scholarly journals Aptamer-modified polymer nanoparticles for targeted drug delivery

2016 ◽  
Vol 17 (1-2) ◽  
Author(s):  
Julia Modrejewski ◽  
Johanna-Gabriela Walter ◽  
Imme Kretschmer ◽  
Evren Kemal ◽  
Mark Green ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Mode Of Delivery ◽  
Delivery Systems ◽  
The Body ◽  
Lung Cancer Cells ◽  
Targeted Drug

AbstractThe purpose of this study was to develop a model system for targeted drug delivery. This system should enable targeted drug release at a certain tissue in the body. In conventional drug delivery systems, drugs are often delivered unspecifically resulting in unwarranted adverse effects. To circumvent this problem, there is an increasing demand for the development of intelligent drug delivery systems allowing a tissue-specific mode of delivery. Within this study, nanoparticles consisting of two biocompatible polymers are used. Because of their small size, nanoparticles are well-suited for effective drug delivery. The small size affects their movement through cell and tissue barriers. Their cellular uptake is easier when compared to larger drug delivery systems. Paclitaxel was encapsulated into the nanoparticles as a model drug, and to achieve specific targeting an aptamer directed against lung cancer cells was coupled to the nanoparticles surface. Nanoparticles were characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), and nanotracking analysis (NTA). Also their surface charge was characterized from ζ-potential measurements. Their preparation was optimized and subsequently specificity of drug-loaded and aptamer-functionalized nanoparticles was investigated using lung cancer cells.

Improved Therapeutic Efficacy of Topotecan Against A549 Lung Cancer Cells with Folate-targeted Topotecan Liposomes

2020 ◽  
Vol 21 (11) ◽  
pp. 902-909
Author(s):  
Jingxin Zhang ◽  
Weiyue Shi ◽  
Gangqiang Xue ◽  
Qiang Ma ◽  
Haixin Cui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Lung Tumor ◽  
A549 Cells ◽  
Delivery Systems ◽  
Lung Cancer Cells

Background: Among all cancers, lung cancer has high mortality among patients in most of the countries in the world. Targeted delivery of anticancer drugs can significantly reduce the side effects and dramatically improve the effects of the treatment. Folate, a suitable ligand, can be modified to the surface of tumor-selective drug delivery systems because it can selectively bind to the folate receptor, which is highly expressed on the surface of lung tumor cells. Objective: This study aimed to construct a kind of folate-targeted topotecan liposomes for investigating their efficacy and mechanism of action in the treatment of lung cancer in preclinical models. Methods: We conjugated topotecan liposomes with folate, and the liposomes were characterized by particle size, entrapment efficiency, cytotoxicity to A549 cells and in vitro release profile. Technical evaluations were performed on lung cancer A549 cells and xenografted A549 cancer cells in female nude mice, and the pharmacokinetics of the drug were evaluated in female SD rats. Results: The folate-targeted topotecan liposomes were proven to show effectiveness in targeting lung tumors. The anti-tumor effects of these liposomes were demonstrated by the decreased tumor volume and improved therapeutic efficacy. The folate-targeted topotecan liposomes also lengthened the topotecan blood circulation time. Conclusion: The folate-targeted topotecan liposomes are effective drug delivery systems and can be easily modified with folate, enabling the targeted liposomes to deliver topotecan to lung cancer cells and kill them, which could be used as potential carriers for lung chemotherapy.

scholarly journals MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells

2009 ◽  
Vol 7 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Jagadeesh Setti Guthi ◽  
Su-Geun Yang ◽  
Gang Huang ◽  
Shunzi Li ◽  
Chalermchai Khemtong ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Lung Cancer Cells ◽  
Targeted Drug

Targeted Drug Delivery in Cancer Treatment

2021 ◽  
pp. 356-381
Author(s):  
Farhad Bano ◽  
Khalid Umar Fakhri ◽  
M. Moshahid Alam Rizvi
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Cytotoxic Agents ◽  
Potential Candidate ◽  
Tumor Site ◽  
Innovative Methods ◽  
Targeted Drug

In a conventional oral or intravascular drug delivery approach, therapeutic factors are distributed throughout the body and only a limited part of the drug reaches to tumor site. Packaging of cytotoxic agents in drug delivery systems like nanoparticles could enhance its delivery to specific targets in the tumors and could be potential candidate for therapeutics advancement. Targeted drug delivery holds the potential to overcome the present therapeutics of cancer by selective delivery of an arbitrary amount of drug at the tumor site. Loading of cytotoxic agents in drug delivery systems could enhance its delivery to specific targets based on strategy to reach the tumor site. This chapter explores the detailed of innovative methods of drug delivery, challenges of targeted drug delivery, and their implications.

