. Guibert ◽  
R. Fini ◽  
J. Fresnais ◽  
S. H. Pulcinelli ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Hybrid Material ◽  
Magnetic Hyperthermia ◽  
Stimuli Responsive

A multifunctional hybrid material suitable for cancer therapy, combining stimuli-responsive properties for drug delivery and magnetic hyperthermia.

Photodynamic therapy-mediated remote control of chemotherapy toward synergistic anticancer treatment

Nanoscale ◽  
2018 ◽  
Vol 10 (30) ◽  
pp. 14554-14562 ◽  
Author(s):  
Yongjuan Li ◽  
Shixian Lv ◽  
Ziyuan Song ◽  
Juanjuan Dang ◽  
Xudong Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Remote Control ◽  
Cancer Therapy ◽  
Drug Release ◽  
Stimuli Responsive ◽  
On Demand ◽  
Release Property ◽  
Anticancer Treatment

Stimuli-responsive nanomedicine (NM) with an on-demand drug release property has demonstrated promising utility toward cancer therapy.

scholarly journals T1-Positive Mn2+-Doped Multi-Stimuli Responsive poly(L-DOPA) Nanoparticles for Photothermal and Photodynamic Combination Cancer Therapy

Biomedicines ◽  
2020 ◽  
Vol 8 (10) ◽  
pp. 417
Author(s):  
Sumin Kang ◽  
Rengarajan Baskaran ◽  
Busra Ozlu ◽  
Enkhzaya Davaa ◽  
Jung Joo Kim ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Near Infrared ◽  
Therapeutic Potential ◽  
Drug Loading ◽  
Positive Contrast ◽  
Stimuli Responsive ◽  
Pheophorbide A ◽  
Π Stacking

In this study, we designed near-infrared (NIR)-responsive Mn2+-doped melanin-like poly(L-DOPA) nanoparticles (MNPs), which act as multifunctional nano-platforms for cancer therapy. MNPs, exhibited favorable π-π stacking, drug loading, dual stimuli (NIR and glutathione) responsive drug release, photothermal and photodynamic therapeutic activities, and T1-positive contrast for magnetic resonance imaging (MRI). First, MNPs were fabricated via KMnO4 oxidation, where the embedded Mn2+ acted as a T1-weighted contrast agent. MNPs were then modified using a photosensitizer, Pheophorbide A, via a reducible disulfide linker for glutathione-responsive intracellular release, and then loaded with doxorubicin through π-π stacking and hydrogen bonding. The therapeutic potential of MNPs was further explored via targeted design. MNPs were conjugated with folic acid (FA) and loaded with SN38, thereby demonstrating their ability to bind to different anti-cancer drugs and their potential as a versatile platform, integrating targeted cancer therapy and MRI-guided photothermal and chemotherapeutic therapy. The multimodal therapeutic functions of MNPs were investigated in terms of T1-MR contrast phantom study, photothermal and photodynamic activity, stimuli-responsive drug release, enhanced cellular uptake, and in vivo tumor ablation studies.

Stepwise dual pH and redox-responsive cross-linked polypeptide nanoparticles for enhanced cellular uptake and effective cancer therapy

2019 ◽  
Vol 7 (45) ◽  
pp. 7129-7140 ◽  
Author(s):  
Jing Qu ◽  
Rui Wang ◽  
Si Peng ◽  
Mengyao Shi ◽  
Sheng-Tao Yang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Cellular Uptake ◽  
Systemic Toxicity ◽  
Cellular Internalization ◽  
Redox Responsive ◽  
Effective Cancer Therapy

The systemic toxicity, reduced cellular internalization, and uncontrollable intracellular drug release of smart nanoparticles (NPs) still need to be overcome for effective cancer therapy.

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