Ouabain Induces Apoptosis on PHA-Activated Lymphocytes
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Apoptotic cell death plays a critical role in immune system homeostasis, and c-myc protooncogene deregulated expression is a component of this programmed genomic response. Pharmacological intervention and modulation of peripheral lymphocytes apoptosis would have important implications. The present results indicate that ouabain, a specific inhibitor of Na+ K+-ATPase, promotes an increased expression of c-myc mRNA, and induces apoptosis in PHA-stimulated lymphocytes. Furthermore, this ouabain-induced apoptosis cannot be counteracted by the addition of exogenous IL-2.
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2011 ◽
Vol 8
(3)
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pp. 210-218
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1998 ◽
Vol 274
(1)
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pp. H242-H248
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2013 ◽
Vol 33
(16)
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pp. 3137-3149
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