scholarly journals Half-Antibody Functionalized Lipid−Polymer Hybrid Nanoparticles for Targeted Drug Delivery to Carcinoembryonic Antigen Presenting Pancreatic Cancer Cells

2010 ◽  
Vol 7 (3) ◽  
pp. 914-920 ◽  
Author(s):  
Che-Ming Jack Hu ◽  
Sharmeela Kaushal ◽  
Hop S. Tran Cao ◽  
Santosh Aryal ◽  
Marta Sartor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Carcinoembryonic Antigen ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Pancreatic Cancer Cells ◽  
Targeted Drug ◽  
Antigen Presenting

Lipid-polymer hybrid nanoparticles as a targeted drug delivery system for melanoma treatment

2020 ◽  
pp. 1-12 ◽  
Author(s):  
Rodrigo Scopel ◽  
Manuel A. Falcão ◽  
Angélica Regina Cappellari ◽  
Fernanda B. Morrone ◽  
Silvia S. Guterres ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Melanoma Treatment ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

scholarly journals Discovery and in Vivo Evaluation of Novel RGD-Modified Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery

2014 ◽  
Vol 15 (10) ◽  
pp. 17565-17576 ◽  
Author(s):  
Yinbo Zhao ◽  
Dayong Lin ◽  
Fengbo Wu ◽  
Li Guo ◽  
Gu He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Hybrid Nanoparticles ◽  
In Vivo Evaluation ◽  
Polymer Hybrid ◽  
Targeted Drug

Hyaluronic acid modified mesoporous carbon nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells

2016 ◽  
Vol 27 (13) ◽  
pp. 135102 ◽  
Author(s):  
Long Wan ◽  
Jian Jiao ◽  
Yu Cui ◽  
Jingwen Guo ◽  
Ning Han ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Carbon Nanoparticles ◽  
Mesoporous Carbon ◽  
Targeted Drug

scholarly journals Aptamer-modified polymer nanoparticles for targeted drug delivery

2016 ◽  
Vol 17 (1-2) ◽  
Author(s):  
Julia Modrejewski ◽  
Johanna-Gabriela Walter ◽  
Imme Kretschmer ◽  
Evren Kemal ◽  
Mark Green ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Mode Of Delivery ◽  
Delivery Systems ◽  
The Body ◽  
Lung Cancer Cells ◽  
Targeted Drug

AbstractThe purpose of this study was to develop a model system for targeted drug delivery. This system should enable targeted drug release at a certain tissue in the body. In conventional drug delivery systems, drugs are often delivered unspecifically resulting in unwarranted adverse effects. To circumvent this problem, there is an increasing demand for the development of intelligent drug delivery systems allowing a tissue-specific mode of delivery. Within this study, nanoparticles consisting of two biocompatible polymers are used. Because of their small size, nanoparticles are well-suited for effective drug delivery. The small size affects their movement through cell and tissue barriers. Their cellular uptake is easier when compared to larger drug delivery systems. Paclitaxel was encapsulated into the nanoparticles as a model drug, and to achieve specific targeting an aptamer directed against lung cancer cells was coupled to the nanoparticles surface. Nanoparticles were characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), and nanotracking analysis (NTA). Also their surface charge was characterized from ζ-potential measurements. Their preparation was optimized and subsequently specificity of drug-loaded and aptamer-functionalized nanoparticles was investigated using lung cancer cells.

In vitro study of doxorubicin-loaded thermo- and pH-tunable carriers for targeted drug delivery to liver cancer cells

2021 ◽  
Vol 104 ◽  
pp. 93-105
Author(s):  
Sikhumbuzo Charles Kunene ◽  
Kuen-Song Lin ◽  
Meng-Tzu Weng ◽  
Maria Janina Carrera Espinoza ◽  
Chun-Ming Wu
Keyword(s):  
Drug Delivery ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
In Vitro Study ◽  
Vitro Study ◽  
Liver Cancer Cells ◽  
Targeted Drug

Design and Function of Engineered Protein Nanocages as a Drug Delivery System for Targeting Pancreatic Cancer Cells via Neuropilin-1

2015 ◽  
Vol 12 (5) ◽  
pp. 1422-1430 ◽  
Author(s):  
Masaharu Murata ◽  
Sayoko Narahara ◽  
Takahito Kawano ◽  
Nobuhito Hamano ◽  
Jing Shu Piao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Pancreatic Cancer Cells ◽  
Neuropilin 1 ◽  
And Function
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