Innovative Biomimetic Hybrid Composites to Repair Multifunctional Anatomical Region

2010 ◽  
Author(s):  
A. Tampieri ◽  
M. Sandri ◽  
T. D’Alessandro ◽  
M. Banobre-Lopez ◽  
J. Rivas
Keyword(s):  
Hybrid Composites ◽  
Osteochondral Lesions ◽  
Artificial Bone ◽  
Mineral Phase ◽  
Biologically Inspired ◽  
New Class ◽  
Self Assembling ◽  
Physico Chemical ◽  
Biomimetic Approach ◽  
Composition Structure

The development of biomimetic materials for osteochondral tissue substitution and repair can be the start for a revolution in the classical procedures of orthopaedic surgery. The persisting problems, linked to the absence of a complete functional recovery of the articulation and to the stabilization and protraction of the half-life of an articular prosthesis can be overcome by the new class of osteochondral substitutes. The characteristics of the artificial bone tissue are drastically different from those of the natural one and this is mainly due to the absence of the peculiar self-organizing interaction between apatite crystals and proteic matrix. At this purpose a biomimetic approach was used in which apatitic phases are directly nucleated on different macromolecular matrices, which act as template and induce peculiar physico-chemical features in the mineral phase to create a substitute for osteochondral lesions. In particular a biologically inspired approach was applied to nucleate bone-like hydroxyapatite (HA) nanocrystals on self-assembling collagen fibers. Biohybrid composite materials were obtained mimicking composition, structure and morphology of human osteochondral interfaces. [1–4]

In Vitro Bio-Mineralization Process

2007 ◽  
Vol 361-363 ◽  
pp. 543-546
Author(s):  
Monica Sandri ◽  
Anna Tampieri ◽  
Luca Bertinetti ◽  
Adele Boskey
Keyword(s):  
Bone Tissue ◽  
Mineralization Process ◽  
Mineral Phase ◽  
Composites Materials ◽  
Physico Chemical ◽  
Biomimetic Approach

The present work describes the development of biomimetic composites materials for bone tissue substitution and repair. At this purpose a biomimetic approach was used and apatitic phases were nucleated on macromolecular matrices like natural collagen, which act as template and induce peculiar physico-chemical features in the mineral phase.

scholarly journals Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1108
Author(s):  
Manuela Curcio ◽  
Alessandro Paolì ◽  
Giuseppe Cirillo ◽  
Sebastiano Di Pietro ◽  
Martina Forestiero ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Metastatic Cancer ◽  
Stimuli Responsive ◽  
Cancer Disease ◽  
New Class ◽  
Self Assembling ◽  
Redox Responsive ◽  
Potential Applicability ◽  
Mean Size

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

scholarly journals Cube-Rhombellane Related Structures: A Drug Perspective

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2533 ◽  
Author(s):  
Mircea Vasile Diudea ◽  
Claudiu Nicolae Lungu ◽  
Csaba Levente Nagy
Keyword(s):  
Single Point ◽  
Molecular Graph ◽  
Molecular Structures ◽  
Combinatorial Synthesis ◽  
Stability Evaluation ◽  
New Class ◽  
Physico Chemical ◽  
Molecular Stability ◽  
Internal Mobility ◽  
Point Data

Rhombellanes represent a new class of structures, of which homeomorphs may be synthesized as real molecules. Cube-rhombellane is a double-shell structure, with vertices of degree 3 and 6, respectively. Several hypothetical structures/molecules were proposed and computed using molecular graph theory and coordination chemistry principles. Some geometries were optimized at the B3LYP/6-31G (d, p) level of theory, followed by harmonic vibrational frequency analysis at the same level of theory, single point data were collected in view of molecular stability evaluation. Some of the bioactive functionalized structures were also proposed and explored by molecular mechanics (MM)-based conformational analysis, to check their internal mobility. Drug-like properties of the proposed molecular structures were compared with some existing nano-molecules (fullerenes, nanotubes). ADME and other physico-chemical characteristics were computed using commercial software. Substructures of the proposed molecules, useful in a future synthesis, were provided by retro combinatorial synthesis (RECAP). Computational results obtained are promising regarding ADME properties, drug-likeness and nano-properties.

