Early-Stage Imaging of Nanocarrier-Enhanced Chemotherapy Response in Living Subjects by Scalable Photoacoustic Microscopy

AbstractBreast cancer is a heterogeneous disease and patients are managed clinically based on ER, PR, HER2 expression, and key risk factors. The use of gene expression assays for early stage disease is already common practice. These tests have found a place in risk stratifying the heterogeneous group of stage I–II breast cancers for recurrence, for predicting chemotherapy response, and for predicting breast cancer-related mortality. Most guidelines for hormone receptor (HR)–positive early breast cancer recommend addition of adjuvant chemotherapy for most women, leading to overtreatment, which causes considerable morbidity and cost. Expert oncologist discussed about strategies of gene expression assays and aid in chemotherapy recommendations for treatment of HR + ve EBC and the expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at this practical consensus recommendations for the benefit of community oncologists.

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Caspase-3 can not be Used to Predict the Response to Neoadjuvant Chemotherapy Regiment PVB in Cervical Cancer Stage IB-IIA

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v1i3.357 ◽

2016 ◽

pp. 156-160

Author(s):

Ediwibowo Ambari ◽

Hariyono Winarto ◽

Bambang Sutrisna ◽

Budiningsih Siregar

Keyword(s):

Cervical Cancer ◽

Neoadjuvant Chemotherapy ◽

Caspase 3 ◽

Early Stage ◽

Response To Therapy ◽

Bivariate Analysis ◽

Chemotherapy Response ◽

Cancer Stage ◽

Significant Difference ◽

Early Stage Cervical Cancer

Objectives: To determine the factors that may be used as the prognostic parameter for the therapeutic efficacy of neoadjuvant chemotherapy, which can be used to revising the management of early stage cervical cancer patients with large lesions. Methods: This was a retrospective cohort study. The study was conducted in the Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia. The subjects were 15 cervical cancer stage IB2 and IIA patients with lesions’ size of > 4 cm, who would be treated with neoadjuvant chemotherapy, consisted of cisplatin 50 mg/m2, vincristine 2 mg/m2 and bleomycin 15 mg regiment. The patients’ response would be evaluated after completing 3 series of chemotherapy. Data was retrieved from medical records and cervical biopsy paraffin blocks and examined histopathologically using IHC staining to see expression of caspase-3 with histoscore assessment score. Data was analyzed by univariate, bivariate analysis. Results: Response to PVB neoadjuvant chemotherapy was found in 5 out of 15 patients. None of the clinicopathology variables can be used to predict response to therapy. Expression of caspase-3 as a marker of apoptosis, can not predict the response of the therapy before administrating neoadjuvant chemotherapy either. There is a significant difference between the levels of caspase-3 in epidermoid carcinoma with adenocarcinoma, with p value of 0.02 (RR 6;95% CI 1.69-21.26). Conclusion: Clinicopathologic factors and the expression of caspase-3 before getting chemotherapy neoadjuvant can not predict the succeed of the therapy. [Indones J Obstet Gynecol 2013; 1-3: 156-60] Keywords: caspase -3, clinicopathologic, early-stage cervical cancer lession in large, neoadjuvant chemotherapy response to therapy

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Inflammatory markers in early-stage breast cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.e11537 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. e11537-e11537

Author(s):

Hilbrahim Petekkaya ◽

Sercan Aksoy ◽

Gizem Gecmez ◽

Emre Kulahcioglu ◽

Alexis K. Okoh ◽

...

Keyword(s):

Breast Cancer ◽

Inflammatory Markers ◽

Early Stage ◽

Disease Free Survival ◽

Serum Markers ◽

Early Stage Breast Cancer ◽

Chemotherapy Response ◽

Significant Difference ◽

Stage Ia

e11537 Background: In a few number of studies a possible relationship between inflammatory markers and the prognosis, chemotherapy response and survival in breast cancer has been reported. The aim of this study is to point out the place of serum markers as a prognostic factor in early stage breast cancer. Methods: This study was conducted in Hacettepe University Cancer Institute. Patients operated and stage IA to III C for breast cancer between December 2009 and June 2012 were included the study. Before the any adjuvant therapy inflammation markers were studied. Results: A total of 704 patients were included in the study. The median age of the patients was 50 (25-92). 42,8% of the patients were premenopausal and 48,2% postmenopausal. The median follow up period for the whole study group was 22 months (3-287). We studied the CRP, erythrocyte sedimentation rate, B2 microglobulin, LDH, albumin, and ferritin studied and values for each marker were grouped as high and normal. There was no statistically significant difference in disease free survival and overall survival for each marker who had high and normal levels. Conclusions: We did not found any inflammatory markers as a prognostic value. However our follow up time is short and we should be wait for more mature data.