Tumor-targeted drug delivery systems for anticancer therapies can selectively provide an appropriate cytotoxic payload to cancer cells, reducing the side effects of chemo.

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Increased Risk ◽  
Long Term Treatment ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Anticancer drugs aim to quickly divide and kill or destroy cells. Chemotherapy is effective, but it has the drawback of being unspecific. Other disadvantages of classical chemotherapy include inadequate drug therapy indices, evident toxicity, and increased risk of multidrug resistance (MDR) in long-term treatment. Furthermore, when these chemotherapy drugs are usually supplied, the dose may cause harm to many other critical organs in addition to healthy cells. Anticancer therapies are intensely interested in tumor-targeted drug delivery systems, since they not only boost the safety and efficacy of the drug, but also reduce the catastrophic side effects associated with chemotherapy. Such dynamically customized drug delivery devices can selectively provide an appropriate cytotoxic payload to cancer cells. They are beneficial in reducing some of the primary limitations of conventional medicines, such as bypassing biological barriers and overcoming drug resistance. Targeted medications limit harm to healthy cells while killing cancer cells. Because of their obvious benefits, customized medication delivery systems have taken their position in the drug delivery industry. Various ligands have grabbed researchers' attention in biological and therapeutic contexts and will continue to do so. FA-targeted delivery methods have already shown great effectiveness in preclinical models and considerable promise for future clinical applications. Because FR is overexpressed in a number of malignancies, FA must be employed as the preferred ligand to selectively target tumor cells and enjoy the benefits. Under in vitro, physiological and different storage circumstances, FA-(co)polymer and FA-drug conjugates were substantially more stable. To summarize, the major advantages of cancer targeting FA-nanoconjugates include selective internalization of nanoconjugates by cells (over) expressing FRs, simple conjugation chemistry, non-immunogenicity, and retention of nanoconjugate cargo in the endocytic vesicle after internalization rather than lysosomal processing as is the case with antibody.

Recent Advances in the Development of Polymeric Nanocarrier Formulations for the Treatment of Colon Cancer

2019 ◽  
Vol 9 (1) ◽  
pp. 2-14
Author(s):  
Sahil Kumar ◽  
Bandna Sharma ◽  
Kiran Thakur ◽  
Tilak R. Bhardwaj ◽  
Deo N. Prasad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Hyaluronic Acid ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Near Ir ◽  
Targeted Drug ◽  
Poly Ethylene ◽  
Novel Drug

Background: Many efforts have been explored in the last decade to treat colon cancer but nanoparticulate drug delivery systems are making a vital contribution in the improvement of drug delivery to colon cancer cells. Objective: In this review, we attempt to highlight recent advancements in the development of novel drug delivery systems of nanoparticles for the targeted drug delivery to colon. Polymers like Epithelial Cell Adhesion Molecule (EpCAM) aptamer chitosan, Hyaluronic Acid (HA), Chitosan (CS)– Carboxymethyl Starch (CMS), silsesquioxane capped mesoporous silica, Near IR (NIR) fluorescent Human Serum Albumin (HAS), poly(ethylene glycol)-conjugated hyaluronic acid etc. have been discussed by employing various anticancer drugs like doxorubicin, oxaliplatin, paclitaxel, 5-fluorouracil etc. Conclusion: These novel drug delivery systems have been determined to be more efficacious in terms of stability, sustained and targeted drug delivery, therapeutic efficacy, improved bioavailability and enhanced anticancer activity.

scholarly journals Design of a novel curcumin-soybean phosphatidylcholine complex-based targeted drug delivery systems

Drug Delivery ◽  
2017 ◽  
Vol 24 (1) ◽  
pp. 707-719 ◽  
Author(s):  
Jiajiang Xie ◽  
Yanxiu Li ◽  
Liang Song ◽  
Zhou Pan ◽  
Shefang Ye ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems
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