Biomimetic Hybrid Composites to Repair Osteochondral Lesions

2007 ◽  
pp. 927-930
Author(s):  
Anna Tampieri ◽  
Monica Sandri ◽  
Elena Landi ◽  
Daniele Pressato
Keyword(s):  
Hybrid Composites ◽  
Osteochondral Lesions

scholarly journals Sperm Cell Driven Microrobots—Emerging Opportunities and Challenges for Biologically Inspired Robotic Design

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 448 ◽  
Author(s):  
Ajay Singh ◽  
Mohammad Ansari ◽  
Mihir Mahajan ◽  
Shubhangi Srivastava ◽  
Shubham Kashyap ◽  
...  
Keyword(s):  
Targeted Drug Delivery ◽  
State Of The Art ◽  
Cell Manipulation ◽  
Small Scale ◽  
Sperm Cells ◽  
Biologically Inspired ◽  
New Class ◽  
Targeted Drug ◽  
New Applications ◽  
Coupling Mechanisms

With the advent of small-scale robotics, several exciting new applications like Targeted Drug Delivery, single cell manipulation and so forth, are being discussed. However, some challenges remain to be overcome before any such technology becomes medically usable; among which propulsion and biocompatibility are the main challenges. Propulsion at micro-scale where the Reynolds number is very low is difficult. To overcome this, nature has developed flagella which have evolved over millions of years to work as a micromotor. Among the microscopic cells that exhibit this mode of propulsion, sperm cells are considered to be fast paced. Here, we give a brief review of the state-of-the-art of Spermbots—a new class of microrobots created by coupling sperm cells to mechanical loads. Spermbots utilize the flagellar movement of the sperm cells for propulsion and as such do not require any toxic fuel in their environment. They are also naturally biocompatible and show considerable speed of motion thereby giving us an option to overcome the two challenges of propulsion and biocompatibility. The coupling mechanisms of physical load to the sperm cells are discussed along with the advantages and challenges associated with the spermbot. A few most promising applications of spermbots are also discussed in detail. A brief discussion of the future outlook of this extremely promising category of microrobots is given at the end.

scholarly journals Synthesis, Spectroscopic and Toxicity Studies of Titanocene Chelates of Isatin-3-Thiosemicarbazones

2005 ◽  
Vol 3 (3-4) ◽  
pp. 151-160 ◽  
Author(s):  
Garima Vatsa ◽  
O. P. Pandey ◽  
S. K. Sengupta
Keyword(s):  
Enzyme Inhibitor ◽  
Spectral Studies ◽  
Inhibitor Complex ◽  
New Class ◽  
Toxicity Studies ◽  
Physico Chemical ◽  
Acetylcholinesterase Enzyme ◽  
Lymnaea Acuminata ◽  
Coordinate Structures

The reactions of bis(cyclopentadienyl)titanium(IV) dichloride with a new class of thiosemicarbazone (LH2), derived by condensing isatin with different N(4)-substituted thiosemicarbazides, have been studied and products of type [Cp2Ti(L)] have been isolated. On the basis of various physico-chemical and spectral studies, five coordinate structures have been assigned to these derivatives. Toxicity studies of titanocene complexes at tbur different concentrations have been carried out against snailLymnaea acuminata. The effect of most potent compounds on the activity of acetylcholinesterase enzyme, which inhibits the activity of enzyme, possibly by the formation of enzyme-inhibitor complex, was also studied.

scholarly journals Self-Assembling Peptides and Carbon Nanomaterials Join Forces for Innovative Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4084
Author(s):  
Petr Rozhin ◽  
Costas Charitidis ◽  
Silvia Marchesan
Keyword(s):  
Carbon Nanostructures ◽  
Biomedical Applications ◽  
Carbon Nanomaterials ◽  
Chemical Properties ◽  
Building Blocks ◽  
Research Areas ◽  
Self Assembling ◽  
Concise Review ◽  
Physico Chemical ◽  
Great Progress

Self-assembling peptides and carbon nanomaterials have attracted great interest for their respective potential to bring innovation in the biomedical field. Combination of these two types of building blocks is not trivial in light of their very different physico-chemical properties, yet great progress has been made over the years at the interface between these two research areas. This concise review will analyze the latest developments at the forefront of research that combines self-assembling peptides with carbon nanostructures for biological use. Applications span from tissue regeneration, to biosensing and imaging, and bioelectronics.

Gemini surfactants: a new class of self-assembling molecules

1993 ◽  
Vol 115 (22) ◽  
pp. 10083-10090 ◽  
Author(s):  
F. M. Menger ◽  
C. A. Littau
Keyword(s):  
Gemini Surfactants ◽  
New Class ◽  
Self Assembling
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