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Optical Tomography with Ultrasound Localization: Initial Clinical Results and Technical Challenges

Technology in Cancer Research & Treatment ◽

10.1177/153303460500400302 ◽

2005 ◽

Vol 4 (3) ◽

pp. 235-244 ◽

Cited By ~ 12

Author(s):

Quing Zhu

Keyword(s):

Optical Imaging ◽

Early Stage ◽

Optical Tomography ◽

Hemoglobin Concentration ◽

Clinical Results ◽

Optical Measurements ◽

Chemotherapy Response ◽

Ultrasound Localization ◽

Imaging Reconstruction ◽

Distorted Distributions

Optical tomography with ultrasound localization utilizes co-registered ultrasound lesion structure information to guide optical imaging reconstruction. A hand-held probe consisting of a commercial ultrasound transducer and near infrared optical imaging sensors was used to simultaneously acquire ultrasound images and optical measurements. A dual-mesh scheme was used to map the ultrasound-visible lesions to finer-grid lesion regions and coarser-grid background regions for optical imaging reconstruction. As a result, optical imaging reconstruction was well-conditioned for inverse mapping of lesion hemoglobin concentration and blood oxygen saturation. Initial clinical results have shown that early stage invasive cancers may be distinguished by a two-fold greater total hemoglobin concentration compared with fibroadenomas and other benign lesions. Initial results of advanced cancers have shown that the hemoglobin distribution is highly distorted and heterogeneous and the distorted distributions correlate with histological microvessel density counts and could be used to assess chemotherapy response.

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Testicular Seminoma: Correlation Between Staging and Chemotherapy Response, Two Years Overall Survival Rate

JBN (Jurnal Bedah Nasional) ◽

10.24843/jbn.2019.v03.i01.p05 ◽

2019 ◽

Vol 3 (1) ◽

pp. 24

Author(s):

Ida Bagus Putra Pramana ◽

Lukman Hakim ◽

Wahjoe Djatisoesanto ◽

Sunaryo Hardjowijoto

Keyword(s):

Overall Survival ◽

Survival Rate ◽

Early Stage ◽

Tumor Staging ◽

Previous History ◽

Stage I ◽

Chemotherapy Response ◽

Overall Survival Rate ◽

Testicular Seminoma ◽

Response To Chemotherapy

Objective: to determine the patient’s characteristics, correlation between staging and chemotherapy response, furthermore two years overall survival rate. Methods: a retrospective analytic study was conducted. Data were obtained from medical records in January 2008 to December 2014 and analyzed using SPSS 17.0. All of correlation between staging and chemotherapy response, primary tumor staging (pT) and metastasis (M), regional lymph nodes staging (N) and metastasis (M), serum tumor marker and chemotherapy response were tested by Spearman correlation test. Two years overall survival rate was analyzed by Kaplan-Meier. Data ratio with normal distribution was tested by Paired T-test. Results: the mean age of patients were 31.03 ± 13.751 years, with seven patients (15.6%) had previous history of undescended testis. Based on TNM staging, we found that most patients had already develop into stage pT3 (46.7%), N3 (57.7%), and M0 (57.7%). A significant correlation between staging and chemotherapy response was shown with stage I of testicular seminoma had completely chemotherapy response (100%) and two years overall survival rate in stage I was 100%, whereas in metastatic seminoma (stage II and III) was 60%, with Hazard Ratio 0.63 (p=0.294; 95%CI 0.276-1.476). Conclusion: patients in early stage of testicular seminoma will give a better response to chemotherapy and will have better survival rate compared to those with metastatic seminoma.

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Photoacoustic microscopy of arteriovenous shunts and blood diffusion in early-stage tumors

Journal of Biomedical Optics ◽

10.1117/1.jbo.21.2.020501 ◽

2016 ◽

Vol 21 (02) ◽

pp. 1 ◽

Cited By ~ 3

Author(s):

Chenghung Yeh ◽

Jinyang Liang ◽

Yong Zhou ◽

Song Hu ◽

Rebecca E. Sohn ◽

...

Keyword(s):

Early Stage ◽

Photoacoustic Microscopy ◽

Arteriovenous Shunts

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Correlations Between Staging and Chemotheraphy Response with Testicular Carcinoma Non-Seminoma at Dr. Soetomo Hospital, Surabaya, Indonesia

Folia Medica Indonesiana ◽

10.20473/fmi.v56i3.22164 ◽

2020 ◽

Vol 56 (3) ◽

pp. 178

Author(s):

Achmad Nugroho ◽

Johan Renaldo ◽

Wahjoe Djatisoesanto

Keyword(s):

Side Effects ◽

Tumor Marker ◽

Complete Blood Count ◽

Early Stage ◽

Tumor Staging ◽

Serum Levels ◽

Chemotherapy Response ◽

Serum Tumor Marker ◽

Regional Lymph Nodes ◽

Response To Chemotherapy

The purpose of this study was to describe patients’ characteristics, correlation between staging non-seminoma cancer and chemotherapy response. Data on age, location of tumor, staging, serum levels of the tumor marker post operative, adjuvant therapy, chemotherapy side effects, and response of patient to chemotherapy were gained from medical records in Soetomo Hospital Surabaya from January 2012 to December 2015, and analyzed with SPSS. Correlation between staging and chemotherapy response, correlation primary tumor staging (pT) and Metastasis (M), correlation regional lymph nodes staging (N) and metastasis (M), correlation serum tumor marker and chemotherapy response was proccessed by Spearman correlation test. There were no significant correlation between pT staging and M and no significant correlation between N and M staging. Based on tumor markers (S), mostly patients were S2. There were no significant correlation between the response to chemotherapy and serum tumor marker levels. In category of staging group, the most are 14 patients stage III. BEP was the most adjuvant Chemotherapy. Nausea and vomiting were The most complained during chemotherapy. Anemia were the most hematologic side effects of chemotherapy. There are no significant correlation between the staging of non-seminoma and the response to chemotherapy. Conclusion: Non seminoma mostly happened in young males. Non-seminoma responses to chemotherapy. Patients in early stage would give a good response to chemotherapy compared to those with advanced stage. After chemotherapy, evaluation should be done to the patients' complaints and complete blood count to detect side effects.

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